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Hemato-oncology / Original Article
Real-world use of polatuzumab vedotin combined with bendamustine and rituximab for patients with relapsed or refractory large B-cell lymphoma
Changgon Kim, Sang Eun Yoon, Hyun-Young Kim, Duck Cho, Junhun Cho, Won Seog Kim, Seok Jin Kim
Korean J Intern Med. 2026;41(2):296-306. Published online March 1, 2026
Background/Aims: Polatuzumab vedotin combined with bendamustine and rituximab (Pola-BR) is a treatment option for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL), particularly as bridging therapy before chimeric antigen receptor (CAR) T-cell infusion. However, real-world data regarding..
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Endocrinology-metabolism / Review
From bench to bedside: adipose tissue fibrosis in obesity, anti-diabetic therapies, and bariatric surgery
Mihye Seo, Kyoil Suh, Hyeong Kyu Park, Kae Won Cho
Korean J Intern Med. 2026;41(2):210-229. Published online December 23, 2025
This review provides a comprehensive examination of the recent research findings concerning the pathophysiology and clinical implications of adipose tissue fibrosis in obesity and metabolic diseases. Recent large-scale studies, including a longitudinal study spanning 24 years (Swedish Obese Subjects..
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Nephrology / Original Article
Arteriovenous fistulas are associated with superior outcomes in very elderly hemodialysis patients: a nationwide cohort study
Hyung Duk Kim, Do Hyoung Kim, Hyangkyoung Kim, Hyung-Seok Lee, Seung Boo Yang, Seok Joon Shin, Hoon Suk Park; on behalf of the vascular access working group of the Korean Society of Dialysis Access
Korean J Intern Med. 2026;41(1):152-162. Published online January 1, 2026
Background/Aims: The optimal vascular access strategy for very elderly patients initiating hemodialysis (HD) remains unclear. Arteriovenous fistulas (AVFs) offer long-term benefits but may be limited due to vascular aging. This study evaluated vascular access outcomes in patients aged ≥ 80 years.
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Cardiology / Original Article
Comparative efficacy and safety of warfarin and direct oral anticoagulants in patients with end-stage kidney disease and atrial fibrillation
Yujin Yang, Sun Hwa Lee, Wonmook Hwang, Ji Hoon Jung, Jae-Hyeong Park
Korean J Intern Med. 2026;41(1):107-117. Published online January 1, 2026
Background/Aims: Patients with atrial fibrillation (AF) and end-stage kidney disease (ESKD) require careful anticoagulation because thrombotic and bleeding risks are both elevated. We evaluated the efficacy and safety of warfarin, direct oral anticoagulants (DOACs), and no anticoagulation in Korean ..
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Gastroenterology / Original Article
Risk factors for bleeding from gastric antral vascular ectasia
Sung Hyun Cho, Jinyoung Kim, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Korean J Intern Med. 2026;41(1):74-84. Published online January 1, 2026
Background/Aims: Gastric antral vascular ectasia (GAVE) is a rare but important cause of gastrointestinal (GI) bleeding. The clinical course of GAVE is not well-known, and recurrent bleeding from GAVE is a therapeutic challenge. Therefore, we investigated the clinical course of GAVE and identified t..
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Endocrinology-metabolism / Original Article
Comprehensive approaches to diabetes in the elderly: adapting to evolving trends
Jeongmin Lee, Kwang Joon Kim, Yang Sun Park, Yong-ho Lee, Kyeong Hye Park, Hee-Won Jung, Bong-Soo Cha, Hun-Sung Kim, Chang Oh Kim
Korean J Intern Med. 2025;40(6):1017-1028. Published online October 31, 2025
Background/Aims: The prevalence of diabetes mellitus (DM) is increasing worldwide owing to aging. This nationwide study aimed to investigate the prevalence of DM and its management status among elderly Koreans.
Methods: We analyzed data from the Korea National Health and Nutrition Examination Survey..
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Nephrology / Review
Clinical challenges and individualized approaches to dialysis therapy in older adults
Sungmi Kim, Yu Ah Hong
Korean J Intern Med. 2025;40(6):909-926. Published online October 31, 2025
Global population aging has substantially increased in the number of older adults who undergo kidney replacement therapy (KRT). Age-related physiological changes and functional dependence in this population lead to the multifaceted clinical and ethical challenges associated with KRT. Geriatric syndr..
