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Allergy / Original Article
Drug hypersensitivity leading to emergency department visit: a comprehensive analysis of clinical features and management
Soo Jie Chung, Na Young Kim, So Jeong Kim, Junghyun Kim, Hang A Park, Jeong-Hee Choi
Korean J Intern Med. 2026;41(2):328-340. Published online March 1, 2026
Background/Aims: Drug hypersensitivity reactions (DHRs) are unpredictable adverse drug reactions that can present with varied clinical manifestations, including anaphylaxis. However, data on DHRs initially diagnosed in the emergency department (ED) and subsequently confirmed by allergy specialists r..
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Hemato-oncology / Original Article
Real-world use of polatuzumab vedotin combined with bendamustine and rituximab for patients with relapsed or refractory large B-cell lymphoma
Changgon Kim, Sang Eun Yoon, Hyun-Young Kim, Duck Cho, Junhun Cho, Won Seog Kim, Seok Jin Kim
Korean J Intern Med. 2026;41(2):296-306. Published online March 1, 2026
Background/Aims: Polatuzumab vedotin combined with bendamustine and rituximab (Pola-BR) is a treatment option for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL), particularly as bridging therapy before chimeric antigen receptor (CAR) T-cell infusion. However, real-world data regarding..
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Gastroenterology / Original Article
The effect of HFE gene mutation and iron overload on sustained virological response in Egyptian chronic hepatitis C patients treated with daclatasvir and sofosbuvir
Emad M. Kodsi, Hisham Ismail, Randa Issa, Ahmed Elshaarawy, Moustafa A. Sakr, Eman L. Shehata, Emad R Issak
Korean J Intern Med. 2026;41(2):265-276. Published online March 1, 2026
Background/Aims: This matched case-control study investigated the impact of HFE gene mutations on sustained virological response (SVR) in Egyptian patients with chronic hepatitis C (CHC) treated with daclatasvir and sofosbuvir.
Methods: A total of 150 CHC patients were enrolled (75 responders and 7..
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Infectious diseases / Review
Updates on epidemiology and diagnostic tests of syphilis in South Korea
Dong Youn Kim, Ki-Ho Park
Korean J Intern Med. 2026;41(2):242-254. Published online March 1, 2026
Syphilis is a sexually transmitted disease caused by the spirochete Treponema pallidum. Recently, there has been a global resurgence of syphilis cases. In South Korea, the reported rate of syphilis steadily increased from 1.93 per 100,000 individuals in 2011 to 3.41 per 100,000 individuals in 2019. ..
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Hemato-oncology / Review
Assessment tools for peripheral neuropathy in multiple myeloma
Sung-Soo Park, Kunye Kwak, Seol-Hee Baek, Changgon Kim, Yoon Seok Choi, Yong Park, Byung Soo Kim, Jin Seok Kim, Chang-Ki Min, Ka-Won Kang
Korean J Intern Med. 2026;41(2):230-241. Published online March 1, 2026
Advances in treating multiple myeloma (MM) have improved survival, shifting the management focus toward quality of life. Peripheral neuropathy (PN) is a common treatment-related toxicity that significantly impairs quality of life. However, standardized assessment methods for PN in patients with MM a..
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Endocrinology-metabolism / Original Article
Analysis of experiences on telemedicine pilot projects from the perspectives of doctors, pharmacists, and patients
Yeryeon Jung, Hyunah Kim, Jeong-Yeon Kim, Seongwoo Seo, Youseok Kim, Min Jung Ko, Hun-Sung Kim
Korean J Intern Med. 2026;41(1):131-142. Published online January 1, 2026
Background/Aims: This study is the first to analyze telemedicine pilot project experiences from doctors, pharmacists, and patients with different roles to support sustainable commercialization.
Methods: An online survey targeted individuals (patients, doctors, and pharmacists) who participated in t..
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Cardiology / Original Article
Enhanced prediction of left ventricular ejection fraction using electrocardiography with the addition of clinical metadata
Hyun Woong Park, Taeseen Kang, Young-Hoon Seo, Jae-Hyeong Park
Korean J Intern Med. 2026;41(1):118-130. Published online January 1, 2026
Background/Aims: Left ventricular ejection fraction (LVEF) is a key echocardiographic parameter for assessing LV systolic function, guiding the management of many cardiovascular diseases, including heart failure (HF). While traditional electrocardiography (ECG) has been widely used in clinical pract..
