| Reviews |
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Pulmonology / Review
Epidemiology of interstitial lung diseases in Asia
Hee-Young Yoon, Felicia S. W. Teo, Ju Hyun Oh, Jin Woo Song
Korean J Intern Med. 2026;41(6):969-981. Published online November 1, 2026
The epidemiology of interstitial lung diseases (ILDs) in Asia has gained increasing attention with the emergence of new population- based datasets and national registries. Current evidence demonstrates that the burden and subtype distribution of ILDs vary considerably across regions, reflecting diff..
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Pulmonology / Review
Epidemiology and clinical characteristics of progressive pulmonary fibrosis in Asia
Ju Hyun Oh, Felicia S. W. Teo, Hee-Young Yoon, Jin Woo Song
Korean J Intern Med. 2026;41(6):982-994. Published online November 1, 2026
Progressive pulmonary fibrosis (PPF) represents a progressive phenotype across various fibrosing interstitial lung diseases (ILDs). The epidemiology of PPF is confounded by differences in the defining criteria for PPF, data capture sources, as well as the heterogeneity of ILD subtype diagnoses. In As..
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Pulmonology / Review
Gastroesophageal reflux disease as a comorbidity in chronic lung diseases: mechanism, clinical impacts and therapeutic uncertainty
Jin-Young Huh, Jin Woo Song
Korean J Intern Med. 2026;41(6):995-1009. Published online November 1, 2026
Chronic lung diseases, particularly chronic obstructive pulmonary disease and interstitial lung disease, are major contributors to global morbidity and mortality. Gastroesophageal reflux disease (GERD) is highly prevalent in these populations and has been implicated in exacerbations and disease prog..
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Infectious diseases / Review
Diagnosis and treatment of extrapulmonary tuberculosis in HIV-infected patients: a persistent challenge
Jihwan Bang
Korean J Intern Med. 2026;41(6):1010-1019. Published online November 1, 2026
This review summarizes the current knowledge regarding the epidemiology, diagnostic challenges, and therapeutic considerations of extrapulmonary tuberculosis (EPTB) in HIV-infected patients. Individuals with advanced HIV infection are particularly vulnerable to EPTB and disseminated disease; extrapu..
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Infectious diseases / Review
Pneumocystis jirovecii pneumonia in non-human immunodeficiency virus patients
Jinnam Kim, Choseok Yoon, Bongyoung Kim, Se Yoon Park
Korean J Intern Med. 2026;41(6):1020-1039. Published online November 1, 2026
Pneumocystis jirovecii pneumonia (PJP) is an important opportunistic fungal infection in immunocompromised hosts. Although its incidence has declined markedly in people with human immunodeficiency virus (HIV) following the widespread use of antiretroviral therapy and prophylaxis, PJP is incre..
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| Original Articles |
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Gastroenterology / Original Article
Association of age-adjusted skeletal muscle index and modest alcohol intake with hepatic steatosis and fibrosis in males
Janghan Jung, Jin Lee, Dong Hee Koh, Jung Hee Kim
Korean J Intern Med. 2026;41(6):1065-1076. Published online November 1, 2026
Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern linked to obesity, insulin resistance, and metabolic syndrome. Although body composition and alcohol intake influence disease progression, their specific associations with hepatic ste..
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Cardiology / Original Article
The efficacy and safety of on-label reduced-dose apixaban in patients with atrial fibrillation in real-world practice
Min-Su Jung, Jongmin Hwang, Seongwook Han, Hyoung-Seob Park, Tae-Wan Chung, Eue-Keun Choi, Il-Young Oh, Hyung Wook Park, Sung Ho Lee, Jong-Sung Park, Yae Min Park, Gyo-Seung Hwang, Dong-Hyeok Kim, Jin-Kyu Park, Jong-Il Choi; on behalf of the INSPIRE study investigators
Korean J Intern Med. 2026;41(6):1077-1086. Published online November 1, 2026
Background/Aims: In pivotal randomized trials, only a small proportion of patients received the reduced apixaban dose, limiting the generalizability of those findings. We evaluated the efficacy and safety of on-label reduced-dose apixaban in Korean patients with atrial fibrillation (AF).
