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Endocrinology-metabolism / Original Article
Comprehensive approaches to diabetes in the elderly: adapting to evolving trends
Jeongmin Lee, Kwang Joon Kim, Yang Sun Park, Yong-ho Lee, Kyeong Hye Park, Hee-Won Jung, Bong-Soo Cha, Hun-Sung Kim, Chang Oh Kim
Korean J Intern Med. 2025;40(6):1017-1028. Published online October 31, 2025
Background/Aims: The prevalence of diabetes mellitus (DM) is increasing worldwide owing to aging. This nationwide study aimed to investigate the prevalence of DM and its management status among elderly Koreans.
Methods: We analyzed data from the Korea National Health and Nutrition Examination Survey..
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Gastroenterology / Original Article
Risk of colorectal cancer in kidney transplant recipients and patients with end-stage renal disease undergoing hemodialysis
Yongchel Ahn, Hoon Yu, Yoonjong Bae, Mina Kim, Seung Bum Lee
Korean J Intern Med. 2025;40(6):952-960. Published online October 28, 2025
Background/Aims: Assessing the risk of colorectal cancer (CRC) after kidney transplantation (KT) in patients with endstage renal disease (ESRD) receiving dialysis is crucial to determine KT’s risks and benefits. In Korea, the study results remain unclear. Therefore, using a nationwide health scree..
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Pulmonology / Review
Shared decision-making for kidney replacement therapy: a comprehensive review and a proposed model
Hyun Jung Shin, Seoyoung Choi, Sejoong Kim
Korean J Intern Med. 2025;40(6):890-908. Published online October 31, 2025
Shared decision-making (SDM) enables patients to actively engage in healthcare decisions by ensuring that treatment options align with their values and preferences. The use of SDM is increasingly recognized in the context of selecting kidney replacement therapy (KRT) for patients with chronic kidney..
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Pulmonology / Review
Managing dyslipidemia in chronic kidney disease: a comprehensive overview of evidence and recommendations
Ji Yoon Kim, Suk Min Chung, Nam Hoon Kim
Korean J Intern Med. 2025;40(6):876-889. Published online October 31, 2025
Patients with chronic kidney disease (CKD) have a significantly increased risk of developing cardiovascular disease (CVD), making dyslipidemia management a critical component of cardiovascular risk reduction in this population. However, as the estimated glomerular filtration rate declines, distinct p..
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Nephrology / Original Article
Impaired aldosterone response to potassium and hyperkalemia in patients receiving a renin-angiotensin-aldosterone system inhibitor
Miyeon Kim, Hwa Young Lee, Hyunwoo Kim
Korean J Intern Med. 2025;40(3):468-481. Published online April 30, 2025
Background/Aims: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are associated with the development of hyperkalemia. We evaluated the relationship between the serum aldosterone-to-potassium ratio (APR) and the risk of developing hyperkalemia in patients ..
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Nephrology / Review
Glial cell line-derived neurotrophic factor and its role in attenuating renal fibrosis: a review
Yousuf Abdulkarim Waheed, Wokuheleza Buberwa, Dong Sun
Korean J Intern Med. 2025;40(2):219-229. Published online December 13, 2023
Chronic kidney disease is estimated to affect approximately 10 to 15% of the Chinese population. Renal fibrosis is characterized by progressive extracellular matrix deposition in the kidney parenchyma with eventual tissue scarring and inevitable deterioration of renal function. Vascular rarefaction,..
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Pulmonology / Original Article
Blood eosinophil count and treatment patterns of chronic obstructive pulmonary disease patients in South Korea using real-world data
Chin Kook Rhee, Yu-Fan Ho, Sumitra Shantakumar, Tim Holbrook, Yein Nam, Kwang‑Ha Yoo
Korean J Intern Med. 2025;40(1):78-91. Published online January 1, 2025
Background/Aims: Chronic obstructive pulmonary disease (COPD) management guidelines have increasingly emphasised the importance of exacerbation prevention, and the role of blood eosinophil count (BEC) as a biomarker for inhaled corticosteroids (ICS) response. This study aimed to describe the distrib..
