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Original Article
A Comparison of Active Surveillance Programs Including a Spontaneous Reporting Model for Phamacovigilance of Adverse Drug Events in a Hospital
Il Seon Yun, Myung Jin Koo, Eun Hye Park, Sung-Eun Kim, Jae-Hyun Lee, Jung-Won Park, Chein-Soo Hong
Korean J Intern Med. 2012;27(4):443-450. Published online November 27, 2012
Background/AimsSpontaneous reporting systems have several weak points, such as low reporting rates and insufficient clinical information. Active surveillance programs, such as ward rounds and a clinical data repository (CDR), may supplement the weak points of such systems. We ..
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Original Article
Patient's Perception of Symptoms Related to Morning Activity in Chronic Obstructive Pulmonary Disease: The SYMBOL Study
Yeon Jae Kim, Byung Ki Lee, Chi Young Jung, Young June Jeon, Dae Sung Hyun, Kyung Chan Kim, Sung Ken Yu, Hye Sook Choi, Won Hyuk Shin, Kwan Ho Lee
Korean J Intern Med. 2012;27(4):426-435. Published online November 27, 2012
Background/AimsPatients with chronic obstructive pulmonary disease (COPD) experience more problematic respiratory symptoms and have more trouble performing daily activities in the morning. The aim of this study was to assess the perception of COPD symptoms related to morning a..
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Original Article
Comparison of Drug-Eluting Stents in Acute Myocardial Infarction Patients with Chronic Kidney Disease
Daisuke Hachinohe, Myung Ho Jeong, Shigeru Saito, Min Chol Kim, Kyung Hoon Cho, Khurshid Ahmed, Seung Hwan Hwang, Min Goo Lee, Doo Sun Sim, Keun-Ho Park, Ju Han Kim, Young Joon Hong, Youngkeun Ahn, Jung Chaee Kang, Jong Hyun Kim, Shung Chull Chae, Young Jo Kim, Seung Ho Hur, In Whan Seong, Taek Jong Hong, Donghoon Choi, Myeong Chan Cho, Chong Jin Kim, Ki Bae Seung, Wook Sung Chung, Yang Soo Jang, Seung Woon Rha, Jang Ho Bae, Seung Jung Park,
Korean J Intern Med. 2012;27(4):397-406. Published online November 27, 2012
Background/AimsTo determine which drug-eluting stents are more effective in acute myocardial infarction (MI) patients with chronic kidney disease (CKD). MethodsThis study included a total of 3,566 acute MI survivors with CKD from the Korea Acute..
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Letter to the editor
Strangulated Small Bowel Obstruction Following Endoscopic Retrograde Cholangiopancreatography
Do Young Kim, Yong Jin Kim, Tae Yoon Lee, Chan Sup Shim, Hyun Ah Chung, In Sung Son, Young Koog Cheon
Korean J Intern Med. 2012;27(3):363-365. Published online September 1, 2012
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Case Report
A Case of Severe Coronary Spasm Associated with 5-Fluorouracil Chemotherapy
Sang-Min Kim, Cheol-Hoon Kwak, Bora Lee, Seong Beom Kim, Jung-Ju Sir, Wook-Hyun Cho, Suk-Koo Choi
Korean J Intern Med. 2012;27(3):342-345. Published online September 1, 2012
Cardiotoxicity associated with 5-fluorouracil (FU) is an uncommon, but potentially lethal, condition. The case of an 83-year-old man with colon cancer who developed chest pain during 5-FU infusion is presented. The electrocardiogram (ECG) showed pronounced ST elevation in the lateral leads, and t..
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Case Report
Acute Viral Myopericarditis Presenting as a Transient Effusive-Constrictive Pericarditis Caused by Coinfection with Coxsackieviruses A4 and B3
Wang-Soo Lee, Kwang Je Lee, Jee Eun Kwon, Min Seok Oh, Jeong Eun Kim, Eun Jung Cho, Chee Jeong Kim
Korean J Intern Med. 2012;27(2):216-220. Published online May 31, 2012
Acute myopericarditis is usually caused by viral infections, and the most common cause of viral myopericarditis is coxsackieviruses. Diagnosis of myopericarditis is made based on clinical manifestations of myocardial (such as myocardial dysfunction and elevated serum cardiac enzyme levels) and pe..
