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Infectious diseases / Original Article
Diagnostic role of mean platelet volume and neutrophil to lymphocyte ratio in childhood brucellosis
Şefika Elmas Bozdemir, Yasemin Ay Altıntop, Salih Uytun, Humeyra Aslaner, Yasemin Altuner Torun
Korean J Intern Med. 2017;32(6):1075-1081. Published online December 14, 2016
Background/Aims: Brucellosis patients present various non-specific clinical symptoms, such as fever, fatigue, sweating, joint pain, arthritis, myalgia, and headache. Based on the nonspecifity of its clinical signs and symtoms, we decided to evaluate whether mean platelet volume (MPV) , neutrophil to..
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Endocrinology-metabolism / Original Article
p22phox C242T gene polymorphism and overt diabetic nephropathy: a meta-analysis of 1,452 participants
Yan-yan Li, Ge Gong, Hong-yu Geng, Yun Qian
Korean J Intern Med. 2017;32(6):1045-1052. Published online December 8, 2016
Background/Aims: The p22phox C242T gene polymorphism (rs4673) may be linked to an increased susceptibility for overt diabetic nephropathy (ODN), but the study results are still inconclusive.
Methods: To explore the relationship between p22phox C242T gene polymorphism and ODN, the curr..
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Pulmonology / Original Article
Epidemiological trend of pulmonary thromboembolism at a tertiary hospital in Korea
Tae Yun Park, Jae-Woo Jung, Jae Chol Choi, Jong Wook Shin, Jae Yeol Kim, Byoung Whui Choi, In Won Park
Korean J Intern Med. 2017;32(6):1037-1044. Published online March 13, 2017
Background/Aims: Despite increasing interest in pulmonary thromboembolism (PTE), data on recent trends in PTE incidence are limited. This study evaluated the recent incidence rate of PTE.
Methods: We performed a retrospective chart review of patients with PTE admitted to Chung-Ang University Hospit..
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Cardiology / Original Article
LPL gene Pvu II polymorphism and hypertriglyceridemia: a meta-analysis involving 1,640 subjects
Yan-yan Li, Yan-hong Zhou, Ge Gong, Hong-yu Geng, Xin-xing Yang, Xiang-ming Wang, Chuan-wei Zhou, Jian Xu, Yun Qian
Korean J Intern Med. 2017;32(6):1018-1024. Published online May 16, 2017
Background/Aims: Although lipoprotein lipase (LPL) gene Pvu II polymorphism has been associated with an increased risk of hypertriglyceridemia (HT), there is no clear consensus within the scientific community.
Methods: A meta-analysis of 1,640 subjects from six individual studies was conduct..
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Rheumatology / Review
New insights into the genetics of fibromyalgia
Dong-Jin Park, Shin-Seok Lee
Korean J Intern Med. 2017;32(6):984-995. Published online October 23, 2017
Although debate on the concept of fibromyalgia (FM) has been vigorous ever since the classification criteria were first published, FM is now better understood and has become recognized as a disorder. Recently, FM has come to be considered a major health problem, affecting 1% to 5% of the general pop..
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Endocrinology-metabolism / Original Article
Low serum bilirubin level predicts the development of chronic kidney disease in patients with type 2 diabetes mellitus
Kang Hee Ahn, Sang Soo Kim, Won Jin Kim, Jong Ho Kim, Yun Jeong Nam, Su Bin Park, Yun Kyung Jeon, Bo Hyun Kim, In Joo Kim, Yong Ki Kim
Korean J Intern Med. 2017;32(5):875-882. Published online May 31, 2017
Background/Aims: We evaluated whether serum bilirubin levels can predict the development of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM).
Methods: This was a retrospective observational longitudinal study of patients presenting at the Pusan National University Hospi..
