|
Cardiology / Original Article
Association of the triglyceride-glucose index with cardiovascular outcomes across cardiovascular-kidney-metabolic syndrome stages
Byung Sik Kim, Hyun-Jin Kim, Shinje Moon, Hasung Kim, Jungkuk Lee, Jeong-Hun Shin
Korean J Intern Med. 2025;40(6):961-974. Published online October 31, 2025
Background/Aims: Cardiovascular-kidney-metabolic (CKM) syndrome reflects the interplay between metabolic dysfunction, chronic kidney disease, and cardiovascular disease. Insulin resistance (IR) is a key driver of CKM and is associated with adverse cardiovascular outcomes. The triglyceride-glucose (T..
|
|
|
Infectious diseases / Review
Current perspectives on sarcopenia: diagnosis and therapeutic approaches
Jung-Yeon Choi, Kwang-il Kim, Cheol-Ho Choi
Korean J Intern Med. 2025;40(6):927-938. Published online October 31, 2025
Korea is experiencing rapid population aging and entered a super-aged society in December 2024. This demographic shift underscores the growing prevalence of sarcopenia, a progressive skeletal muscle disorder related to aging, characterized by reduced muscle mass, strength, and function, which signif..
|
|
|
Pulmonology / Review
Managing dyslipidemia in chronic kidney disease: a comprehensive overview of evidence and recommendations
Ji Yoon Kim, Suk Min Chung, Nam Hoon Kim
Korean J Intern Med. 2025;40(6):876-889. Published online October 31, 2025
Patients with chronic kidney disease (CKD) have a significantly increased risk of developing cardiovascular disease (CVD), making dyslipidemia management a critical component of cardiovascular risk reduction in this population. However, as the estimated glomerular filtration rate declines, distinct p..
|
|
|
Rheumatology / Original Article
Altered polyunsaturated fatty acids and oxylipins profile in Behçet’s disease
Mohamed Kacem Ben-Fradj, Ines Naceur, Emna Talbi, Rahma Wada, Omar Feki, Monia Smiti-Khanfir, Moncef Feki
Korean J Intern Med. 2025;40(3):502-511. Published online February 21, 2025
Background/Aims: Behçet’s disease (BD) is an autoinflammatory disease of unknown etiopathogenesis. Oxylipins i.e., prostaglandins, leukotrienes, lipoxins, resolvins, and protectins are bioactive polyunsaturated fatty acids (PUFAs) derivatives involved in inflammatory response induction and resolu..
|
|
|
Cardiology / Review
2024 KSoLA consensus on secondary dyslipidemia
Hoyoun Won, Jae Hyun Bae, Hyunjung Lim, Minji Kang, Minjoo Kim, Sang-Hak Lee; on behalf of the Clinical Practice Guidelines Committee, Korean Society of Lipid and Atherosclerosis (KSoLA)
Korean J Intern Med. 2024;39(5):717-730. Published online August 30, 2024
Elevated blood cholesterol and triglyceride levels induced by secondary causes are frequently observed. The identification and appropriate handling of these causes are essential for secondary dyslipidemia treatment. Major secondary causes of hypercholesterolemia and hypertriglyceridemia include an u..
|
|
|
Rheumatology / Original Article
Effectiveness of Korean Red Ginseng on fatigue in patients with rheumatic diseases: a randomized, double-blind, placebo-controlled study
Soo-Kyung Cho, Yeo-Jin Song, Jung-Yong Han, Hye Won Kim, Eunwoo Nam, Yoon-Kyoung Sung
Korean J Intern Med. 2024;39(4):680-690. Published online April 5, 2024
Background: To evaluate the effectiveness of Korean Red Ginseng (KRG) in managing fatigue in Korean patients with rheumatic diseases
Methods: Patients were randomly assigned to KRG (2 g/day, n = 60) or placebo (n = 60) groups for 12 weeks of blind phase and then open-label KRG from weeks 12 to 24 (..
|
|
|
Pulmonology / Original Article
Development and validation of novel simple prognostic model for predicting mortality in Korean intensive care units using national insurance claims data
Ah Young Leem, Soyul Han, Kyung Soo Chung, Su Hwan Lee, Moo Suk Park, Bora Lee, Young Sam Kim
Korean J Intern Med. 2024;39(4):625-639. Published online April 19, 2024
Background/Aims: Intensive care unit (ICU) quality is largely determined by the mortality rate. Therefore, we aimed to develop and validate a novel prognostic model for predicting mortality in Korean ICUs, using national insurance claims data.