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Case Report
A Case of Adenocarcinoma in situ of the Distal Common Bile Duct Diagnosed by Percutaneous Transhepatic Cholangioscopy
Hyo Joon Yang, Jai Hwan Kim, Jae Young Chun, Su Jin Kim, Sang Hyub Lee, Haeryoung Kim, Jin-Hyeok Hwang
Korean J Intern Med. 2012;27(2):211-215. Published online May 31, 2012
Extrahepatic cholangiocarcinoma is often clinically challenging to diagnose. Even multidisciplinary approaches which include computed tomography, magnetic resonance imaging, and endoscopic retrograde cholangiography are unsatisfactory in some cases, especially with biliary stricture. Percutaneous..
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Original Article
Prognosis in Patients Having Chronic Obstructive Pulmonary Disease with Significant Coronary Artery Lesion Angina
Tae Yun Park, Kyung Hee Kim, Hyun Kyoung Koo, Ji Yeon Lee, Sang-Min Lee, Jae-Jun Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Seok-Chul Yang
Korean J Intern Med. 2012;27(2):189-196. Published online May 31, 2012
Background/AimsMany studies have investigated angina and its relationship with chronic obstructive pulmonary disease (COPD). However, angina was diagnosed only by noninvasive tests or only by clinical symptoms in most of these studies. The aim of this study was to compare the ..
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Original Article
Different Impact of Diabetes Mellitus on In-Hospital and 1-Year Mortality in Patients with Acute Myocardial Infarction Who Underwent Successful Percutaneous Coronary Intervention: Results from the Korean Acute Myocardial Infarction Registry
Keun-Ho Park, Youngkeun Ahn, Myung Ho Jeong, Shung Chull Chae, Seung Ho Hur, Young Jo Kim, In Whan Seong, Jei Keon Chae, Taek Jong Hong, Myeong Chan Cho, Jang Ho Bae, Seung Woon Rha, Yang Soo Jang,
Korean J Intern Med. 2012;27(2):180-188. Published online May 31, 2012
Background/AimsThe aim of this study was to evaluate the impact of diabetes mellitus (DM) on in-hospital and 1-year mortality in patients who suffered acute myocardial infarction (AMI) and underwent successful percutaneous coronary intervention (PCI). Meth..
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Original Article
The Causes and Treatment Outcomes of 91 Patients with Adult Nosocomial Meningitis
Hye-In Kim, Shin-Woo Kim, Ga-Young Park, Eu-Gene Kwon, Hyo-Hoon Kim, Ju-Young Jeong, Hyun-Ha Chang, Jong-Myung Lee, Neung-Su Kim
Korean J Intern Med. 2012;27(2):171-179. Published online May 31, 2012
Background/AimsFrequent pathogens of nosocomial meningitis were investigated and the adequacy of empiric antibiotic therapy was assessed. Outcomes of nosocomial meningitis were also evaluated. MethodsNinety-one patients, who were diagnosed and t..
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Review
Current Epidemiology and Growing Resistance of Gram-Negative Pathogens
David M. Livermore
Korean J Intern Med. 2012;27(2):128-142. Published online May 31, 2012
In the 1980s, Gram-negative pathogens appeared to have been beaten by oxyimino-cephalosporins, carbapenems, and fluoroquinolones. Yet these pathogens have fought back, aided by their membrane organization, which promotes the exclusion and efflux of antibiotics, and by a remarkable propensity to ..
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Case Report
Spontaneous Non-Traumatic Stress Fractures in Bilateral Femoral Shafts in a Patient Treated with Bisphosphonates
Dong Yeob Shin, Cheol Ryong Ku, Kyung Min Kim, Han Seok Choi, Yumie Rhee, Eun Jig Lee, Sung-Kil Lim
Korean J Intern Med. 2012;27(1):98-102. Published online February 28, 2012
Bisphosphonates are potent inhibitors of bone resorption and widely used to treat osteoporosis. Extensive studies have shown that therapy with bisphosphonates improves bone density and decreases fracture risk. However, concerns have been raised about potential over-suppression of bone turnover du..
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Case Report
Ewing's Sarcoma of the Lesser Sac Masquerading as a Pancreatic Tumor
Lakshmi Rao, Vidya Monappa, Gabriel Rodrigues, B P Suresh
Korean J Intern Med. 2012;27(1):91-94. Published online February 28, 2012
Extraosseous Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) is an uncommon, aggressive, and malignant tumor with a poor patient outcome. Its occurrence in the lesser sac is a rare event and to the best of our knowledge, has not been previously described. The present case was clinically..