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Endocrinology-metabolism / Review
Advanced strategies for the management of patients with diabetic foot ulcers: a comprehensive review
Ji Min Kim, Chong Hwa Kim, Seon Mee Kang, Jung Hwa Jung, Ki Chun Kim, Sanghyun Ahn, Tae Sun Park, Ie Byung Park
Korean J Intern Med. 2026;41(1):47-59. Published online January 1, 2026
Diabetic foot ulcers (DFUs) are among the most serious and common complications of diabetes mellitus. They significantly affect patients’ quality of life and impose a substantial economic burden on healthcare systems worldwide. In Korea, the prevalence of diabetes and related complications, such a..
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Gastroenterology / Review
Clinical management of gastric mucosa-associated lymphoid tissue lymphoma
Ji Yong Ahn
Korean J Intern Med. 2026;41(1):8-14. Published online December 23, 2025
Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is often associated with chronic Helicobacter pylori infection. For an accurate diagnosis of gastric MALT lymphoma, clinical suspicion and careful endoscopic examination with multiple biopsies should be performed, and the final patholo..
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Rheumatology / Original Article
Real-world clinical response and efficacy of tacrolimus-based maintenance therapy for Korean patients with lupus nephritis
Ji-Won Kim, Ju-Yang Jung, Hyoun-Ah Kim, Chang-Hee Suh
Korean J Intern Med. 2025;40(6):1052-1064. Published online October 28, 2025
Background/Aims: We evaluated the efficacy and safety of tacrolimus as maintenance therapy in Korean patients with lupus nephritis (LN).
Methods: A total of 179 patients with biopsy-proven LN were included, of whom 92 received tacrolimus and 87 did not. Clinical parameters were assessed at six mont..
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Cardiology / Original Article
Automatic quantitative analysis of atherosclerotic aortic plaques in patients with embolic cerebral infarction using deep learning
Hye Jin Bang, Jae-Hyeong Park, Sun Geu Chae, Suk Joo Bae, Ji-Hoon Jung, You Hee Cho, Jong Won Park, Dae-Won Kim, Jung Sun Cho
Korean J Intern Med. 2025;40(5):767-779. Published online August 26, 2025
Background/Aims: Transesophageal echocardiography (TEE) is a commonly used imaging modality for assessing embolic stroke of undetermined source (ESUS) in clinical practice. We aimed to develop an automatic plaque segmentation model based on U-net and evaluate its clinical usefulness in patients with..
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Hemato-oncology / Original Article
Decreased frequency and inflammatory change of FoxP3+ regulatory T cells in immunopathogenesis of human acute graft-versus-host disease
Nayeon Seong, Cheongin Yang, Kunye Kwak, Ka-Won Kang, Yong Park, Byung Soo Kim, Seong Hyun Jeong, Joon Seong Park, Yoon Seok Choi
Korean J Intern Med. 2025;40(4):657-666. Published online July 1, 2025
Background/Aims: Acute graft-versus-host disease (GvHD) is a severe complication of allogeneic stem cell transplantation, characterized by immune-mediated tissue damage primarily affecting the skin, liver, and gastrointestinal tract. Regulatory T (Treg) cells play a critical role in maintaining immu..
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Cardiology / Original Article
Detection rate by time period and predictors of serious arrhythmias in unexplained syncope: a multicenter implantable loop recorder registry study
Juwon Kim, Il-Young Oh, Myung-Jin Cha, Jinhee Ahn, So-Ryoung Lee, Sung Ho Lee, Jae-Sun Uhm, Pil-Sung Yang, Jaemin Shim, Hyoung-Seob Park, Junbeom Park, Jun Hyung Kim, Ki-Hun Kim, Jumsuk Ko, Hong Euy Lim, Ju Youn Kim
Korean J Intern Med. 2025;40(4):616-625. Published online July 1, 2025
Background/Aims: Although an implantable loop recorder (ILR) is a valuable tool for investigation of unexplained syncope, there are limited data regarding time course to diagnosis and predictors of serious arrhythmias as a cause of unexplained syncope. We sought to investigate diagnosis rate by time..
