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Infectious diseases / Original Article
Amikacin therapy for urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli
Sung-Yeon Cho, Su-Mi Choi, Sun Hee Park, Dong-Gun Lee, Jung-Hyun Choi, Jin-Hong Yoo
Korean J Intern Med. 2016;31(1):156-161. Published online December 28, 2015
Background/Aims: The number of urinary tract infections (UTIs) caused by extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) is increasing. In an outpatient setting, there are limited therapeutic options to treat ESBL-producing pathogens. We evaluated the outcomes of amikacin..
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Infectious diseases / Original Article
Use of cefuroxime for women with community-onset acute pyelonephritis caused by cefuroxime-susceptible or -resistant Escherichia coli
U-Im Chang, Hyung Wook Kim, Seong-Heon Wie
Korean J Intern Med. 2016;31(1):145-155. Published online December 28, 2015
Background/Aims: Efforts to decrease the use of extended-spectrum cephalosporins are required to prevent the selection and transmission of multi-drug resistant pathogens, such as extended-spectrum b-lactamase (ESBL)-producing Enterobacteriaceae. The objectives of this study were to assess the clinic..
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Hemato-oncology / Original Article
Evaluation of treatment response and tissue necrosis as prognostic indicators following neoadjuvant chemoradiotherapy in rectal cancer patients
Ji-Han Jung, Ho Jung An, Hyung-Jin Kim, Jonghoon Lee, Kang-Moon Lee, Sung Hwan Kim, Hyeon-Min Cho, Byoung Yong Shim
Korean J Intern Med. 2016;31(1):134-144. Published online December 28, 2015
Background/Aims: The objective of this study was to assess the prognostic roles of treatment response and tissue necrosis after chemoradiotherapy (CRT) in locally advanced rectal cancer.
Methods: A total of 243 patients with locally advanced rectal cancer who underwent neoadjuvant CRT were included..
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Nephrology / Original Article
Advanced chronic kidney disease: a strong risk factor for Clostridium difficile infection
Sun Chul Kim, Min Young Seo, Jun Yong Lee, Ki Tae Kim, Eunjung Cho, Myung-Gyu Kim, Sang-Kyung Jo, Won-Yong Cho, Hyoung-Kyu Kim
Korean J Intern Med. 2016;31(1):125-133. Published online December 28, 2015
Background/Aims: It has been suggested that chronic kidney disease (CKD) is a risk factor for Clostridium difficile infection (CDI) and is associated with increased mortality among patients infected with C. difficile. However, recent studies of the clinical impact of CKD on CDI in Asia..
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Nephrology / Original Article
Angiotensin III increases monocyte chemoattractant protein-1 expression in cultured human proximal tubular epithelial cells
Hyung Wook Kim, Young Ok Kim, Sun Ae Yoon, Jeong-Sun Han, Hyun-Bae Chun, Young Soo Kim
Korean J Intern Med. 2016;31(1):116-124. Published online December 28, 2015
Background/Aims: We investigated whether angiotensin III (Ang III) is involved in monocyte recruitment through regulation of the chemokine monocyte chemoattractant protein-1 (MCP-1) in cultured human proximal tubular epithelial cells (HK-2 cells).
Methods: We measured MCP-1 levels in HK-2 cells tha..
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Nephrology / Original Article
Impact of dialysis modality on technique survival in end-stage renal disease patients
Jong-Hak Lee, Sun-Hee Park, Jeong-Hoon Lim, Young-Jae Park, Sang Un Kim, Kyung-Hee Lee, Kyung-Hoon Kim, Seung Chan Park, Hee-Yeon Jung, Owen Kwon, Ji-Young Choi, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim
Korean J Intern Med. 2016;31(1):106-115. Published online December 28, 2015
Background/Aims: This study analyzed the risk factors for technique survival in dialysis patients and compared technique survival rates between hemodialysis (HD) and peritoneal dialysis (PD) in a prospective cohort of Korean patients.
Methods: A total of 1,042 patients undergoing dialysis from Sept..
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Endocrinology-metabolism / Original Article
Relationship between metabolic syndrome and thyroid nodules in healthy Koreans
Juyoung Shin, Min-Hee Kim, Kun-Ho Yoon, Moo-Il Kang, Bong-Yun Cha, Dong-Jun Lim
Korean J Intern Med. 2016;31(1):98-105. Published online December 28, 2015
Background/Aims: This study evaluated the relationship between thyroid nodules and metabolic syndrome (MS) and its components in apparently healthy Koreans.
Methods: We reviewed the records of 3,298 subjects with no noticeable symptoms who underwent thyroid ultrasound imaging as part of a routine c..
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Pulmonology / Original Article
Effect of intranasal rosiglitazone on airway inflammation and remodeling in a murine model of chronic asthma
Hwa Young Lee, Chin Kook Rhee, Ji Young Kang, Chan Kwon Park, Sook Young Lee, Soon Suk Kwon, Young Kyoon Kim, Hyoung Kyu Yoon
Korean J Intern Med. 2016;31(1):89-97. Published online December 28, 2015
Background/Aims: Asthma is characterized by airway hyperresponsiveness, inflammation, and remodeling. Peroxisome proliferator-activated receptors have been reported to regulate inflammatory responses in many cells. In this study, we examined the effects of intranasal rosiglitazone on airway remodeli..
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Pulmonology / Original Article
Clinical efficacy of high-flow nasal cannula compared to noninvasive ventilation in patients with post-extubation respiratory failure
Jung-Wan Yoo, Ara Synn, Jin Won Huh, Sang-Bum Hong, Younsuck Koh, Chae-Man Lim
Korean J Intern Med. 2016;31(1):82-88. Published online December 28, 2015
Background/Aims: Post-extubation respiratory failure (PERF) is associated with poor clinica l outcomes. High-f low nasa l cannula (HF NC) ox ygen therapy has been used in patients with respiratory failure, but the clinical benefit in patients with PERF remains unclear. The aim of this study was to e..
