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Endocrinology-metabolism / Original Article
Does physical activity reduce cardiovascular risk associated with knee osteoarthritis in type 2 diabetes? A nationwide cohort study
Dojoon Park, Kyuho Kim, Hae-Seok Koh, Kyungdo Han, Youn-Ho Choi
Korean J Intern Med. 2026;41(3):485-500. Published online May 1, 2026
Background/Aims: Knee osteoarthritis (OA), type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD) share overlapping mechanisms but are often managed independently. We evaluated whether knee OA increases CVD risk in Korean T2DM patients and whether physical activity (PA) modifies this risk..
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Gastroenterology / Original Article
Incidence and risk factors of rebleeding in Crohn’s disease patients with acute lower gastrointestinal bleeding
Gabin Moon, Kyeong Ok Kim, Sung Noh Hong, Seong Joon Koh, Sung Hoon Jung, Chang Hwan Choi, Eun Mi Song, Hong Sub Lee, Yoo Jin Lee, Ki Bae Bang; On behalf of the IBD Research Group of the Korean Association for the Study of Intestinal Diseases
Korean J Intern Med. 2026;41(3):454-461. Published online May 1, 2026
Background/Aims: Acute lower gastrointestinal bleeding (LGIB) in Crohn’s disease (CD) is a rare but potentially life-threatening complication. This study aimed to investigate the incidence and risk factors of rebleeding in CD patients with LGIB.
Methods: We retrospectively analyzed 137 CD patient..
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Gastroenterology / Original Article
Association between remnant cholesterol and colorectal cancer risk in Korea: a nationwide population-based study
Minkook Son, Jong Yoon Lee, Chi Hyeon Choi, Yeo Wool Kang, Sang Yi Moon, Myeonseok Koh
Korean J Intern Med. 2026;41(3):443-453. Published online May 1, 2026
Background/Aims: Remnant cholesterol (RC) has emerged as a novel lipid marker with potential implications in cardiovascular and metabolic diseases. However, its association with colorectal cancer (CRC) remains unclear.
Methods: We conducted a retrospective cohort study using data from 364,626 Korea..
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Gastroenterology / Original Article
Comparison between ligation-assisted and precutting endoscopic mucosal resection for small rectal neuroendocrine tumors: a CHASID study
Sunghyeok Ryou, Yunho Jung, Dae Sung Kim, Hee Seok Moon, Hoon Sup Koo, Hyun Deok Shin, Ki Bae Bang, Kyu Chan Huh; Chungcheong-Daejeon Association for the Study of Intestinal Diseases (CHASID)
Korean J Intern Med. 2026;41(3):432-440. Published online May 1, 2026
Background/Aims: Few studies have compared modified endoscopic mucosal resection (EMR) techniques for small rectal neuroendocrine tumors (NETs). This study evaluated the clinical outcomes of ligation-assisted EMR (EMR-L) and precutting EMR (EMR-P) for the treatment of small rectal NETs.
Methods: We..
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Allergy / Review
Eperisone-induced immediate hypersensitivity reactions
Gyu-Young Hur, Jung-Won Park
Korean J Intern Med. 2026;41(3):411-417. Published online May 1, 2026
Eperisone hydrochloride is a centrally acting muscle relaxant commonly prescribed for musculoskeletal pain, particularly in Korea and Japan. It induces relaxation of skeletal and vascular smooth muscle through central nervous system modulation and peripheral mechanisms, although its precise biochemi..
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Hospital medicine / Original Article
Global burden of adverse effects of medical treatment from 1990 to 2021: a Global Burden of Disease Study 2021
GBD 2021 AEMT Collaborators, Yi Deun Jeong, Seoyoung Park, Wonwoo Jang, Min Seo Kim, A Bhoomadevi et al.
Korean J Intern Med. 2026;41(2):350-366. Published online March 1, 2026
Background/Aims: This study aims to evaluate the global burden of adverse effects of medical treatment (AEMT) using data from the Global Burden of Disease Study (GBD) 2021.
Methods: Data were extracted from the GBD 2021, covering 204 countries/territories from 1990 to 2021. AEMT was defined using I..