Methods: Pat..
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Cardiology / Original Article
Syncope as a predictor of sudden cardiac arrest: a nationwide population-based study
Yun Gi Kim, Yeji Kim, Joo Hee Jeong, Kyung-Do Han, Chang-Ok Seo, Hyoung Seok Lee, Jaemin Shim, Young-Hoon Kim, Jong-Il Choi
Korean J Intern Med. 2026;41(6):1087-1100. Published online November 1, 2026
Background/Aims: The risk of sudden cardiac arrest (SCA) in patients with prior syncope events is not fully understood. We examined the association between syncope and the risk of future SCA.
Methods: Data were obtained from the Korean National Health Insurance Service database. Of those individua..
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| Editorial |
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Editorial
Syncope and sudden cardiac arrest: a warning sign or a marker of cardiovascular risk?
Dong-Hyeok Kim
Korean J Intern Med. 2026;41(6):1101-1103. Published online November 1, 2026
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Pulmonology / Original Article
Pleural fluid cytokines in malignant pleural effusion: associations with lung expandability and prediction of pleurodesis outcome
Jarudul Phocharoen, Pimpayao Sodsai, Virissorn Wongsrichanalai, Vorawut Thanthitaweewat, Thitiwat Sriprasart, Nophol Leelayuwatanakul
Korean J Intern Med. 2026;41(6):1104-1113. Published online November 1, 2026
Background/Aims: Lung expandability is a key determinant of successful pleurodesis in malignant pleural effusion (MPE). Although pleural elastance is widely used to assess expandability, pleurodesis may still fail in some patients with low elastance. This study investigated pleural fluid cytokines as..
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Endocrinology-metabolism / Original Article
Metabolic syndrome and risk of suicide death in South Korea: a nationwide cohort study
Jin Hwa Kim, Young Sang Lyu, Mee Kyoung Kim, Sang Yong Kim, Ki-Hyun Baek, Ki-Ho Song, Kyungdo Han, Hyuk-Sang Kwon
Korean J Intern Med. 2026;41(6):1114-1125. Published online November 1, 2026
Background/Aims: South Korea has one of the highest suicide rates worldwide. This study examined the association between metabolic syndrome (MetS) and suicide death using nationwide data.
Methods: The study used the National Health Insurance Service database in South Korea. A total of 3,951,398 ind..
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Infectious diseases / Original Article
Aspergillus positivity in lower respiratory specimens as a predictor of poor prognosis in invasive pulmonary aspergillosis
Ka Eun Kim, Jung Soo Son, Hyeon Jae Jo, Chan Mi Lee, Jae Hyeon Park, Chang Kyung Kang, Taek Soo Kim, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim
Korean J Intern Med. 2026;41(6):1126-1137. Published online November 1, 2026
Background/Aims: In patients with invasive pulmonary aspergillosis (IPA), the clinical significance of culture positivity is unclear. Here we evaluated whether Aspergillus isolation from lower respiratory tract (LRT) specimens was associated with greater disease severity and higher mortality ..
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| Editorial |
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Allergy / Original Article
Clinical features of moderate-to-severe antibiotic allergy in Korea: analysis from the drug allergy safety information sharing system database
Eunsik Bang, Min-Ho Kang, Jee Hyun Kim, Won Jong Song, Su Jeong Song, Eunyoung Sa, Jeong-Min Park, Ji-Hyang Lee, Jeong-Eun Yun, Jiung Jeong, Sujeong Kim, Hwa Young Lee, Kyung Hee Park, Min-Gyu Kang, Sang Min Lee, So Ri Kim, Sae-Hoon Kim, Hye-Ryun Kang
Korean J Intern Med. 2026;41(6):1141-1151. Published online November 1, 2026
Background/Aims: Antibiotics are major causes of drug allergy. Sharing standardized information on culprit agents is essential to prevent recurrent drug allergy. In 2024, the Ministry of Health and Welfare established the Drug Allergy Safety Information Sharing System (DASI), integrated with the Per..
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| Correspondence |
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