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Infectious diseases / Original Article
Lopinavir-ritonavir versus hydroxychloroquine for viral clearance and clinical improvement in patients with mild to moderate coronavirus disease 2019
Ji-Won Kim, Eun Jin Kim, Hyun Hee Kwon, Chi Young Jung, Kyung Chan Kim, Jung-Yoon Choe, Hyo-Lim Hong
Korean J Intern Med. 2021;36(Suppl 1):S253-S263. Published online June 16, 2020
Background/Aims: The efficacies of lopinavir-ritonavir or hydroxychloroquine remain to be determined in patients with coronavirus disease 2019 (COVID-19). To compare the virological and clinical responses to lopinavir-ritonavir and hydroxychloroquine treatment in COVID-19 patients.
Methods: This re..
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Cardiology / Original Article
Update on association between exposure to renin-angiotensin-aldosterone system inhibitors and coronavirus disease 2019 in South Korea
Jeongkuk Seo, Minkook Son
Korean J Intern Med. 2021;36(Suppl 1):S114-S122. Published online February 25, 2021
Background/Aims: Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, there have been concerns about the association between exposure to renin-angiotensin-aldosterone system (RAAS) inhibitors and the risk and severity of COVID-19.
Methods: We performed a case-control study that util..
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Infectious diseases / Original Article
Can reactogenicity predict immunogenicity after COVID-19 vaccination?
Young Hoon Hwang, Kyoung-Ho Song, Yunsang Choi, Suryeong Go, Su-Jin Choi, Jongtak Jung, Chang Kyung Kang, Pyoeng Gyun Choe, Nam-Joong Kim, Wan Beom Park, Myoung-don Oh
Korean J Intern Med. 2021;36(6):1486-1491. Published online May 28, 2021
Background/Aims: This study aimed to assess the association between local and systemic reactogenicity and humoral immunogenicity after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination.
Methods: Adverse events were prospectively evaluated using an electronic diary in 135 heal..
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Pulmonology / Original Article
Changes in respiratory virus infection trends during the COVID-19 pandemic in South Korea: the effectiveness of public health measures
Ji Young Park, Hwan Il Kim, Joo-Hee Kim, Sunghoon Park, Yong Il Hwang, Seung Hun Jang, Yong Kyun Kim, Ki-Suck Jung
Korean J Intern Med. 2021;36(5):1157-1168. Published online August 18, 2021
Background/Aims: Studies on the effectiveness of public health measures to prevent respiratory virus transmission in real-world settings are lacking. We investigated the effectiveness of universal mask use and adherence to other personal preventive measures on the changing viral respiratory infectio..
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Gastroenterology / Original Article
Impact of liver cirrhosis on the clinical outcomes of patients with COVID-19: a nationwide cohort study of Korea
Dongsub Jeon, Minkook Son, Jonggi Choi
Korean J Intern Med. 2021;36(5):1092-1101. Published online August 18, 2021
Background/Aims: The impact of liver cirrhosis (LC) on the clinical outcomes of patients with coronavirus disease 2019 (COVID-19) remains elusive. This study evaluated the association between LC and the development of severe complications from COVID-19.
Methods: We used the National Health Insuranc..
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Endocrinology-metabolism / Original Article
Impact of urgently initiated tele-prescription due to COVID-19 on glycemic control in patients with type 2 diabetes
Sung-Don Park, Na-young Kim, Jae-Han Jeon, Jung-Guk Kim, In-Kyu Lee, Keun-Gyu Park, Yeon-Kyung Choi
Korean J Intern Med. 2021;36(4):942-948. Published online June 7, 2021
Background/Aims: Coronavirus disease 2019 (COVID-19) is a global pandemic that had affected more than 13,000 people in South Korea by July 2020. To prevent spread of COVID-19, tele-prescription was permitted temporarily. This study investigated the impact of tele-prescription on glycemic control in ..
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Cardiology / Original Article
Different therapeutic associations of renin-angiotensin system inhibitors with coronavirus disease 2019 compared with usual pneumonia
Hae-Young Lee, Juhee Ahn, Juhong Park, Chang Kyung Kang, Sung-Ho Won, Dong Wook Kim, Jong-Heon Park, Ki-Hyun Chung, Joon-Sung Joh, JI Hwan Bang, Cheong Hee Kang, Myoung-don Oh, Wook Bum Pyun; The Korean Society of Hypertension; The National Committee for Clinical Management of Emerging Infectious Diseases
Korean J Intern Med. 2021;36(3):617-628. Published online April 16, 2021
Background/Aims: Although it is near concluded that renin-angiotensin system inhibitors do not have a harmful effect on coronavirus disease 2019 (COVID-19), there is no report about whether angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) offer any protective..
