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Case Report
Unpredicted Severe Toxicity after 5-Fluorouracil Treatment due to Dihydropyrimidine Dehydrogenase Deficiency
Jin Ho Baek, Jong Gwang Kim, Shi Nae Kim, Dong Hwan Kim, Sang Kyun Sohn, Young Jun Hong, Kyu Bo Lee
Korean J Intern Med. 2006;21(1):43-45. Published online March 30, 2006
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU). Thus, patients with a DPD deficiency are at risk of developing severe 5-FU-associated toxicity. A 37-year-old female with gastric cancer underwent a curative operation, ..
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Original Article
Expression of Cyclooxygenase-2 and Bcl-2 in Human Gastric Adenomas
Jee Hyun Park, Kyung Hee Kang, Se Hwan Kim, Jong Hyup Lee, Chang Min Cho, Young Oh Kweon, Sung Kook Kim, Yong Hwan Choi, Han Ik Bae, Mi Sung Kim
Korean J Intern Med. 2005;20(3):198-204. Published online September 30, 2005
BackgroundCyclooxygenase (COX)-2 is the rate-limiting enzyme in prostaglandin synthesis. An increased expression has been implicated in the development and progression of human gastric cancers and colorectal adenomas and cancers. This study aimed to determine the involvement a..
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Original Article
The Efficacy of Paclitaxel and Cisplatin Combination Chemotherapy for the Treatment of Metastatic or Recurrent Gastric Cancer: a Multicenter Phase II Study
Sang Joon Shin, Sung Ho Chun, Kyeong Ok Kim, Min Kyoung Kim, Kyung Hee Lee, Myung Soo Hyun, Sung Hwa Bae, Hun Mo Ryoo, Young Rok Do, Ki Young Kwon, Hong Suk Song
Korean J Intern Med. 2005;20(2):135-140. Published online June 30, 2005
BackgroundAlthough many treatments for advanced gastric cancer have been developed, only poor treatment results have generally been obtained. We performed a prospective study on the combination chemotherapy of paclitaxel and cisplatin (PC). The primary objectives of the study ..
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