|
Endocrinology-metabolism / Original Article
Analysis of experiences on telemedicine pilot projects from the perspectives of doctors, pharmacists, and patients
Yeryeon Jung, Hyunah Kim, Jeong-Yeon Kim, Seongwoo Seo, Youseok Kim, Min Jung Ko, Hun-Sung Kim
Korean J Intern Med. 2026;41(1):131-142. Published online January 1, 2026
Background/Aims: This study is the first to analyze telemedicine pilot project experiences from doctors, pharmacists, and patients with different roles to support sustainable commercialization.
Methods: An online survey targeted individuals (patients, doctors, and pharmacists) who participated in t..
|
|
|
Cardiology / Original Article
Enhanced prediction of left ventricular ejection fraction using electrocardiography with the addition of clinical metadata
Hyun Woong Park, Taeseen Kang, Young-Hoon Seo, Jae-Hyeong Park
Korean J Intern Med. 2026;41(1):118-130. Published online January 1, 2026
Background/Aims: Left ventricular ejection fraction (LVEF) is a key echocardiographic parameter for assessing LV systolic function, guiding the management of many cardiovascular diseases, including heart failure (HF). While traditional electrocardiography (ECG) has been widely used in clinical pract..
|
|
|
Endocrinology-metabolism / Review
Advanced strategies for the management of patients with diabetic foot ulcers: a comprehensive review
Ji Min Kim, Chong Hwa Kim, Seon Mee Kang, Jung Hwa Jung, Ki Chun Kim, Sanghyun Ahn, Tae Sun Park, Ie Byung Park
Korean J Intern Med. 2026;41(1):47-59. Published online January 1, 2026
Diabetic foot ulcers (DFUs) are among the most serious and common complications of diabetes mellitus. They significantly affect patients’ quality of life and impose a substantial economic burden on healthcare systems worldwide. In Korea, the prevalence of diabetes and related complications, such a..
|
|
|
Gastroenterology / Review
Clinical management of gastric mucosa-associated lymphoid tissue lymphoma
Ji Yong Ahn
Korean J Intern Med. 2026;41(1):8-14. Published online December 23, 2025
Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is often associated with chronic Helicobacter pylori infection. For an accurate diagnosis of gastric MALT lymphoma, clinical suspicion and careful endoscopic examination with multiple biopsies should be performed, and the final patholo..
|
|
|
Rheumatology / Original Article
Real-world clinical response and efficacy of tacrolimus-based maintenance therapy for Korean patients with lupus nephritis
Ji-Won Kim, Ju-Yang Jung, Hyoun-Ah Kim, Chang-Hee Suh
Korean J Intern Med. 2025;40(6):1052-1064. Published online October 28, 2025
Background/Aims: We evaluated the efficacy and safety of tacrolimus as maintenance therapy in Korean patients with lupus nephritis (LN).
Methods: A total of 179 patients with biopsy-proven LN were included, of whom 92 received tacrolimus and 87 did not. Clinical parameters were assessed at six mont..
|
|
|
Cardiology / Original Article
Automatic quantitative analysis of atherosclerotic aortic plaques in patients with embolic cerebral infarction using deep learning
Hye Jin Bang, Jae-Hyeong Park, Sun Geu Chae, Suk Joo Bae, Ji-Hoon Jung, You Hee Cho, Jong Won Park, Dae-Won Kim, Jung Sun Cho
Korean J Intern Med. 2025;40(5):767-779. Published online August 26, 2025
Background/Aims: Transesophageal echocardiography (TEE) is a commonly used imaging modality for assessing embolic stroke of undetermined source (ESUS) in clinical practice. We aimed to develop an automatic plaque segmentation model based on U-net and evaluate its clinical usefulness in patients with..
|
|
|
Hemato-oncology / Original Article
Decreased frequency and inflammatory change of FoxP3+ regulatory T cells in immunopathogenesis of human acute graft-versus-host disease
Nayeon Seong, Cheongin Yang, Kunye Kwak, Ka-Won Kang, Yong Park, Byung Soo Kim, Seong Hyun Jeong, Joon Seong Park, Yoon Seok Choi
Korean J Intern Med. 2025;40(4):657-666. Published online July 1, 2025
Background/Aims: Acute graft-versus-host disease (GvHD) is a severe complication of allogeneic stem cell transplantation, characterized by immune-mediated tissue damage primarily affecting the skin, liver, and gastrointestinal tract. Regulatory T (Treg) cells play a critical role in maintaining immu..