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Pulmonology / Original Article
The activation of NLRP3-inflammsome by stimulation of diesel exhaust particles in lung tissues from emphysema model and RAW 264.7 cell line
Soo-Taek Uh, So My Koo, Yangki Kim, Kiup Kim, Sungwoo Park, An Soo Jang, Dojin Kim, Yong Hoon Kim, Choon-Sik Park
Korean J Intern Med. 2017;32(5):865-874. Published online August 18, 2017
Background/Aims: Diesel exhaust particles (DEPs) lead to elevation of reactive oxygen species, which can activate the nucleotide-binding oligomerization domain-like receptor (NLR) family members containing the pyrin domain 3 (NLRP3)-inf lammasome. In this study, we elucidated whether NLRP3 -inf lamm..
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Cardiology / Original Article
Geographic and demographic variabilities of quantitative parameters in stress myocardial computed tomography perfusion
Jinoh Park, Hyun-Sook Kim, Hye Jeon Hwang, Dong Hyun Yang, Hyun Jung Koo, Joon-Won Kang, Young-Hak Kim
Korean J Intern Med. 2017;32(5):847-854. Published online July 28, 2017
Background/Aims: To evaluate the geographic and demographic variabilities of the quantitative parameters of computed tomography perfusion (CTP) of the left ventricular (LV) myocardium in patients with normal coronary artery on computed tomography angiography (CTA).
Methods: From a multicenter CTP r..
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Letter to the editor
The clinical usefulness of serum procalcitonin level in patients with scrub typhus
Chang-Seop Lee, Jeong-Hwan Hwang, Jeong-Mi Lee, Jae Hoon Lee
Korean J Intern Med. 2017;32(4):761-763. Published online February 4, 2016
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Letter to the editor
Thrombophilia after total gastrectomy for morbid obesity
Sae-Bom Shin, Yu-Na Jang, Hyeon-Jeong Lee, Yun-Mi Yi, Jong-Wook Lee, Woo-Sung Min, Ki-Seong Eom
Korean J Intern Med. 2017;32(4):758-760. Published online February 25, 2016
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Letter to the editor
Repeated isolated bilateral coronary ostial stenosis related to the syphilitic aortitis
Sang Min Kim, Sang Yeub Lee, Ju-Hee Lee, Jang-Whan Bae, Kyung-Kuk Hwang
Korean J Intern Med. 2017;32(4):747-749. Published online June 26, 2017
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Infectious diseases / Original Article
In vitro antiviral activity of ribavirin against severe fever with thrombocytopenia syndrome virus
Myung Jin Lee, Kye-Hyung Kim, Jongyoun Yi, Su Jin Choi, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Myoung-don Oh
Korean J Intern Med. 2017;32(4):731-737. Published online November 30, 2016
Background/Aims: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus. As yet, there is no effective antiviral therapy for SFTS. Ribavirin is a broad-spectrum antiviral agent, whic..
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Hemato-oncology / Original Article
Myeloma prognostic index at diagnosis might be a prognostic marker in patients newly diagnosed with multiple myeloma
Dae Sik Kim, Eun Sang Yu, Ka-Won Kang, Se Ryeon Lee, Yong Park, Hwa Jung Sung, Chul Won Choi, Byung Soo Kim
Korean J Intern Med. 2017;32(4):711-721. Published online November 4, 2016
Background/Aims: The aims of this study were to identify the value of inflammatory markers as pretreatment prognostic factors for patients with multiple myeloma (MM) and to estimate the value of a prognostic index including these markers at diagnosis.
Methods: A total of 273 newly diagnosed MM pati..
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Cardiology / Original Article
Maximal pericoronary adipose tissue thickness is associated with hypertension in nonobese
patients with acute or chronic illness
Shinhae Chang, Wangjin Lee, Byounggyu Kwag, Yun Hee Chung, In Sook Kang
Korean J Intern Med. 2017;32(4):668-674. Published online December 6, 2016
Background/Aims: Recent studies have shown an association of epicardial fat thickness with diabetes and hypertension (HTN) in asymptomatic populations. However, there is lack of information as to whether there is similar association between pericoronary adipose tissue (PAT) and HTN in the patients w..
