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Cardiology / Original Article
Clinical significance of high on-treatment platelet reactivity in patients with prolonged clopidogrel therapy
Sehun Kim, Donghoon Han, Jae Hyuk Choi, Eun-Joo Park, Dong Geum Shin, Min-Kyung Kang, Seonghoon Choi, Namho Lee, Jung Rae Cho
Korean J Intern Med. 2021;36(Suppl 1):S80-S89. Published online February 25, 2021
Background/Aims: Prolonged dual antiplatelet therapy (DAPT) with aspirin and clopidogrel beyond 1 year has been shown to reduce ischemic events at the expense of increased bleeding. However, limited data are available on the clinical significance of platelet reactivity (PR) at 1 year.
Methods: We r..
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Hemato-oncology / Original Article
Pediatric-inspired regimen with late intensification and increased dose of L-asparaginase for adult acute lymphoblastic leukemia: the KALLA 1406/1407 study
Dong Won Baek, Dae Young Kim, Sang Kyun Sohn, Youngil Koh, Sung-Hoon Jung, Ho-Young Yhim, Yunsuk Choi, Joon Ho Moon
Korean J Intern Med. 2021;36(6):1471-1485. Published online September 24, 2021
Background/Aims: The objective of this study was to evaluate the efficacy and feasibility of the pediatric-inspired regimen of the adult acute lymphoblastic leukemia (ALL) Working Party, the Korean Society of Hematology.
Methods: Data of 99 patients with newly diagnosed ALL, who were treated with t..
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Gastroenterology / Original Article
Clinical analysis of 117 cases with synchronous multiple primary esophageal squamous cell carcinomas
Zhiqin Chen, Sihan Li, Zheng He, Guang Li
Korean J Intern Med. 2021;36(6):1356-1364. Published online April 29, 2020
Background/Aims: We aimed to study the clinical characteristics, treatment modality, and the prognosis of synchronous multiple primary esophageal squamous cell carcinomas (SMPESCC).
Methods: A total of 117 SMPESCC cases were evaluated retrospectively from 2010 to 2015.
Results: The most common loc..
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Hemato-oncology / Original Article
Temporal evolution of programmed death-ligand 1 expression in patients with non-small cell lung cancer
Chang Hyun Nam, Jaemoon Koh, Chan-Young Ock, Miso Kim, Bhumsuk Keam, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Doo Hyun Chung, Dae Seog Heo
Korean J Intern Med. 2021;36(4):975-984. Published online April 6, 2021
Background/Aims: Programmed death-ligand 1 (PD-L1) expression, a validated predictive biomarker for anti-PD-1/PD-L1 inhibitors, is reported to change over time. This poses challenges during clinical application in non-small cell lung cancer.
Methods: This study included patients with non-small cell..
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Hemato-oncology / Original Article
Pulmonary toxicities of molecular targeted antineoplastic agents: a single-center 10-year experience
Min-Young Lee, Seug Yun Yoon, Kyoung Ha Kim, Namsu Lee, Ha Youn Kim, Jung Hwa Hwang, Jong-Ho Won
Korean J Intern Med. 2021;36(3):689-698. Published online January 8, 2021
Background/Aims: A better understanding of cancer cell biology has led to the discovery and development of several new targeted agents for cancer. These drugs are widely used in cancer treatment and have good toxicity profiles. However, some patients are extremely sensitive to these drugs and can de..
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Review
Recent advances in the diagnosis and management of interstitial pneumonia with autoimmune features: the perspective of rheumatologists
Hong Ki Min, Se-Hee Kim, Sang-Heon Lee, Hae-Rim Kim
Korean J Intern Med. 2021;36(3):515-526. Published online February 8, 2021
Interstitial pneumonia with autoimmune feature (IPAF) is a recently established disease entity that is comprised of interstitial lung diseases with evidence of autoimmune features but that does not fulfill the criteria for definite autoimmune rheumatic diseases. The classification criteria for IPAF ..
