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Infectious diseases / Original Article
Changing trends in clinical characteristics and antibiotic susceptibility of Klebsiella pneumoniae bacteremia
Miri Hyun, Chang In Noh, Seong Yeol Ryu, Hyun Ah Kim
Korean J Intern Med. 2018;33(3):595-603. Published online November 10, 2017
Background/Aims: Klebsiella pneumoniae is second most common organism of gram-negative bacteremia in Korea and one of the most common cause of urinary tract infection, and intra-abdominal infection.
Methods: We compared clinical and microbiological characteristics about K. pneumoniae ..
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Infectious diseases / Review
Epidemiology and treatment of antimicrobialresistant gram-negative bacteria in Korea
Young Ah Kim, Yoon Soo Park
Korean J Intern Med. 2018;33(2):247-255. Published online February 27, 2018
Antimicrobial resistance is becoming one of the greatest challenges to public health worldwide. Infections by antimicrobial-resistant organisms could result in the failure of treatment, increased medical costs, prolonged hospital stays, and an increased socioeconomic burden. Antimicrobial usage in K..
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Infectious diseases / Original Article
Risk factors and molecular epidemiology of community-onset, multidrug resistance extended-spectrum β-lactamase-producing Escherichia coli infections
So Yeon Park, Cheol-In Kang, Yu Mi Wi, Doo Ryeon Chung, Kyong Ran Peck, Nam-Yong Lee, Jae-Hoon Song
Korean J Intern Med. 2017;32(1):146-157. Published online April 20, 2016
Background/Aims: Although multidrug resistance (MDR) among extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) poses significant therapeutic challenges, little is known regarding the risk factors and epidemiology of community-onset MDR‑ESBL‑EC infections. We performed this study t..
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Hemato-oncology / Original Article
Use of deferasirox, an iron chelator, to overcome imatinib resistance of chronic myeloid leukemia cells
Dae Sik Kim, Yoo Jin Na, Myoung Hee Kang, Soo-Young Yoon, Chul Won Choi
Korean J Intern Med. 2016;31(2):357-366. Published online February 15, 2016
Background/Aims: The treatment of chronic myeloid leukemia (CML) has achieved impressive success since the development of the Bcr-Abl tyrosine kinase inhibitor, imatinib mesylate. Nevertheless, resistance to imatinib has been observed, and a substantial number of patients need alternative treatment ..
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Infectious diseases / Review
Emerging strategies for the treatment of pulmonary tuberculosis: promise and limitations?
Wing Wai Yew, Won-Jung Koh
Korean J Intern Med. 2016;31(1):15-29. Published online December 28, 2015
A worsening scenario of drug-resistant tuberculosis has increased the need for new treatment strategies to tackle this worldwide emergency. There is a pressing need to simplify and shorten the current 6-month treatment regimen for drug-susceptible tuberculosis. Rifamycins and fluoroquinolones, as we..
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Pulmonology / Original Article
Clinical manifestations of pneumonia according to the causative organism in patients in the intensive care unit
Jung-Kyu Lee, Jinwoo Lee, Young Sik Park, Chang Hoon Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Sang-Min Lee
Korean J Intern Med. 2015;30(6):829-836. Published online October 30, 2015
Background/Aims: Whether the causative organism influences the clinical course of pneumonia in the intensive care unit (ICU) is controversial. We assessed the clinical manifestations and prognosis of pneumonia according to the causative pathogens in patients in a medical ICU.
Methods: A retrospecti..
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Infectious diseases / Original Article
Drug utilization review of mupirocin ointment in a Korean university-affiliated hospital
Sung Hee Youn, Seung Soon Lee, Sukyeon Kim, Jeong-a Lee, Bum Joon Kim, Jounghee Kim, Hye-kyung Han, Jae-Seok Kim
Korean J Intern Med. 2015;30(4):515-520. Published online June 29, 2015
Background/Aims: Intranasa l mupirocin and chlorhexidine bathing are candidate strategies to prevent healthcare-associated infections caused by methicillin-resistant Staphylococcus aureus (MRSA). In Korea, intranasal mupirocin is not available, and mupirocin ointment, an over-the-counter drug..
