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Hemato-oncology / Original Article
Association between serum ferritin levels and colorectal cancer risk in Korea
Hyunho Kim, Kyungdo Han, Seung-Hyun Ko, Ho Jung An
Korean J Intern Med. 2022;37(6):1205-1215. Published online October 25, 2022
Background/Aims: The concentration of serum ferritin, a storage form of iron, may be associated with carcinogenesis in various cancers. There are only limited studies on the relationship between serum ferritin levels and colorectal cancer (CRC) risk, especially in the Asian population. This study ai..
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Gastroenterology / Original Article
Factors associated with the risk of colorectal neoplasia in young adults under age 40
Ilsoo Kim, Han Hee Lee, Young Jae Ko, Ho Eun Chang, Dae Young Cheung, Bo-In Lee, Young-Seok Cho, Jin Il Kim, Myung-Gyu Choi
Korean J Intern Med. 2022;37(5):969-978. Published online July 25, 2022
Background/Aims: Recent epidemiologic studies have shown a continued increase in colorectal cancer incidence among younger adults. Little is known about the factors that contribute to the development of young-onset colorectal neoplasia (CRN).
Methods: A cross-sectional analysis was performed for ind..
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Pulmonology / Original Article
Prognostic outcome of treatment modalities for epidermal growth factor receptor-mutated advanced lung cancer
Seung Hun Jang, Dong Yoon Lee, Jihyeon Jeong, Won-Il Choi
Korean J Intern Med. 2022;37(4):811-820. Published online June 3, 2022
Background/Aims: The treatment of epidermal growth factor receptor (EGFR)-mutated lung cancer cases has shown remarkable development in the past two decades. However, there have been limited studies comparing the prognostic effects of EGFR-tyrosine kinase inhibitor (TKI) and other treatment modaliti..
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Hemato-oncology / Original Article
Geriatric functional assessment for decision-making on adjuvant chemotherapy in older colon cancer patients
Hyun Jin Bang, Hyun Jeong Shim, Ga Ram Kim, Jun Eul Hwang, Woo Kyun Bae, Ik Joo Chung, Sang Hee Cho
Korean J Intern Med. 2022;37(3):660-672. Published online April 15, 2022
Background/Aims: Despite the increasing need for geriatric assessment prior to chemotherapy, the method for this assessment remains inadequate for older cancer patients. We aimed to propose a simple assessment method to predict the performance of adjuvant chemotherapy in older patients after colon c..
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Hemato-oncology / Original Article
Analysis of thromboembolic events in head and neck cancer patients who underwent concurrent chemoradiotherapy with cisplatin
[corrected-article]
Hundo Cho, Jin-Hyuk Choi, Seok Yun Kang, Hyun Woo Lee, Yong Won Choi, Tae-Hwan Kim, Mi Sun Ahn, Chul-Ho Kim, Yoo Seob Shin, Jeon Yeob Jang, Young-Taek Oh, Jaesung Heo, Seung Soo Sheen
Korean J Intern Med. 2022;37(3):653-659. Published online April 20, 2022
Background/Aims: The study investigated the incidence of thromboembolic events (TEE) in head and neck (H&N) cancer patients who received concurrent chemoradiotherapy (CCRT) with cisplatin, and analyzed the factors affecting TEE occurrence
Methods: Two hundred and fifty-seven patients who started CC..
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Rheumatology / Original Article
Cancer risk in Korean patients with gout
Yoon-Jeong Oh, Yun Jong Lee, Eunyoung Lee, Bumhee Park, Jae-Woo Kwon, Jeongwon Heo, Ki Won Moon
Korean J Intern Med. 2022;37(2):460-467. Published online March 23, 2021
Background/Aims: Using a nationwide cohort, we investigated the cancer risk in Korean patients with gout.
Methods: Data were obtained from the Korean National Health Insurance Service Database. Patients with gout were defined as those aged ≥ 20 years who were diagnosed with gout and received anti..
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Endocrinology-metabolism / Original Article
Clinical features and signaling effects of RET D631Y variant multiple endocrine neoplasia type 2 (MEN2)
Ji-young Lee, Su Yeon Kim, Kwan Hoon Jo, Eun Yeong Mo, Eun Sook Kim, Hye Soo Kim, Je Ho Han, Sung-dae Moon
Korean J Intern Med. 2022;37(2):398-410. Published online December 15, 2021
Background/Aims: Germline mutations of the rearranged during transfection (RET) gene cause multiple endocrine neoplasia type 2 (MEN2). About 85% of RET mutations in MEN2 occur in codon Cys634. The RET D631Y mutation has recently been discovered, and we have studied its molecular expres..