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Rheumatology / Original Article
Cross-cultural adaptation and preliminary validation of the Korean version of the Psoriatic Arthritis Impact of Disease-12 questionnaire
Bon San Koo, Jung Gon Kim, Bo Young Yoon, Ji-Hyoun Kang, Sung-Eun Choi, Sooin Jung, Seyeong Kim, Tae-Jong Kim
Korean J Intern Med. 2026;41(2):341-349. Published online March 1, 2026
Background/Aims: The Psoriatic Arthritis Impact of Disease (PsAID-12) questionnaire was developed to measure quality of life and disease impact in patients with psoriatic arthritis (PsA). We aimed to translate the English PsAID-12 into Korean and to evaluate its reliability and validity.
Methods: T..
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Infectious diseases / Original Article
Hemodialysis vascular access infections: epidemiology and risk factors for treatment failure
Shi Nae Yu, Eunjung Lee, Se Yoon Park, Oh-Hyun Cho, Sangchul Yun, Tark Kim, Min Seo Kang, Yae Jee Baek, Jongtak Jung, Tae Hyong Kim
Korean J Intern Med. 2026;41(2):317-327. Published online March 1, 2026
Background/Aims: Infection remains the second leading cause of mortality in patients with end-stage renal disease (ESRD). Despite the direct relationship between hemodialysis vascular access-related infections (HD-VARI) and both prognosis and mortality in ESRD patients, there is a paucity of researc..
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Hemato-oncology / Original Article
High diffuse bone marrow uptake in 18F-FDG PET/CT may reflect the diverse mutational characteristics of multiple myeloma
Hee Jeong Cho, Donghyeon Lee, Tan Minh Le, Hong Duc Thi Nguyen, Juhyung Kim, Jung Min Lee, Dong Won Baek, Ha-Jeong Kim, Hyung Soo Han, Sang Kyun Sohn, Chae Moon Hong, Joon Ho Moon
Korean J Intern Med. 2026;41(2):307-316. Published online March 1, 2026
Background/Aims: To explore the biological implications of positron emission tomography/computed tomography (PET/CT) findings in multiple myeloma (MM), we investigated the mutational characteristics relevant to PET/CT findings using targeted DNA sequencing.
Methods: Fourteen newly diagnosed patient..
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Endocrinology-metabolism / Original Article
Risk of atrial fibrillation in patients with differentiated thyroid cancer: a nationwide population-based analysis
Jung Heo, Seo Young Sohn, Yun Jin Kim, Sung Woo Cho
Korean J Intern Med. 2026;41(2):286-295. Published online March 1, 2026
Background/Aims: Thyroid hormone suppression therapy (THST) is widely used for long-term management of differentiated thyroid cancer (DTC). However, studies have suggested that THST may increase the risk of atrial fibrillation (AF) in patients with DTC. We aimed to evaluate whether the risk of AF in..
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Endocrinology-metabolism / Original Article
Development of Simple Assessment tool for predict imminent risk of Fracture in Elderly women
So Young Park, Sujin Kwon, Kyoung Jin Kim, Seong Hee Ahn, Ha Young Kim, Kyoung Min Kim; the Epidemiology Committee of the Korean Society of Bone Metabolism
Korean J Intern Med. 2026;41(2):277-285. Published online March 1, 2026
Background/Aims: Previously developed fracture risk prediction models primarily estimate long-term risk and are limited in their ability to predict imminent fractures. We developed a simplified and practical model to predict the short-term fracture risk (1- to 3-year risk) in elderly Korean women.
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Hemato-oncology / Review
Assessment tools for peripheral neuropathy in multiple myeloma
Sung-Soo Park, Kunye Kwak, Seol-Hee Baek, Changgon Kim, Yoon Seok Choi, Yong Park, Byung Soo Kim, Jin Seok Kim, Chang-Ki Min, Ka-Won Kang
Korean J Intern Med. 2026;41(2):230-241. Published online March 1, 2026
Advances in treating multiple myeloma (MM) have improved survival, shifting the management focus toward quality of life. Peripheral neuropathy (PN) is a common treatment-related toxicity that significantly impairs quality of life. However, standardized assessment methods for PN in patients with MM a..
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Endocrinology-metabolism / Original Article
Association between diabetes duration and hyperuricemia: Korea National Health and Nutrition Examination Survey 2016 to 2021
Kyuho Kim, Kyungdo Han, In Young Kim, Kyuna Lee, Yu-Bae Ahn, Seung-Hyun Ko, Jae-Seung Yun
Korean J Intern Med. 2026;41(1):143-151. Published online January 1, 2026
Background/Aims: We examined the association between diabetes duration and hyperuricemia in Korean subjects based on data from the Korea National Health and Nutrition Examination Survey (KNHANES).