|
|
|
Cardiology / Original Article
Detection rate by time period and predictors of serious arrhythmias in unexplained syncope: a multicenter implantable loop recorder registry study
Juwon Kim, Il-Young Oh, Myung-Jin Cha, Jinhee Ahn, So-Ryoung Lee, Sung Ho Lee, Jae-Sun Uhm, Pil-Sung Yang, Jaemin Shim, Hyoung-Seob Park, Junbeom Park, Jun Hyung Kim, Ki-Hun Kim, Jumsuk Ko, Hong Euy Lim, Ju Youn Kim
Korean J Intern Med. 2025;40(4):616-625. Published online July 1, 2025
Background/Aims: Although an implantable loop recorder (ILR) is a valuable tool for investigation of unexplained syncope, there are limited data regarding time course to diagnosis and predictors of serious arrhythmias as a cause of unexplained syncope. We sought to investigate diagnosis rate by time..
|
|
|
Gastroenterology / Original Article
Submucosal saline injection and mini-probe endoscopic ultrasound to assess endoscopic resectability of colorectal subepithelial tumors
Jung-Bin Park, Ji Eun Baek, June Hwa Bae, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Dong-Hoon Yang
Korean J Intern Med. 2025;40(4):592-605. Published online July 1, 2025
Background/Aims: This study aimed to evaluate the feasibility and outcomes of mini-probe endoscopic ultrasound (mEUS) followed by submucosal saline injection (SSI-mEUS) for assessing the endoscopic resectability of colorectal subepithelial lesions (SELs).
Methods: From January 2020 to December 2023..
|
|
|
Pulmonology / Review
Updates on lung cancer screening for early detection
Se Hyun Kwak, Chi Young Kim, Sang Hoon Lee, Eun Young Kim, Eun Hye Lee, Yoon Soo Chang
Korean J Intern Med. 2025;40(4):546-556. Published online July 1, 2025
This review examines the current status and recent progress in lung cancer screening programs, focusing on low-dose computed tomography (LDCT) and emerging liquid biopsy technologies. In Korea, the National Lung Cancer Screening Program has shown promising results in reducing lung cancer mortality s..
|
|
|
Rheumatology / Original Article
Clinical perspective on serum periostin in antineutrophil-cytoplasmic antibody-associated vasculitis
Taejun Yoon, Jiyeol Yoon, Eunhee Ko, Yong-Beom Park, Sang-Won Lee
Korean J Intern Med. 2025;40(3):512-523. Published online April 30, 2025
Background/Aims: This study evaluated the clinical utility of serum periostin measured at diagnosis in reflecting activity at diagnosis and predicting all-cause mortality during follow-up in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV).
Methods: This study included ..
|
|
|
Infectious diseases / Original Article
Clinical approach to sexually transmitted infections and pelvic inflammatory disease in women with acute pyelonephritis
Mi-Hee Kim, Hyojin Ahn, Soyeon Kang, Ahra Lee, Seong-Heon Wie
Korean J Intern Med. 2025;40(3):482-490. Published online April 30, 2025
Background/Aims: This study aimed to investigate co-occurrence and clinical characteristics of sexually transmitted infections (STIs) and pelvic inflammatory disease (PID) in women hospitalized for acute pyelonephritis (APN).
Methods: This single-center retrospective study reviewed medical records ..
|
|
|
Hemato-oncology / Review
Follicular lymphoma: contemporary clinical management with a focus on recent therapeutic advances
Robert Kridel
Korean J Intern Med. 2025;40(3):371-393. Published online February 21, 2025
Follicular lymphoma (FL) is the most common type of indolent lymphoma, and the prognosis is favorable for most patients. However, FL remains generally incurable, and relapse is common. Patients are at risk of developing treatment-resistant lymphoma, particularly when early disease progression occurs..
