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Nephrology / Original Article
The dose of cyclophosphamide for treating paraquat-induced rat lung injury
Jae-Sung Choi, Sung-Shick Jou, Mee-Hye Oh, Young-Hee Kim, Min-Ju Park, Hyo-Wook Gil, Ho-Yeon Song, Sae-Yong Hong
Korean J Intern Med. 2013;28(4):420-427. Published online July 1, 2013
Background/AimsCyclophosphamide (CP) is a promising treatment for severe cases of paraquat (PQ) poisoning. We investigated the effective dose of CP for mitigating PQ-induced lung injury. MethodsAdult male Sprague-Dawley rats were allocated into ..
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Letter to the editor
Spontaneous coronary artery dissection diagnosed by intravascular ultrasound and followed up by cardiac computed tomography
Sang-Woong Choi, Chang-Wook Nam, Han-Jun Bae, Yun-Kyeong Cho, Hyuck-Jun Yoon, Seung-Ho Hur, Kwon-Bae Kim
Korean J Intern Med. 2013;28(3):370-373. Published online May 1, 2013
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Case Report
A case of hemophagocytic syndrome in a patient with fulminant ulcerative colitis superinfected by cytomegalovirus
Jun Il Mun, Sung Jae Shin, Byung Hyun Yu, Jee Hoon Koo, Dong Hoon Kim, Ki Myoung Lee, Kwang Jae Lee
Korean J Intern Med. 2013;28(3):352-355. Published online May 1, 2013
Hemophagocytic syndrome (HPS) is an uncommon hematological disorder that manifests as fever, splenomegaly, and jaundice, with hemophagocytosis in the bone marrow and other tissues pathologically. Secondary HPS is associated with malignancy and infection, especially viral infection. The prevalence..
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Nephrology / Original Article
Clinical characteristics and outcomes in renal transplant recipients with renal cell carcinoma in the native kidney
In O Sun, Yu Mi Ko, Eun Young Kim, Kyung Seon Park, Hong Soon Jung, Sun Hye Ko, Byung Ha Chung, Bum Soon Choi, Cheol Whee Park, Yong Soo Kim, Chul Woo Yang
Korean J Intern Med. 2013;28(3):347-351. Published online May 1, 2013
Background/AimsWe investigated the incidence and clinical characteristics of renal cell carcinoma (RCC) in the native kidney of renal transplant recipients. MethodsBetween 1991 and 2010, 1,425 patients underwent kidney transplantation at our ins..
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Hemato-oncology / Review
Diagnosis and therapy of multiple myeloma
Antonio Palumbo, Chiara Cerrato
Korean J Intern Med. 2013;28(3):263-273. Published online May 1, 2013
Many advances in the treatment of multiple myeloma have been made due to the use of transplantation and the introduction of novel agents including thalidomide, lenalidomide, and bortezomib. The first step is recognizing the symptoms and starting prompt treatment. Different strategies should be se..
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Letter to the editor
A third case of USA300 community-associated methicillin-resistant Staphylococcus aureus infection in Korea
Seungjin Lim, Doo Ryeon Chung, Jin Yang Baek, So Hyun Kim, Kyong Ran Peck, Nam-Yong Lee, Jae-Hoon Song
Korean J Intern Med. 2013;28(2):258-260. Published online February 27, 2013
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Case Report
Electrocardiographic artefacts mimicking atrial tachycardia resulted in unnecessary diagnostic and therapeutic measures
Shams Y-Hassan, Christer Sylvén
Korean J Intern Med. 2013;28(2):224-230. Published online February 27, 2013
Electrocardiographic (ECG) artefacts may closely simulate both supraventricular and ventricular tachycardias. We describe a case initially diagnosed as rapid atrial fibrillation, based on 12-lead surface ECG (especially the limb leads) and monitor tracing. The arrhythmia was resistant to beta blo..
