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Allergy / Original Article
Association between specific IgE to staphylococcal enterotoxin B and the eosinophilic phenotype of asthma
Soyoon Sim, Youngwoo Choi, Eun-Mi Yang, Hae-Sim Park
Korean J Intern Med. 2024;39(4):659-667. Published online July 1, 2024
Background/Aims: Sensitization to staphylococcal superantigens (SAgs) could contribute to asthma severity. However, its relevance with eosinophilic phenotype has not yet been clarified. This study aimed to investigate associations between serum specific IgE levels to SAg and eosinophilic airway infl..
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Gastroenterology / Original Article
Clinical course of asymptomatic duodenal subepithelial lesions
Seokin Kang, Kwangbeom Park, Do Hoon Kim, Yuri Kim, Hee Kyong Na, Jeong Hoon Lee, Ji Yong Ahn, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Korean J Intern Med. 2024;39(4):603-611. Published online June 13, 2024
Background/Aims: There is limited knowledge regarding the management of duodenal subepithelial lesions (SELs) owing to a lack of understanding of their natural course. This study aimed to assess the natural course of asymptomatic duodenal SELs and provide management recommendations.
Methods: Patien..
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Gastroenterology / Original Article
Increasing correlation between oral and gastric microbiota during gastric carcinogenesis
Hee Sang You, Jae Yong Park, Hochan Seo, Beom Jin Kim, Jae Gyu Kim
Korean J Intern Med. 2024;39(4):590-602. Published online June 24, 2024
Background/Aims: Recent research has increasingly focused on the role of the gastric microbiome in the development of gastric cancer. We aimed to investigate the changes in the microbiome during gastric carcinogenesis in structural and functional aspects, with a specific focus on the association bet..
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Gastroenterology / Review
Artificial intelligence in colonoscopy: from detection to diagnosis
Eun Sun Kim, Kwang-Sig Lee
Korean J Intern Med. 2024;39(4):555-562. Published online May 2, 2024
This study reviews the recent progress of artificial intelligence for colonoscopy from detection to diagnosis. The source of data was 27 original studies in PubMed. The search terms were “colonoscopy” (title) and “deep learning” (abstract). The eligibility criteria were: (1) the dependent varia..
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Gastroenterology / Review
Strategies to improve screening colonoscopy quality for the prevention of colorectal cancer
Joo Hye Song, Eun Ran Kim
Korean J Intern Med. 2024;39(4):547-554. Published online January 22, 2024
The incidence and mortality of colorectal cancer (CRC) have decreased through regular screening colonoscopy, surveillance, and endoscopic treatment. However, CRC can still be diagnosed after negative colonoscopy. Such CRC is called interval CRC and accounts for 1.8–9.0% of all CRC cases. Most case..
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Hemato-oncology / Original Article
Geriatric risk model for older patients with diffuse large B-cell lymphoma (GERIAD): a prospective multicenter cohort study
Ho-Young Yhim, Yong Park, Jeong-A Kim, Ho-Jin Shin, Young Rok Do, Joon Ho Moon, Min Kyoung Kim, Won Sik Lee, Dae Sik Kim, Myung-Won Lee, Yoon Seok Choi, Seong Hyun Jeong, Kyoung Ha Kim, Jinhang Kim, Chang-Hoon Lee, Ga-Young Song, Deok-Hwan Yang, Jae-Yong Kwak
Korean J Intern Med. 2024;39(3):501-512. Published online January 30, 2024
Background/Aims: Optimal risk stratification based on simplified geriatric assessment to predict treatment-related toxicity and survival needs to be clarified in older patients with diffuse large B-cell lymphoma (DLBCL).
Methods: This multicenter prospective cohort study enrolled newly diagnosed pat..
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Hemato-oncology / Original Article
Prognostic Significance Of Sequential 18f-fdg Pet/Ct During Frontline Treatment Of Peripheral T Cell Lymphomas
Ga-Young Song, Sung-Hoon Jung, Seo-Yeon Ahn, Mihee Kim, Jae-Sook Ahn, Je-Jung Lee, Hyeoung-Joon Kim, Jang Bae Moon, Su Woong Yoo, Seong Young Kwon, Jung-Joon Min, Hee-Seung Bom, Sae-Ryung Kang, Deok-Hwan Yang
Korean J Intern Med. 2024;39(2):327-337. Published online January 25, 2024
Background/Aims: The prognostic significance of 18F-fluorodeoxyglucose (FDG)-positron emission tomography-computed tomography (PET/CT) in peripheral T-cell lymphomas (PTCLs) are controversial. We explored the prognostic impact of sequential 18F-FDG PET/CT during frontline chemo..
