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Rheumatology / Original Article
The role of 18F-fluorodeoxyglucose positron emission tomography in the assessment of disease activity of adult-onset Still’s disease
Young-Sil An, Chang-Hee Suh, Ju-Yang Jung, Hundo Cho, Hyoun-Ah Kim
Korean J Intern Med. 2017;32(6):1082-1089. Published online December 7, 2016
Background/Aims: 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has been suggested as a reliable imaging technique for monitoring of disease activity in patients with adult-onset Still’s disease (AOSD). Therefore, we investigated the ..
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Nephrology / Original Article
Blocking junctional adhesion molecule C promotes the recovery of cisplatin-induced acute kidney injury
Sun Chul Kim, Yoon Sook Ko, Hee Young Lee, Myung-Gyu Kim, Sang-Kyung Jo, Won-Yong Cho
Korean J Intern Med. 2017;32(6):1053-1061. Published online February 15, 2017
Background/Aims: Recent findings have demonstrated the occurrence of neutrophil transendothelial migration in the reverse direction (reverse TEM) and that endothelial junctional adhesion molecule C (JAM-C) is a negative regulator of reverse TEM. In this study, we tested the effects of a JAM-C blocki..
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Pulmonology / Original Article
Epidemiological trend of pulmonary thromboembolism at a tertiary hospital in Korea
Tae Yun Park, Jae-Woo Jung, Jae Chol Choi, Jong Wook Shin, Jae Yeol Kim, Byoung Whui Choi, In Won Park
Korean J Intern Med. 2017;32(6):1037-1044. Published online March 13, 2017
Background/Aims: Despite increasing interest in pulmonary thromboembolism (PTE), data on recent trends in PTE incidence are limited. This study evaluated the recent incidence rate of PTE.
Methods: We performed a retrospective chart review of patients with PTE admitted to Chung-Ang University Hospit..
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Gastroenterology / Original Article
Clinical implication of serum uric acid level in pegylated interferon and ribavirin combination therapy for chronic hepatitis C infection
In Soo Oh, Joung Won Won, Hyung Joon Kim, Hyun Woong Lee
Korean J Intern Med. 2017;32(6):1010-1017. Published online August 11, 2017
Background/Aims: Combined treatment of pegylated interferon-α (PEG-IFN) and ribavirin (RBV) has long been accepted as the standard treatment for chronic hepatitis C virus (HCV) infection. Many predictive factors for treatment response have been identified. The aim of this study was to evaluate the..
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Endocrinology-metabolism / Review
Combination therapy of oral hypoglycemic agents in patients with type 2 diabetes mellitus
Min Kyong Moon, Kyu Yeon Hur, Seung-Hyun Ko, Seok-O Park, Byung-Wan Lee, Jin Hwa Kim, Sang Youl Rhee, Hyun Jin Kim, Kyung Mook Choi, Nan-Hee Kim; on behalf of the Committee of Clinical Practice Guidelines of the Korean Diabetes Association
Korean J Intern Med. 2017;32(6):974-983. Published online October 27, 2017
The Korean Diabetes Association (KDA) recently updated the Clinical Practice Guidelines on antihyperglycemic agent therapy for adult patients with type 2 diabetes mellitus (T2DM). In combination therapy of oral hypoglycemic agents (OHAs), general recommendations were not changed from those of the 20..
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Endocrinology-metabolism / Review
Insulin therapy for adult patients with type 2 diabetes mellitus: a position statement of the Korean Diabetes Association, 2017
Byung-Wan Lee, Jin Hwa Kim, Seung-Hyun Ko, Kyu Yeon Hur, Nan-Hee Kim, Sang Youl Rhee, Hyun Jin Kim, Min Kyong Moon, Seok-O Park, Kyung Mook Choi; on behalf of the Committee of Clinical Practice Guideline of Korean Diabetes Association
Korean J Intern Med. 2017;32(6):967-973. Published online October 23, 2017
The Korean Diabetes Association (KDA) has regularly updated its Clinical Practice Guidelines. In 2017, the KDA published a position statement on the use of antihyperglycemic agents for patients with type 2 diabetes mellitus (T2DM). Growing evidence from new multinational clinical trials using novel ..
