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Allergy / Original Article
Effect of the anti-IL-17 antibody on allergic inflammation in an obesity-related asthma model
Lin Liang, Jung Hur, Ji Young Kang, Chin Kook Rhee, Young Kyoon Kim, Sook Young Lee
Korean J Intern Med. 2018;33(6):1210-1223. Published online April 19, 2018
Background/Aims: The co-occurrence of obesity aggravates asthma symptoms. Diet-induced obesity increases helper T cell (TH) 17 cell differentiation in adipose tissue and the spleen. The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pravastatin can potentially be used to treat asthma in o..
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Allergy / Original Article
Methacholine bronchial provocation test in patients with asthma: serial measurements and clinical significance
Hyun-Jung Seo, Pureun-Haneul Lee, Byeong-Gon Kim, Sun-Hye Lee, Jong-Sook Park, Junehyuck Lee, Sung-Woo Park, Do-Jin Kim, Choon-Sik Park, An-Soo Jang
Korean J Intern Med. 2018;33(4):807-814. Published online January 17, 2018
Background/Aims: The methacholine bronchial provocation test (MBPT) is used to detect and quantify airway hyper-responsiveness (AHR). Since improvements in the severity of asthma are associated with improvements in AHR, clinical studies of asthma therapies routinely use the change of airway responsi..
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Allergy / Original Article
The virtual asthma guideline e-learning program: learning effectiveness and user satisfaction
Sung-Yoon Kang, Sae-Hoon Kim, Yong-Eun Kwon, Tae-Bum Kim, Hye-Kyung Park, Heung-Woo Park, Yoon-Seok Chang, Young-Koo Jee, Hee-Bom Moon, Kyung-Up Min, Sang-Heon Cho
Korean J Intern Med. 2018;33(3):604-611. Published online July 21, 2017
Background/Aims: Effective educational tools are important for increasing adherence to asthma guidelines and clinical improvement of asthma patients. We developed a computer-based interactive education program for asthma guideline named the Virtual Learning Center for Asthma Management (VLCAM). We e..
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Pulmonology / Original Article
Clinical significance of serum vascular endothelial growth factor in young male asthma patients
Hea Yon Lee, Kyung Hoon Min, Sang Min Lee, Ji Eun Lee, Chin Kook Rhee
Korean J Intern Med. 2017;32(2):295-301. Published online March 21, 2016
Background/Aims: Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis. However, little is known about the potential use of serum levels of VEGF as a biomarker for asthma. We investigated the differences in VEGF levels among normal controls, stable asthma patients, and t..
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Allergy / Original Article
Relationship between serum IgA level and allergy/asthma
Woo-Jin Kim, Inseon S. Choi, Chang Seong Kim, Jeong-Hyeon Lee, Hyeon-Wook Kang
Korean J Intern Med. 2017;32(1):137-145. Published online September 2, 2016
Background/Aims: Mucosal immunoglobulin A (IgA) may prevent the entrance of allergens. This study examined the relationship between serum IgA levels (within the normal range) and sensitization to house dust mites (HDM) or airway hyper-responsiveness (AHR). Methods: The clinical records of 1,136 adul..
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Allergy / Original Article
Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma
Duy Le Pham, Seung-Hyun Kim, Purevsuren Losol, Eun-Mi Yang, Yoo Seob Shin, Young-Min Ye, Hae-Sim Park
Korean J Intern Med. 2016;31(2):375-385. Published online December 23, 2015
Background/Aims: Role of autophagy in neutrophil function and the association of autophagy and autophagy related (ATG) gene polymorphisms with asthma susceptibility were suggested. In this study, we investigated the genetic association of ATG5 and ATG7 polymorphisms with asthma risk, s..
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Pulmonology / Original Article
Effect of intranasal rosiglitazone on airway inflammation and remodeling in a murine model of chronic asthma
Hwa Young Lee, Chin Kook Rhee, Ji Young Kang, Chan Kwon Park, Sook Young Lee, Soon Suk Kwon, Young Kyoon Kim, Hyoung Kyu Yoon
Korean J Intern Med. 2016;31(1):89-97. Published online December 28, 2015
Background/Aims: Asthma is characterized by airway hyperresponsiveness, inflammation, and remodeling. Peroxisome proliferator-activated receptors have been reported to regulate inflammatory responses in many cells. In this study, we examined the effects of intranasal rosiglitazone on airway remodeli..
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Pulmonology / Review
Phenotype of asthma-chronic obstructive pulmonary disease overlap syndrome
Chin Kook Rhee
Korean J Intern Med. 2015;30(4):443-449. Published online June 29, 2015
Many patients with asthma or chronic obstructive pulmonary disease (COPD) have overlapping characteristics of both diseases. By spirometric definition, patients with both fixed airflow obstruction (AO) and bronchodilator reversibility or fixed AO and bronchial hyperresponsiveness can be considered t..
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Allergy / Original Article
A polymorphism in the histone deacetylase 1 gene is associated with the response to corticosteroids in asthmatics
Min-Hye Kim, Sae-Hoon Kim, Yook-Keun Kim, Soo-Jong Hong, Kyung-Up Min, Sang-Heon Cho, Heung-Woo Park
Korean J Intern Med. 2013;28(6):708-714. Published online October 29, 2013
Background/AimsRecent investigations suggest that histone deacetylase 1 (HDAC1) and HDAC2 may be target molecules to predict therapeutic responses to corticosteroids. We evaluated the effects of variation in HDAC1 and ..