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Gastroenterology / Original Article
Submucosal saline injection and mini-probe endoscopic ultrasound to assess endoscopic resectability of colorectal subepithelial tumors
Jung-Bin Park, Ji Eun Baek, June Hwa Bae, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Dong-Hoon Yang
Korean J Intern Med. 2025;40(4):592-605. Published online July 1, 2025
Background/Aims: This study aimed to evaluate the feasibility and outcomes of mini-probe endoscopic ultrasound (mEUS) followed by submucosal saline injection (SSI-mEUS) for assessing the endoscopic resectability of colorectal subepithelial lesions (SELs).
Methods: From January 2020 to December 2023..
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Pulmonology / Review
Updates on lung cancer screening for early detection
Se Hyun Kwak, Chi Young Kim, Sang Hoon Lee, Eun Young Kim, Eun Hye Lee, Yoon Soo Chang
Korean J Intern Med. 2025;40(4):546-556. Published online July 1, 2025
This review examines the current status and recent progress in lung cancer screening programs, focusing on low-dose computed tomography (LDCT) and emerging liquid biopsy technologies. In Korea, the National Lung Cancer Screening Program has shown promising results in reducing lung cancer mortality s..
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Rheumatology / Original Article
Clinical perspective on serum periostin in antineutrophil-cytoplasmic antibody-associated vasculitis
Taejun Yoon, Jiyeol Yoon, Eunhee Ko, Yong-Beom Park, Sang-Won Lee
Korean J Intern Med. 2025;40(3):512-523. Published online April 30, 2025
Background/Aims: This study evaluated the clinical utility of serum periostin measured at diagnosis in reflecting activity at diagnosis and predicting all-cause mortality during follow-up in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV).
Methods: This study included ..
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Infectious diseases / Original Article
Clinical approach to sexually transmitted infections and pelvic inflammatory disease in women with acute pyelonephritis
Mi-Hee Kim, Hyojin Ahn, Soyeon Kang, Ahra Lee, Seong-Heon Wie
Korean J Intern Med. 2025;40(3):482-490. Published online April 30, 2025
Background/Aims: This study aimed to investigate co-occurrence and clinical characteristics of sexually transmitted infections (STIs) and pelvic inflammatory disease (PID) in women hospitalized for acute pyelonephritis (APN).
Methods: This single-center retrospective study reviewed medical records ..
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Hemato-oncology / Review
Follicular lymphoma: contemporary clinical management with a focus on recent therapeutic advances
Robert Kridel
Korean J Intern Med. 2025;40(3):371-393. Published online February 21, 2025
Follicular lymphoma (FL) is the most common type of indolent lymphoma, and the prognosis is favorable for most patients. However, FL remains generally incurable, and relapse is common. Patients are at risk of developing treatment-resistant lymphoma, particularly when early disease progression occurs..
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Cardiology / Original Article
Explainable paroxysmal atrial fibrillation diagnosis using an artificial intelligence-enabled electrocardiogram
Yeongbong Jin, Bonggyun Ko, Woojin Chang, Kang-Ho Choi, Ki Hong Lee
Korean J Intern Med. 2025;40(2):251-261. Published online February 21, 2025
Background/Aims: Atrial fibrillation (AF) significantly contributes to global morbidity and mortality. Paroxysmal atrial fibrillation (PAF) is particularly common among patients with cryptogenic strokes or transient ischemic attacks and has a silent nature. This study aims to develop reliable artifi..
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Gastroenterology / Original Article
Clinical outcomes of esophageal squamous cell carcinoma in patients aged over 80 years
Dae Gon Ryu, Cheol Woong Choi, Su Jin Kim, Su Bum Park, Jin Ook Jang, Bong Soo Son
Korean J Intern Med. 2025;40(2):230-242. Published online February 21, 2025
Background/Aims: The clinical outcomes and optimal treatment of esophageal squamous cell carcinoma (ESCC) in elderly patients are unclear. This study aimed to assess the clinical outcomes of ESCC in patients aged ≥ 80 years.
Methods: Medical records of patients diagnosed with ESCC between Decembe..
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