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Nephrology / Original Article
Reduction in proteinuria after immunosuppressive therapy and long-term kidney outcomes in patients with immunoglobulin A nephropathy
Shin Chan Kang, Hyung Woo Kim, Tae Ik Chang, Ea Wha Kang, Beom Jin Lim, Jung Tak Park, Tae-Hyun Yoo, Hyeon Joo Jeong, Shin-Wook Kang, Seung Hyeok Han
Korean J Intern Med. 2021;36(5):1169-1180. Published online February 10, 2021
Background/Aims: Despite controversy regarding the benefits of immunosuppressive therapy in immunoglobulin A nephropathy (IgAN), clinical outcomes may vary depending on the patient’s responsiveness to this therapy. This study evaluated long-term kidney outcomes according to the extent of proteinur..
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Pulmonology / Original Article
Estimating the burden of nosocomial exposure to tuberculosis in South Korea, a nationwide population based cross-sectional study
Hyung Woo Kim, Jun-Pyo Myong, Ju Sang Kim
Korean J Intern Med. 2021;36(5):1134-1145. Published online December 18, 2020
Background/Aims: The aim of the study was to investigate the current nationwide burden of nosocomial exposure to tuberculosis (TB) using national health insurance claims data.
Methods: All patients who had claims for drug susceptibility testing for TB from 2012 to 2016, which indicated culture-prov..
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Cardiology / Original Article
Prevalence and characteristics of isolated nocturnal hypertension in the general population
Moo-Yong Rhee, Je Sang Kim, Chee Hae Kim, Ji-Hyun Kim, Jung-Ha Lee, Sun-Woong Kim, Deuk-Young Nah, Namyi Gu, Eun-Joo Cho, Ki-Chul Sung, Kyung-Soon Hong
Korean J Intern Med. 2021;36(5):1126-1133. Published online April 5, 2021
Background/Aims: Ascertaining the prevalence of isolated nocturnal hypertension (INHT) in the general population and identifying the characteristics of patients with INHT may be important to determine patients who should receive 24- hour ambulatory blood pressure (BP) measurements. This study aimed ..
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Gastroenterology / Original Article
Risk of colorectal cancer in patients with positive results of fecal immunochemical test performed within 5 years since the last colonoscopy
Yoon Suk Jung, Jinhee Lee, Chang Mo Moon
Korean J Intern Med. 2021;36(5):1083-1091. Published online June 18, 2021
Background/Aims: Annual fecal immunochemical tests (FITs) are often repeated within the recommended colonoscopy surveillance intervals. However, it remains unclear whether interval FITs are useful. To answer this question, we assessed the risk of colorectal cancer (CRC) according to the interval fro..
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Hemato-oncology / Original Article
Temporal evolution of programmed death-ligand 1 expression in patients with non-small cell lung cancer
Chang Hyun Nam, Jaemoon Koh, Chan-Young Ock, Miso Kim, Bhumsuk Keam, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Doo Hyun Chung, Dae Seog Heo
Korean J Intern Med. 2021;36(4):975-984. Published online April 6, 2021
Background/Aims: Programmed death-ligand 1 (PD-L1) expression, a validated predictive biomarker for anti-PD-1/PD-L1 inhibitors, is reported to change over time. This poses challenges during clinical application in non-small cell lung cancer.
Methods: This study included patients with non-small cell..
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Endocrinology-metabolism / Original Article
Weight change and microvascular outcomes in patients with new-onset diabetes: a nationwide cohort study
Eun Sil Koh, Kyung Do Han, Mee Kyoung Kim, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Hyuk-Sang Kwon
Korean J Intern Med. 2021;36(4):932-941. Published online May 13, 2021
Background/Aims: Because weight control is important in treatment of type 2 diabetes, it is essential to understand the associations between weight change and the risk of microvascular complications among patients with type 2 diabetes. We examined whether weight changes early after new-onset diabete..
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Pulmonology / Original Article
Pulse pressure during the initial resuscitative period in patients with septic shock treated with a protocol-driven resuscitation bundle therapy
Sang-Hun Lee, Youn-Jung Kim, Gi Na Yu, Jae Cheon Jeon, Won Young Kim
Korean J Intern Med. 2021;36(4):924-931. Published online August 20, 2020
Background/Aims: Maintaining a mean arterial pressure (MAP) ≥ 65 mmHg during septic shock should be based on individual circumstances, but specific target is poorly understood. We investigated associations between time-weighted average (TWA) hemodynamic parameters during the initial resuscitative ..