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Cardiology / Original Article
Automatic quantitative analysis of atherosclerotic aortic plaques in patients with embolic cerebral infarction using deep learning
Hye Jin Bang, Jae-Hyeong Park, Sun Geu Chae, Suk Joo Bae, Ji-Hoon Jung, You Hee Cho, Jong Won Park, Dae-Won Kim, Jung Sun Cho
Korean J Intern Med. 2025;40(5):767-779. Published online August 26, 2025
Background/Aims: Transesophageal echocardiography (TEE) is a commonly used imaging modality for assessing embolic stroke of undetermined source (ESUS) in clinical practice. We aimed to develop an automatic plaque segmentation model based on U-net and evaluate its clinical usefulness in patients with..
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Infectious diseases / Review
Appropriate timing of antibiotic initiation in patients with sepsis or septic shock: a systematic review and meta-analysis
Nam Su Ku, Yongseop Lee, Dae Won Park
Korean J Intern Med. 2025;40(5):725-733. Published online August 26, 2025
Evidence supporting antibiotic administration within 3 hours in sepsis without shock is limited. Therefore, we conducted a systematic review and meta-analysis to determine whether the timing of antibiotic initiation influences mortality in patients with sepsis or septic shock. We comprehensively searched Pub..
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Pulmonology / Original Article
Efficacy and safety of first-line afatinib in older patients with advanced EGFR-mutated non-small cell lung cancer
Mi-Hyun Kim, Hayoung Seong, Soo Han Kim, Min Ki Lee, Insu Kim, Kyung Soo Hong, June Hong Ahn, Jung Seop Eom
Korean J Intern Med. 2025;40(4):626-633. Published online July 1, 2025
Background/Aims: This study investigated the efficacy and safety of first-line afatinib treatment in older patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC).
Methods: This retrospective, multicenter, observational cohort study included 103 patients aged..
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Gastroenterology / Original Article
Clinical outcomes of esophageal squamous cell carcinoma in patients aged over 80 years
Dae Gon Ryu, Cheol Woong Choi, Su Jin Kim, Su Bum Park, Jin Ook Jang, Bong Soo Son
Korean J Intern Med. 2025;40(2):230-242. Published online February 21, 2025
Background/Aims: The clinical outcomes and optimal treatment of esophageal squamous cell carcinoma (ESCC) in elderly patients are unclear. This study aimed to assess the clinical outcomes of ESCC in patients aged ≥ 80 years.
Methods: Medical records of patients diagnosed with ESCC between Decembe..
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Gastroenterology / Original Article
Association between acid-suppressive drugs and risk of psoriasis: retrospective study using Korean National Health Insurance Service-National Sample Cohort
Ji Hyun Kim, Joon-hong Min, Young Woo Jo, Jae Woo Kwon, Young Her
Korean J Intern Med. 2025;40(1):57-64. Published online January 1, 2025
Background/Aims: Psoriasis is a common inflammatory skin disorder following non-specific triggers. Involvement of immune system is widely accepted for pathogenesis studies have demonstrated importance of gut microbiota in pathogenesis of inflammatory skin diseases. Proton pump inhibitor (PPI) and hi..
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Infectious diseases / Original Article
Adverse drug reactions following treatment of latent tuberculosis infection: a linked national tuberculosis surveillance with claims database
Yu-Seon Jung, Sun-Young Jung, Jae-Eun Lee, Kyungeun Lee, Jae Chol Choi
Korean J Intern Med. 2024;39(6):979-988. Published online October 22, 2024
Background/Aims: Few real-world studies explored factors associated with latent tuberculosis infection (LTBI) treatment-related adverse drug reactions (ADRs). This study evaluate ADRs that lead to the discontinuation of LTBI treatment and identify the associated factors, including age groups and dru..
