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Review
Angiotensin receptor-neprilysin inhibitor for the treatment of heart failure: a review of recent evidence
Hong-Mi Choi, Mi-Seung Shin
Korean J Intern Med. 2020;35(3):498-513. Published online April 29, 2020
Heart failure (HF) is a growing health concern in aging societies worldwide. Sacubitril/valsartan is changing the real-world treatment in the whole spectrum of HF. The beginning was the PARADIGM-HF trial published in 2014, which demonstrated the beneficial effects of inhibiting natriuretic peptide b..
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Review
Current status of heart failure: global and Korea
Jin Joo Park, Dong-Ju Choi
Korean J Intern Med. 2020;35(3):487-497. Published online April 29, 2020
Heart failure (HF) is a condition in which the heart is unable to pump enough blood to meet the body’s needs for blood and oxygen. Thus, HF is a grave disease with high morbidity and mortality. Because the prevalence of and exposure to the risk factors for HF increase with age, the prevalence of H..
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Cardiology / Original Article
Attitudes toward advance directives and prognosis in patients with heart failure: a pilot study
JinShil Kim, Minjeong An, Seongkum Heo, Mi-Seung Shin
Korean J Intern Med. 2020;35(1):109-118. Published online February 15, 2019
Background/Aims: Advance directives (ADs) in Korean patients with heart failure (HF) and the associations of attitude towards ADs and HF prognosis with ADs were initially assessed using the model of the Korean-Advance Directive (K-AD).
Methods: Twenty-four patients with HF (age, 67.1 years; men, 58..
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Cardiology / Original Article
The mortality benefit of carvedilol versus bisoprolol in patients with heart failure with reduced ejection fraction
Ki Hong Choi, Ga Yeon Lee, Jin-Oh Choi, Eun-Seok Jeon, Hae-Young Lee, Sang Eun Lee, Jae-Joong Kim, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Myeong-Chan Cho, Hyun-Young Park, Byung-Hee Oh
Korean J Intern Med. 2019;34(5):1030-1039. Published online October 16, 2018
Background/Aims: It is unknown whether different β-blockers (BBs) have variable effects on long-term survival of patients with heart failure with reduced ejection fraction (HFrEF). This study compares the effects of two BBs, carvedilol and bisoprolol, on survival in patients with HFrEF.
Methods: ..
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Cardiology / Original Article
Serum levels of carbohydrate antigen 125 in combination with N-terminal pro-brain natriuretic peptide in patients with acute decompensated heart failure
Jae Yong Yoon, Dong Heon Yang, Hyun Jun Cho, Nam Kyun Kim, Chang-Yeon Kim, Jihyun Son, Jae-Hyung Roh, Se Yong Jang, Myung Hwan Bae, Jang Hoon Lee, Hun Sik Park, Yongkeun Cho, Shung Chull Chae
Korean J Intern Med. 2019;34(4):811-818. Published online December 31, 2018
Background/Aims: Carbohydrate antigen 125 (CA-125) is an emerging prognostic biomarker for heart failure. We aimed to test the long-term prognostic value of CA-125 in combination with N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with acute decompensated heart failure (ADHF).
Met..
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Cardiology / Original Article
Pre-discharge anemia as a predictor of adverse clinical outcomes in patients with acute decompensated heart failure
Min Chul Kim, Kye Hun Kim, Jae Yeong Cho, Ki Hong Lee, Doo Sun Sim, Hyun Ju Yoon, Nam Sik Yoon, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park
Korean J Intern Med. 2019;34(3):549-558. Published online March 23, 2018
Background/Aims: The impact of the timing of anemia during hospitalization on future clinical outcomes after surviving discharge from an index heart failure (HF) has been poorly studied in patients with acute decompensated heart failure (ADHF).
Methods: A total of 384 surviving patients with acute ..
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Cardiology / Review
Update on heart failure management and future directions
[corrected-article]
Hong-Mi Choi, Myung-Soo Park, Jong-Chan Youn
Korean J Intern Med. 2019;34(1):11-43. Published online December 28, 2018
Heart failure (HF) is an important cardiovascular disease because of its increasing prevalence, significant morbidity, high mortality, and rapidly expanding health care cost. The number of HF patients is increasing worldwide, and Korea is no exception. There have been marked advances in definition, ..
