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Original Article
Increased Expression of Cyclooxygenase-2 is Associated with the Progression to Cirrhosis
Soung Won Jeong, Jae Young Jang, Sae Hwan Lee, Sang Gyun Kim, Young Koog Cheon, Young Seok Kim, Young Deok Cho, Hong Soo Kim, Joon Seong Lee, So-Young Jin, Chan Sup Shim, Boo Sung Kim
Korean J Intern Med. 2010;25(4):364-371. Published online November 27, 2010
Background/AimsTo investigate the degree of cyclooxygenase-2 (COX-2) protein expression in chronic hepatitis and cirrhosis. MethodsCOX-2 protein expression was evaluated in 43 cases of chronic hepatitis and 24 cases of cirrhosis using immunohist..
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Original Article
Usual Dose of Simvastatin Does Not Inhibit Plaque Progression and Lumen Loss at the Peri-Stent Reference Segments after Bare-Metal Stent Implantation: A Serial Intravascular Ultrasound Analysis
Young Joon Hong, Myung Ho Jeong, Yun Ha Choi, Eun Hye Ma, Jum Suk Ko, Min Goo Lee, Keun Ho Park, Doo Sun Sim, Nam Sik Yoon, Hyun Ju Youn, Kye Hun Kim, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang
Korean J Intern Med. 2010;25(4):356-363. Published online November 27, 2010
Background/AimsThe aim of this study was to assess the effects of a usual dose of simvastatin (20 mg/day) on plaque regression and vascular remodeling at the peri-stent reference segments after bare-metal stent implantation. MethodsWe retrospect..
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Review
The Role of Photodynamic Therapy for Hilar Cholangiocarcinoma
Young Koog Cheon
Korean J Intern Med. 2010;25(4):345-352. Published online November 27, 2010
The prognosis for hilar cholangiocarcinoma is limited by tumor spread along the biliary tree leading to refractory obstructive cholestasis, cholangitis, and liver failure. Palliation with biliary endoprostheses results in median survival times of 4-6 months for advanced bile duct cancer. Photodyn..
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Case Report
High-Dose Fentanyl Patch for Cancer Pain of a Patient with Cholangiocarcinoma
Jung Han Kim, Mi Kim, Chong Won Sung, Hyeoung Su Kim, Hyun Joo Jang, Young Chul Shin, Joo Young Jung
Korean J Intern Med. 2010;25(3):337-340. Published online August 31, 2010
We describe here a patient who obtained a good analgesic effect with high-dose fentanyl patches for controlling cancer pain. A 52-year-old man was referred to our hospital because of severe cancer pain that was 7/10 on a numeric rating scale (NRS). He had been diagnosed with locally advanced cho..
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Case Report
Primary Pulmonary Biphasic Synovial Sarcoma Confirmed by Molecular Detection of a SYT-SSX2 Fusion Gene: Report of 1 Case
Jae Seok Park, Bo Ram Min, Soon Hyo Park, Kun Young Kwon, Dong-Yoon Keum, Won-Il Choi
Korean J Intern Med. 2010;25(3):331-336. Published online August 31, 2010
We experienced a case of primary pulmonary biphasic synovial sarcoma, which was confirmed by immunohistochemistry and molecular testing of SYT-SSX2 fusion transcripts. The patient was a 61-year-old man who presented with a well-defined mass in the left upper lung field on chest radiography. Left ..
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Original Article
Induction of Macrophage Migration Inhibitory Factor in ConA-Stimulated Rheumatoid Arthritis Synovial Fibroblasts through the P38 MAP Kinase-Dependent Signaling Pathway
Hae-Rim Kim, Mi-Kyung Park, Mi-La Cho, Kyoung-Woon Kim, Hye-Joa Oh, Jin-Sil Park, Yang-Mi Heo, Sang-Heon Lee, Ho-Youn Kim, Sung-Hwan Park
Korean J Intern Med. 2010;25(3):317-326. Published online August 31, 2010
Background/AimsThis study was undertaken to identify the intracellular signaling pathway involved in induction of macrophage migration inhibitory factor (MIF) in human rheumatoid arthritis (RA) synovial fibroblasts. MethodsHuman RA synovial fibr..