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Nephrology / Review
Kidney transplantation in the elderly
Byung Hwa Park, Song Yi Kil, Ye Na Kim, Ho Sik Shin, Yeonsoon Jung, Hark Rim
Korean J Intern Med. 2024;39(6):875-881. Published online October 24, 2024
Interest in kidney transplant studies in the elderly population is increasing as more research has been conducted on the immune system. With this review, we hope to encourage the need for research on kidney transplantation in the elderly.
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Nephrology / Original Article
Obesity is associated with incident chronic kidney disease in individuals with normal renal function
Su Hyun Song, Tae Ryom Oh, Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae
Korean J Intern Med. 2024;39(5):813-822. Published online August 13, 2024
Background/Aims: Obesity has known to be a modifiable risk factor associated with worse outcomes in chronic kidney disease (CKD), but few studies have examined the impact of obesity on CKD incidence in the general population. The purpose of this study was to investigate the role of body mass index (..
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Cardiology / Review
Current evidence for prognostic benefit of intravascular imaging-guided percutaneous coronary intervention in chronic total occlusion intervention
David Hong, Sung Eun Kim, Seung Hun Lee, Seung-Jae Lee, Jong-Young Lee, Sang Min Kim, Sang Yeub Lee, Woochan Kwon, Ki Hong Choi, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Joo-Yong Hahn, Joo Myung Lee; The RENOVATE-COMPLEX-PCI Investigators
Korean J Intern Med. 2024;39(5):702-716. Published online February 29, 2024
Although percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) has been increasing in recent years, CTO PCI is still one of the most challenging procedures with relatively higher rates of procedural complications and adverse clinical events after PCI. Due to the innate limitatio..
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Gastroenterology / Original Article
Efficacy comparison of high-genetic barrier nucleos(t)ide analogues in treatment-naïve chronic hepatitis B patients: a network meta-analysis
Jaejun Lee, Ahlim Lee, Pil Soo Sung, Jeong Won Jang, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Hyun Yang
Korean J Intern Med. 2024;39(4):577-589. Published online June 13, 2024
Background/Aims: Four high-genetic barrier nucleos(t)ide analogues (NAs) for chronic hepatitis B (CHB), namely entecavir (ETV), tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF), and besifovir dipivoxil maleate (BSV), have been established. The aim of this study is to investigate the ..
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Endocrinology-metabolism / Original Article
Efficacy and safety of denosumab treatment for Korean patients with Stage 3b–4 chronic kidney disease and osteoporosis
Jin Taek Kim, You Mi Kim, Kyong Yeun Jung, Hoonsung Choi, So Young Lee, Hyo-Jeong Kim
Korean J Intern Med. 2024;39(1):148-159. Published online December 22, 2023
Background/Aims: We evaluated the efficacy and safety of denosumab treatment in severe chronic kidney disease (CKD) patients with osteoporosis. We also investigated whether the treatment affects the coronary artery calcifications.
Methods: Twenty-seven postmenopausal women with Stage 3b–4 CKD and..
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Pulmonology / Original Article
Sex differences in chronic obstructive pulmonary disease characteristics: the Korea National Health and Nutrition Examination Survey 2007–2018
Moon Seong Baek, Haegwang Shin, Kang-Mo Gu, Hae In Jung, Won Young Kim, Jae-Woo Jung, Jong-Wook Shin, Sun-Young Jung, Jae-Yeol Kim
Korean J Intern Med. 2024;39(1):137-147. Published online December 14, 2023
Background/Aims: Chronic obstructive pulmonary disease (COPD) is less prevalent in females than males, but it affects mortality in females. There may be sex differences in the clinical characteristics of COPD.
Methods: We analyzed the Korea National Health and Nutrition Examination Survey dataset f..