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Allergy / Original Article
The effects of pycnogenol on antioxidant enzymes in a mouse model of ozone exposure
Min-Sung Lee, Kuk-Young Moon, Da-Jeong Bae, Moo-Kyun Park, An-Soo Jang
Korean J Intern Med. 2013;28(2):216-223. Published online February 27, 2013
Background/AimsOzone is an environmentally reactive oxidant, and pycnogenol is a mixture of flavonoid compounds extracted from pine tree bark that have antioxidant activity. We investigated the effects of pycnogenol on reactive nitrogen species, antioxidant responses, and airw..
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Pulmonology / Original Article
Clinical characteristics and treatment responses of patients who developed tuberculosis following use of a tumor necrosis factor-α inhibitor
Keun Bum Chung, Eun Young Lee, Jong Pil Im, Sung Koo Han, Jae-Joon Yim
Korean J Intern Med. 2013;28(2):174-179. Published online February 27, 2013
Background/AimsIndividuals being treated with tumor necrosis factor (TNF)-α inhibitors are at increased risk of developing tuberculosis (TB). We determined the clinical characteristics and treatment response of patients who developed TB after using TNF-α inhibitors. ..
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Cardiology / Original Article
Interleukin-33, matrix metalloproteinase-9, and tissue ınhibitor of matrix metalloproteinase-1 in myocardial infarction
Savas Guzel, Ozden Serin, Eda Celik Guzel, Banu Buyuk, Güzin Yılmaz, Guvenc Güvenen
Korean J Intern Med. 2013;28(2):165-173. Published online February 27, 2013
Background/AimsAcute coronary syndrome (ACS) is characterized by increased inflammatory processes and endothelial activation. We investigated the association between ACS and inflammatory mediators and matrix-degrading enzymes. MethodsWe prospect..
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Case Report
Tuberculosis of the urachal cyst
Tarun Jindal, Mir Reza Kamal, Jayesh Kumar Jha
Korean J Intern Med. 2013;28(1):103-105. Published online December 28, 2012
Urachal cysts are uncommon. Rarely, these cysts can become infected. Tuberculosis of the urachal cyst is exceedingly rare, with only one case reported previously in the English language literature. Here we report the case of a 23-year-old male who presented with an infra-umbilical mass that turne..
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Case Report
Mycobacterium avium lung disease combined with a bronchogenic cyst in an immunocompetent young adult
Yong Soo Kwon, Joungho Han, Ki Hwan Jung, Je Hyeong Kim, Won-Jung Koh
Korean J Intern Med. 2013;28(1):94-97. Published online December 28, 2012
We report a very rare case of a bronchogenic cyst combined with nontuberculous mycobacterial pulmonary disease in an immunocompetent patient. A 21-year-old male was referred to our institution because of a cough, fever, and worsening of abnormalities on his chest radiograph, despite anti-tubercul..
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Gastroenterology / Original Article
Rectal hyposensitivity and functional anorectal outlet obstruction are common entities in patients with functional constipation but are not significantly associated
Tae Hee Lee, Joon Seong Lee, Su Jin Hong, Seong Ran Jeon, Soon Ha Kwon, Wan Jung Kim, Hyun Gun Kim, Won Young Cho, Joo Young Cho, Jin-Oh Kim, Ji Sung Lee
Korean J Intern Med. 2013;28(1):54-61. Published online December 28, 2012
Background/AimsThe causes of functional anorectal outlet obstruction (outlet obstruction) include functional defecation disorder (FDD), rectocele, and rectal intussusception (RI). It is unclear whether outlet obstruction is associated with rectal hyposensitivity (RH) in patien..
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Rheumatology / Original Article
Greater prevalence of seropositivity for anti-cyclic citrullinated peptide antibody in unaffected first-degree relatives in multicase rheumatoid arthritis-affected families
Seong-Kyu Kim, Jisuk Bae, Hwajeong Lee, Ji Hun Kim, Sung-Hoon Park, Jung-Yoon Choe
Korean J Intern Med. 2013;28(1):45-53. Published online December 28, 2012
Background/AimsThis study determined the prevalence and determinants of seropositivity for rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP) antibody, and anti-mutated citrullinated vimentin (anti-MCV) antibody in unaffected first-degree relatives (FDRs) of ..
