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Infectious diseases / Original Article
Eosinophil-mediated lung inflammation associated with elevated natural killer T cell response in COVID-19 patients
Dong-Min Kim, Jun-Won Seo, Yuri Kim, Uni Park, Na-Young Ha, Hyoree Park, Na Ra Yun, Da Young Kim, Sung Ho Yoon, Yong Sub Na, Do Sik Moon, Sung-Chul Lim, Choon-Mee Kim, Yeon-Sook Kim, Nam-Hyuk Cho
Korean J Intern Med. 2022;37(1):201-209. Published online September 27, 2021
Background/Aims: Coronavirus disease 2019 (COVID-19) is associated with acute respiratory syndrome. The mechanisms underlying the different degrees of pneumonia severity in patients with COVID-19 remain elusive. This study provides evidence that COVID-19 is associated with eosinophil-mediated inflam..
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Hemato-oncology / Original Article
Characteristics and treatment patterns in older patients with locally advanced head and neck cancer (KCSG HN13-01)
Eun Joo Kang, Yun-Gyoo Lee, Bhumsuk Keam, Jin-Hyuk Choi, Jin-Soo Kim, Keon Uk Park, Kyoung Eun Lee, Hyo Jung Kim, Keun-Wook Lee, Min Kyoung Kim, Hee Kyung Ahn, Seong Hoon Shin, Jii Bum Lee, Jung Hye Kwon, Hye Ryun Kim, Sung-Bae Kim, Hwan Jung Yun
Korean J Intern Med. 2022;37(1):190-200. Published online December 21, 2021
Background/Aims: Treatment decisions for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) are complicated, and multi-modal treatments are usually indicated. However, it is challenging for older patients to complete treatments. Thus, we investigated disease characteristics, real-world..
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Nephrology / Original Article
Plasma oxalic acid and cardiovascular risk in end-stage renal disease patients: a prospective, observational cohort pilot study
Natalia Stepanova, Victoria Driianska, Lesya Korol, Lyudmyla Snisar, Larysa Lebed
Korean J Intern Med. 2022;37(1):167-178. Published online June 25, 2021
Background/Aims: It was hypothesized that oxalate might be strongly involved in atherogenesis and the inflammatory pathway that could result in an increased risk of cardiovascular disease (CVD) in end-stage renal disease (ESRD) patients. Therefore, this study aimed to address two primary research qu..
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Hemato-oncology / Original Article
Surtuin 1 as a potential prognostic biomarker in very elderly patients with colorectal cancer
Guk Jin Lee, Yun Hwa Jung, Tae-Jung Kim, Yosep Chong, Seo-Won Jeong, In Kyu Lee, In Sook Woo
Korean J Intern Med. 2021;36(Suppl 1):S235-S244. Published online July 2, 2020
Background/Aims: Colorectal cancer (CRC) rate increases with aging. Aging-related proteins, such as sirtuins (SIRTs) may be a potential therapeutic target in the elderly patients with CRC. The clinical implications of SIRT1 and SIRT2 have not been reported for elderly patients with cancer. The aim of..
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Hemato-oncology / Original Article
Physical activity of Korean cancer survivors is associated with age and sex
Jae Hyeon Park, Jung Soo Lee, Yoon Ho Ko, Yeo Hyung Kim
Korean J Intern Med. 2021;36(Suppl 1):S225-S234. Published online May 7, 2020
Background/Aims: This study aimed to assess adherence to physical activity guidelines in cancer survivors and to investigate related factors.
Methods: The cross-sectional data of 39,845 community-dwelling participants aged ≥ 20 years (1,254 cancer survivors) in the Korea National Health and Nutri..
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Cardiology / Original Article
Feasibility of primary percutaneous coronary intervention via the distal radial approach in patients with ST-elevation myocardial infarction
Yongcheol Kim, Jun-Won Lee, Sang Yeub Lee, Jang-Whan Bae, Sang Jun Lee, Myung Ho Jeong, Seung-Hwan Lee, Youngkeun Ahn
Korean J Intern Med. 2021;36(Suppl 1):S53-S61. Published online March 3, 2020
Background/Aims: Recently, distal radial approach (DRA), called as snuffbox approach, has gained the interest of interventional cardiologists, but there is a lack of data about the feasibility of DRA as an alternative route for primary percutaneous coronary intervention (PCI).
Methods: A total of 1..
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Gastroenterology / Original Article
Comparison of loss of response between anti-tumor necrosis factor alone and combined use with immunomodulators in patients with inflammatory bowel disease
Seung Wook Hong, Jaewoo Park, Hyuk Yoon, Hye Ran Yang, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Joo Sung Kim
Korean J Intern Med. 2021;36(Suppl 1):S9-S17. Published online June 25, 2020
Background/Aims: Combination therapy with immunomodulators (IMMs) was proposed as a strategy to prevent the development of loss of response (LOR) to anti-tumor necrosis factor (TNF) for patients with inflammatory bowel disease (IBD). However, the effect is unclear in patients already exposed to IMMs..