Methods: Data were obtained from the health insurance c..
|
|
|
Cardiology / Original Article
Impact of an expanded reimbursement policy on utilization of implantable loop recorders in patients with cryptogenic stroke in Korea
Hye Bin Gwag, Nak Gyeong Ko, Mihyeon Jin
Korean J Intern Med. 2024;39(3):469-476. Published online April 18, 2024
Background/Aims: The reimbursement policy for cryptogenic stroke (CS) was expanded in November 2018 from recurrent strokes to the first stroke episode. No reports have demonstrated whether this policy change has affected trends in implantable loop recorder (ILR) utilization.
Methods: We identified ..
|
|
|
Hemato-oncology / Original Article
Treatment pattern of chronic lymphocytic leukemia/small lymphocytic lymphoma in Korea: a multicenter retrospective study (KCSG LY20-06)
Jung Sun Kim, Tae Min Kim, Myoung Joo Kang, Sung Ae Koh, Hyunkyung Park, Seung-Hyun Nam, Jae Joon Han, Gyeong-Won Lee, Young Jin Yuh, Hee Jeong Lee, Jung Hye Choi
Korean J Intern Med. 2023;38(5):747-757. Published online June 26, 2023
Background/Aims: Little attention is paid to chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in Korea due to the rarity of the disease. With its rising incidence, we aimed to evaluate recent changes in treatment patterns and survival outcomes of patients with CLL/SLL.
Methods: A t..
|
|
|
Nephrology / Review
The role of roxadustat in chronic kidney disease patients complicated with anemia
Jie Liu, Fan Yang, Yousuf Waheed, Shulin Li, Kun Liu, Xinglei Zhou
Korean J Intern Med. 2023;38(2):147-156. Published online January 2, 2023
The incidence of chronic kidney disease (CKD) is increasing worldwide and the current prevalence rate is 13.4%. There are > 120 million CKD patients in China and this number is expected to increase. One of the main abnormalities in patients with CKD and kidney impairment is decreased synthesis of er..
|
|
|
Hemato-oncology / Original Article
Association between serum ferritin levels and colorectal cancer risk in Korea
Hyunho Kim, Kyungdo Han, Seung-Hyun Ko, Ho Jung An
Korean J Intern Med. 2022;37(6):1205-1215. Published online October 25, 2022
Background/Aims: The concentration of serum ferritin, a storage form of iron, may be associated with carcinogenesis in various cancers. There are only limited studies on the relationship between serum ferritin levels and colorectal cancer (CRC) risk, especially in the Asian population. This study ai..
|
|
|
Nephrology / Original Article
Insufficient early renal recovery and progression to subsequent chronic kidney disease in living kidney donors
Yaerim Kim, Eunjeong Kang, Dong-Wan Chae, Jung Pyo Lee, Sik Lee, Soo Wan Kim, Jang-Hee Cho, Miyeun Han, Seungyeup Han, Yong Chul Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Hajeong Lee
Korean J Intern Med. 2022;37(5):1021-1030. Published online April 13, 2022
Background/Aims: Renal recovery of a kidney donor after undergoing nephrectomy though challenging is essential. We aimed to examine the effect of estimated glomerular filtration rate (eGFR) percent change at 1-month post-donation on insufficient kidney function after kidney donation.
Methods: A tot..
|
|
|
Gastroenterology / Original Article
Safety and effectiveness of direct-acting antivirals in patients with chronic hepatitis C and chronic kidney disease
Ji Eun Ryu, Myeong Jun Song, Seok-Hwan Kim, Jung Hyun Kwon, Sun Hong Yoo, Soon Woo Nam, Hee Chul Nam, Hee Yeon Kim, Chang Wook Kim, Hyun Yang, Si Hyun Bae, Do Seon Song, U Im Chang, Jin Mo Yang, Sung Won Lee, Hae Lim Lee, Soon Kyu Lee, Pil Soo Sung, Jeong Won Jang, Jong Young Choi, Seung Kew Yoon
Korean J Intern Med. 2022;37(5):958-968. Published online August 19, 2022
Background/Aims: To evaluate the effectiveness and safety of direct acting antivirals (DAAs) available in chronic kidney disease (CKD) patients with hepatitis C virus (HCV) infection in Korea.