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Endocrinology-metabolism / Original Article
Gender disparity in the secular trends for obesity prevalence in Korea: analyses based on the KNHANES 1998-2009
Sang Youl Rhee, Seok Won Park, Dae Jung Kim, Jeongtaek Woo
Korean J Intern Med. 2013;28(1):29-34. Published online December 28, 2012
Background/AimsA similar gender-associated trend in obesity is observed worldwide. Nevertheless, systematic analyses of gender-specific characteristics in the general Korean population are rare. MethodsWe analyzed the prevalence of obesity in Ko..
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Letter to the editor
An Adult Case of Severe Chronic Active Epstein-Barr Virus Infection with T-Cell Lymphoproliferative Disorder
Se-Kwon Mun, Seung-Sook Lee, Seung-Hwa Kang, Min-Jae Lee, So-Yeon Kim, Hyung-Gyu Choi, Hye Jin Kang
Korean J Intern Med. 2012;27(4):474-477. Published online November 27, 2012
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Case Report
Subaortic Membrane Late after Surgical Correction of Tetralogy of Fallot
Kyung-Hee Kim, Hyung-Kwan Kim, Sung-A Chang, Seil Oh, Kyung-Hwan Kim, Dae-Won Sohn
Korean J Intern Med. 2012;27(4):455-458. Published online November 27, 2012
We herein report a rare case of subaortic stenosis in association with a previous tetralogy of Fallot (TOF) surgical repair, which was not taken into account as a differential diagnosis. Echocardiography plays a pivotal role in identification of this rare combination. Therefore, echocardiography ..
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Original Article
A Comparison of Active Surveillance Programs Including a Spontaneous Reporting Model for Phamacovigilance of Adverse Drug Events in a Hospital
Il Seon Yun, Myung Jin Koo, Eun Hye Park, Sung-Eun Kim, Jae-Hyun Lee, Jung-Won Park, Chein-Soo Hong
Korean J Intern Med. 2012;27(4):443-450. Published online November 27, 2012
Background/AimsSpontaneous reporting systems have several weak points, such as low reporting rates and insufficient clinical information. Active surveillance programs, such as ward rounds and a clinical data repository (CDR), may supplement the weak points of such systems. We ..
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Original Article
Patient's Perception of Symptoms Related to Morning Activity in Chronic Obstructive Pulmonary Disease: The SYMBOL Study
Yeon Jae Kim, Byung Ki Lee, Chi Young Jung, Young June Jeon, Dae Sung Hyun, Kyung Chan Kim, Sung Ken Yu, Hye Sook Choi, Won Hyuk Shin, Kwan Ho Lee
Korean J Intern Med. 2012;27(4):426-435. Published online November 27, 2012
Background/AimsPatients with chronic obstructive pulmonary disease (COPD) experience more problematic respiratory symptoms and have more trouble performing daily activities in the morning. The aim of this study was to assess the perception of COPD symptoms related to morning a..
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Original Article
Comparison of Drug-Eluting Stents in Acute Myocardial Infarction Patients with Chronic Kidney Disease
Daisuke Hachinohe, Myung Ho Jeong, Shigeru Saito, Min Chol Kim, Kyung Hoon Cho, Khurshid Ahmed, Seung Hwan Hwang, Min Goo Lee, Doo Sun Sim, Keun-Ho Park, Ju Han Kim, Young Joon Hong, Youngkeun Ahn, Jung Chaee Kang, Jong Hyun Kim, Shung Chull Chae, Young Jo Kim, Seung Ho Hur, In Whan Seong, Taek Jong Hong, Donghoon Choi, Myeong Chan Cho, Chong Jin Kim, Ki Bae Seung, Wook Sung Chung, Yang Soo Jang, Seung Woon Rha, Jang Ho Bae, Seung Jung Park,
Korean J Intern Med. 2012;27(4):397-406. Published online November 27, 2012
Background/AimsTo determine which drug-eluting stents are more effective in acute myocardial infarction (MI) patients with chronic kidney disease (CKD). MethodsThis study included a total of 3,566 acute MI survivors with CKD from the Korea Acute..
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