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Gastroenterology / Original Article
Positive fecal immunochemical test results are associated with non-colorectal cancer mortality
Yoon Suk Jung, Jinhee Lee, Chang Mo Moon
Korean J Intern Med. 2022;37(2):313-321. Published online September 29, 2021
Background/Aims: Studies have reported an association between fecal occult blood and increased all-cause, non-colorectal cancer (CRC) as well as CRC mortality. This study aimed to determine whether positive fecal immunochemistry test (FIT) results are associated with death from various causes in the..
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Gastroenterology / Original Article
Prevalence and associated risk of advanced colorectal neoplasia in adults with sarcopenia
[letter]
Min Cheol Kim, Kyeong Ok Kim, Min Kyu Kang
Korean J Intern Med. 2022;37(2):294-303. Published online December 16, 2021
Background/Aims: Although several studies have shown that sarcopenia is associated with poor outcomes in colorectal cancer patients, the impact of sarcopenia on the development of colorectal neoplasia remains unclear. We aimed to evaluate the prevalence and association of colorectal neoplasia, espec..
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Hemato-oncology / Original Article
Characteristics and treatment patterns in older patients with locally advanced head and neck cancer (KCSG HN13-01)
Eun Joo Kang, Yun-Gyoo Lee, Bhumsuk Keam, Jin-Hyuk Choi, Jin-Soo Kim, Keon Uk Park, Kyoung Eun Lee, Hyo Jung Kim, Keun-Wook Lee, Min Kyoung Kim, Hee Kyung Ahn, Seong Hoon Shin, Jii Bum Lee, Jung Hye Kwon, Hye Ryun Kim, Sung-Bae Kim, Hwan Jung Yun
Korean J Intern Med. 2022;37(1):190-200. Published online December 21, 2021
Background/Aims: Treatment decisions for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) are complicated, and multi-modal treatments are usually indicated. However, it is challenging for older patients to complete treatments. Thus, we investigated disease characteristics, real-world..
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Hemato-oncology / Original Article
Surtuin 1 as a potential prognostic biomarker in very elderly patients with colorectal cancer
Guk Jin Lee, Yun Hwa Jung, Tae-Jung Kim, Yosep Chong, Seo-Won Jeong, In Kyu Lee, In Sook Woo
Korean J Intern Med. 2021;36(Suppl 1):S235-S244. Published online July 2, 2020
Background/Aims: Colorectal cancer (CRC) rate increases with aging. Aging-related proteins, such as sirtuins (SIRTs) may be a potential therapeutic target in the elderly patients with CRC. The clinical implications of SIRT1 and SIRT2 have not been reported for elderly patients with cancer. The aim of..
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Hemato-oncology / Original Article
Induction chemotherapy followed by concurrent chemoradiotherapy versus CCRT for locally
advanced hypopharynx and base of tongue cancer
Sung Hee Lim, Jong-Mu Sun, Joohyun Hong, Dongryul Oh, Yong Chan Ahn, Man Ki Chung, Han-Sin Jeong, Young-Ik Son, Myung-Ju Ahn, Chung-Hwan Baek, Keunchil Park
Korean J Intern Med. 2021;36(Suppl 1):S217-S224. Published online April 3, 2020
Background/Aims: Clinical trials have not consistently supported the use of induction chemotherapy (IC) for locally advanced head and neck squamous cell cancer. Hypopharynx and base of tongue (BOT) cancer has shown relatively poor survival. We investigated the role of IC in improving outcome over c..
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Hemato-oncology / Original Article
Determination of the relationship between the fatigue and social support levels of cancer patients: a cross-sectional study
Meltem Akbas, Sule Gokyildiz Surucu, Emine Akca, Cemile Onat Koroglu
Korean J Intern Med. 2021;36(Suppl 1):S207-S216. Published online June 12, 2020
Background/Aims: Cancer is seen as one of the most important health problems of our time. In the world and in our country, the most common death cause after cardiovascular diseases in the order of diseases that result in death is cancer. This descriptive, cross-sectional study is done in order to de..