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Endocrinology-metabolism / Review
Monotherapy in patients with type 2 diabetes mellitus
Sang Youl Rhee, Hyun Jin Kim, Seung-Hyun Ko, Kyu Yeon Hur, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Kyung Mook Choi, Jin Hwa Kim; Committee of Clinical Practice Guideline of Korean Diabetes Association
Korean J Intern Med. 2017;32(6):959-966. Published online October 23, 2017
In order to improve the quality of life and to prevent chronic complications related to diabetes mellitus, intensive lifestyle modification and proper medication are needed from the early stage of diagnosis of type 2 diabetes mellitus (T2DM). When using the first medication for diabetic patients, th..
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Endocrinology-metabolism / Review
Antihyperglycemic agent therapy for adult patients with type 2 diabetes mellitus 2017: a position statement of the Korean Diabetes Association
Seung-Hyun Ko, Kyu Yeon Hur, Sang Youl Rhee, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Hyun Jin Kim, Kyung Mook Choi, Jin Hwa Kim; Committee of Clinical Practice Guideline of Korean Diabetes Association
Korean J Intern Med. 2017;32(6):947-958. Published online October 23, 2017
In 2017, the Korean Diabetes Association (KDA) published a position statement on the use of antihyperglycemic agents for patients with type 2 diabetes mellitus (T2DM). The KDA regularly updates its Clinical Practice Guidelines, but since the last update in 2015, many results from clinical trials hav..
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Letter to the editor
Metronomic chemotherapy with capecitabine for metastatic colorectal cancer in very elderly patients
Yun Hwa Jung, Won Jik Lee, Jae Ho Byeon, In Kyu Lee, Chi Wha Han, In Sook Woo
Korean J Intern Med. 2017;32(5):926-929. Published online March 10, 2016
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Pulmonology / Original Article
The activation of NLRP3-inflammsome by stimulation of diesel exhaust particles in lung tissues from emphysema model and RAW 264.7 cell line
Soo-Taek Uh, So My Koo, Yangki Kim, Kiup Kim, Sungwoo Park, An Soo Jang, Dojin Kim, Yong Hoon Kim, Choon-Sik Park
Korean J Intern Med. 2017;32(5):865-874. Published online August 18, 2017
Background/Aims: Diesel exhaust particles (DEPs) lead to elevation of reactive oxygen species, which can activate the nucleotide-binding oligomerization domain-like receptor (NLR) family members containing the pyrin domain 3 (NLRP3)-inf lammasome. In this study, we elucidated whether NLRP3 -inf lamm..
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Cardiology / Original Article
Geographic and demographic variabilities of quantitative parameters in stress myocardial computed tomography perfusion
Jinoh Park, Hyun-Sook Kim, Hye Jeon Hwang, Dong Hyun Yang, Hyun Jung Koo, Joon-Won Kang, Young-Hak Kim
Korean J Intern Med. 2017;32(5):847-854. Published online July 28, 2017
Background/Aims: To evaluate the geographic and demographic variabilities of the quantitative parameters of computed tomography perfusion (CTP) of the left ventricular (LV) myocardium in patients with normal coronary artery on computed tomography angiography (CTA).
Methods: From a multicenter CTP r..
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Infectious diseases / Original Article
In vitro antiviral activity of ribavirin against severe fever with thrombocytopenia syndrome virus
Myung Jin Lee, Kye-Hyung Kim, Jongyoun Yi, Su Jin Choi, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Myoung-don Oh
Korean J Intern Med. 2017;32(4):731-737. Published online November 30, 2016
Background/Aims: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus. As yet, there is no effective antiviral therapy for SFTS. Ribavirin is a broad-spectrum antiviral agent, whic..
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Hemato-oncology / Original Article
Myeloma prognostic index at diagnosis might be a prognostic marker in patients newly diagnosed with multiple myeloma
Dae Sik Kim, Eun Sang Yu, Ka-Won Kang, Se Ryeon Lee, Yong Park, Hwa Jung Sung, Chul Won Choi, Byung Soo Kim
Korean J Intern Med. 2017;32(4):711-721. Published online November 4, 2016
Background/Aims: The aims of this study were to identify the value of inflammatory markers as pretreatment prognostic factors for patients with multiple myeloma (MM) and to estimate the value of a prognostic index including these markers at diagnosis.
Methods: A total of 273 newly diagnosed MM pati..
