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Pulmonology / Review
Phenotype of asthma-chronic obstructive pulmonary disease overlap syndrome
Chin Kook Rhee
Korean J Intern Med. 2015;30(4):443-449. Published online June 29, 2015
Many patients with asthma or chronic obstructive pulmonary disease (COPD) have overlapping characteristics of both diseases. By spirometric definition, patients with both fixed airflow obstruction (AO) and bronchodilator reversibility or fixed AO and bronchial hyperresponsiveness can be considered t..
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Cardiology / Review
Infective endocarditis involving an apparently structurally normal valve: new epidemiological trend?
Jae-Kwan Song
Korean J Intern Med. 2015;30(4):434-442. Published online June 29, 2015
Infective endocarditis (IE) has been increasingly diagnosed in patients without previously detected predisposing heart disease, but its clinical features have yet to be fully determined. A recent single-center study including echocardiographic images and surgical findings investigated the incidence ..
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Rheumatology / Original Article
Predictive factors of radiographic progression in ankylosing spondylitis
Hyungjin Kim, Jaejoon Lee, Joong Kyong Ahn, Jiwon Hwang, Eun-Jung Park, Hyemin Jeong, Hoon-Suk Cha, Eun-Mi Koh
Korean J Intern Med. 2015;30(3):391-397. Published online April 29, 2015
Background/Aims: The course of ankylosing spondylitis (AS) is rather variable, and the factors that predict radiographic progression remain largely obscure. In this study, we tried to determine the clinical factors and laboratory measures that are useful in predicting the radiographic progression of..
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Infectious diseases / Original Article
A comparison of the clinical characteristics of elderly and non-elderly women with community-onset, non-obstructive acute pyelonephritis
U-Im Chang, Hyung Wook Kim, Yong-sun Noh, Seong-Heon Wie
Korean J Intern Med. 2015;30(3):372-383. Published online April 29, 2015
Background/Aims: Acute pyelonephritis (APN) is the most common cause of community-onset bacteremia in hospitalized elderly patients. The objectives of this study were to investigate the differences in the clinical and microbiological data of hospitalized elderly and non-elderly women with community-..
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Hemato-oncology / Original Article
Role of frontline autologous stem cell transplantation in young, high-risk diffuse large B-cell lymphoma patients
Jae-Ho Yoon, Jong-Wook Kim, Young-Woo Jeon, Sung-Eun Lee, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Chang-Ki Min, Jong-Wook Lee, Woo-Sung Min, Chong-Won Park, Seok-Goo Cho
Korean J Intern Med. 2015;30(3):362-371. Published online April 29, 2015
Background/Aims: Several studies have demonstrated the effect of autologous hematopoietic stem cell transplantation (auto-HSCT) as a salvage treatment for patients with relapsed diffuse large B-cell lymphoma (DLBCL). However, the role of auto-HSCT as a frontline treatment has not been fully investig..
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Nephrology / Original Article
High serum and urine neutrophil gelatinase-associated lipocalin levels are independent predictors of renal progression in patients with immunoglobulin A nephropathy
Harin Rhee, Nari Shin, Min Ji Shin, Byung Yun Yang, Il Young Kim, Sang Heon Song, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak, Eun Young Seong
Korean J Intern Med. 2015;30(3):354-361. Published online April 29, 2015
Background/Aims: Tubulointerstitial injury plays an important role in the progression of immunoglobulin A nephropathy (IgAN), and neutrophil gelatinase-associated lipocalin (NGAL) is among the most sensitive tubular biomarkers. We investigated whether serum or urine NGAL predicts prognosis in patien..
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Nephrology / Original Article
Plasma neutrophil gelatinase-associated lipocalin as a potential predictor of adverse renal outcomes in immunoglobulin A nephropathy
Ga-Young Park, Chung-Hoon Yu, Jun-Seop Kim, Yun-Jeong Kang, Owen Kwon, Ji-Young Choi, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim, Sun-Hee Park
Korean J Intern Med. 2015;30(3):345-353. Published online April 29, 2015
Background/Aims: Neutrophil gelatinase-associated lipocalin (NGAL) is a well-known biomarker of acute kidney injury. We evaluated the value of plasma NGAL (pNGAL) as an independent predictor of prognosis in immunoglobulin A nephropathy (IgAN).
Methods: In total, 91 patients with biopsy-proven IgAN ..