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Pulmonology / Original Article
Drug-resistance pattern of Mycobacterium tuberculosis strains from patients with pulmonary and extrapulmonary tuberculosis during 2006 to 2013 in a Korean tertiary medical center
Ho Young Lee, Jin Lee, Young Seok Lee, Mi-Yeong Kim, Hyun-Kyung Lee, Young-Min Lee, Jeong Hwan Shin, Yousang Ko
Korean J Intern Med. 2015;30(3):325-334. Published online April 29, 2015
Background/Aims: We evaluated the trend in the rates of drug-resistant tuberculosis (TB) over time, as well as the difference in the drug-resistance pattern between pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) at a private referral center in South Korea.
Methods: All patients..
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Infectious diseases / Original Article
Clinical and microbiological features of Providencia bacteremia: experience at a tertiary care hospital
Hee Kyoung Choi, Young Keun Kim, Hyo Youl Kim, Jeong Eun Park, Young Uh
Korean J Intern Med. 2015;30(2):219-225. Published online February 27, 2015
Background/Aims: Providencia species frequently colonize urinary catheters and cause urinary tract infections (UTIs); however, bacteremia is uncommon and not well understood. We investigated the clinical features of Providencia bacteremia and the antibiotic susceptibility of Provide..
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Gastroenterology / Original Article
Long-term efficacy of tenofovir disoproxil fumarate therapy after multiple nucleos(t)ide analogue failure in chronic hepatitis B patients
Hyo Jin Kim, Ju-Yeon Cho, Yu Jin Kim, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Kwang Cheol Koh, Seung Woon Paik, Byung Chul Yoo, Joon Hyeok Lee
Korean J Intern Med. 2015;30(1):32-41. Published online December 30, 2014
Background/Aims: The efficacy of tenofovir disoproxil fumarate (TDF) for the treatment of chronic hepatitis B (CHB) patients following prior treatment failure with multiple nucleos(t)ide analogues (NAs) is not well defined, especially in Asian populations. In this study we investigated the efficacy ..
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Letter to the editor
Transformation into large-cell neuroendocrine carcinoma associated with acquired resistance to erlotinib in nonsmall cell lung cancer
Jeong Uk Lim, In Sook Woo, Yun Hwa Jung, Jae Ho Byeon, Chan Kwon Park, Tae Jung Kim, Hyo Rim Kim
Korean J Intern Med. 2014;29(6):830-833. Published online October 31, 2014
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Endocrinology-metabolism / Original Article
The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes
Ohk-Hyun Ryu, Wankyo Chung, Sungwha Lee, Kyung-Soon Hong, Moon-Gi Choi, Hyung Joon Yoo
Korean J Intern Med. 2014;29(5):620-629. Published online August 28, 2014
Background/Aims: Recent epidemiological studies revealed a striking inverse relationship between vitamin D levels, glucose intolerance/insulin resistance (IR), and cardiovascular disease. However, few interventional studies have evaluated the effect of vitamin D supplementation on cardiovascular ris..
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Gastroenterology / Original Article
Effects of D-002, a mixture of high molecular weight beeswax alcohols, on patients with nonalcoholic fatty liver disease
José Illnait, Iván Rodríguez, Sarahí Mendoza, Yolanda Fernández, Rosa Mas, Mirtha Miranda, Jesús Piñera, Julio César Fernández, Meilis Mesa, Lilia Fernández, Daisy Carbajal, Rafael Gámez
Korean J Intern Med. 2013;28(4):439-448. Published online July 1, 2013
Background/AimsNonalcoholic fatty liver disease (NAFLD) is intimately related to insulin resistance and ranges from a benign course to liver fibrosis and cirrhosis. NAFLD management mainly involves dietary modification and weight loss. Although no fully successful pharmacologi..