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Cardiology / Original Article
Predictive value of CHADS2 score for cardiovascular events in patients with acute coronary syndrome and documented coronary artery disease
In Sook Kang, Wook Bum Pyun, Gil Ja Shin
Korean J Intern Med. 2016;31(1):73-81. Published online December 28, 2015
Background/Aims: The CHADS2 score, used to predict the risk of ischemic stroke in atrial fibrillation (AF) patients, has been reported recently to predict ischemic stroke in patients with coronary heart disease, regardless of the presence of AF. However, little data are available regardin..
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Gastroenterology / Original Article
Early monitoring for detection of antituberculous drug-induced hepatotoxicity
Chang Min Lee, Sang Soo Lee, Jeong Mi Lee, Hyun Chin Cho, Wan Soo Kim, Hong Jun Kim, Chang Yoon Ha, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung, Ok Jae Lee
Korean J Intern Med. 2016;31(1):65-72. Published online December 28, 2015
Background/Aims: We investigated the time of onset of antituberculous drug-induced hepatotoxicity (ADIH) and related characteristics.
Methods: Adult patients (n = 1,031) treated with first-line antituberculous drugs between February 2009 and January 2013 were enrolled.
Results: Of the 1,031 pati..
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Gastroenterology / Original Article
Predictive factors of mortality within 30 days in patients with nonvariceal upper gastrointestinal bleeding
Yoo Jin Lee, Bo Ram Min, Eun Soo Kim, Kyung Sik Park, Kwang Bum Cho, Byoung Kuk Jang, Woo Jin Chung, Jae Seok Hwang, Seong Woo Jeon
Korean J Intern Med. 2016;31(1):54-64. Published online December 28, 2015
Background/Aims: Nonvariceal upper gastrointestinal bleeding (NVUGIB) is a common medical emergency that can be life threatening. This study evaluated predictive factors of 30-day mortality in patients with this condition.
Methods: A prospective observational study was conducted at a single hospita..
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Gastroenterology / Original Article
Feasibility of α-fetoprotein as a diagnostic tool for hepatocellular carcinoma in Korea
Dae Geon Ahn, Hyung Joon Kim, Hyun Kang, Hyun Woong Lee, Si Hyun Bae, Joon Hyoek Lee, Yong Han Paik, June Sung Lee
Korean J Intern Med. 2016;31(1):46-53. Published online December 28, 2015
Background/Aims: The aim of this study was to evaluate the feasibility of α-fetoprotein (AFP) as a diagnostic tool for hepatocellular carcinoma (HCC) in Korean patients.
Methods: We retrospectively reviewed the medical records of HCC and cirrhosis patients at three hospitals. For each HCC patient..
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Gastroenterology / Original Article
New monoclonal antibody-based test for Helicobacter pylori urease in gastric tissue
Do Hyun Kim, Ho Dong Kim, Hyeuk Park, Seung Choi, Jae Won Beom, Woo Jong Kim, Chang Kook Park, Young Jik Lee, Ju Young Park, Hyung Rag Kim, Chul Park, Young Eun Joo, Young Do Jung
Korean J Intern Med. 2016;31(1):40-45. Published online December 28, 2015
Background/Aims: To evaluate a new monoclonal antibody for Helicobacter pylori urease in gastric tissue.
Methods: A total of 107 volunteers were enrolled. All subjects underwent a 13C-urea breath test and esophagogastroduodenoscopy. Gastric aspirates were analyzed for pH and ammon..
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Gastroenterology / Review
The antibacterial effect of fatty acids on Helicobacter pylori infection
Sung Woo Jung, Sang Woo Lee
Korean J Intern Med. 2016;31(1):30-35. Published online December 28, 2015
Eradication of Helicobacter pylori is recommended for the management of various gastric diseases, including peptic ulcers and mucosa-associated lymphoid tissue lymphoma. Because of the increasing prevalence of antibiotic resistance, the eradication rates of antibiotic-based therapies have dec..
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Infectious diseases / Review
Emerging strategies for the treatment of pulmonary tuberculosis: promise and limitations?
Wing Wai Yew, Won-Jung Koh
Korean J Intern Med. 2016;31(1):15-29. Published online December 28, 2015
A worsening scenario of drug-resistant tuberculosis has increased the need for new treatment strategies to tackle this worldwide emergency. There is a pressing need to simplify and shorten the current 6-month treatment regimen for drug-susceptible tuberculosis. Rifamycins and fluoroquinolones, as we..
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Cardiology / Review
Breakthrough in heart failure with preserved ejection fraction: are we there yet?
Shir Lynn Lim, Carolyn Su Ping Lam
Korean J Intern Med. 2016;31(1):1-14. Published online December 28, 2015
Heart failure with preserved ejection fraction (HFPEF) is a global health problem of considerable socioeconomic burden. It is projected to worsen with the aging population worldwide. The lack of effective therapies underscores our incomplete understanding of this complex heterogeneous syndrome. A no..
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Image of interest
Extreme septal hypertrophy in an adolescent with congenital familial hypertrophic cardiomyopathy
Byoung-Won Park, Min-Ho Lee, Duk Won Bang, Min-Su Hyon
Korean J Intern Med. 2015;30(6):940-941. Published online October 30, 2015
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Image of interest
Nutmeg liver cardiac cirrhosis caused by constrictive pericarditis
Kyoung Hwang Shin, Hyun Don Joo, Il Han Song
Korean J Intern Med. 2015;30(6):938-939. Published online October 30, 2015
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