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Pulmonology / Original Article
Upregulation of receptor tyrosine kinase-like orphan receptor 2 in idiopathic pulmonary fibrosis
Ji-Hye Son, Jong-Uk Lee, Susie Chin, Eun-Suk Go, Jai-Seong Park, Hwa-Kyun Shin, Hun Soo Chang, Jong-Sook Park, Choon-Sik Park
Korean J Intern Med. 2021;36(4):914-923. Published online September 21, 2020
Background/Aims: Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a major regulator of Wnt signaling, which is involved in fibroblast dysfunction. Because its role has not been evaluated in idiopathic pulmonary fibrosis (IPF), we examined the clinical implications of ROR2 expression.
Metho..
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Gastroenterology / Original Article
Clinical risk factors and pattern of initial fungal contamination in endoscopic biopsy-derived gastrointestinal cancer organoid culture
Su Youn Nam, Seung Jin Lee, Hee Jung Lim, Ji Young Park, Seong Woo Jeon
Korean J Intern Med. 2021;36(4):878-887. Published online April 8, 2021
Background/Aims: Because gastrointestinal tract is not sterile, primary culture has contamination risk despite of massive washing with antimicrobial media. Microbial contamination can play a key role in initial failure during biopsy-derived primary tumor culture.
Methods: Tumor tissue was acquired ..
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Hemato-oncology / Original Article
Association between absolute lymphocyte count and overall mortality in patients with surgically resected gastric cancer
Se Jun Park, Jinsoo Lee, Hyunho Kim, Kabsoo Shin, MyungAh Lee, Jae Myung Park, Myung-Gyu Choi, Cho Hyun Park, Kyo Young Song, Han Hong Lee, In-Ho Kim
Korean J Intern Med. 2021;36(3):679-688. Published online February 19, 2021
Background/Aims: Lymphocytes are an important component of the cell-mediated immune system. As lymphopenia is reportedly associated with poor prognoses in patients with various cancers, we investigated this notion in patients who underwent curative gastrectomy.
Methods: We retrospectively analyzed ..
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Nephrology / Original Article
Effect of urinary angiotensinogen and high-salt diet on blood pressure in patients with chronic kidney disease: results from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease (KNOW-CKD)
Ha Yeon Kim, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Su-Ah Sung, Seung Hyeok Han, Kook-Hwan Oh, Curie Ahn, Soo Wan Kim
Korean J Intern Med. 2021;36(3):659-667. Published online October 8, 2020
Background/Aims: This study aimed to investigate whether urinary angiotensinogen (UAGT) excretion was associated with elevated blood pressure in patients with chronic kidney disease (CKD) and to evaluate the relationship among blood pressure, intra-renal renin-angiotensin system (RAS) activity, and ..
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Cardiology / Original Article
The change in high-sensitivity troponin-T as a risk factor for significant coronary stenosis in patients with acute coronary syndrome
Min Chul Kim, Seok Oh, Youngkeun Ahn, Keumyi Moon, Joon Ho Ahn, Dae Young Hyun, Kyung Hoon Cho, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park
Korean J Intern Med. 2021;36(3):608-616. Published online January 4, 2021
Background/Aims: High-sensitivity cardiac troponin (hs-TnT) assays detect very low levels of cardiac troponin. This study examined the interval change between initial and subsequent hs-TnT levels and evaluated its ability to predict significant coronary stenosis.
Methods: The study analyzed 163 pat..
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Gastroenterology / Original Article
Impact of nonalcoholic fatty liver disease on the risk of metachronous colorectal neoplasia after polypectomy
Nam Hee Kim, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
Korean J Intern Med. 2021;36(3):557-567. Published online July 7, 2020
Background/Aims: Metabolic syndrome has been reported to be a risk factor for metachronous colorectal neoplasia (CRN). However, the impact of nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of metabolic syndrome, on the development of metachronous CRN after polypectomy has been rar..
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Gastroenterology / Original Article
The predictors of sustained virological response with sofosbuvir and ribavirin in patients with chronic hepatitis C genotype 2
Sung Yong Han, Hyun Young Woo, Jeong Heo, Sang Gyu Park, Sung Ik Pyeon, Young Joo Park, Dong Uk Kim, Gwang Ha Kim, Hyung Hoi Kim, Geun Am Song, Mong Cho
Korean J Intern Med. 2021;36(3):544-556. Published online March 19, 2019
Background/Aims: Real-world, clinical practice data are lacking about sofosbuvir/ ribavirin (SOF/RBV) treatment of Korean patients with hepatitis C virus genotype 2 (HCV GT2) infection. This study investigated the efficacy and safety of SOF/RBV in Korean patients with HCV GT2 infection and clinical ..