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Pulmonology / Original Article
Clinical impact of pleural fluid carcinoembryonic antigen on therapeutic strategy and efficacy in lung adenocarcinoma patients with malignant pleural effusion
Jaehee Lee, Deok Heon Lee, Ji Eun Park, Yong Hoon Lee, Sun Ha Choi, Hyewon Seo, Seung Soo Yoo, Shin Yup Lee, Seung-Ick Cha, Jae Yong Park, Chang Ho Kim
Korean J Intern Med. 2024;39(2):318-326. Published online February 14, 2024
Background/Aims: Epidermal growth factor receptor (EGFR) mutation is important in determining the treatment strategy for advanced lung cancer patients with malignant pleural effusion (MPE). Contrary to serum carcinoembryonic antigen (S-CEA) levels, the associations between pleural fluid CEA (PF-CEA)..
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Pulmonology / Original Article
Relationship between metformin use and mortality in tuberculosis patients with diabetes: a nationwide cohort study
Eunki Chung, Dawoon Jeong, Jeongha Mok, Doosoo Jeon, Hee-Yeon Kang, Heejin Kim, Heesun Kim, Hongjo Choi, Young Ae Kang
Korean J Intern Med. 2024;39(2):306-317. Published online February 6, 2024
Background/Aims: To determine whether metformin, which is considered a host-directed therapy for tuberculosis (TB), is effective in improving the prognosis of patients with TB and diabetes mellitus (DM), who have higher mortality than those without DM.
Methods: This cohort study included patients w..
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Cardiology / Review
Nighttime administration of antihypertensive medication: a review of chronotherapy in hypertension
Hyun-Jin Kim, Sang-Ho Jo
Korean J Intern Med. 2024;39(2):205-214. Published online November 16, 2023
Hypertension remains a global health concern because of suboptimal blood pressure control despite advancements in antihypertensive treatments. Chronotherapy, defined as evening or bedtime administration of medication based on biological rhythms, is emerging as a potential strategy to improve blood p..
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Rheumatology / Original Article
Clinical characteristics and prognostic factors of non-tuberculous mycobacterial disease in patients with rheumatoid arthritis
Hyemin Kim, Soyoung Lee, Ji-Won Kim, Ju-Yang Jung, Chang-Hee Suh, Hyoun-Ah Kim
Korean J Intern Med. 2024;39(1):172-183. Published online November 30, 2023
Background/Aims: This study aimed to identify the clinical characteristics of patients with concurrent rheumatoid arthritis (RA) and suspected non-tuberculous mycobacterial (NTM) infections as well as determine their prognostic factors.
Methods: We retrospectively reviewed the medical records of 91..
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Endocrinology-metabolism / Original Article
Efficacy and safety of denosumab treatment for Korean patients with Stage 3b–4 chronic kidney disease and osteoporosis
Jin Taek Kim, You Mi Kim, Kyong Yeun Jung, Hoonsung Choi, So Young Lee, Hyo-Jeong Kim
Korean J Intern Med. 2024;39(1):148-159. Published online December 22, 2023
Background/Aims: We evaluated the efficacy and safety of denosumab treatment in severe chronic kidney disease (CKD) patients with osteoporosis. We also investigated whether the treatment affects the coronary artery calcifications.
Methods: Twenty-seven postmenopausal women with Stage 3b–4 CKD and..
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Cardiology / Original Article
Sex differences in clinical characteristics and long-term outcome in patients with heart failure: data from the KorAHF registry
Hyue Mee Kim, Hack-Lyoung Kim, Myung-A Kim, Hae-Young Lee, Jin Joo Park, Dong-Ju Choi; on the behalf of the KorAHF Investigators
Korean J Intern Med. 2024;39(1):95-109. Published online December 14, 2023
Background/Aims: Sex differences in the prognosis of heart failure (HF) have yielded inconsistent results, and data from Asian populations are even rare. This study aimed to investigate sex differences in clinical characteristics and long-term prognosis among Korean patients with HF.