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Nephrology / Original Article
Mortality prediction of serum neutrophil gelatinase-associated lipocalin in patients requiring continuous renal replacement therapy
Yohan Park, Tae Hyun Ban, Hyung Duk Kim, Eun Jeong Ko, Jongmin Lee, Seok Chan Kim, Cheol Whee Park, Chul Woo Yang, Yong-Soo Kim, Byung Ha Chung
Korean J Intern Med. 2021;36(2):392-400. Published online July 7, 2020
Background/Aims: We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) can predict mortality in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT).
Methods: This study enrolled 169 patients who underwent serum NGAL testing at CRRT..
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Hemato-oncology / Original Article
Maintenance chemotherapy after 6 cycles of platinum-doublet regimen in anthracycline-and taxane-pretreated metastatic breast cancer
Eun Kyo Joung, Ji Hyun Yang, Sooeun Oh, Se Jun Park, Jieun Lee
Korean J Intern Med. 2021;36(1):182-193. Published online February 28, 2020
Background/Aims: Sequential monotherapy is recommended for anthracycline-and taxane-resistant metastatic breast cancer (MBC), but combination chemotherapy is considered in patients with visceral crisis. Cisplatin-doublet chemotherapy is a combination regimen for MBC, but prolonged treatment is chall..
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Hemato-oncology / Original Article
Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma
Hyerim Ha, Bhumsuk Keam, Chan-Young Ock, Tae Min Kim, Jin Ho Kim, Eun-Jae Chung, Seong Keun Kwon, Soon-Hyun Ahn, Hong-Gyun Wu, Myung-Whun Sung, Dae Seog Heo
Korean J Intern Med. 2021;36(1):175-181. Published online March 30, 2020
Background/Aims: Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor characterized by indolence, with a high rate of local recurrence and distant metastasis. This study aimed to investigate the effect of concurrent chemoradiation (CCRT) on locally advanced unresectable ACC.
Methods: We re..
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Hemato-oncology / Original Article
Clinical outcome and predictive factors for docetaxel and epirubicin neoadjuvant chemotherapy of locally advanced breast cancer
Hye Sung Won, Yong Seok Kim, Jeong Soo Kim, Eun Deok Chang, Sae Jung Na, In Yong Whang, Dong Soo Lee
Korean J Intern Med. 2020;35(6):1489-1496. Published online February 21, 2020
Background/Aims: We evaluated the efficacy of docetaxel and epirubicin as neoadjuvant chemotherapy in locally advanced breast cancer and assessed the predictive factors for response to neoadjuvant chemotherapy and prognostic factors related to relapse-free survival.
Methods: Forty patients who rece..
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Hemato-oncology / Original Article
Impact of subsequent chemotherapy on the survival of elderly patients with extensive stage small cell lung cancer
Eun Joo Kang, Yoon Ji Choi, Se Ryeon Lee, Hwa Jung Sung, Jung Sun Kim
Korean J Intern Med. 2020;35(6):1468-1476. Published online April 29, 2020
Background/Aims: The prognosis of small cell lung cancer (SCLC) is still poor because of rapid recurrence, despite good response to initial chemotherapy. Additionally, patients’ old ages and comorbidities are often obstacles that make it difficult to apply subsequent treatment after initial treatm..
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Hemato-oncology / Original Article
Strong association between herpes simplex virus-1 and chemotherapy-induced oral mucositis in patients with hematologic malignancies
Junshik Hong, Hee-Kyung Park, Suhyun Park, Ahreum Lee, Yeon-Hee Lee, Dong-Yeop Shin, Youngil Koh, Ji-Yeob Choi, Sung-Soo Yoon, Youngnim Choi, Inho Kim
Korean J Intern Med. 2020;35(5):1188-1198. Published online September 9, 2019
Background/Aims: A link between oral cavity infections and chemotherapy-induced oral mucositis (CIOM) in patients with hematological malignancies (HMs) undergoing intensive chemotherapy (IC) or hematopoietic stem cell transplantation (HSCT) has been suggested. However, conclusive data are lacking, a..
