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Endocrinology-metabolism / Original Article
The clinical meaning of pre- and post-ablation thyroglobulin levels at first radioiodine therapy in patients with papillary thyroid cancer
Hee Kyung Kim, Jee Hee Yoon, Jin Seong Cho, Seong Young Kwon, Su Woong Yoo, Ho-Cheol Kang
Korean J Intern Med. 2020;35(5):1164-1172. Published online July 29, 2019
Background/Aims: This study was conducted to identify prognostic factors in patients with papillary thyroid cancer (PTC) at the time of first radioactive iodine (RAI) therapy, and to evaluate the clinical value of the thyroglobulin (Tg) increase after RAI.
Methods: Serum Tg was sampled prior to (pr..
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Pulmonology / Original Article
Impact of gender on chronic obstructive pulmonary disease outcomes: a propensity score-matched analysis of a prospective cohort study
Jaeyoung Cho, Chang-Hoon Lee, Deog Kyeom Kim, Hun-Gyu Hwang, Yu-Il Kim, Hye Sook Choi, Jeong-Woong Park, Kwang Ha Yoo, Ki-Suck Jung, Sang-Do Lee; the KOLD and KOCOSS Investigators
Korean J Intern Med. 2020;35(5):1154-1163. Published online February 27, 2020
Background/Aims: Despite increasing awareness of the burden of chronic obstructive pulmonary disease (COPD) in women, knowledge regarding gender differences in COPD outcomes is limited. Therefore, we aimed to evaluate whether COPD outcomes, including exacerbations, lung function, and symptoms differ..
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Pulmonology / Original Article
The health-related quality-of-life of chronic obstructive pulmonary disease patients and disease-related indirect burdens
Hye Sook Choi, Dong-Wook Yang, Chin Kook Rhee, Hyoung Kyu Yoon, Jin Hwa Lee, Seong Yong Lim, Yu-Il Kim, Kwang Ha Yoo, Yong-Il Hwang, Sang Haak Lee, Yong Bum Park
Korean J Intern Med. 2020;35(5):1136-1144. Published online February 20, 2020
Background/Aims: Many chronic obstructive pulmonary disease (COPD) patients have physical limitations. We investigated EuroQol five-dimensions five-level (EQ-5D-5L) of COPD patients to assess quality of life, and assessed indirect burden including time expenditure to visit doctor, home care rate, an..
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Gastroenterology / Original Article
Impact of early anti-TNF use on clinical outcomes in Crohn’s disease: a nationwide population-based study
Yoon Suk Jung, Minkyung Han, Sohee Park, Jae Hee Cheon
Korean J Intern Med. 2020;35(5):1104-1113. Published online April 21, 2020
Background/Aims: The optimal timing for initiation of anti-tumor necrosis factor (TNF) therapy in Crohn’s disease (CD) is still debated. Little is known about the clinical outcomes of early versus late administration of anti-TNF agents, especially in Asian CD patients. We aimed to evaluate the imp..
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Gastroenterology / Original Article
Impact of previous metronidazole exposure on metronidazole-based second-line quadruple therapy for Helicobacter pylori infection
Gil Ho Lee, Kee Myung Lee, Sung Jae Shin, Joon Koo Kang, Choong-Kyun Noh, Jin Hong Kim, Sun Gyo Lim
Korean J Intern Med. 2020;35(5):1094-1103. Published online July 31, 2020
Background/Aims: The negative effects on the eradication success of Helicobacter pylori infection after previous exposure to macrolides, including clarithromycin on clarithromycin-based first-line therapy have been demonstrated. However, whether this is true for metronidazole-based second-lin..
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Gastroenterology / Original Article
Proton pump inhibitor use is associated with hip fracture development: a nationwide population-based cohort study
Yang Won Min, Yeong Chan Lee, Kyunga Kim, Seungho Ryu, Kyoung Sub Hong, Han Ho Jeon, Yong Sung Kim, Jong Heon Park, Hee Jung Son, Poong-Lyul Rhee
Korean J Intern Med. 2020;35(5):1084-1093. Published online November 4, 2019
Background/Aims: Effect of proton pump inhibitor (PPI) use on the risk of hip fracture is controversial. This study aimed to clarify the association between PPI use and hip fracture risk using a large cohort.
Methods: This study recruited participants from the nationwide cohort (n = 1,025,340). Aft..
