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Rheumatology / Original Article
Concomitant cryoglobulinaemic vasculitis alongside ANCA-associated vasculitis: concurrence or coincidental individual occurrence
Jeong Yeop Whang, Jang Woo Ha, Jihye Chung, Yong-Beom Park, Jaewoo Song, Younhee Park, Sang-Won Lee
Korean J Intern Med. 2026;41(5):952-960. Published online September 1, 2026
Background/Aims: Cryoglobulinaemic vasculitis (CryoVas) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) share the common characteristic of being small vessel vasculitides but exhibit significant differences in pathologic findings. This study investigated the incidence rate of cry..
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Cardiology / Original Article
Prognostic significance of artificial intelligence-quantified late gadolinium enhancement on cardiac magnetic resonance in hypertrophic cardiomyopathy
Young-Sang Jeong, Jong-Il Park, Kang-Un Choi, Jong-Ho Nam, Chan-Hee Lee, Jang-Won Son, Ung Kim, Jong-Seon Park, Eunjung Kong
Korean J Intern Med. 2026;41(5):884-893. Published online September 1, 2026
Background/Aims: This study aimed to evaluate the prognostic value of artificial intelligence (AI)-based late gadolinium enhancement (LGE) quantification using cardiovascular magnetic resonance (CMR) in patients with hypertrophic cardiomyopathy (HCM).
Methods: We retrospectively analyzed 142 patien..
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Cardiology / Original Article
Prognostic implications of functional significance, high-risk plaque and vessel characteristics in patients with diabetes mellitus
Jin-Eun Song, Seokhun Yang, Masahiro Hoshino, Taishi Yonetsu, Jinlong Zhang, Eun-Seok Shin, Joon-Hyung Doh, Chang-Wook Nam, Jianan Wang, Shaoliang Chen, Nobuhiro Tanaka, Hitoshi Matsuo, Takashi Kubo, Hyuk-Jae Chang, Tsunekazu Kakuta, Bon-Kwon Koo
Korean J Intern Med. 2026;41(5):873-883. Published online September 1, 2026
Background/Aims: We investigated the prognostic value of high-risk plaque (HRP) and high-risk vessel (HRV) characteristics on coronary computed tomography angiography (CCTA) alongside fractional flow reserve (FFR) in patients with diabetes mellitus (DM).
Methods: We analyzed 307 vessels from 184 dia..
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Gastroenterology / Review
Epidemiological and clinical trends of malignant small-bowel tumors in Asia
Jung Rock Moon, Seong Ran Jeon
Korean J Intern Med. 2026;41(5):799-807. Published online August 26, 2026
Malignant small-bowel tumors are uncommon, accounting for < 5% of all gastrointestinal cancers, yet their incidence has exhibited a steady rise in both Western and Asian populations. This increase is attributed to expanded use of advanced diagnostic modalities and improved registry completeness. Mali..
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Cardiology / Original Article
Distal radial access in acute coronary syndrome patients with good arterial pulsation: a subgroup analysis from the KODRA registry
Jun-Won Lee, Su Yong Kim, Jung Ho Heo, Han-Young Jin, Sung Woo Cho, Yongcheol Kim, Bong-Ki Lee, Sang-Yong Yoo, Sang Yeub Lee, Chan Joon Kim, Jin Sup Park, Do Hoi Kim, Jin Bae Lee, Dong-Kie Kim, Jun Ho Bae, Sung-Yun Lee, Seung-Hwan Lee
Korean J Intern Med. 2026;41(4):663-675. Published online July 1, 2026
Background/Aims: Distal radial access (DRA) has been associated with fewer access-site complications, but evidence in acute coronary syndrome (ACS) remains limited. This study evaluated the feasibility and safety of DRA in ACS patients with good arterial pulsation.
Methods: Patients with good arter..
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Gastroenterology / Original Article
Comparison of the efficacy and safety of endoscopic and fluoroscopic balloon dilatation in benign esophageal strictures
Kwangbeom Park, Chang Hoon Oh, Do Hoon Kim, Ji Hoon Shin, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Korean J Intern Med. 2026;41(3):462-473. Published online May 1, 2026
Background/Aims: Balloon dilatation under endoscopic or fluoroscopic guidance is regarded as the gold standard for treating benign esophageal strictures. However, no prior studies have compared endoscopic balloon dilatation (EBD) with fluoroscopic balloon dilatation (FBD). We aimed to compare the ef..