Methods: This cross-sectional study included 4,575 subjects aged 30 years and older with type 2 diabet..
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Endocrinology-metabolism / Original Article
Analysis of experiences on telemedicine pilot projects from the perspectives of doctors, pharmacists, and patients
Yeryeon Jung, Hyunah Kim, Jeong-Yeon Kim, Seongwoo Seo, Youseok Kim, Min Jung Ko, Hun-Sung Kim
Korean J Intern Med. 2026;41(1):131-142. Published online January 1, 2026
Background/Aims: This study is the first to analyze telemedicine pilot project experiences from doctors, pharmacists, and patients with different roles to support sustainable commercialization.
Methods: An online survey targeted individuals (patients, doctors, and pharmacists) who participated in t..
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Cardiology / Original Article
Enhanced prediction of left ventricular ejection fraction using electrocardiography with the addition of clinical metadata
Hyun Woong Park, Taeseen Kang, Young-Hoon Seo, Jae-Hyeong Park
Korean J Intern Med. 2026;41(1):118-130. Published online January 1, 2026
Background/Aims: Left ventricular ejection fraction (LVEF) is a key echocardiographic parameter for assessing LV systolic function, guiding the management of many cardiovascular diseases, including heart failure (HF). While traditional electrocardiography (ECG) has been widely used in clinical pract..
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Cardiology / Original Article
Comparative efficacy and safety of warfarin and direct oral anticoagulants in patients with end-stage kidney disease and atrial fibrillation
Yujin Yang, Sun Hwa Lee, Wonmook Hwang, Ji Hoon Jung, Jae-Hyeong Park
Korean J Intern Med. 2026;41(1):107-117. Published online January 1, 2026
Background/Aims: Patients with atrial fibrillation (AF) and end-stage kidney disease (ESKD) require careful anticoagulation because thrombotic and bleeding risks are both elevated. We evaluated the efficacy and safety of warfarin, direct oral anticoagulants (DOACs), and no anticoagulation in Korean ..
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Gastroenterology / Original Article
The effects of Helicobacter pylori eradication and development of immune-mediated disorder in children: a nationwide population-based study in Korea
You Ie Kim, Joon Sung Kim, Sang Yong Kim, Byung-Wook Kim
Korean J Intern Med. 2026;41(1):85-94. Published online January 1, 2026
Background/Aims: Helicobacter pylori may protect against immune-mediated disorders such as inflammatory bowel disease (IBD) and asthma. This study evaluated whether eradication was associated with IBD and asthma in Korean children.
Methods: Data were collected from the Korean National Health..
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Gastroenterology / Original Article
Risk factors for bleeding from gastric antral vascular ectasia
Sung Hyun Cho, Jinyoung Kim, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Korean J Intern Med. 2026;41(1):74-84. Published online January 1, 2026
Background/Aims: Gastric antral vascular ectasia (GAVE) is a rare but important cause of gastrointestinal (GI) bleeding. The clinical course of GAVE is not well-known, and recurrent bleeding from GAVE is a therapeutic challenge. Therefore, we investigated the clinical course of GAVE and identified t..
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Gastroenterology / Review
Clinical management of gastric mucosa-associated lymphoid tissue lymphoma
Ji Yong Ahn
Korean J Intern Med. 2026;41(1):8-14. Published online December 23, 2025
Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is often associated with chronic Helicobacter pylori infection. For an accurate diagnosis of gastric MALT lymphoma, clinical suspicion and careful endoscopic examination with multiple biopsies should be performed, and the final patholo..
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Rheumatology / Original Article
Treatment satisfaction and its determinants in Korean patients with rheumatoid arthritis and systemic lupus erythematosus
Hyo Jin Choi, Mi Ryoung Seo, Eunji Kim, Han Joo Baek
Korean J Intern Med. 2025;40(6):1042-1051. Published online October 28, 2025
Background/Aims: This study aimed to evaluate the treatment satisfaction and its determinants in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
Methods: This cross-sectional study was conducted between September 2021 and December 2021. Data on demographics, clinical..
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