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Review
How lessons learned from the 2015 Middle East respiratory syndrome outbreak affected the response to coronavirus disease 2019 in the Republic of Korea
Tae Un Yang, Ji Yun Noh, Joon-Young Song, Hee Jin Cheong, Woo Joo Kim
Korean J Intern Med. 2021;36(2):271-285. Published online February 5, 2021
The Republic of Korea (ROK) experienced a public health crisis due to Middle East respiratory syndrome (MERS) in 2015 and is currently going through the coronavirus disease 2019 (COVID-19) pandemic. Lessons learned from the disastrous MERS outbreak were ref lected in the preparedness system, and the..
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Review
Angiotensin-converting enzyme 2 and kidney diseases in the era of coronavirus disease 2019
Sang Heon Suh, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae
Korean J Intern Med. 2021;36(2):247-262. Published online October 16, 2020
In the decades since the discovery of angiotensin-converting enzyme 2 (ACE2), its protective role in terms of antagonizing activation of the classical renin-angiotensin system (RAS) axis has been recognized in clinical and experimental studies on kidney and cardiovascular diseases. The effects of AC..
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Rapid Communication / Brief Communication
Dynamics of viral load and anti-SARS-CoV-2 antibodies in patients with positive RT-PCR results after recovery from COVID-19
Kyoung-Ho Song, Dong-Min Kim, Hyunju Lee, Sin Young Ham, Sang-Min Oh, Hyeonju Jeong, Jongtak Jung, Chang Kyung Kang, Ji Young Park, Yu Min Kang, Ji-Yeon Kim, Jeong Su Park, Kyoung Un Park, Eu Suk Kim, Hong Bin Kim
Korean J Intern Med. 2021;36(1):11-14. Published online November 25, 2020
Recently, the number of patients with coronavirus disease 2019 (COVID-19) who have tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), via the reverse transcription polymerase chain reaction (RT-PCR) test, after recovery has increased; this has caused a dilemma regardin..
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Original Article / Brief Communication
Clinical implication and risk factor of pneumonia development in mild coronavirus disease 2019 patients
Hyun Woo Lee, Seo-Young Yoon, Jung-Kyu Lee, Tae Yeon Park, Deog Kyeom Kim, Hee Soon Chung, Eun Young Heo
Korean J Intern Med. 2021;36(1):1-10. Published online December 1, 2020
Background/Aims: Although a majority of coronavirus disease 2019 (COVID-19) cases were characterized as mild, data assessing the development of pneumonia in mild COVID-19 patients are limited. We aimed to examine the effect of pneumonia development on the clinical course of mild COVID-19 in hospital..
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Original Article / Brief Communication
What should we prepare for the next coronavirus disease 2019 outbreak? A survey on the opinions of infectious diseases specialists in South Korea
Bongyoung Kim, Se Yoon Park, Dong Sik Jung, Sook In Jung, Won Sup Oh, Shin-Woo Kim, Kyong Ran Peck, Hyun-Ha Chang; The Korean Society of Infectious Diseases
Korean J Intern Med. 2020;35(6):1270-1278. Published online September 23, 2020
Background/Aims: This study aimed to collect information on the opinions of Korean infectious disease (ID) experts on coronavirus disease 2019 (COVID-19) and related issues in preparation for a future outbreak.
Methods: A survey was conducted over the course of 5 days (from April 21 to 25, 2020), t..
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Original Article / Brief Communication
Clinical characteristics of coronavirus disease 2019 patients with diarrhea in Daegu
Min Kyu Kang, Kyeong Ok Kim, Min Cheol Kim, Joon Hyun Cho, Sung Bum Kim, Jung Gil Park, Kook Hyun Kim, See Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
Korean J Intern Med. 2020;35(6):1261-1269. Published online September 23, 2020
Background/Aims: Coronavirus disease 2019 (COVID-19) can reportedly cause gastrointestinal symptoms. Therefore, we investigated the clinical characteristics of COVID-19 patients with diarrhea.
Methods: We included 118 COVID-19 patients admitted to a single hospital from February 20 to March 31, 202..
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Rapid Communication
The proposed algorithm for emergency endoscopy during the coronavirus disease 2019 outbreak
Sung Bum Kim, Kook Hyun Kim
Korean J Intern Med. 2020;35(5):1027-1030. Published online July 16, 2020
Following the coronavirus disease 2019 outbreak in China, more than 10,765 patients tested positive for severe acute respiratory syndrome coronavirus 2 from February 18, 2020 to April 30, 2020 in South Korea. Performing emergency endoscopy is extremely challenging from the clinicians’ viewpoint du..