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Pulmonology / Review
Biomarkers of the relationship of particulate matter exposure with the progression of chronic respiratory diseases
Junghyun Kim, Soo Jie Chung, Woo Jin Kim
Korean J Intern Med. 2024;39(1):25-33. Published online January 1, 2024
A high level of particulate matter (PM) in air is correlated with the onset and development of chronic respiratory diseases. We conducted a systematic literature review, searching the MEDLINE, EMBASE, and Cochrane databases for studies of biomarkers of the effect of PM exposure on chronic respirator..
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Pulmonology / Review
Long term management of people with post-tuberculosis lung disease
Wan Seo, Hyung Woo Kim, Ju Sang Kim, Jinsoo Min
Korean J Intern Med. 2024;39(1):7-24. Published online January 1, 2024
Post-tuberculosis lung disease (PTLD) is emerging as a significant area of global interest. As the number of patients surviving tuberculosis (TB) increases, the subsequent long-term repercussions have drawn increased attention due to their profound clinical and socioeconomic impacts. A primary obsta..
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Hemato-oncology / Original Article
Treatment pattern of chronic lymphocytic leukemia/small lymphocytic lymphoma in Korea: a multicenter retrospective study (KCSG LY20-06)
Jung Sun Kim, Tae Min Kim, Myoung Joo Kang, Sung Ae Koh, Hyunkyung Park, Seung-Hyun Nam, Jae Joon Han, Gyeong-Won Lee, Young Jin Yuh, Hee Jeong Lee, Jung Hye Choi
Korean J Intern Med. 2023;38(5):747-757. Published online June 26, 2023
Background/Aims: Little attention is paid to chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in Korea due to the rarity of the disease. With its rising incidence, we aimed to evaluate recent changes in treatment patterns and survival outcomes of patients with CLL/SLL.
Methods: A t..
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Nephrology / Original Article
Prognostic role of the neutrophil-to-lymphocyte ratio in patients with chronic kidney disease
Jin Kim, Su Hyun Song, Tae Ryom Oh, Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae
Korean J Intern Med. 2023;38(5):725-733. Published online August 17, 2023
Background/Aims: The neutrophil-to-lymphocyte ratio (NLR) has a prognostic value in cardiovascular disease, infection, inflammatory disease, and several malignancies. Therefore, the NLR has a possible predictive value in patients with chronic kidney disease (CKD), but this predictive value has not b..
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Pulmonology / Original Article
The serotype-specific prevalence of pneumococci in hospitalized pneumonia patients with COPD: a prospective, multi-center, cohort study
Jae Yeol Kim, Jae-Woo Jung, Min-Jong Kang, Deog Kyeom Kim, Hayoung Choi, Young-Jae Cho, Seung Hun Jang, Chang-Hoon Lee, Yeon Mok Oh, Ji Sook Park
Korean J Intern Med. 2023;38(5):714-724. Published online August 17, 2023
Background/Aims: The overall incidence of pneumococcal pneumonia is declining. However, the change in the pathogenic distribution of community-acquired pneumonia (CAP) in chronic obstructive pulmonary disease (COPD) patients and the serotype specificity of Streptococcus pneumoniae have not be..
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Nephrology / Review
Sarcopenia in chronic kidney disease: from bench to bedside
Da Woon Kim, Sang Heon Song
Korean J Intern Med. 2023;38(3):303-321. Published online April 20, 2023
Sarcopenia is a condition characterized by a loss of muscle mass and function. In chronic kidney disease (CKD), where a chronic catabolic state exists, sarcopenia commonly occurs through various mechanisms, resulting in muscle wasting and decreased muscle endurance. Sarcopenic patients with CKD have..
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Nephrology / Review
The role of roxadustat in chronic kidney disease patients complicated with anemia
Jie Liu, Fan Yang, Yousuf Waheed, Shulin Li, Kun Liu, Xinglei Zhou
Korean J Intern Med. 2023;38(2):147-156. Published online January 2, 2023
The incidence of chronic kidney disease (CKD) is increasing worldwide and the current prevalence rate is 13.4%. There are > 120 million CKD patients in China and this number is expected to increase. One of the main abnormalities in patients with CKD and kidney impairment is decreased synthesis of er..
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