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Allergy / Review
What we know about nonsteroidal anti-inflammatory drug hypersensitivity
Duy Le Pham, Ji-Hye Kim, Tu Hoang Kim Trinh, Hae-Sim Park
Korean J Intern Med. 2016;31(3):417-432. Published online March 31, 2016
Nonsteroidal anti-inf lammatory drugs (NSAIDs) are widely prescribed for the treatment of inflammatory diseases, but their use is frequently related to hypersensitivity reactions. This review outlines our current knowledge of NSAID hypersensitivity (NHS) with regard to its pathogenic, molecular, and..
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Letter to the editor
Paraneoplastic dermatomyositis presenting myopathy combined with synchronous cervical and sigmoid colon cancer
Jae Heun Chung, Min Wook So, Seong-Geun Kim
Korean J Intern Med. 2016;31(2):413-416. Published online January 29, 2016
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Letter to the editor
Painful immunoglobulin G4-related thyroiditis treated by total thyroidectomy
Ihn Suk Lee, Jung Uee Lee, Kwan-Ju Lee, Yi Sun Jang, Jong Min Lee, Hye Soo Kim
Korean J Intern Med. 2016;31(2):399-402. Published online February 26, 2016
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Rheumatology / Review
The specialist physician’s approach to rheumatoid arthritis in South Africa
Frederik C. J. Bester, Fredricka J. Bosch, Barend J. Jansen van Rensburg
Korean J Intern Med. 2016;31(2):219-236. Published online February 26, 2016
Rheumatoid arthritis (RA) is expected to increase in Africa and South Africa. Due to the low numbers of rheumatologists in South Africa, specialist physicians also have to care for patients with RA. Furthermore several new developments have taken place in recent years which improved the management a..
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Letter to the editor
Fabry disease previously diagnosed as Henoch-Schonlein purpura
Ji Hyeong Kim, Dong Hoon Han, Moo Yong Park, Soo Jeong Choi, Jin Kuk Kim, Seung Duk Hwang, So Young Jin
Korean J Intern Med. 2015;30(6):925-927. Published online October 30, 2015
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Hemato-oncology / Original Article
Clinical efficacy of erlotinib, a salvage treatment for non-small cell lung cancer patients following gefitinib failure
Kyoung Min Cho, Bhumsuk Keam, Tae Min Kim, Se-Hoon Lee, Dong-Wan Kim, Dae Seog Heo
Korean J Intern Med. 2015;30(6):891-898. Published online October 30, 2015
Background/Aims: The purpose of this study was to identify predictive factors for erlotinib treatment in non-small cell lung cancer (NSCLC) patients following gefitinib failure.
Methods: Forty-five patients with NSCLC who were treated with erlotinib following gefitinib failure at Seoul National Uni..
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Gastroenterology / Original Article
Trends in Helicobacter pylori eradication rates by first-line triple therapy and related factors in eradication therapy
Sung Eun Kim, Moo In Park, Seun Ja Park, Won Moon, Youn Jung Choi, Ji Hyun Cheon, Hye Jung Kwon, Ki Hwan Ku, Chang Hun Yoo, Jae Hyun Kim, Gyu Won Lee, Sung Eun Song
Korean J Intern Med. 2015;30(6):801-807. Published online October 30, 2015
Background/Aims: Trends in successful eradication of Helicobacter pylori using first-line triple therapy, consisting of a proton pump inhibitor, amoxicillin, and clarithromycin, have been understudied. We evaluated H. pylori eradication rates at a single center over the last 10 years a..
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Gastroenterology / Original Article
Incidence of and risk factors for thyroid dysfunction during peginterferon α and ribavirin treatment in patients with chronic hepatitis C
Yong Hwang, Won Kim, So Young Kwon, Hyung Min Yu, Jeong Han Kim, Won Hyeok Choe
Korean J Intern Med. 2015;30(6):792-800. Published online October 30, 2015
Background/Aims: Thyroid dysfunction (TD) is more likely to occur in patients with chronic hepatitis C (CHC) and is particularly associated with interferon (IFN) treatment. The purpose of this study was to investigate the incidence, outcomes, and risk factors for TD during pegylated interferon (PEG-..