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Hemato-oncology / Original Article
Immature platelet fraction based diagnostic predictive scoring model for immune thrombocytopenia
Min Ji Jeon, Eun Sang Yu, Ka-Won Kang, Byung-Hyun Lee, Yong Park, Se Ryeon Lee, Hwa Jung Sung, Soo Yong Yoon, Chul Won Choi, Byung Soo Kim, Dae Sik Kim
Korean J Intern Med. 2020;35(4):970-978. Published online April 10, 2020
Background/Aims: The diagnosis of immune thrombocytopenia (ITP) is based on clinical manifestations and there is no gold standard. Thus, even hematologic malignancy is sometimes misdiagnosed as ITP and adequate treatment is delayed. Therefore, novel diagnostic parameters are needed to distinguish IT..
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Endocrinology-metabolism / Original Article
Predictive costs in medical care for Koreans with metabolic syndrome from 2009 to 2013 based on the National Health Insurance claims dataset
Jeong Seon Yoo, Eun Yeong Choe, Yoo Mee Kim, Se Hwa Kim, Young Jun Won
Korean J Intern Med. 2020;35(4):936-945. Published online August 19, 2019
Background/Aims: Although metabolic syndrome has been associated with increasing medical costs worldwide, there have been no studies using a nationwide and longitudinal South Korean dataset. We investigated trends in subsidized medical costs among Korean adults with metabolic syndrome.
Methods: Thi..
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Cardiology / Original Article
Clinical significance of postoperative atrial arrhythmias in patients who underwent lung transplantation
Byung Gyu Kim, Jae-Sun Uhm, Pil-Sung Yang, Hee Tae Yu, Tae-Hoon Kim, Boyoung Joung, Hui-Nam Pak, Song Yee Kim, Moo Suk Park, Jin Gu Lee, Hyo Chae Paik, Moon-Hyoung Lee
Korean J Intern Med. 2020;35(4):897-905. Published online November 25, 2019
Background/Aims: Atrial arrhythmia (AA) occasionally occurs after lung transplantation (LT); however, risk factors for AA and their impact on clinical outcomes are inconsistent. We aimed to investigate the incidence, predisposing factors, and clinical outcomes of AA after LT.
Methods: We retrospect..
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Guideline / Brief Communication
Consensus statement on coronary intervention during the coronavirus disease 19 pandemic: from the Korean Society of Interventional Cardiology
Kwan Yong Lee, Bong-Ki Lee, Won-Jang Kim, Se Hun Kang, Taek Kyu Park, Song-Yi Kim, Jung-Won Suh, Chang-Hwan Yoon, Dong Heon Yang, Sung Kee Ryu, Sang-Hyun Kim, Sung Yun Lee, In-Ho Chae; The Korean Society of Interventional Cardiology COVID-19 Task Force Team
Korean J Intern Med. 2020;35(4):749-757. Published online July 1, 2020
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the novel virus severe acute respiratory syndrome coronavirus 2. The first case developed in December, 2019 in Wuhan, China; several months later, COVID-19 has become pandemic, and there is no end in sight. This disaster is..
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Review / Brief Communication
Current laboratory diagnosis of coronavirus disease 2019
Jihyang Lim, Jehoon Lee
Korean J Intern Med. 2020;35(4):741-748. Published online July 1, 2020
Coronavirus disease 2019 (COVID-19) emerged in December 2019 in Wuhan, China; it has since caused a pandemic, with more than 10,000 confirmed cases (> 800,000 tests) in Korea as of May 2020. Real-time reverse transcription polymerase chain reaction (RT-PCR) is currently the most commonly used method..
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Rheumatology / Original Article
Liver enzyme elevation in patients with ankylosing spondylitis treated with tumor necrosis factor inhibitors: a single-center historical cohort study
Su Jin Choi, Ji Seon Oh, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Yong-Gil Kim
Korean J Intern Med. 2020;35(3):723-731. Published online December 26, 2019
Background/Aims: Tumor necrosis factor inhibitors (TNFi) have been known to induce liver enzyme elevation, sometimes associated with viral reactivation or toxic hepatitis. We evaluated the incidence and risk factors of TNFi-associated liver enzyme elevation in Korean ankylosing spondylitis (AS) pati..
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Allergy / Original Article
Incidence of teicoplanin adverse drug reactions among patients with vancomycin-associated adverse drug reactions and its risk factors
Byung-Keun Kim, Jung-Hyun Kim, Kyoung-Hee Sohn, Ju-Young Kim, Yoon-Seok Chang, Sae-Hoon Kim
Korean J Intern Med. 2020;35(3):714-722. Published online November 15, 2019
Background/Aims: Teicoplanin can be used as an alternative to vancomycin when treating beta-lactam-resistant gram-positive bacterial infections. Both vancomycin and teicoplanin are associated with relatively high rates of adverse drug reactions (ADRs), including hypersensitivity reactions. There is ..