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Endocrinology-metabolism / Original Article
Insulin secretion and insulin resistance in Korean women with gestational diabetes mellitus and impaired glucose tolerance
Sae Jeong Yang, Tae Nyun Kim, Sei Hyun Baik, Tae Sun Kim, Kwan Woo Lee, Moonsuk Nam, Yong Soo Park, Jeong-Teak Woo, Young Seol Kim, Sung-Hoon Kim
Korean J Intern Med. 2013;28(3):306-313. Published online May 1, 2013
Background/AimsThe aim was to compare the insulin sensitivity and secretion index of pregnant Korean women with normal glucose tolerance (NGT), gestational impaired glucose tolerance (GIGT; only one abnormal value according to the Carpenter and Coustan criteria), and gestation..
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Letter to the editor
A third case of USA300 community-associated methicillin-resistant Staphylococcus aureus infection in Korea
Seungjin Lim, Doo Ryeon Chung, Jin Yang Baek, So Hyun Kim, Kyong Ran Peck, Nam-Yong Lee, Jae-Hoon Song
Korean J Intern Med. 2013;28(2):258-260. Published online February 27, 2013
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Rheumatology / Original Article
Is the frequency of metabolic syndrome higher in South Korean women with rheumatoid arthritis than in healthy subjects?
Seung-Geun Lee, Ji-Min Kim, Sun-Hee Lee, Kye-Hyung Kim, Ji-Hye Kim, Ji-Won Yi, Woo-Jin Jung, Young-Eun Park, Seong-Hu Park, Joung-Wook Lee, Seung-Hoon Baek, Jun-Hee Lee, Geun-Tae Kim
Korean J Intern Med. 2013;28(2):206-215. Published online February 27, 2013
Background/AimsTo compare the frequency of metabolic syndrome (MetS) and magnitude of insulin resistance, measured by the homeostatic model assessment of insulin resistance (HOMA-IR), between South Korean women with rheumatoid arthritis (RA) and healthy subjects, and to evalua..
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Original Article
The Causes and Treatment Outcomes of 91 Patients with Adult Nosocomial Meningitis
Hye-In Kim, Shin-Woo Kim, Ga-Young Park, Eu-Gene Kwon, Hyo-Hoon Kim, Ju-Young Jeong, Hyun-Ha Chang, Jong-Myung Lee, Neung-Su Kim
Korean J Intern Med. 2012;27(2):171-179. Published online May 31, 2012
Background/AimsFrequent pathogens of nosocomial meningitis were investigated and the adequacy of empiric antibiotic therapy was assessed. Outcomes of nosocomial meningitis were also evaluated. MethodsNinety-one patients, who were diagnosed and t..
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Review
Steroid Response in Refractory Asthmatics
An-Soo Jang
Korean J Intern Med. 2012;27(2):143-148. Published online May 31, 2012
Inhaled glucocorticosteroids are currently the most effective anti-inflammatory controller medications for treating persistent asthma. The efficacies of glucocorticoids include reducing asthma symptoms, reducing exacerbation frequency, improving quality of life, improving lung function, decreasin..
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Original Article
Associations among Body Mass Index, Insulin Resistance, and Pancreatic β-Cell Function in Korean Patients with New-Onset Type 2 Diabetes
Jin Ook Chung, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
Korean J Intern Med. 2012;27(1):66-71. Published online February 28, 2012
Background/AimsWe investigated the associations among body mass index (BMI), insulin resistance, and β-cell function in Korean patients newly presenting with type 2 diabetes. MethodsIn total, 132 patients with new-onset type 2 diabetes mellitu..
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Original Article
Insulin Resistance as a Risk Factor for Gallbladder Stone Formation in Korean Postmenopausal Women
Sang Soo Kim, Jeong Gyu Lee, Dong Wok Kim, Bo Hyun Kim, Yun Kyung Jeon, Mi Ra Kim, Jeong Eun Huh, Ji Young Mok, Seong-Jang Kim, Yong Ki Kim, In Joo Kim
Korean J Intern Med. 2011;26(3):285-293. Published online September 13, 2011
Background/AimsThe objective of this study was to determine whether insulin resistance is associated with gallbladder stone formation in Korean women based on menopausal status. MethodsThe study included 4,125 consecutive Korean subjects (30-79 ..
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