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Cardiology / Review
Palliative and end-of-life care for heart failure patients in an aging society
Takahiro Okumura, Akinori Sawamura, Toyoaki Murohara
Korean J Intern Med. 2018;33(6):1039-1049. Published online May 23, 2018
The populations of Asian countries are expected to age rapidly in the near future, with a dramatic increase in the number of heart failure (HF) patients also anticipated. The need for palliative and end-of-life care for elderly patients with advanced HF is currently recognized in aging societies. Ho..
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Cardiology / Original Article
Body fluid status assessment by bio-impedance analysis in patients presenting to the emergency department with dyspnea
Chan Soon Park, Sang-Eun Lee, Hyun-Jai Cho, Yong-Jin Kim, Hyun-Jae Kang, Byung-Hee Oh, Hae-Young Lee
Korean J Intern Med. 2018;33(5):911-921. Published online December 18, 2017
Background/Aims: Fluid retention occurs in patients with heart failure, accounting for dyspnea. We investigated the diagnostic implication of body fluid status, assessed by bio-impedance analysis (BIA), in acute heart failure (AHF) among patients who presented with dyspnea.
Methods: A total of 100 ..
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Nephrology / Original Article
Comparison of tolvaptan treatment between patients with the SIADH and congestive heart failure: a single-center experience
Gun Ha Park, Chang Min Lee, Jae Won Song, Moon Chan Jung, Jwa Kyung Kim, Young Rim Song, Hyung Jik Kim, Sung Gyun Kim
Korean J Intern Med. 2018;33(3):561-567. Published online March 13, 2017
Background/Aims: Tolvaptan is a very effective treatment for hypervolemic or euvolemic hyponatremia. We compared the clinical efficacy of and response to tolvaptan in patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and congestive heart failure (CHF).
Methods: We r..
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Cardiology / Original Article
Prognostic value of total triiodothyronine and free thyroxine levels for the heart failure in patients with acute myocardial infarction
Min Gyu Kang, Jong Ryeal Hahm, Kye-Hwan Kim, Hyun-Woong Park, Jin-Sin Koh, Seok-Jae Hwang, Jin-Yong Hwang, Jong Hwa Ahn, Yongwhi Park, Young-Hoon Jeong, Jeong Rang Park, Choong Hwan Kwak
Korean J Intern Med. 2018;33(3):512-521. Published online January 11, 2017
Background/Aims: Although a low triiodothyronine (T3) state is closely associated with heart failure (HF), it is uncertain whether total T3 levels on admission is correlated with the clinical outcomes of acute myocardial infarction (AMI). The aim of this study is to investigate the prognostic value..
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Cardiology / Review
How to tackle congestion in acute heart failure
Pieter Martens, Wilfried Mullens
Korean J Intern Med. 2018;33(3):462-473. Published online April 11, 2018
Acute heart failure is a common complication of chronic heart failure and is associated with a high risk for subsequent mortality and morbidity. In 90% of case acute heart failure is the resultant of congestion, a manifestation of fluid build-up due to increased filling pressures. As residual conges..
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Endocrinology-metabolism / Review
Diabetic cardiomyopathy: where we are and where we are going
Wang-Soo Lee, Jaetaek Kim
Korean J Intern Med. 2017;32(3):404-421. Published online April 18, 2017
The global burden of diabetes mellitus and its related complications are currently increasing. Diabetes mellitus affects the heart through various mechanisms including microvascular impairment, metabolic disturbance, subcellular component abnormalities, cardiac autonomic dysfunction, and a maladapti..
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Cardiology / Review
Practical management of peripartum cardiomyopathy
Mi-Jeong Kim, Mi-Seung Shin
Korean J Intern Med. 2017;32(3):393-403. Published online April 14, 2017
Peripartum cardiomyopathy (PPCM) is an idiopathic cardiomyopathy that causes systolic heart failure (HF) in previously healthy young women. Despite latest remarkable achievement, unifying pathophysiologic mechanism is not well established. Considering close temporal relationship to pregnancy, the re..