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Original Article
Modified Number of Extranodal Involved Sites as a Prognosticator in R-CHOP-Treated Patients with Disseminated Diffuse Large B-Cell Lymphoma
Changhoon Yoo, Shin Kim, Byeong Seok Sohn, Jeong-Eun Kim, Dok Hyun Yoon, Jooryung Huh, Dae Ho Lee, Sang-We Kim, Jung-Shin Lee, Cheolwon Suh
Korean J Intern Med. 2010;25(3):301-308. Published online August 31, 2010
Background/AimsRituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy (R-CHOP) has improved survival in patients with diffuse large B-cell lymphoma (DLBCL) and weakened the prognostic power of the international prognostic index (IPI). We evaluat..
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Original Article
Changing Donor Source Pattern for Kidney Transplantation over 40 Years: A Single-Center Experience
Byung Ha Chung, Mi Hyang Jung, Sung Ha Bae, Suk Hui Kang, Hyeon Seok Hwang, Bok Jin Hyoung, So Young Lee, Youn Ju Jeon, Bum Soon Choi, Cheol Whee Park, Yong-Soo Kim, Ji-Il Kim, In Sung Moon, Chul Woo Yang
Korean J Intern Med. 2010;25(3):288-293. Published online August 31, 2010
Background/AimsKidney transplantations at our center rely mainly on living donors. The purpose of this study was to suggest future donor supply directions by reviewing changing trends in donor type. MethodsDuring the past 40 years, 1,690 kidney ..
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Original Article
Variable Association between Components of the Metabolic Syndrome and Electrocardiographic Abnormalities in Korean Adults
Hong-Kyu Kim, Chul-Hee Kim, Kwan-Ho Ko, Seong-Wook Park, Joong-Yeol Park, Ki-Up Lee
Korean J Intern Med. 2010;25(2):174-180. Published online June 1, 2010
Background/AimsResting electrocardiogram (ECG) abnormalities have been strongly associated with cardiovascular disease mortality. Little is known, however, about the association between individual components of metabolic syndrome and ECG abnormalities, especially in Asian popu..
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Original Article
The Impact of Generic Clopidogrel Bisulfate on Platelet Inhibition in Patients with Coronary Artery Stents: Results of the ACCEL-GENERIC Study
Young-Hoon Jeong, Jin-Sin Koh, Min-Kyung Kang, Yeon-Jeong Ahn, In-Suk Kim, Yongwhi Park, Seok-Jae Hwang, Choong Hwan Kwak, Jin-Yong Hwang
Korean J Intern Med. 2010;25(2):154-161. Published online June 1, 2010
Background/AimsIn patients with coronary artery stents, the cost of clopidogrel has been cited as a factor in the premature discontinuation of therapy. Thus, the introduction of lower-cost generic clopidogrel may increase patient compliance. However, platelet inhibition by ge..
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Original Article
Clinical Characteristics of Colonic Diverticulosis in Korea: A Prospective Study
Jung Hoon Song, You Sun Kim, Jin Ho Lee, Kyung Sun Ok, Soo Hyung Ryu, Jung Hwan Lee, Jeong Seop Moon
Korean J Intern Med. 2010;25(2):140-146. Published online June 1, 2010
Background/AimsThe prevalence of colonic diverticulosis has been reported to be lower in Korea than in Western countries. This disease also shows markedly different characteristics in the Korean population. We describe herein a prospective investigation, based on colonoscopic ..
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Original Article
Severe Pulmonary Adverse Effects in Lymphoma Patients Treated with Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) Regimen Plus Rituximab
Kyu-Hyoung Lim, Ho-Il Yoon, Young Ae Kang, Keun-Wook Lee, Jee Hyun Kim, Soo-Mee Bang, Jae Ho Lee, Choon-Taek Lee, Jong Seok Lee
Korean J Intern Med. 2010;25(1):86-92. Published online February 26, 2010
Background/AimsThe aim of our study was to determine the incidence and clinical features of severe pulmonary complications in patients receiving cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or rituximab plus CHOP (R-CHOP) as the initial treatment for lymph..
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Original Article
Ultrasonographic Features of Papillary Thyroid Carcinoma in Patients with Graves' Disease
Jin Ook Chung, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
Korean J Intern Med. 2010;25(1):71-76. Published online February 26, 2010
Background/AimsTo characterize ultrasonographic findings in papillary thyroid carcinoma (PTC) combined with Graves' disease. MethodsMedical records and ultrasonographic findings of 1,013 patients with Graves' disease and 3,380 patients without G..