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Rheumatology / Original Article
Cross-cultural adaptation and validation of the Behcet’s Disease Current Activity Form in Korea
Hyo Jin Choi, Mi Ryoung Seo, Hee Jung Ryu, Han Joo Baek
Korean J Intern Med. 2015;30(5):714-718. Published online August 27, 2015
Background/Aims: This study was undertaken to perform a cross-cultural adaptation of the Behcet’s Disease Current Activity Form (BDCAF, version 2006) questionnaire to the Korean language and to evaluate its reliability and validity in a population of Korean patients with Behcet’s disease (BD).
..
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Nephrology / Original Article
Time points for obtaining representative values of 24-hour blood pressure in chronic kidney disease
Jiwon Ryu, Ran-hui Cha, Dong Ki Kim, Ju Hyun Lee, Sun Ae Yoon, Dong Ryeol Ryu, Jieun Oh, Sejoong Kim, Sang-Youb Han, Eun Young Lee, Yon Su Kim
Korean J Intern Med. 2015;30(5):665-674. Published online August 27, 2015
Background/Aims: Ambulatory blood pressure (BP) monitoring has been widely recommended for evaluating the status of BP, but is lacking in practicality. Determination of the specific time points for BP measurement that are representative of 24-hour mean BP could be useful and convenient in hypertensi..
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Pulmonology / Original Article
Chronic obstructive pulmonary disease (COPD) assessment test scores corresponding to modified Medical Research Council grades among COPD patients
Chang-Hoon Lee, Jinwoo Lee, Young Sik Park, Sang-Min Lee, Jae-Joon Yim, Young Whan Kim, Sung Koo Han, Chul-Gyu Yoo
Korean J Intern Med. 2015;30(5):629-637. Published online August 27, 2015
Background/Aims: In assigning patients with chronic obstructive pulmonary disease (COPD) to subgroups according to the updated guidelines of the Global Initiative for Chronic Obstructive Lung Disease, discrepancies have been noted between the COPD assessment test (CAT) criteria and modified Medical ..
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Hemato-oncology / Original Article
Clinical features and outcomes of systemic amyloidosis with gastrointestinal involvement: a single-center experience
A Young Lim, Ji Hyeon Lee, Ki Sun Jung, Hye Bin Gwag, Do Hee Kim, Seok Jin Kim, Ga Yeon Lee, Jung Sun Kim, Hee-Jin Kim, Soo-Youn Lee, Jung Eun Lee, Eun-Seok Jeon, Kihyun Kim
Korean J Intern Med. 2015;30(4):496-505. Published online June 29, 2015
Background/Aims: The gastrointestinal (GI) tract often becomes involved in patients with systemic amyloidosis. As few GI amyloidosis data have been reported, we describe the clinical features and outcomes of patients with pathologically proven GI amyloidosis.
Methods: We identified 155 patients dia..
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Pulmonology / Review
Phenotype of asthma-chronic obstructive pulmonary disease overlap syndrome
Chin Kook Rhee
Korean J Intern Med. 2015;30(4):443-449. Published online June 29, 2015
Many patients with asthma or chronic obstructive pulmonary disease (COPD) have overlapping characteristics of both diseases. By spirometric definition, patients with both fixed airflow obstruction (AO) and bronchodilator reversibility or fixed AO and bronchial hyperresponsiveness can be considered t..
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Rheumatology / Original Article
Predictive factors of radiographic progression in ankylosing spondylitis
Hyungjin Kim, Jaejoon Lee, Joong Kyong Ahn, Jiwon Hwang, Eun-Jung Park, Hyemin Jeong, Hoon-Suk Cha, Eun-Mi Koh
Korean J Intern Med. 2015;30(3):391-397. Published online April 29, 2015
Background/Aims: The course of ankylosing spondylitis (AS) is rather variable, and the factors that predict radiographic progression remain largely obscure. In this study, we tried to determine the clinical factors and laboratory measures that are useful in predicting the radiographic progression of..