Methods: A tot..
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Gastroenterology / Original Article
Usefulness of nasal cavity evaluation before high-resolution esophageal manometry in high-risk patients
Hyun Jin Min, Jae Yong Park
Korean J Intern Med. 2024;39(1):86-94. Published online November 30, 2023
Background/Aims: A catheter is inserted through the nasal cavity during high-resolution esophageal manometry (HRM), which may cause adverse events such as pain or epistaxis. Despite these possible safety considerations, studies on this subject are very limited. We aimed to investigate the usefulness..
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Gastroenterology / Original Article
Histologic features and predicting prognosis in ulcerative colitis patients with mild endoscopic activity
Seung Yong Shin, Hee Sung Kim, Kisung Kim, Chang Won Choi, Jung Min Moon, Jeong Wook Kim, Hyun Jin Joo, Jeongkuk Seo, Muhyeon Sung, Chang Hwan Choi
Korean J Intern Med. 2024;39(1):68-76. Published online December 13, 2023
Background/Aims: We aimed to evaluate the histologic features predictive of prognosis and correlate them with endoscopic findings in patients with ulcerative colitis (UC) having complete or partial mucosal healing (MH).
Methods: We prospectively collected and reviewed data from patients with UC who..
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Hemato-oncology / Review
Diagnostic and therapeutic advances in adults with acute lymphoblastic leukemia in the era of gene analysis and targeted immunotherapy
Jae-Ho Yoon, Seok Lee
Korean J Intern Med. 2024;39(1):34-56. Published online January 1, 2024
Acute lymphoblastic leukemia (ALL) is one of the most rapidly changing hematological malignancies with advanced understanding of the genetic landscape, detection methods of minimal residual disease (MRD), and the development of immunotherapeutic agents with good clinical outcomes. The annual inciden..
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Pulmonology / Original Article
Alterations in lung and gut microbiota reduce diversity in patients with nontuberculous mycobacterial pulmonary disease
Ji Yeon Choi, Bora Shim, Youngmok Park, Young Ae Kang
Korean J Intern Med. 2023;38(6):879-892. Published online October 23, 2023
Background/Aims: Although the incidence of nontuberculous mycobacteria pulmonary disease (NTM-PD), a chronic infectious disease, is increasing, lung and gut microbiota dysbiosis in NTM patients has rarely been studied and was therefore the focus of this study.
Methods: We analyzed the microbiota di..
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Cardiology / Original Article
Identification of novel variants for complicating cardiac disease in the scrub typhus infection using whole genome sequencing
Ki-Woon Kang, Kyung-Won Hong, Seong-Kyu Lee
Korean J Intern Med. 2023;38(6):865-871. Published online November 1, 2023
Background/Aims: Scrub typhus infection has been known to complicate cardiovascular diseases mainly attributing to high mortality. Genetic susceptibility loci for complicating cardiac diseases such as atrial fibrillation, heart failure, and ischemic heart disease identified by genomic study have bee..
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Gastroenterology / Original Article
Hepatic hemangioma: proportion and predictor of surgical treatment with emphasis on its growth rate
Young Cheol Shin, Eun Ju Cho, Hee Young Na, Jai Young Cho, Ho-Seong Han, Yoon Jin Lee, Haeryoung Kim, Sangmi Jang, Gwang Hyeon Choi, Eun Sun Jang, Jin-Wook Kim, Sook-Hyang Jeong
Korean J Intern Med. 2023;38(6):818-830. Published online November 1, 2023
Background/Aims: There are limited studies on the management of hepatic hemangiomas (HHs). We investigated the proportion and predictors of surgical resection and analyzed HH growth rates in addition to associated factors.
Methods: A retrospective case-control study of patients treated in 2 centers..
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Pulmonology / Review
Perioperative immunotherapy in stage IB-III non-small cell lung cancer: a critical review of its rationale and considerations
Jae Kyeom Sim, Juwhan Choi, Sung Yong Lee
Korean J Intern Med. 2023;38(6):787-796. Published online November 1, 2023
Lung cancer is a dismal disease as a leading cause of overall cancer death, but the development of immune checkpoint inhibitors (ICIs) in driver gene mutation negative metastatic non-small cell lung cancer (NSCLC) is changing the paradigm of lung cancer treatment. Recently, ICIs are expanding their ..
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