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Allergy / Review
Eperisone-induced immediate hypersensitivity reactions
Gyu-Young Hur, Jung-Won Park
Korean J Intern Med. 2026;41(3):411-417. Published online May 1, 2026
Eperisone hydrochloride is a centrally acting muscle relaxant commonly prescribed for musculoskeletal pain, particularly in Korea and Japan. It induces relaxation of skeletal and vascular smooth muscle through central nervous system modulation and peripheral mechanisms, although its precise biochemi..
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Allergy / Original Article
Drug hypersensitivity leading to emergency department visit: a comprehensive analysis of clinical features and management
Soo Jie Chung, Na Young Kim, So Jeong Kim, Junghyun Kim, Hang A Park, Jeong-Hee Choi
Korean J Intern Med. 2026;41(2):328-340. Published online March 1, 2026
Background/Aims: Drug hypersensitivity reactions (DHRs) are unpredictable adverse drug reactions that can present with varied clinical manifestations, including anaphylaxis. However, data on DHRs initially diagnosed in the emergency department (ED) and subsequently confirmed by allergy specialists r..
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Hemato-oncology / Original Article
Real-world use of polatuzumab vedotin combined with bendamustine and rituximab for patients with relapsed or refractory large B-cell lymphoma
Changgon Kim, Sang Eun Yoon, Hyun-Young Kim, Duck Cho, Junhun Cho, Won Seog Kim, Seok Jin Kim
Korean J Intern Med. 2026;41(2):296-306. Published online March 1, 2026
Background/Aims: Polatuzumab vedotin combined with bendamustine and rituximab (Pola-BR) is a treatment option for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL), particularly as bridging therapy before chimeric antigen receptor (CAR) T-cell infusion. However, real-world data regarding..
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Gastroenterology / Original Article
The effect of HFE gene mutation and iron overload on sustained virological response in Egyptian chronic hepatitis C patients treated with daclatasvir and sofosbuvir
Emad M. Kodsi, Hisham Ismail, Randa Issa, Ahmed Elshaarawy, Moustafa A. Sakr, Eman L. Shehata, Emad R Issak
Korean J Intern Med. 2026;41(2):265-276. Published online March 1, 2026
Background/Aims: This matched case-control study investigated the impact of HFE gene mutations on sustained virological response (SVR) in Egyptian patients with chronic hepatitis C (CHC) treated with daclatasvir and sofosbuvir.
Methods: A total of 150 CHC patients were enrolled (75 responders and 7..
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Infectious diseases / Review
Updates on epidemiology and diagnostic tests of syphilis in South Korea
Dong Youn Kim, Ki-Ho Park
Korean J Intern Med. 2026;41(2):242-254. Published online March 1, 2026
Syphilis is a sexually transmitted disease caused by the spirochete Treponema pallidum. Recently, there has been a global resurgence of syphilis cases. In South Korea, the reported rate of syphilis steadily increased from 1.93 per 100,000 individuals in 2011 to 3.41 per 100,000 individuals in 2019. ..
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Hemato-oncology / Review
Assessment tools for peripheral neuropathy in multiple myeloma
Sung-Soo Park, Kunye Kwak, Seol-Hee Baek, Changgon Kim, Yoon Seok Choi, Yong Park, Byung Soo Kim, Jin Seok Kim, Chang-Ki Min, Ka-Won Kang
Korean J Intern Med. 2026;41(2):230-241. Published online March 1, 2026
Advances in treating multiple myeloma (MM) have improved survival, shifting the management focus toward quality of life. Peripheral neuropathy (PN) is a common treatment-related toxicity that significantly impairs quality of life. However, standardized assessment methods for PN in patients with MM a..
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Endocrinology-metabolism / Original Article
Analysis of experiences on telemedicine pilot projects from the perspectives of doctors, pharmacists, and patients
Yeryeon Jung, Hyunah Kim, Jeong-Yeon Kim, Seongwoo Seo, Youseok Kim, Min Jung Ko, Hun-Sung Kim
Korean J Intern Med. 2026;41(1):131-142. Published online January 1, 2026
Background/Aims: This study is the first to analyze telemedicine pilot project experiences from doctors, pharmacists, and patients with different roles to support sustainable commercialization.
Methods: An online survey targeted individuals (patients, doctors, and pharmacists) who participated in t..