|
|
|
Cardiology / Original Article
Explainable paroxysmal atrial fibrillation diagnosis using an artificial intelligence-enabled electrocardiogram
Yeongbong Jin, Bonggyun Ko, Woojin Chang, Kang-Ho Choi, Ki Hong Lee
Korean J Intern Med. 2025;40(2):251-261. Published online February 21, 2025
Background/Aims: Atrial fibrillation (AF) significantly contributes to global morbidity and mortality. Paroxysmal atrial fibrillation (PAF) is particularly common among patients with cryptogenic strokes or transient ischemic attacks and has a silent nature. This study aims to develop reliable artifi..
|
|
|
Gastroenterology / Original Article
Clinical outcomes of esophageal squamous cell carcinoma in patients aged over 80 years
Dae Gon Ryu, Cheol Woong Choi, Su Jin Kim, Su Bum Park, Jin Ook Jang, Bong Soo Son
Korean J Intern Med. 2025;40(2):230-242. Published online February 21, 2025
Background/Aims: The clinical outcomes and optimal treatment of esophageal squamous cell carcinoma (ESCC) in elderly patients are unclear. This study aimed to assess the clinical outcomes of ESCC in patients aged ≥ 80 years.
Methods: Medical records of patients diagnosed with ESCC between Decembe..
|
|
|
Nephrology / Review
Glial cell line-derived neurotrophic factor and its role in attenuating renal fibrosis: a review
Yousuf Abdulkarim Waheed, Wokuheleza Buberwa, Dong Sun
Korean J Intern Med. 2025;40(2):219-229. Published online December 13, 2023
Chronic kidney disease is estimated to affect approximately 10 to 15% of the Chinese population. Renal fibrosis is characterized by progressive extracellular matrix deposition in the kidney parenchyma with eventual tissue scarring and inevitable deterioration of renal function. Vascular rarefaction,..
|
|
|
Gastroenterology / Review
Role of endoscopic ultrasound in the diagnosis and local ablative therapy of pancreatic neuroendocrine tumors
Yun Je Song, Jun Kyeong Lim, Jun-Ho Choi
Korean J Intern Med. 2025;40(2):170-180. Published online February 25, 2025
Advancements in diagnostic technology have led to the improved detection of pancreatic neuroendocrine tumors (PNETs) and thus to an increase in the number of reported cases. Endoscopic ultrasound (EUS) technology, including in combination with contrast-enhanced harmonic imaging, aids in distinguishi..
|
|
|
Rheumatology / Original Article
Reclassification of the overlap syndrome of Behçet’s disease and antineutrophil cytoplasmic antibody-associated vasculitis in patients with Behçet’s disease
Tae Geom Lee, Jang Woo Ha, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
Korean J Intern Med. 2025;40(1):135-147. Published online January 1, 2025
Background/Aims: This study applied the 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR) criteria for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) to patients with Behçet’s disease (BD) to investigate the proportion and..
|
|
|
Hemato-oncology / Original Article
Reduced-intensity chemotherapy with tyrosine kinase inhibitor followed by allogeneic transplantation is effective in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia
Jung Min Lee, Do Young Kim, Hee Jeong Cho, Joon Ho Moon, Sang Kyun Sohn, Ho Jin Shin, Young Rok Do, Mi Hwa Heo, Min Kyoung Kim, Young Seob Park, Dong Won Baek
Korean J Intern Med. 2025;40(1):124-134. Published online January 1, 2025
Background/Aims: To determine the effectiveness of tyrosine kinase inhibitor (TKI) plus reduced-intensity therapy in adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-positive ALL), this retrospective study compared treatment outcomes and induction..
|
|
|
Endocrinology-metabolism / Original Article
Fisher discriminant analysis of multimodal ultrasound in diagnosis of cervical metastatic lymph nodes in papillary thyroid cancer
Yixuan Wang, Yue Han, Fei Li, Yuyang Lin, Bei Wang
Korean J Intern Med. 2025;40(1):103-114. Published online October 29, 2024
Background/Aims: The purpose of this study was to develop a diagnostic model utilizing multimodal ultrasound parameters to aid in the detection of cervical lymph node metastasis in papillary thyroid cancer (PTC) patients.
Methods: The study included 84 suspicious lymph nodes from 69 PTC patients, a..
|
|
|