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Case Report
A Case of Pulmonary Langerhans' Cell Histiocytosis Mimicking Hematogenous Pulmonary Metastases
Suyeon Chon, Sun Young Kyung, Sang Pyo Lee, Jeong-Woong Park, Sung Hwan Jeong, Soo Jin Choi, Seung Yeon Ha
Korean J Intern Med. 2009;24(4):393-396. Published online November 27, 2009
A 31-year-old man presented with a dry cough and exertional dyspnea. The chest X-ray showed multiple nodular opacities throughout the entire lung field. Chest computed tomography (CT) revealed variable-sized nodules with a peribronchiolar or centrilobular distribution, some of which revealed thic..
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Case Report
Infectious Mononucleosis Hepatitis in Young Adults: Two Case Reports
Min-Jung Kang, Tae-Hun Kim, Ki-Nam Shim, Sung-Ae Jung, Min-Sun Cho, Kwon Yoo, Kyu Won Chung
Korean J Intern Med. 2009;24(4):381-387. Published online November 27, 2009
Infectious mononucleosis due to Epstein-Barr virus (EBV) infection sometimes causes acute hepatitis, which is usually self-limiting with mildly elevated transaminases, but rarely with jaundice. Primary EBV infection in children is usually asymptomatic, but in a small number of healthy individuals..
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Original Article
Factors for Determining Survival in Acute Organophosphate Poisoning
Eun-Jung Kang, Su-Jin Seok, Kwon-Hyun Lee, Hyo-Wook Gil, Jong-Oh Yang, Eun-Young Lee, Sae-Yong Hong
Korean J Intern Med. 2009;24(4):362-367. Published online November 27, 2009
Background/AimsOrganophosphate poisoning has a high mortality rate. Recently, differences among organophosphorus insecticides in human self-poisoning were reported. This study investigated the prognostic risk factors and the mortality of different organophosphates following ac..
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Original Article
Natural History and Renal Pathology in Patients with Isolated Microscopic Hematuria
Byung Soo Kim, Yong Kyun Kim, Young Shin Shin, Young Ok Kim, Ho Cheol Song, Yong Soo Kim, Euy Jin Choi
Korean J Intern Med. 2009;24(4):356-361. Published online November 27, 2009
Background/AimsNo definite conclusions have been reached about the natural history of patients with isolated microscopic hematuria (IMH). In this study, we observed the natural history of patients with IMH and examined factors related to a pathologic diagnosis and subsequent p..
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Original Article
Comparison of Sirolimus and Paclitaxel-Eluting Stents for Complex Coronary Lesions: An Intravascular Ultrasound Study
Yun-Kyeong Cho, Seung-Ho Hur, Hyun-Tae Kim, In-Cheol Kim, Hyoung-Seob Park, Hyuck-Jun Yoon, Chang-Wook Nam, Hyungseop Kim, Seong-Wook Han, Yoon-Nyun Kim, Kwon-Bae Kim
Korean J Intern Med. 2009;24(4):323-329. Published online November 27, 2009
Background/AimsRecent intravascular ultrasound (IVUS) studies of sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) have demonstrated a significant reduction in neointimal hyperplasia (NIH) based on simple coronary lesions. In this study, we evaluated the effic..
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Original Article
Significance of Anti-HCV Signal-to-Cutoff Ratio in Predicting Hepatitis C Viremia
Yeon Seok Seo, Eun Suk Jung, Jeong Han Kim, Young Kul Jung, Ji Hoon Kim, Hyonggin An, Hyung Joon Yim, Jong Eun Yeon, Kwan Soo Byun, Chang Duck Kim, Ho Sang Ryu, Soon Ho Um
Korean J Intern Med. 2009;24(4):302-308. Published online November 27, 2009
Background/AimsHepatitis C virus (HCV) RNA testing can be performed using qualitative or quantitative assays, and it is still unclear which is more useful as a primary test in patients positive for anti-HCV. The present study evaluated the usefulness of anti-HCV signal-to-cuto..
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Review
Graft-versus-Leukemia Effect of Nonmyeloablative Stem Cell Transplantation
Masahiro Imamura, Junji Tanaka
Korean J Intern Med. 2009;24(4):287-298. Published online November 27, 2009
Nonmyeloablative stem cell transplantation (NST) is increasingly used with beneficial effects because it can be applied to older patients with hematological malignancies and those with various complications who are not suitable for conventional myeloablative stem cell transplantation (CST). Vario..
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