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Endocrinology-metabolism / Original Article
Reference interval for thyrotropin in a ultrasonography screened Korean population
Mijin Kim, Tae Yong Kim, Soo Han Kim, Yunkyoung Lee, Su-yeon Park, Hyung-Don Kim, Hyemi Kwon, Yun Mi Choi, Eun Kyung Jang, Min Ji Jeon, Won Gu Kim, Young Kee Shong, Won Bae Kim
Korean J Intern Med. 2015;30(3):335-344. Published online April 29, 2015
Background/Aims: The diagnostic accuracy of thyroid dysfunctions is primarily affected by the validity of the reference interval for serum thyroid-stimulating hormone (TSH). Thus, the present study aimed to establish a reference interval for TSH using a normal Korean population.
Methods: This study..
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Gastroenterology / Original Article
Use of 18F-FDG PET to predict tumor progression and survival in patients with intermediate hepatocellular carcinoma treated by transarterial chemoembolization
Min Jin Kim, Young Seok Kim, Youn Hee Cho, Hee Yoon Jang, Jeong-Yeop Song, Sae Hwan Lee, Soung Won Jeong, Sang Gyune Kim, Jae Young Jang, Hong Su Kim, Boo Sung Kim, Won Hyung Lee, Jung Mi Park, Jae Myung Lee, Min Hee Lee, Deuk Lin Choi
Korean J Intern Med. 2015;30(3):308-315. Published online April 29, 2015
Background/Aims: 18F-Fluorodeoxyglucose positron-emission tomography (18F-FDG PET) has been used to assess the biological behavior of hepatocellular carcinoma (HCC). In this study, we investigated the usefulness of 18F-FDG PET for predicting tumor progression and sur..
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Gastroenterology / Review
Recent trends in diagnostic techniques for inflammatory bowel disease
Makoto Naganuma, Naoki Hosoe, Takanori Kanai, Haruhiko Ogata
Korean J Intern Med. 2015;30(3):271-278. Published online April 29, 2015
Although ileocolonoscopy is the gold standard for diagnosis of inflammatory bowel disease and is useful for assessing the disease severity in the colon and terminal ileum, several alternative diagnostic techniques have been developed recently. For ulcerative colitis (UC), magnification colonoscopy, ..
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Rheumatology / Original Article
Clinical characteristics of male and female Korean patients with systemic lupus erythematosus: a comparative study
Jiwon Hwang, Jaejoon Lee, Joong Kyoung Ahn, Eun-Jung Park, Hoon-Suk Cha, Eun-Mi Koh
Korean J Intern Med. 2015;30(2):242-249. Published online February 27, 2015
Background/Aims: To compare the clinical characteristics and outcomes of systemic lupus erythematosus between male and female Korean patients.
Methods: A retrospective analysis was performed at a single tertiary hospital from August 1994 to May 2010. Male patients were matched with two to three fem..
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Allergy / Original Article
Association of nasal inflammation and lower airway responsiveness in schoolchildren based on an epidemiological survey
Jun-Ho Myung, Hyun-Jeong Seo, Soo-Jeong Park, Bo-Young Kim, Il-Sang Shin, Jun-Hak Jang, Yun-Kyung Kim, An-Soo Jang
Korean J Intern Med. 2015;30(2):226-231. Published online February 27, 2015
Background/Aims: We sought to increase our understanding of the rhinitis-asthma relationship and improve strategies for the treatment of patients with these diseases. The aim of this study was to identify a connection between upper airway inflammation and lower airway responsiveness.
Methods: We co..
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Nephrology / Original Article
The association between an abnormal post-voiding urine volume and a lower estimated glomerular filtration rate in patients with type 2 diabetes with no voiding symptoms
A Jin Cho, Sung Tae Cho, Young-Ki Lee, Jieun Oh, Sung Gyun Kim, Jang Won Seo, Jong-Woo Yoon, Ja-Ryong Koo, Hyung Jik Kim, Yong Seong Lee, Young-Goo Lee, Jung Woo Noh
Korean J Intern Med. 2015;30(1):82-87. Published online December 30, 2014
Background/Aims: Diabetic cystopathy is a frequent complication of diabetes mellitus. This study assessed the association between the post-voiding residual (PVR) urine volume and diabetic nephropathy in type 2 diabetics with no voiding symptoms.
Methods: This study investigated 42 patients with typ..