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Original Article
Normalization of Negative T-Wave on Electrocardiography and Right Ventricular Dysfunction in Patients with an Acute Pulmonary Embolism
Bo-Youn Choi, Dae-Gyun Park
Korean J Intern Med. 2012;27(1):53-59. Published online February 28, 2012
Background/AimsRight ventricular dysfunction (RVD) is associated with poor prognosis in patients with acute pulmonary embolism (APE). Echocardiography and computed tomography (CT)-angiography may be difficult to perform in a serial follow up, unlike electrocardiography (ECG). ..
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Case Report
An Adult Case of Chronic Active Epstein-Barr Virus Infection with Interstitial Pneumonitis
Eun-Jeong Joo, Young Eun Ha, Dong Sik Jung, Hae Suk Cheong, Yu Mi Wi, Jae-Hoon Song, Kyong Ran Peck
Korean J Intern Med. 2011;26(4):466-469. Published online November 28, 2011
Chronic active Epstein-Barr virus (CAEBV) infection is characterized by persistent infectious mononucleosis-like symptoms, an unusual pattern of Epstein-Barr virus (EBV) antibodies, detection of the EBV genome in affected tissues or peripheral blood, and chronic illness that cannot be attributed ..
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Original Article
Serum TSH Level in Healthy Koreans and the Association of TSH with Serum Lipid Concentration and Metabolic Syndrome
Yeo Kyung Lee, Jo Eun Kim, Hyun Ju Oh, Kyung Sun Park, Soo Kyung Kim, Seok Won Park, Moon Jong Kim, Yong Wook Cho
Korean J Intern Med. 2011;26(4):432-439. Published online November 28, 2011
Background/AimsThe proper treatment of subclinical hypothyroidism and the normal range of serum thyroid stimulating hormone (TSH) concentration are intensely debated. However, few reports have investigated TSH concentrations in Asian ethnic groups. Therefore, the present study..
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Original Article
Gender Differences in Susceptibility to Smoking among Patients with Lung Cancer
Jeong-Seon Ryu, Sang-Hoon Jeon, Jung-Soo Kim, Jung Hwan Lee, Seong Hyun Kim, Ji Taek Hong, Ju Hong Jeong, Ji Joong Jeong, Myung Dong Lee, Sang Joon Min, Hae-Seong Nam, Jae-Hwa Cho, Seung-Min Kwak, Hong Lyeol Lee, Hyun-Jung Kim
Korean J Intern Med. 2011;26(4):427-431. Published online November 28, 2011
Background/AimsTo determine whether female smokers are more or less susceptible to the detrimental pulmonary-function effects of smoking when compared to male smokers among patients with lung cancer. MethodsPack-years and pulmonary function indi..
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Original Article
Sound Analysis in an In Vitro Endotracheal Tube Model
Young Sik Park, Young Wook Kee, Kwang Suk Park, Jinwoo Lee, Sang-Min Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Seok-Chul Yang
Korean J Intern Med. 2011;26(4):421-426. Published online November 28, 2011
Background/AimsComplete endotracheal tube obstruction is a medical emergency, and partial occlusion causes increased breathing rates and failure to wean off mechanical ventilation. Partial occlusion may be underestimated due to the lack of proper detection methods. We tested w..
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Review
Recent Advances in Mechanisms and Treatments of Airway Remodeling in Asthma: A Message from the Bench Side to the Clinic
Jae Youn Cho
Korean J Intern Med. 2011;26(4):367-383. Published online November 28, 2011
Airway remodeling in asthma is a result of persistent inflammation and epithelial damage in response to repetitive injury. Recent studies have identified several important mediators associated with airway remodeling in asthma, including transforming growth factor-β, interleukin (IL)-5, basic fib..
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Original Article
Nuclear factor E2-related factor 2 Dependent Overexpression of Sulfiredoxin and Peroxiredoxin III in Human Lung Cancer
Young Sun Kim, Hye Lim Lee, Ki Bum Lee, Joo Hun Park, Wou Young Chung, Keu Sung Lee, Seung Soo Sheen, Kwang Joo Park, Sung Chul Hwang
Korean J Intern Med. 2011;26(3):304-313. Published online September 13, 2011
Background/AimsOxidative stress results in protein oxidation and is implicated in carcinogenesis. Sulfiredoxin (Srx) is responsible for the enzymatic reversal of inactivated peroxiredoxin (Prx). Nuclear factor E2-related factor 2 (Nrf2) binds to antioxidant responsive elements..
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