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Gastroenterology / Original Article
Expression of procaspase 3 and activated caspase 3 and its relevance in hormone-responsive gallbladder carcinoma chemotherapy
Sanjeev Kumar Maurya, Mallika Tewari, Bechan Sharma, Hari Shanker Shukla
Korean J Intern Med. 2013;28(5):573-578. Published online August 14, 2013
Background/AimsThe higher incidence of gallbladder cancer (GBC) in females has been accredited to the involvement of hormones. The clinical implications of sex hormone receptors in GBC are well established. Cysteine proteases (such as caspase-3-9, etc.) are known to play a cen..
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Cardiology / Original Article
Impact of family history on the presentation and clinical outcomes of coronary heart disease: data from the Korea Acute Myocardial Infarction Registry
Choongki Kim, Hyuk-Jae Chang, Iksung Cho, Ji Min Sung, Donghoon Choi, Myung Ho Jeong, Yang Soo Jang,
Korean J Intern Med. 2013;28(5):547-556. Published online August 14, 2013
Background/AimsFamily history (FHx) of coronary heart disease (CHD) is a well-known risk factor for CHD. However, the prognostic implication of FHx has not been established clearly in patients with acute myocardial infarction (AMI). MethodsIn t..
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Gastroenterology / Review
Current evidence of effects of Helicobacter pylori eradication on prevention of gastric cancer
Il Ju Choi
Korean J Intern Med. 2013;28(5):525-537. Published online August 14, 2013
Gastric cancer is the second most common cause of cancer death worldwide and is usually detected at a late stage, except in Korea and Japan where early screening is in effect. Results from animal and epidemiological studies suggest that Helicobacter pylori infection, and subseque..
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Gastroenterology / Review
Current status of chemotherapy for the treatment of advanced biliary tract cancer
Takashi Sasaki, Hiroyuki Isayama, Yousuke Nakai, Kazuhiko Koike
Korean J Intern Med. 2013;28(5):515-524. Published online August 14, 2013
Chemotherapy is indispensable for the treatment of advanced biliary tract cancer. Recently, reports regarding first-line chemotherapy have increased, and first-line chemotherapy treatment has become gradually more sophisticated. Gemcitabine and cisplatin combination therapy (or gemcitabine and ox..
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Case Report
A case of fulminant community-acquired Acinetobacter baumannii pneumonia in Korea
Yoon Jung Oh, Sung Heon Song, Seung Hee Baik, Hak Hyun Lee, In Mee Han, Dong Hyun Oh
Korean J Intern Med. 2013;28(4):486-490. Published online July 1, 2013
Acinetobacter baumannii (AB) is a common pathogen found in patients with hospital-acquired pneumonia all over the world. Community-acquired AB pneumonia, however, is very rare and has seldom been reported in Asia-Pacific countries. Community-acquired AB pneumonia has a fulminant ..
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Endocrinology-metabolism / Original Article
Adipokines, insulin-like growth factor binding protein-3 levels, and insulin sensitivity in women with polycystic ovary syndrome
Hyejin Lee, Jee-Young Oh, Yeon-Ah Sung
Korean J Intern Med. 2013;28(4):456-463. Published online July 1, 2013
Background/AimsMany women with polycystic ovary syndrome (PCOS) exhibit insulin resistance. Adipose tissue plays an important role in insulin resistance, and adipokines including tumor necrosis factor (TNF)-α and adiponectin are altered in PCOS. Insulin-like growth factor bin..
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Gastroenterology / Original Article
Factors influencing hepatocellular carcinoma prognosis after hepatectomy: a single-center experience
Sung Keun Park, Young Kul Jung, Dong Hae Chung, Keon Kuk Kim, Yeon Ho Park, Jung Nam Lee, Oh Sang Kwon, Yun Soo Kim, Duck Joo Choi, Ju Hyun Kim
Korean J Intern Med. 2013;28(4):428-438. Published online July 1, 2013
Background/AimsRecurrence after hepatic resection is one of the most important factors impacting the prognosis and survival of patients with hepatocellular carcinoma (HCC). We identified prognostic factors affecting overall survival (OS) and disease-free survival (DFS) in pati..
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Nephrology / Original Article
The dose of cyclophosphamide for treating paraquat-induced rat lung injury
Jae-Sung Choi, Sung-Shick Jou, Mee-Hye Oh, Young-Hee Kim, Min-Ju Park, Hyo-Wook Gil, Ho-Yeon Song, Sae-Yong Hong
Korean J Intern Med. 2013;28(4):420-427. Published online July 1, 2013
Background/AimsCyclophosphamide (CP) is a promising treatment for severe cases of paraquat (PQ) poisoning. We investigated the effective dose of CP for mitigating PQ-induced lung injury. MethodsAdult male Sprague-Dawley rats were allocated into ..
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Letter to the editor
Spontaneous coronary artery dissection diagnosed by intravascular ultrasound and followed up by cardiac computed tomography
Sang-Woong Choi, Chang-Wook Nam, Han-Jun Bae, Yun-Kyeong Cho, Hyuck-Jun Yoon, Seung-Ho Hur, Kwon-Bae Kim
Korean J Intern Med. 2013;28(3):370-373. Published online May 1, 2013
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Case Report
A case of hemophagocytic syndrome in a patient with fulminant ulcerative colitis superinfected by cytomegalovirus
Jun Il Mun, Sung Jae Shin, Byung Hyun Yu, Jee Hoon Koo, Dong Hoon Kim, Ki Myoung Lee, Kwang Jae Lee
Korean J Intern Med. 2013;28(3):352-355. Published online May 1, 2013
Hemophagocytic syndrome (HPS) is an uncommon hematological disorder that manifests as fever, splenomegaly, and jaundice, with hemophagocytosis in the bone marrow and other tissues pathologically. Secondary HPS is associated with malignancy and infection, especially viral infection. The prevalence..