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Rheumatology / Original Article
Sleep quality in rheumatoid arthritis, and its association with disease activity in a Korean population
Chang-Nam Son, Go Choi, So-Yeon Lee, Ji-Min Lee, Tae-Han Lee, Hye-Jin Jeong, Chang-Gyu Jung, Ji-Min Kim, Yong-Won Cho, Sang-Hyon Kim
Korean J Intern Med. 2015;30(3):384-390. Published online April 29, 2015
Background/Aims: The aim of this study was to compare the sleep quality between rheumatoid arthritis (RA) patients and healthy controls; and to evaluate the relationship between RA disease activity and sleep quality in Korea.
Methods: A total of 130 RA patients and 67 age- and sex-matched healthy c..
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Gastroenterology / Review
Recent trends in diagnostic techniques for inflammatory bowel disease
Makoto Naganuma, Naoki Hosoe, Takanori Kanai, Haruhiko Ogata
Korean J Intern Med. 2015;30(3):271-278. Published online April 29, 2015
Although ileocolonoscopy is the gold standard for diagnosis of inflammatory bowel disease and is useful for assessing the disease severity in the colon and terminal ileum, several alternative diagnostic techniques have been developed recently. For ulcerative colitis (UC), magnification colonoscopy, ..
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Pulmonology / Original Article
Awareness of chronic obstructive pulmonary disease in current smokers: a nationwide survey
So Yeong Mun, Yong Il Hwang, Joo Hee Kim, Sunghoon Park, Seung Hun Jang, Jae Yong Seo, Ja Kyung Kim, Yong Bum Park, Jae Jung Shim, Ki-Suck Jung
Korean J Intern Med. 2015;30(2):191-197. Published online February 27, 2015
Background/Aims: Cigarette smoking is the most common risk factor for chronic obstructive pulmonary disease (COPD). However, few studies of the attitudes toward COPD of smokers, the group at risk of developing this condition, have been conducted. The purpose of this study was to explore the awarenes..
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Rheumatology / Review
Applications of systems approaches in the study of rheumatic diseases
Ki-Jo Kim, Saseong Lee, Wan-Uk Kim
Korean J Intern Med. 2015;30(2):148-160. Published online February 27, 2015
The complex interaction of molecules within a biological system constitutes a functional module. These modules are then acted upon by both internal and external factors, such as genetic and environmental stresses, which under certain conditions can manifest as complex disease phenotypes. Recent adva..
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Rheumatology / Original Article
Mortality in patients with rheumatoid arthritis-associated interstitial lung disease treated with an anti-tumor necrosis factor agent
Bon San Koo, Seokchan Hong, You Jae Kim, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo
Korean J Intern Med. 2015;30(1):104-109. Published online December 30, 2014
Background/Aims: To evaluate the impact on mortality of anti-tumor necrosis factor (anti-TNF) treatment of rheumatoid arthritis-associated interstitial lung disease (RA-ILD).
Methods: We retrospectively reviewed the medical records of 100 RA-ILD patients who visited our tertiary care medical center..
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Pulmonology / Original Article
Proteomic differences with and without ozone-exposure in a smoking-induced emphysema lung model
Soo-Taek Uh, So-My Koo, An Soo Jang, Sung Woo Park, Jae Sung Choi, Yong-Hoon Kim, Choon Sik Park
Korean J Intern Med. 2015;30(1):62-72. Published online December 30, 2014
Background/Aims: Acute exacerbations in chronic obstructive pulmonary disease may be related to air pollution, of which ozone is an important constituent. In this study, we investigated the protein profiles associated with ozone-induced exacerbations in a smoking-induced emphysema model.
Methods: M..
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