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Infectious diseases / Original Article
Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013
Bongyoung Kim, Hyeonjun Hwang, Jieun Kim, Myoung-jae Lee, Hyunjoo Pai
Korean J Intern Med. 2020;35(3):703-713. Published online September 27, 2018
Background/Aims: This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea.
Methods: This study collated antibiotic prescription data and total patient days for inpatients at a tertiary care hospital in Korea between 2004 and 2013. The consumption of each ..
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Hemato-oncology / Original Article
Risk factors for primary lung cancer among never-smoking women in South Korea: a retrospective nationwide population-based cohort study
Yoon Ho Ko, Seung Joon Kim, Wan-Seop Kim, Chan Kwon Park, Cheol-Kyu Park, Yang-Gun Suh, Jung Seop Eom, Sukki Cho, Jae Young Hur, Sung Ho Hwang, Jun-Pyo Myong
Korean J Intern Med. 2020;35(3):692-702. Published online February 19, 2020
Background/Aims: We performed a large-scale, retrospective, nationwide, cohort study to investigate the risk factors for lung cancer among never-smoking Korean females.
Methods: The study data were collected from a general health examination and questionnaire survey of eligible populations conducte..
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Nephrology / Original Article
Urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 as biomarkers of patients with established acute kidney injury
Won Yong Cho, Sung Yoon Lim, Ji Hyun Yang, Se Won Oh, Myung-Gyu Kim, Sang-Kyung Jo
Korean J Intern Med. 2020;35(3):662-671. Published online December 23, 2019
Background/Aims: Urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been recently discovered and validated as sensitive biomarkers that can predict stage 2 or 3 acute kidney injury (AKI) development in high-risk patients. We aimed ..
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Cardiology / Original Article
Prevention of medical malpractice and disputes through analysis of lawsuits related to coronary angiography and intervention
Cheol Won Hyeon, Won Lee, So Yoon Kim, Ji Yong Park, Su Hwan Shin
Korean J Intern Med. 2020;35(3):605-618. Published online June 14, 2019
Background/Aims: Possible fatal complications arising from coronary angiography (CAG), percutaneous coronary intervention (PCI), and coronary artery disease itself, are likely to cause medical disputes. Presenting the current status and reasons for judgments given in lawsuits related to CAG/PCI, thi..
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Cardiology / Original Article
Gender differences in the presentation of chest pain in obstructive coronary artery disease: results from the Korean Women’s Chest Pain Registry
Dong-Hyuk Cho, Jimi Choi, Mi-Na Kim, Hack-Lyoung Kim, Yong Hyun Kim, Jin Oh Na, Jin-Ok Jeong, Hyun Ju Yoon, Mi-Seung Shin, Myung-A Kim, Kyung-Soon Hong, Gil Ja Shin, Seong-Mi Park, Wan Joo Shim
Korean J Intern Med. 2020;35(3):582-592. Published online March 19, 2019
Background/Aims: Chest pain in patients with obstructive coronary artery disease (OCAD) is affected by several social factors. The gender-based differences in chest pain among Koreans have yet to be investigated.
Methods: The study consecutively enrolled 1,549 patients (male/female, 514/1,035; 61 ..
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Gastroenterology / Original Article
Effects of probiotics or broccoli supplementation on Helicobacter pylori eradication with standard clarithromycin-based triple therapy
Young Woon Chang, Yoo Min Park, Chi Hyuk Oh, Shin Ju Oh, Jun-Hyung Cho, Jung-Wook Kim, Jae-Young Jang
Korean J Intern Med. 2020;35(3):574-581. Published online December 12, 2019
Background/Aims: The eradication failure rate of standard triple therapy (proton pump inhibitor, clarithromycin, and amoxicillin) for Helicobacter pylori infection has increased owing to antibiotic resistance in Korea. We assessed whether Saccharomyces boulardii probiotic or broccoli s..
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Review
Heart failure with preserved ejection fraction: insights from recent clinical researches
[corrected-article]
Mi-Na Kim, Seong-Mi Park
Korean J Intern Med. 2020;35(3):514-534. Published online April 29, 2020
Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for nearly half of the cases of HF and its incidence might be increasing with the aging society. Patients with HFpEF present with significant symptoms, including exercise intolerance, impaired quality of life, and have a poor progn..
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