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Pulmonology / Original Article
Prevalence and risk factors for reduced pulmonary function in diabetic patients: The Korea National Health and Nutrition Examination Survey
Hee Yeon Kim, Tae Seo Sohn, Hannah Seok, Chang Dong Yeo, Young Soo Kim, Jae Yen Song, Young Bok Lee, Dong-Hee Lee, Jae-Im Lee, Tae-Kyu Lee, Seong Cheol Jeong, Mihee Hong, Hiun Suk Chae
Korean J Intern Med. 2017;32(4):682-689. Published online February 1, 2017
Background/Aims: An association between reduced pulmonary function and diabetes has been observed. Our aim was to evaluate the prevalence and risk factors associated with reduced pulmonary function in diabetic patients.
Methods: We analyzed data from the Korea National Health and Nutrition Examinati..
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Cardiology / Original Article
Maximal pericoronary adipose tissue thickness is associated with hypertension in nonobese
patients with acute or chronic illness
Shinhae Chang, Wangjin Lee, Byounggyu Kwag, Yun Hee Chung, In Sook Kang
Korean J Intern Med. 2017;32(4):668-674. Published online December 6, 2016
Background/Aims: Recent studies have shown an association of epicardial fat thickness with diabetes and hypertension (HTN) in asymptomatic populations. However, there is lack of information as to whether there is similar association between pericoronary adipose tissue (PAT) and HTN in the patients w..
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Cardiology / Original Article
Efficacy and safety of pitavastatins in patients with acute myocardial infarction: Livalo in Acute Myocardial Infarction Study (LAMIS) II
Young Joon Hong, Myung Ho Jeong, Jang Ho Bae, Seok Kyu Oh, Seung Woon Rha, Seung Ho Hur, Sung Yun Lee, Sang Wook Kim, Kwang Soo Cha, In Ho Chae, Tae Hoon Ahn, Kee Sik Kim
Korean J Intern Med. 2017;32(4):656-667. Published online June 16, 2017
Background/Aims: We evaluated the efficacy and safety and influence on glucose tolerance by different doses of pitavastatins in acute myocardial infarction (AMI) patients.
Methods: Consecutive 1,101 AMI patients who were enrolled in Livalo in Acute Myocardial Infarction Study (LAMIS)-II were random..
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Gastroenterology / Original Article
Negative pathology after endoscopic resection of gastric epithelial neoplasms: importance of pit
dysplasia
Joon Hyung Jhi, Gwang Ha Kim, Ahrong Kim, Young-Geum Kim, Cheong Su Hwang, Sojeong Lee, Bong Eun Lee, Geun Am Song, Do Youn Park
Korean J Intern Med. 2017;32(4):647-655. Published online January 20, 2017
Background/Aims: Endoscopic resection (ER) is a well-established treatment modality for gastric epithelial neoplasm. However, there is a discrepancy between forceps biopsy and ER specimen pathology, including a negative pathologic diagnosis (NPD) after ER. It has been suggested that pit dysplasia (P..
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Pulmonology / Review
Treatment of connective tissue disease-associated interstitial lung disease: the pulmonologist’s point of view
So-My Koo, Soo-Taek Uh
Korean J Intern Med. 2017;32(4):600-610. Published online June 30, 2017
Interstitial lung disease (ILD) occurs in 15% of patients with collagen vascular disease (CVD), referred to as connective tissue disease (CTD). Despite advances in management strategies, ILD continues to be a significant cause of mortality in patients with CVD-associated ILD (CTD-ILD). There is a la..
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Cardiology / Review
Three-dimensional echocardiography in adult congenital heart disease
Hyun Suk Yang
Korean J Intern Med. 2017;32(4):577-588. Published online June 30, 2017
Congenital heart disease (CHD) is now more common in adults than in children due to improvements in fetal echo, neonatal and pediatric care, and surgical techniques leading to dramatically increased survivability into adulthood. Adult patients with CHD, regardless of prior cardiac surgery, experienc..
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Letter to the editor
Left ventricular thrombi after simultaneous thrombotic occlusions of multiple coronary arteries presenting acute myocardial infarction: need anticoagulant?
Hyun Joong Kim, Kyung Jin Choe, Woo-Dae Bang, Sang Jin Ha, Sang-Yong Yoo, Sangsig Cheong
Korean J Intern Med. 2017;32(3):552-554. Published online December 20, 2016
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