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Pulmonology / Original Article
Proteomic differences with and without ozone-exposure in a smoking-induced emphysema lung model
Soo-Taek Uh, So-My Koo, An Soo Jang, Sung Woo Park, Jae Sung Choi, Yong-Hoon Kim, Choon Sik Park
Korean J Intern Med. 2015;30(1):62-72. Published online December 30, 2014
Background/Aims: Acute exacerbations in chronic obstructive pulmonary disease may be related to air pollution, of which ozone is an important constituent. In this study, we investigated the protein profiles associated with ozone-induced exacerbations in a smoking-induced emphysema model.
Methods: M..
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Cardiology / Original Article
Clinical impact of routine follow-up coronary angiography after second- or third-generation drug-eluting stent insertion in clinically stable patients
Seonghoon Choi, Hee-Sun Mun, Min-Kyung Kang, Jung Rae Cho, Seong Woo Han, Namho Lee Lee
Korean J Intern Med. 2015;30(1):49-55. Published online December 30, 2014
Background/Aims: In the bare-metal stent era, routine follow-up coronary angiography (RFU CAG) was used to ensure stent patency. With the advent of drug-eluting stents (DESs) with better safety and efficacy profiles, RFU CAG has been performed less often. There are few data on the clinical impact of..
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Rheumatology / Review
Methods for the morphological and functional evaluation of microvascular damage in systemic sclerosis
Barbara Ruaro, Vanessa Smith, Alberto Sulli, Saskia Decuman, Carmen Pizzorni, Maurizio Cutolo
Korean J Intern Med. 2015;30(1):1-5. Published online December 30, 2014
Systemic sclerosis is a connective tissue disease characterized by alterations in microvascular structure and function. In these patients, numerous studies have demonstrated a relationship between capillary morphology and peripheral blood perfusion. Nailfold videocapillaroscopy reveals the periphera..
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Letter to the editor
Parvimonas micra chest wall abscess following transthoracic lung needle biopsy
Luis Gorospe, Isabel Bermudez-Coronel-Prats, Carol F. Gomez-Barbosa, Maria E. Olmedo-Garcia, Angel Ruedas-Lopez, Vicente Gomez del Olmo
Korean J Intern Med. 2014;29(6):834-837. Published online October 31, 2014
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Rheumatology / Original Article
Complex repetitive discharge on electromyography as a risk factor for malignancy in idiopathic inflammatory myopathy
Na Ri Kim, Eon Jeong Nam, Jong Wan Kang, Hyun Seok Song, Churl Hyun Im, Young Mo Kang
Korean J Intern Med. 2014;29(6):814-821. Published online October 31, 2014
Background/Aims: We investigated the electromyography (EMG) findings and demographic, clinical, and laboratory features that may predict the development of malignancy in patients with idiopathic inflammatory myopathy (IIM).
Methods: In total, 61 patients, 36 with dermatomyositis and 25 with polymyo..
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Allergy / Original Article
Clinical features of elderly chronic urticaria
Ga-Young Ban, Mi-Yea Kim, Hye-Soo Yoo, Dong-Ho Nahm, Young-Min Ye, Yoo-Seob Shin, Hae-Sim Park
Korean J Intern Med. 2014;29(6):800-806. Published online October 31, 2014
Background/Aims: Chronic urticaria (CU) is defined as itchy wheals lasting 6 weeks or more. As the aged population increases worldwide, it is essential to identify the specific features of this disease in the elderly population.
Methods: We investigated the prevalence and clinical features of CU in..
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Hemato-oncology / Original Article
Clinical significance of nuclear factor κB and chemokine receptor CXCR4 expression in patients with diffuse large B-cell lymphoma who received rituximab-based therapy
Ho Cheol Shin, Jongwon Seo, Byung Woog Kang, Joon Ho Moon, Yee Soo Chae, Soo Jung Lee, Yoo Jin Lee, Seoae Han, Sang Kyung Seo, Jong Gwang Kim, Sang Kyun Sohn, Tae-In Park
Korean J Intern Med. 2014;29(6):785-792. Published online October 31, 2014
Background/Aims: This study investigated the expression of nuclear factor κB (NF-κB) and the chemokine receptor (CXCR4) in patients with diffuse large B-cell lymphoma (DLBCL) who received rituximab-based therapy.
Methods: Seventy patients with DLBCL and treated with rituximab-CHOP (R-CHO..
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