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Endocrinology-metabolism / Original Article
The clinical meaning of pre- and post-ablation thyroglobulin levels at first radioiodine therapy in patients with papillary thyroid cancer
Hee Kyung Kim, Jee Hee Yoon, Jin Seong Cho, Seong Young Kwon, Su Woong Yoo, Ho-Cheol Kang
Korean J Intern Med. 2020;35(5):1164-1172. Published online July 29, 2019
Background/Aims: This study was conducted to identify prognostic factors in patients with papillary thyroid cancer (PTC) at the time of first radioactive iodine (RAI) therapy, and to evaluate the clinical value of the thyroglobulin (Tg) increase after RAI.
Methods: Serum Tg was sampled prior to (pr..
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Cardiology / Original Article
Left ventricular response after cardiac resynchronization therapy is related to early left atrial volume reduction
In-Jeong Cho, Jae-Sun Uhm, Jaewon Oh, Jong-Ho Nam, Hee Tae Yu, Taehoon Kim, Boyoung Joung, Seok-Min Kang
Korean J Intern Med. 2020;35(5):1125-1135. Published online February 6, 2020
Background/Aims: The current study aimed to elucidate a time-course change in left atrial volume after cardiac resynchronization therapy (CRT) and to verify factors associated with left atrial volume reduction (LAVR) and its prognostic implications.
Methods: The records of 97 patients were retrospe..
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Gastroenterology / Original Article
Impact of early anti-TNF use on clinical outcomes in Crohn’s disease: a nationwide population-based study
Yoon Suk Jung, Minkyung Han, Sohee Park, Jae Hee Cheon
Korean J Intern Med. 2020;35(5):1104-1113. Published online April 21, 2020
Background/Aims: The optimal timing for initiation of anti-tumor necrosis factor (TNF) therapy in Crohn’s disease (CD) is still debated. Little is known about the clinical outcomes of early versus late administration of anti-TNF agents, especially in Asian CD patients. We aimed to evaluate the imp..
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Review
Squamous cell carcinoma of head and neck: what internists should know
Kyungsuk Jung, Manpreet Narwal, Seon Young Min, Bhumsuk Keam, Hyunseok Kang
Korean J Intern Med. 2020;35(5):1031-1044. Published online July 14, 2020
Squamous cell carcinoma of head and neck (SCCHN) is a group of cancer arising from mucosal surfaces of the head and neck. Optimal management of SCCHN requires a multidisciplinary team of surgical oncologists, radiation oncologists, medical oncologists, nutritionist, and speech-language pathologists,..
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Review
Systemic treatment for advanced urothelial cancer: an update on recent clinical trials and current treatment options
Inkeun Park, Jae Lyun Lee
Korean J Intern Med. 2020;35(4):834-853. Published online July 1, 2020
After cisplatin-based chemotherapy became the standard treatment for metastatic urothelial cancer (mUC), very little progress has been made in the treatment landscape of this condition until recently. With increased knowledge about the molecular biology of mUC and advances in the field of cancer imm..
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Review
Heart failure with preserved ejection fraction: insights from recent clinical researches
[corrected-article]
Mi-Na Kim, Seong-Mi Park
Korean J Intern Med. 2020;35(3):514-534. Published online April 29, 2020
Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for nearly half of the cases of HF and its incidence might be increasing with the aging society. Patients with HFpEF present with significant symptoms, including exercise intolerance, impaired quality of life, and have a poor progn..
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Review
Current status of heart failure: global and Korea
Jin Joo Park, Dong-Ju Choi
Korean J Intern Med. 2020;35(3):487-497. Published online April 29, 2020
Heart failure (HF) is a condition in which the heart is unable to pump enough blood to meet the body’s needs for blood and oxygen. Thus, HF is a grave disease with high morbidity and mortality. Because the prevalence of and exposure to the risk factors for HF increase with age, the prevalence of H..
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Nephrology / Review
Continuous renal replacement therapy in elderly with acute kidney injury
[corrected-article]
Kristianne Rachel P. Medina-Liabres, Sejoong Kim
Korean J Intern Med. 2020;35(2):284-294. Published online February 28, 2020
The objective of this article is to raise awareness among physicians of the increasing incidence of acute kidney injury in the elderly population and the utility of continuous renal replacement therapy (CRRT) in its management. While CRRT is frequently applied in younger patients, its use in elderly..
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