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Rapid Communication / Brief Communication
Persistent severe acute respiratory syndrome coronavirus 2 detection after resolution of coronavirus disease 2019-associated symptoms/signs
Se Yoon Park, Soon Gyu Yun, Jeong Won Shin, Bo Young Lee, Hyo-Ju Son, Seungjae Lee, Eunjung Lee, Tae Hyong Kim
Korean J Intern Med. 2020;35(4):793-796. Published online June 19, 2020
There are limited data on the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in respiratory specimens after resolution of coronavirus disease 2019 (COVID-19)-associated symptoms/signs. We determined duration of SARS-CoV-2 virus shedding in symptomatic patients after rem..
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Original Article / Brief Communication
In vitro activity of lopinavir/ritonavir and hydroxychloroquine against severe acute respiratory syndrome coronavirus 2 at concentrations achievable by usual doses
Chang Kyung Kang, Moon-Woo Seong, Su-Jin Choi, Taek Soo Kim, Pyoeng Gyun Choe, Sang Hoon Song, Nam-Joong Kim, Wan Beom Park, Myoung-don Oh
Korean J Intern Med. 2020;35(4):782-787. Published online May 29, 2020
Background/Aims: As the coronavirus disease-2019 global pandemic progresses, screening of antiviral agents effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is urgently needed. In addition, considering the viral load kinetics of SARS-CoV-2, which peaks early in the illne..
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Original Article / Brief Communication
Lung ultrasound for early diagnosis and severity assessment of pneumonia in patients with coronavirus disease 2019
[corrected-article]
Young-Jae Cho, Kyoung-Ho Song, Yunghee Lee, Joo Heung Yoon, Ji Young Park, Jongtak Jung, Sung Yoon Lim, Hyunju Lee, Ho Il Yoon, Kyoung Un Park, Hong Bin Kim, Eu Suk Kim
Korean J Intern Med. 2020;35(4):771-781. Published online July 1, 2020
Background/Aims: Current evidence supports lung ultrasound as a point-ofcare alternative diagnostic tool for various respiratory diseases. We sought to determine the utility of lung ultrasound for early detection of pneumonia and for assessment of respiratory failure among patients with coronavirus ..
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Original Article / Brief Communication
Selecting coronavirus disease 2019 patients with negligible risk of progression: early experience from non-hospital isolation facility in Korea
Pyoeng Gyun Choe, Eun Kyo Kang, Sun Young Lee, Boram Oh, Dahae Im, Hyo Yeon Lee, Hyemin Jung, Chang Kyung Kang, Min Sun Kim, Wan Beom Park, Eun Hwa Choi, BeLong Cho, Myoung-don Oh, Nam Joong Kim
Korean J Intern Med. 2020;35(4):765-770. Published online May 29, 2020
Background/Aims: As the novel coronavirus (coronavirus disease 2019 [COVID-19]) outbreak progresses rapidly, staying home is recommended for suspected patients; however, the safety of this recommendation is uncertain. In Korea, non-hospital facilities called “living and treatment centers (LTCs)” ..
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Original Article / Brief Communication
A cluster of tertiary transmissions of 2019 novel coronavirus (SARS-CoV-2) in the community from infectors with common cold symptoms
Nam Joong Kim, Pyoeng Gyun Choe, Sang-Joon Park, Jaegyun Lim, Wang Jun Lee, Chang Kyung Kang, Wan Beom Park, Moon-Woo Seong, Myoung-don Oh
Korean J Intern Med. 2020;35(4):758-764. Published online June 11, 2020
Background/Aims: As the global impact of the novel coronavirus disease 2019 (COVID-19) has been severe, many countries have intensified containment activities to eliminate virus transmission, through early detection and isolation strategies. To establish a proper quarantine strategy, it is essential..
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Guideline / Brief Communication
Consensus statement on coronary intervention during the coronavirus disease 19 pandemic: from the Korean Society of Interventional Cardiology
Kwan Yong Lee, Bong-Ki Lee, Won-Jang Kim, Se Hun Kang, Taek Kyu Park, Song-Yi Kim, Jung-Won Suh, Chang-Hwan Yoon, Dong Heon Yang, Sung Kee Ryu, Sang-Hyun Kim, Sung Yun Lee, In-Ho Chae; The Korean Society of Interventional Cardiology COVID-19 Task Force Team
Korean J Intern Med. 2020;35(4):749-757. Published online July 1, 2020
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the novel virus severe acute respiratory syndrome coronavirus 2. The first case developed in December, 2019 in Wuhan, China; several months later, COVID-19 has become pandemic, and there is no end in sight. This disaster is..
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