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Cardiology / Review
Three-dimensional echocardiography in adult congenital heart disease
Hyun Suk Yang
Korean J Intern Med. 2017;32(4):577-588. Published online June 30, 2017
Congenital heart disease (CHD) is now more common in adults than in children due to improvements in fetal echo, neonatal and pediatric care, and surgical techniques leading to dramatically increased survivability into adulthood. Adult patients with CHD, regardless of prior cardiac surgery, experienc..
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Letter to the editor
Successful desensitization of pemetrexed-induced anaphylaxis in a patient with malignant mesothelioma
Jeonghwan Youk, Hyunkyung Park, Kwang Nam Jin, Hyun Jong Moon, Min-Suk Yang, Ki Hwan Kim, Jin-Soo Kim
Korean J Intern Med. 2017;32(3):563-565. Published online November 25, 2016
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Hemato-oncology / Original Article
Evaluation of the prevalence and clinical impact of toxocariasis in patients with eosinophilia of unknown origin
Hong-Beum Kim, Jun-Won Seo, Jun-Hyung Lee, Byung-Seok Choi, Sang-Gon Park
Korean J Intern Med. 2017;32(3):523-529. Published online March 30, 2017
Background/Aims: Eosinophilia has numerous diverse causes, and in many patients, it is not possible to establish the cause of eosinophilia. Recently, toxocariasis was introduced as one cause of eosinophilia. The aims of this study were to evaluate the prevalence of toxocariasis and the clinical impa..
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Cardiology / Original Article
Fragmented QRS and abnormal creatine kinase-MB are predictors of coronary artery disease in patients with angina and normal electrocardiographys
Jung Joo Lee, Jae Hoon Lee, Jin Woo Jeong, Jun Young Chung
Korean J Intern Med. 2017;32(3):469-477. Published online April 17, 2017
Background/Aims: Patients with symptoms of coronary artery disease (CAD) often display normal tracings or only nonspecific changes on electrocardiography (ECG). The aim of this study was to explore strategic elements of the ECG and other potential factors that are predictive of CAD in this scenario...
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Gastroenterology / Original Article
Clinical implications of endoscopic ultrasonography non-traversability in patients with locoregional esophageal cancer receiving multimodality therapy
Charles J. Cho, Ho June Song, Gin Hyug Lee, Kee Don Choi, Yong-Hee Kim, Jin-Sook Ryu, Sung-Bae Kim, Jong Hoon Kim, Seung-Il Park, Hwoon-Yong Jung
Korean J Intern Med. 2017;32(3):443-451. Published online March 14, 2016
Background/Aims: Approximately 30% of esophageal cancer (EC) patients cannot complete endoscopic ultrasonography (EUS) due to malignant stricture (EUS non-traversability). This study examines clinical implications of EUS non-traversability in patients with advanced locoregional squamous EC receiving..
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Hemato-oncology / Original Article
Clinicopathologic significance of tumor microenvironment CD11c, and FOXP3 expression in diffuse large B-cell lymphoma patients receiving rituximab, cyclophosphamide, anthracycline, vincristine, and prednisone (R-CHOP) combination chemotherapy
Seul Lee, Dong Hyun Kim, Sung Yong Oh, So Yeon Kim, Myeong Seok Koh, Ji Hyun Lee, Suee Lee, Sung-Hyun Kim, Jong-Young Kwak, Min Gyoung Pak, Mi Ha Ju, Hyo-Jin Kim, Jin Sook Jeong
Korean J Intern Med. 2017;32(2):335-344. Published online March 11, 2016
Background/Aims: CD11c is a dendritic cell marker in humans, which potentially induces a cytotoxic effect on lymphoma cells. Forkhead boxP3 (FOXP3) is a regulator of T lymphocyte in the microenvironment of the lymphoma. The principal objective of this study was to determine whether the tumors’ mic..
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