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Gastroenterology / Original Article
Increased risk of gastric cancer in workers with occupational dust exposure
Mo-Yeol Kang, Jiyoun Jung, Jung-Wan Koo, Inah Kim, Hyoung-Ryoul Kim, Jun-Pyo Myong
Korean J Intern Med. 2021;36(Suppl 1):S18-S26. Published online May 7, 2020
Background/Aims: Workers who are exposed to dust in the workplace tend to show a higher incidence of gastric cancer. Nevertheless, scientific evidence to support an association between dust exposure and the risk of gastric cancer is inadequate. This study aimed to investigate whether or not occupati..
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Gastroenterology / Original Article
Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
Young Jung Kim, Young Koog Cheon, Tae Yoon Lee, Seong-Hwan Chang, Mi-Hye Yu
Korean J Intern Med. 2021;36(6):1338-1346. Published online June 21, 2021
Background/Aims: Postoperative abdominal fluid collection (PAFC) is a frequent complication of pancreatobiliary cancer surgery. The effects of the existence and duration of PAFC are not well known. This study aimed to assess the effects of PAFC on patient prognosis after surgery for pancreatobiliary..
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Gastroenterology / Original Article
HER-2 positivity is a high risk of recurrence of stage I gastric cancer
Seonhoo Kim, Yeon-Ji Kim, Woo Chul Chung
Korean J Intern Med. 2021;36(6):1327-1337. Published online August 26, 2021
Background/Aims: The treatment of gastric cancer remains unsatisfactory. We aimed to investigate the prognostic value of immunohistochemical staining in gastric cancer.
Methods: We analyzed 505 (279 early staged, 226 advanced-staged) gastric cancer tissues from patients who underwent radical gastri..
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Hemato-oncology / Original Article
Thrombotic and hemorrhagic events in 2016 World Health Organization-defined Philadelphia-negative myeloproliferative neoplasm
Ik-Chan Song, Sang Hoon Yeon, Myung-Won Lee, Hyewon Ryu, Hyo-Jin Lee, Hwan-Jung Yun, Seon Young Kim, Deog-Yeon Jo
Korean J Intern Med. 2021;36(5):1190-1203. Published online July 22, 2021
Background/Aims: Recent changes in the diagnostic criteria for myeloproliferative neoplasms (MPNs) and increasing patient numbers necessitate updating of the data on vascular events in patients with such disorders.
Methods: In this single-center study, thrombotic and hemorrhagic events were retrosp..
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Gastroenterology / Original Article
Risk of colorectal cancer in patients with positive results of fecal immunochemical test performed within 5 years since the last colonoscopy
Yoon Suk Jung, Jinhee Lee, Chang Mo Moon
Korean J Intern Med. 2021;36(5):1083-1091. Published online June 18, 2021
Background/Aims: Annual fecal immunochemical tests (FITs) are often repeated within the recommended colonoscopy surveillance intervals. However, it remains unclear whether interval FITs are useful. To answer this question, we assessed the risk of colorectal cancer (CRC) according to the interval fro..
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Gastroenterology / Original Article
Risk stratification of patients with gastric lesions indefinite for dysplasia
Young Sin Cho, Il-Kwun Chung, Yunho Jung, Su Jung Han, Jae Kook Yang, Tae Hoon Lee, Sang-Heum Park, Sun-Joo Kim
Korean J Intern Med. 2021;36(5):1074-1082. Published online September 9, 2020
Background/Aims: There are no definite guidelines for the management of gastric lesions diagnosed as indefinite for dysplasia (IND) by endoscopic forceps biopsy (EFB). Therefore, this study aimed to evaluate the clinical outcomes of gastric IND and predictive factors for gastric neoplasm.
Methods: ..
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Gastroenterology / Original Article
Second-look endoscopy findings after endoscopic submucosal dissection for colorectal epithelial neoplasms
Soo-kyung Park, Hyeon Jeong Goong, Bong Min Ko, Haewon Kim, Hyo Sun Seok, Moon Sung Lee
Korean J Intern Med. 2021;36(5):1063-1073. Published online June 9, 2021
Background/Aims: Although second-look endoscopy (SLE) is frequently performed after gastric endoscopic submucosal dissection (ESD) to prevent bleeding, no studies have reported SLE findings after colorectal ESD. This study aimed to investigate SLE findings and their role in preventing delayed bleedi..
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