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Cardiology / Original Article
Impact of the β-1 adrenergic receptor polymorphism on tolerability and efficacy of bisoprolol therapy in Korean heart failure patients: association between β adrenergic receptor polymorphism and bisoprolol therapy in heart failure (ABBA) study
Hae-Young Lee, Wook-Jin Chung, Hui-Kyung Jeon, Hong-Seog Seo, Dong-Ju Choi, Eun-Seok Jeon, Jae-Joong Kim, Joon Han Shin, Seok-Min Kang, Sung Cil Lim, Sang-Hong Baek
Korean J Intern Med. 2016;31(2):277-287. Published online February 16, 2016
Background/Aims: We evaluated the association between coding region variants of adrenergic receptor genes and therapeutic effect in patients with congestive heart failure (CHF).
Methods: One hundred patients with stable CHF (left ventricular ejection fraction [LVEF] < 45%) were enrolled. Enrolled ..
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Cardiology / Review
Breakthrough in heart failure with preserved ejection fraction: are we there yet?
Shir Lynn Lim, Carolyn Su Ping Lam
Korean J Intern Med. 2016;31(1):1-14. Published online December 28, 2015
Heart failure with preserved ejection fraction (HFPEF) is a global health problem of considerable socioeconomic burden. It is projected to worsen with the aging population worldwide. The lack of effective therapies underscores our incomplete understanding of this complex heterogeneous syndrome. A no..
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Cardiology / Original Article
Prognostic value of hyponatremia in heart failure patients: an analysis of the Clinical Characteristics and Outcomes in the Relation with Serum Sodium Level in Asian Patients Hospitalized for Heart Failure (COAST) study
[editorial]
Byung-Su Yoo, Jin Joo Park, Dong-Ju Choi, Seok-Min Kang, Juey-Jen Hwang, Shing-Jong Lin, Ming-Shien Wen, Jian Zhang, Junbo Ge, on behalf of the COAST investigators
Korean J Intern Med. 2015;30(4):460-470. Published online June 29, 2015
Background/Aims: Hyponatremia is a well-known risk factor for poor outcomes in Western studies of heart failure (HF) patients. We evaluated the predictive value of hyponatremia in hospitalized Asian HF patients.
Methods: The Clinical Characteristics and Outcomes in the Relation with Serum Sodium Le..
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Cardiology / Original Article
Effects of intensive versus mild lipid lowering by statins in patients with ischemic congestive heart failure: Korean Pitavastatin Heart Failure (SAPHIRE) study
Hae-Young Lee, Hyun-Jai Cho, Hee-Yul Kim, Hee-Kyung Jeon, Joon Han Shin, Suk-Min Kang, Sang Hong Baek
Korean J Intern Med. 2014;29(6):754-763. Published online October 31, 2014
Background/Aims: This study was designed to evaluate the dose-effect relationship of statins in patients with ischemic congestive heart failure (CHF), since the role of statins in CHF remains unclear.
Methods: The South koreAn Pitavastatin Heart FaIluRE (SAPHIRE) study was designed to randomize pat..
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Letter to the editor
Acute right heart failure caused by iatrogenic brachiocephalic arteriovenous fistula following orthopedic surgery
Kye Hun Kim, Hyun Ju Yoon, Youngkeun Ahn, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang
Korean J Intern Med. 2014;29(4):529-531. Published online June 27, 2014
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Cardiology / Original Article
Serum bilirubin as a prognostic marker in patients with acute decompensated heart failure
Jayakrishna Chintanaboina, Matthew S. Haner, Arjinder Sethi, Nimesh Patel, Walid Tanyous, Alexander Lalos, Sameer Pancholy
Korean J Intern Med. 2013;28(3):300-305. Published online May 1, 2013
Background/AimsSeveral prognostic markers for heart failure (HF) have been determined but the importance of liver function tests (LFTs) remains unknown. The aim of this study was to determine the prognostic significance, if any, of abnormal LFTs in acute decompensated HF. <..
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