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Nephrology / Original Article
Clinical characteristics and outcomes in renal transplant recipients with renal cell carcinoma in the native kidney
In O Sun, Yu Mi Ko, Eun Young Kim, Kyung Seon Park, Hong Soon Jung, Sun Hye Ko, Byung Ha Chung, Bum Soon Choi, Cheol Whee Park, Yong Soo Kim, Chul Woo Yang
Korean J Intern Med. 2013;28(3):347-351. Published online May 1, 2013
Background/AimsWe investigated the incidence and clinical characteristics of renal cell carcinoma (RCC) in the native kidney of renal transplant recipients. MethodsBetween 1991 and 2010, 1,425 patients underwent kidney transplantation at our ins..
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Hemato-oncology / Review
Diagnosis and therapy of multiple myeloma
Antonio Palumbo, Chiara Cerrato
Korean J Intern Med. 2013;28(3):263-273. Published online May 1, 2013
Many advances in the treatment of multiple myeloma have been made due to the use of transplantation and the introduction of novel agents including thalidomide, lenalidomide, and bortezomib. The first step is recognizing the symptoms and starting prompt treatment. Different strategies should be se..
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Letter to the editor
A third case of USA300 community-associated methicillin-resistant Staphylococcus aureus infection in Korea
Seungjin Lim, Doo Ryeon Chung, Jin Yang Baek, So Hyun Kim, Kyong Ran Peck, Nam-Yong Lee, Jae-Hoon Song
Korean J Intern Med. 2013;28(2):258-260. Published online February 27, 2013
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Case Report
Electrocardiographic artefacts mimicking atrial tachycardia resulted in unnecessary diagnostic and therapeutic measures
Shams Y-Hassan, Christer Sylvén
Korean J Intern Med. 2013;28(2):224-230. Published online February 27, 2013
Electrocardiographic (ECG) artefacts may closely simulate both supraventricular and ventricular tachycardias. We describe a case initially diagnosed as rapid atrial fibrillation, based on 12-lead surface ECG (especially the limb leads) and monitor tracing. The arrhythmia was resistant to beta blo..
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Allergy / Original Article
The effects of pycnogenol on antioxidant enzymes in a mouse model of ozone exposure
Min-Sung Lee, Kuk-Young Moon, Da-Jeong Bae, Moo-Kyun Park, An-Soo Jang
Korean J Intern Med. 2013;28(2):216-223. Published online February 27, 2013
Background/AimsOzone is an environmentally reactive oxidant, and pycnogenol is a mixture of flavonoid compounds extracted from pine tree bark that have antioxidant activity. We investigated the effects of pycnogenol on reactive nitrogen species, antioxidant responses, and airw..
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Pulmonology / Original Article
Clinical characteristics and treatment responses of patients who developed tuberculosis following use of a tumor necrosis factor-α inhibitor
Keun Bum Chung, Eun Young Lee, Jong Pil Im, Sung Koo Han, Jae-Joon Yim
Korean J Intern Med. 2013;28(2):174-179. Published online February 27, 2013
Background/AimsIndividuals being treated with tumor necrosis factor (TNF)-α inhibitors are at increased risk of developing tuberculosis (TB). We determined the clinical characteristics and treatment response of patients who developed TB after using TNF-α inhibitors. ..
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Cardiology / Original Article
Interleukin-33, matrix metalloproteinase-9, and tissue ınhibitor of matrix metalloproteinase-1 in myocardial infarction
Savas Guzel, Ozden Serin, Eda Celik Guzel, Banu Buyuk, Güzin Yılmaz, Guvenc Güvenen
Korean J Intern Med. 2013;28(2):165-173. Published online February 27, 2013
Background/AimsAcute coronary syndrome (ACS) is characterized by increased inflammatory processes and endothelial activation. We investigated the association between ACS and inflammatory mediators and matrix-degrading enzymes. MethodsWe prospect..
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Case Report
Tuberculosis of the urachal cyst
Tarun Jindal, Mir Reza Kamal, Jayesh Kumar Jha
Korean J Intern Med. 2013;28(1):103-105. Published online December 28, 2012
Urachal cysts are uncommon. Rarely, these cysts can become infected. Tuberculosis of the urachal cyst is exceedingly rare, with only one case reported previously in the English language literature. Here we report the case of a 23-year-old male who presented with an infra-umbilical mass that turne..
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Case Report
Mycobacterium avium lung disease combined with a bronchogenic cyst in an immunocompetent young adult
Yong Soo Kwon, Joungho Han, Ki Hwan Jung, Je Hyeong Kim, Won-Jung Koh
Korean J Intern Med. 2013;28(1):94-97. Published online December 28, 2012
We report a very rare case of a bronchogenic cyst combined with nontuberculous mycobacterial pulmonary disease in an immunocompetent patient. A 21-year-old male was referred to our institution because of a cough, fever, and worsening of abnormalities on his chest radiograph, despite anti-tubercul..
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