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Allergy / Review
The role of rhinosinusitis in severe asthma
An-Soo Jang
Korean J Intern Med. 2013;28(6):646-651. Published online October 29, 2013
The prevalence of asthma is approximately 5% to 10% in the general population. Of these, approximately 5% to 10% are severe asthmatics who respond poorly to asthmatic drugs, including high-dose inhaled steroids. Severe asthmatics have persistent symptoms, frequent symptom exacerbation, and sever..
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Review
Steroid Response in Refractory Asthmatics
An-Soo Jang
Korean J Intern Med. 2012;27(2):143-148. Published online May 31, 2012
Inhaled glucocorticosteroids are currently the most effective anti-inflammatory controller medications for treating persistent asthma. The efficacies of glucocorticoids include reducing asthma symptoms, reducing exacerbation frequency, improving quality of life, improving lung function, decreasin..
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Original Article
Effects of Add-On Therapy with NDC-052, an Extract from Magnoliae Flos, in Adult Asthmatic Patients Receiving Inhaled Corticosteroids
Chan Sun Park, Tae-Bum Kim, Jae-Young Lee, Jae Yong Park, Yong Chul Lee, Seong Su Jeong, Yang Deok Lee, You Sook Cho, Hee-Bom Moon
Korean J Intern Med. 2012;27(1):84-90. Published online February 28, 2012
Background/AimsThere is a need for new anti-asthmatic medications with fewer side effects. NDC-052, an extract of the medicinal herb Magnoliae flos, which has a long history of clinical use, was recently found to have anti-inflammatory effects. Herein, we eval..
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Review
Impact of Air Pollution on Allergic Diseases
Hajime Takizawa
Korean J Intern Med. 2011;26(3):262-273. Published online September 13, 2011
The incidence of allergic diseases in most industrialized countries has increased. Although the exact mechanisms behind this rapid increase in prevalence remain uncertain, a variety of air pollutants have been attracting attention as one causative factor. Epidemiological and toxicological researc..
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Review
Prostaglandin D2 and TH2 Inflammation in the Pathogenesis of Bronchial Asthma
Masafumi Arima, Takeshi Fukuda
Korean J Intern Med. 2011;26(1):8-18. Published online March 2, 2011
Prostaglandin D2 (PGD2) is a major prostanoid, produced mainly by mast cells, in allergic diseases, including bronchial asthma. PGD2-induced vasodilatation and increased permeability are well-known classical effects that may be involved in allergic inflammation. R..
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Original Article
Airway Responsiveness to Inhaled Aspirin is Influenced by Airway Hyperresponsiveness in Asthmatic Patients
Sungsoo Kim, Inseon S. Choi, Yeon-Joo Kim, Chang-Seong Kim, Eui-Ryoung Han, Dong-Jin Park, Dae-Eun Kim
Korean J Intern Med. 2010;25(3):309-316. Published online August 31, 2010
Background/AimsMany patients with aspirin-induced asthma have severe methacholine airway hyperresponsiveness (AHR), suggesting a relationship between aspirin and methacholine in airway response. This study was performed to determine whether methacholine AHR affects the respons..
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Original Article
Prevalence of Depression and Anxiety in Outpatients with Chronic Airway Lung Disease
Yon Ju Ryu, Eun-Mi Chun, Jin Hwa Lee, Jung Hyun Chang
Korean J Intern Med. 2010;25(1):51-57. Published online February 26, 2010
Background/AimsPatients with chronic airway lung diseases often experience depression and anxiety, but little information is available regarding Koreans with these conditions. We thus assessed depression and anxiety in Korean patients with chronic airway lung diseases.
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Original Article
Effects of dehydroepiandrosterone on Th2 cytokine production in peripheral blood mononuclear cells from asthmatics
Inseon S. Choi, Yong Cui, Young-Ah Koh, Hyun-Chul Lee, Yong-Bum Cho, Young-Ho Won
Korean J Intern Med. 2008;23(4):176-181. Published online December 30, 2008
Background/AimsThe androgen dehydroepiandrosterone (DHEA) attenuates allergic inflammatory airway reactions by down-regulating the Th2 response in mice. The purpose of this study was to investigate whether DHEA suppresses Th2 cytokine production in cultured peripheral blood m..
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Original Article
Factors for poor prognosis of near-fatal asthma after recovery from a life-threatening asthma attack
Myung-Shin Kim, Young-Joo Cho, Hee-Bom Moon, Sang Heon Cho
Korean J Intern Med. 2008;23(4):170-175. Published online December 29, 2008
Background/AimsThe aim of this study was to investigate poor prognostic factors associated with a near-fatal asthma attack following patient recovery. MethodsWe enrolled 68 patients who suffered near-fatal asthma attacks and w..
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Original Article
Clinical findings of the patients with legal pulmonary disability - Short-term follow-up at a tertiary university hospital in Korea
Sun Young Kyung, Yu Jin Kim, Chang Hyeok An, Sang Pyo Lee, Jeong Woong Park, Sung Hwan Jeong
Korean J Intern Med. 2008;23(2):72-77. Published online June 20, 2008
Background/AimsLegal pulmonary disability in Korea is decided for chronic respiratory patients who have been diagnosed for a year or more, and the patients haven't gotten better after more than 2 months of sufficient treatment and they have shown no change in their pulmonary f..
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Original Article
Benzalkonium Chloride Induced Bronchoconstriction in Patients with Stable Bronchial Asthma
Byoung Hoon Lee, Sang-Hoon Kim
Korean J Intern Med. 2007;22(4):244-248. Published online December 20, 2007
BackgroundAlthough benzalkonium chloride (BAC)-induced bronchoconstriction occurs in patients with bronchial asthma, BAC-containing nebulizer solutions are still being used in daily practice in Korea. The aim of this study was to evaluate the effects of inhaled aqueous soluti..
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