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Cardiology / Original Article
Enhanced prediction of left ventricular ejection fraction using electrocardiography with the addition of clinical metadata
Hyun Woong Park, Taeseen Kang, Young-Hoon Seo, Jae-Hyeong Park
Korean J Intern Med. 2026;41(1):118-130. Published online January 1, 2026
Background/Aims: Left ventricular ejection fraction (LVEF) is a key echocardiographic parameter for assessing LV systolic function, guiding the management of many cardiovascular diseases, including heart failure (HF). While traditional electrocardiography (ECG) has been widely used in clinical pract..
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Endocrinology-metabolism / Review
Advanced strategies for the management of patients with diabetic foot ulcers: a comprehensive review
Ji Min Kim, Chong Hwa Kim, Seon Mee Kang, Jung Hwa Jung, Ki Chun Kim, Sanghyun Ahn, Tae Sun Park, Ie Byung Park
Korean J Intern Med. 2026;41(1):47-59. Published online January 1, 2026
Diabetic foot ulcers (DFUs) are among the most serious and common complications of diabetes mellitus. They significantly affect patients’ quality of life and impose a substantial economic burden on healthcare systems worldwide. In Korea, the prevalence of diabetes and related complications, such a..
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Gastroenterology / Review
Clinical management of gastric mucosa-associated lymphoid tissue lymphoma
Ji Yong Ahn
Korean J Intern Med. 2026;41(1):8-14. Published online December 23, 2025
Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is often associated with chronic Helicobacter pylori infection. For an accurate diagnosis of gastric MALT lymphoma, clinical suspicion and careful endoscopic examination with multiple biopsies should be performed, and the final patholo..
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Rheumatology / Original Article
Real-world clinical response and efficacy of tacrolimus-based maintenance therapy for Korean patients with lupus nephritis
Ji-Won Kim, Ju-Yang Jung, Hyoun-Ah Kim, Chang-Hee Suh
Korean J Intern Med. 2025;40(6):1052-1064. Published online October 28, 2025
Background/Aims: We evaluated the efficacy and safety of tacrolimus as maintenance therapy in Korean patients with lupus nephritis (LN).
Methods: A total of 179 patients with biopsy-proven LN were included, of whom 92 received tacrolimus and 87 did not. Clinical parameters were assessed at six mont..
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Cardiology / Original Article
Automatic quantitative analysis of atherosclerotic aortic plaques in patients with embolic cerebral infarction using deep learning
Hye Jin Bang, Jae-Hyeong Park, Sun Geu Chae, Suk Joo Bae, Ji-Hoon Jung, You Hee Cho, Jong Won Park, Dae-Won Kim, Jung Sun Cho
Korean J Intern Med. 2025;40(5):767-779. Published online August 26, 2025
Background/Aims: Transesophageal echocardiography (TEE) is a commonly used imaging modality for assessing embolic stroke of undetermined source (ESUS) in clinical practice. We aimed to develop an automatic plaque segmentation model based on U-net and evaluate its clinical usefulness in patients with..
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Hemato-oncology / Original Article
Decreased frequency and inflammatory change of FoxP3+ regulatory T cells in immunopathogenesis of human acute graft-versus-host disease
Nayeon Seong, Cheongin Yang, Kunye Kwak, Ka-Won Kang, Yong Park, Byung Soo Kim, Seong Hyun Jeong, Joon Seong Park, Yoon Seok Choi
Korean J Intern Med. 2025;40(4):657-666. Published online July 1, 2025
Background/Aims: Acute graft-versus-host disease (GvHD) is a severe complication of allogeneic stem cell transplantation, characterized by immune-mediated tissue damage primarily affecting the skin, liver, and gastrointestinal tract. Regulatory T (Treg) cells play a critical role in maintaining immu..
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Cardiology / Original Article
Detection rate by time period and predictors of serious arrhythmias in unexplained syncope: a multicenter implantable loop recorder registry study
Juwon Kim, Il-Young Oh, Myung-Jin Cha, Jinhee Ahn, So-Ryoung Lee, Sung Ho Lee, Jae-Sun Uhm, Pil-Sung Yang, Jaemin Shim, Hyoung-Seob Park, Junbeom Park, Jun Hyung Kim, Ki-Hun Kim, Jumsuk Ko, Hong Euy Lim, Ju Youn Kim
Korean J Intern Med. 2025;40(4):616-625. Published online July 1, 2025
Background/Aims: Although an implantable loop recorder (ILR) is a valuable tool for investigation of unexplained syncope, there are limited data regarding time course to diagnosis and predictors of serious arrhythmias as a cause of unexplained syncope. We sought to investigate diagnosis rate by time..
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