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Nephrology / Review
Kidney transplantation in the elderly
Byung Hwa Park, Song Yi Kil, Ye Na Kim, Ho Sik Shin, Yeonsoon Jung, Hark Rim
Korean J Intern Med. 2024;39(6):875-881. Published online October 24, 2024
Interest in kidney transplant studies in the elderly population is increasing as more research has been conducted on the immune system. With this review, we hope to encourage the need for research on kidney transplantation in the elderly.
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Rheumatology / Original Article
Effect of abatacept versus conventional synthetic disease modifying anti-rheumatic drugs on rheumatoid arthritis-associated interstitial lung disease
Kyung-Ann Lee, Bo Young Kim, Sung Soo Kim, Yun Hong Cheon, Sang-Il Lee, Sang-Hyon Kim, Jae Hyun Jung, Geun-Tae Kim, Jin-Wuk Hur, Myeung-Su Lee, Yun Sung Kim, Seung-Jae Hong, Suyeon Park, Hyun-Sook Kim
Korean J Intern Med. 2024;39(5):855-864. Published online August 30, 2024
Background/Aims: To compare the effects of abatacept and conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs) on the progression and development of rheumatoid arthritis-associated interstitial lung disease (RA-ILD).
Methods: This multi-center retrospective study included RA pati..
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Rheumatology / Original Article
Drug retention of biologic and targeted synthetic disease-modifying antirheumatic drugs in Korean patients with seropositive rheumatoid arthritis
Bong-Woo Lee, Jennifer Jooha Lee, Wan-Uk Kim
Korean J Intern Med. 2024;39(5):833-844. Published online May 27, 2024
Background/Aims: The aim of this study was to compare the short- and long-term retention rates of biologic and targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) in Korean patients with seropositive rheumatoid arthritis.
Methods: This study was conducted with 1,538 treatment cou..
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Infectious diseases / Review
Implementing antimicrobial stewardship: lessons and perspectives from a university-affiliated tertiary hospital in Korea
Soo Jin Lee, Raeseok Lee, Sung-Yeon Cho, Dukhee Nho, Hye Lim Ahn, Dong-Gun Lee
Korean J Intern Med. 2024;39(3):399-412. Published online April 30, 2024
Antimicrobial stewardship programs (ASPs) can lower antibiotic use, decrease medical expenses, prevent the emergence of resistant bacteria, and enhance treatment for infectious diseases. This study summarizes the stepwise implementation and effects of ASPs in a single university-affiliated tertiary ..
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Infectious diseases / Review
Quantitative and qualitative evaluation of antimicrobial usage: the first step for antimicrobial stewardship
Song Mi Moon, Bongyoung Kim, Hong Bin Kim
Korean J Intern Med. 2024;39(3):383-398. Published online April 30, 2024
The identification of antimicrobial use patterns is essential for determining key targets for antimicrobial stewardship interventions and evaluating the effectiveness thereof. Accurately identifying antimicrobial use patterns requires quantitative evaluation, which focuses on measuring the quantity ..
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Gastroenterology / Original Article
Reduced risk of gastrointestinal bleeding associated with eupatilin in aspirin plus acid suppressant users: nationwide population-based study
Hyun Seok Lee, Ji Hyung Nam, Dong Jun Oh, Yeo Rae Moon, Yun Jeong Lim
Korean J Intern Med. 2024;39(2):261-271. Published online December 14, 2023
Background/Aims: Mucoprotective agents, such as eupatilin, are often prescribed to prevent gastrointestinal (GI) bleeding in addition to an acid suppressant despite the absence of a large-scale study. We evaluated the additional effect of eupatilin on the prevention of GI bleeding in both the upper ..
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Gastroenterology / Original Article
Model for end-stage liver disease-3.0 vs. model for end-stage liver disease-sodium: mortality prediction in Korea
Jeong Han Kim, Yong Joon Cho, Won Hyeok Choe, So Young Kwon, Byung-Chul Yoo
Korean J Intern Med. 2024;39(2):248-260. Published online February 1, 2024
Background/Aims: The model for end-stage liver disease (MELD) serves as an indicator for short-term mortality among patients diagnosed with liver cirrhosis (LC) and is used to prioritize patients for liver transplantation. In 2021, the updated version of MELD, MELD-3.0, was introduced to improve the..
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