Methods: In a retrospective, multicenter cohort study, 362 patients were enrolled from 2015 to 2019. The e..
|
|
|
Gastroenterology / Original Article
Helicobacter pylori infection and iron deficiency in non-elderly adults participating in a health check-up program
Jun Yeop Lee, Sung Eun Kim, Seun Ja Park, Moo In Park, Won Moon, Jae Hyun Kim, Kyoungwon Jung
Korean J Intern Med. 2022;37(2):304-312. Published online December 16, 2021
Background/Aims: Helicobacter pylori infection is presumably associated with iron deficiency and iron deficiency anemia (IDA). This study aimed to evaluate the relationship between H. pylori infection and the decline in iron stores in non-elderly adults during their health check-ups.
..
|
|
|
Geriatrics / Original Article
Four-year changes in central fatness, risk of diabetes, and metabolic control in older adults: a cohort study with mediation analysis
Xue Cai, Dan Luo, Shuling Liu, Ruxue Li, Yanhui Lu, Mingzi Li, Shanhu Qiu
Korean J Intern Med. 2022;37(1):230-240. Published online December 16, 2021
Background/Aims: Older adults are vulnerable to central obesity, while the association of changes in central fatness with risk of diabetes and metabolic control has not been investigated among this particular population. This study was aimed to address these issues.
Methods: A total of 1,815 adults..
|
|
|
Endocrinology-metabolism / Original Article
Association of serum free thyroxine and glucose homeostasis: Korea National Health and Nutrition Examination Survey
Jeonghoon Ha, Jeongmin Lee, Dong-Jun Lim, Jung-Min Lee, Sang-Ah Chang, Moo-Il Kang, Min-Hee Kim
Korean J Intern Med. 2021;36(Suppl 1):S170-S179. Published online June 9, 2020
Background/Aims: Thyroid hormones are involved in wide range of glucose metabolism functions. Overt thyroid dysfunctions are related to altered glucose homeostasis. However, it is not conclusive as to whether subtle changes in thyroid hormones within normal ranges can induce alterations in glucose h..
|
|
|
Gastroenterology / Original Article
The effect of Hericium erinaceum on the prevention of chemically induced experimental colitis in rats
Ali Durmus, Ilgim Durmus, Omer Bender, Oguzhan Karatepe
Korean J Intern Med. 2021;36(Suppl 1):S44-S52. Published online June 19, 2020
Background/Aims: The aim of this study is to investigate the effects of the Hericium erinaceum on an experimental colitis model.
Methods: Twenty-four Wistar albino were included in this study. Rats were divided into three groups. Group 1 (n = 8) was sham group. Group 2 is the group of chemic..
|
|
|
Gastroenterology / Original Article
Helicobacter pylori-derived outer membrane vesicles stimulate interleukin 8 secretion through nuclear factor kappa B activation
Mun Sun Choi, Eun Young Ze, Jae Yong Park, Tae-Seop Shin, Jae Gyu Kim
Korean J Intern Med. 2021;36(4):854-867. Published online November 27, 2020
Background/Aims: Bacteria-derived outer membrane vesicles (OMVs) are commonly associated with various biological activities and functions. Helicobacter pylori-derived OMVs are thought to contribute to pathogenesis. This study aimed to investigate the effects of H. pylori-derived OMVs.
..
|
|
|
Review
How important is dietary management in chronic kidney disease progression? A role for low protein diets
Gang-Jee Ko, Kamyar Kalantar-Zadeh
Korean J Intern Med. 2021;36(4):795-806. Published online June 22, 2021
High dietary protein intake may lead to increased intraglomerular pressure and glomerular hyperfiltration, which in the long-term can lead to de novo or aggravating preexisting chronic kidney disease (CKD). Hence, a low protein diet (LPD, 0.6 to 0.8 g/kg/day) is recommended for the management of CKD..
|
|
|
Review
Blood pressure control in patients with chronic kidney disease
Jee Young Lee, Seung Hyeok Han
Korean J Intern Med. 2021;36(4):780-794. Published online June 22, 2021
Uncontrolled blood pressure (BP) in patients with chronic kidney disease (CKD) can lead to serious adverse outcomes. To prevent the occurrence of cardiovascular events (CVEs), and end-stage kidney disease, achieving an optimal BP level is important. Recently, there has been a paradigm shift in the m..
|
|
|