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Review
Recent advances in the diagnosis and management of interstitial pneumonia with autoimmune features: the perspective of rheumatologists
Hong Ki Min, Se-Hee Kim, Sang-Heon Lee, Hae-Rim Kim
Korean J Intern Med. 2021;36(3):515-526. Published online February 8, 2021
Interstitial pneumonia with autoimmune feature (IPAF) is a recently established disease entity that is comprised of interstitial lung diseases with evidence of autoimmune features but that does not fulfill the criteria for definite autoimmune rheumatic diseases. The classification criteria for IPAF ..
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Allergy / Original Article
Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population
Byung-Keun Kim, Woo-Jung Song, Bomi Seo, Ju-Young Kim, Sae-Hoon Kim, Hak C. Jang, Ki-Woong Kim, Yoon-Seok Chang
Korean J Intern Med. 2021;36(2):447-455. Published online October 13, 2020
Background/Aims: Recent evidence suggests an association between allergic sensitization and metabolic markers. However, this association has rarely been examined in the elderly. Retinol-binding protein-4 (RBP-4) is a recently identified adipokine that acts on the muscle and liver affecting insulin s..
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Infectious diseases / Original Article
Comparison of antimicrobial resistances and clinical features in community-onset Escherichia coli and Klebsiella pneumoniae bacteremia
Hwa Seok Sung, Je Won Lee, Sohyun Bae, Ki Tae Kwon
Korean J Intern Med. 2021;36(2):433-440. Published online March 31, 2020
Background/Aims: The aim of this study was to compare antimicrobial resistance, clinical features, and outcomes of community-onset Escherichia coli (COEC) and Klebsiella pneumoniae (COKP) bacteremia.
Methods: The medical records of patients diagnosed with E. coli or K. pneum..
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Hemato-oncology / Original Article
Leukemic stem cell phenotype is associated with mutational profile in acute myeloid leukemia
Heejoo Han, Ja Min Byun, Dong-Yeop Shin, Sung-Soo Yoon, Youngil Koh, Junshik Hong, Inho Kim, Chansup Lee, Hyeonjoo Yoo, Hongseok Yun, Man Jin Kim, Sung Im Cho, Moon-Woo Seong, Sung Sup Park
Korean J Intern Med. 2021;36(2):401-412. Published online August 20, 2020
Background/Aims: Understanding leukemic stem cell (LSC) is important for acute myeloid leukemia (AML) treatment. However, association of LSC with patient prognosis and genetic information in AML patients is unclear.
Methods: Here we investigated the associations between genetic information and the ..
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Cardiology / Original Article
Impact of carotid atherosclerosis in CHA2DS2-VASc-based risk score on predicting ischemic stroke in patients with atrial fibrillation
Dong-Hyuk Cho, Jong-Il Choi, Jimi Choi, Yun Gi Kim, Suk-Kyu Oh, Hyungdon Kook, Kwang No Lee, Jaemin Shim, Seong-Mi Park, Wan Joo Shim, Young-Hoon Kim
Korean J Intern Med. 2021;36(2):342-351. Published online February 27, 2020
Background/Aims: Vascular disease is an established risk factor for stroke in patients with atrial fibrillation (AF), which is included in CHA2DS2-VASc score. However, the role of carotid atherosclerosis remains to be determined.
Methods: Three hundred-ten patients with AF who..
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Cardiology / Original Article
Progression of ascending aortopathy may not occur after transcatheter aortic valve replacement in severe bicuspid aortic stenosis
Ji-Hyun Jung, Hyung-Kwan Kim, Jun-Bean Park, Seung-Pyo Lee, Bon-Kwon Koo, Yong-Jin Kim, Hyo-Soo Kim, Dae-Won Sohn
Korean J Intern Med. 2021;36(2):332-341. Published online August 14, 2019
Background/Aims: We evaluated changes in the ascending aorta dimension post-transcatheter aortic valve replacement (TAVR) in bicuspid aortic valve (BiAV) and tricuspid aortic valve (TAV) patients.
Methods: Patients with severe aortic stenosis undergoing TAVR at Seoul National University Hospital we..
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