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Gastroenterology / Original Article
Effectiveness and safety of elbasvir/grazoprevir in Korean patients with hepatitis C virus infection: a nationwide real-world study
Eun Sun Jang, Kyung-Ah Kim, Young Seok Kim, In Hee Kim, Byung Seok Lee, Youn Jae Lee, Woo Jin Chung, Sook-Hyang Jeong
Korean J Intern Med. 2021;36(Suppl 1):S1-S8. Published online June 17, 2020
Background/Aim: This study aimed to establish the real-world effectiveness and safety of grazoprevir/elbasvir (EBR/GZR) therapy in South Korea.
Methods: A total of 242 patients with chronic hepatitis C virus (HCV) genotype 1 or 4 infection who started EBR/GZR were consecutively enrolled from seven..
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Gastroenterology / Original Article
Clinical analysis of 117 cases with synchronous multiple primary esophageal squamous cell carcinomas
Zhiqin Chen, Sihan Li, Zheng He, Guang Li
Korean J Intern Med. 2021;36(6):1356-1364. Published online April 29, 2020
Background/Aims: We aimed to study the clinical characteristics, treatment modality, and the prognosis of synchronous multiple primary esophageal squamous cell carcinomas (SMPESCC).
Methods: A total of 117 SMPESCC cases were evaluated retrospectively from 2010 to 2015.
Results: The most common loc..
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Geriatrics / Original Article
Validity of the Clinical Frailty Scale in Korean older patients at a geriatric clinic
Hee-Won Jung, Il-Young Jang, Ji Yeon Back, Seunghyun Park, Chan MI Park, Seung Jun Han, Eunju Lee
Korean J Intern Med. 2021;36(5):1242-1250. Published online December 30, 2020
Background/Aims: We aimed to assess the validity of the Korean translated version of the Clinical Frailty Scale (CFS) in determining the frailty status in geriatric outpatients.
Methods: The records of 123 ambulatory outpatients who had undergone CFS and comprehensive geriatric assessments (CGAs) i..
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Hemato-oncology / Original Article
Thrombotic and hemorrhagic events in 2016 World Health Organization-defined Philadelphia-negative myeloproliferative neoplasm
Ik-Chan Song, Sang Hoon Yeon, Myung-Won Lee, Hyewon Ryu, Hyo-Jin Lee, Hwan-Jung Yun, Seon Young Kim, Deog-Yeon Jo
Korean J Intern Med. 2021;36(5):1190-1203. Published online July 22, 2021
Background/Aims: Recent changes in the diagnostic criteria for myeloproliferative neoplasms (MPNs) and increasing patient numbers necessitate updating of the data on vascular events in patients with such disorders.
Methods: In this single-center study, thrombotic and hemorrhagic events were retrosp..
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Pulmonology / Original Article
Upregulation of receptor tyrosine kinase-like orphan receptor 2 in idiopathic pulmonary fibrosis
Ji-Hye Son, Jong-Uk Lee, Susie Chin, Eun-Suk Go, Jai-Seong Park, Hwa-Kyun Shin, Hun Soo Chang, Jong-Sook Park, Choon-Sik Park
Korean J Intern Med. 2021;36(4):914-923. Published online September 21, 2020
Background/Aims: Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a major regulator of Wnt signaling, which is involved in fibroblast dysfunction. Because its role has not been evaluated in idiopathic pulmonary fibrosis (IPF), we examined the clinical implications of ROR2 expression.
Metho..
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Gastroenterology / Original Article
Clinical risk factors and pattern of initial fungal contamination in endoscopic biopsy-derived gastrointestinal cancer organoid culture
Su Youn Nam, Seung Jin Lee, Hee Jung Lim, Ji Young Park, Seong Woo Jeon
Korean J Intern Med. 2021;36(4):878-887. Published online April 8, 2021
Background/Aims: Because gastrointestinal tract is not sterile, primary culture has contamination risk despite of massive washing with antimicrobial media. Microbial contamination can play a key role in initial failure during biopsy-derived primary tumor culture.
Methods: Tumor tissue was acquired ..
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Rheumatology / Original Article
Clinical features of Korean elderly patients with antineutrophil cytoplasmic antibody-associated vasculitis
Byung-Woo Yoo, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
Korean J Intern Med. 2021;36(3):731-741. Published online August 20, 2020
Background/Aims: We compared the clinical and laboratory data between elderly and non-elderly patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) at diagnosis; further, we investigated the predictors at diagnosis for all-cause mortality and end-stage renal disease (E..
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Infectious diseases / Original Article
Evaluation of the early fluconazole treatment of candidemia protocol with automated short message service alerts: a before-and-after study
Jeong Rae Yoo, Bo Ra Shin, Sujin Jo, Sang Taek Heo
Korean J Intern Med. 2021;36(3):699-705. Published online July 9, 2020
Background/Aims: We introduced the Early Fluconazole Treatment in Candidemia (EFTC) protocol in August 2015 to improve the outcomes of patients with candidemia. This study evaluated the effectiveness of the EFTC protocol.
Methods: We conducted a retrospective before-and-after study among patients i..
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Pulmonology / Original Article
Changes in chest X-ray findings in 1- and 2-month group after treatment initiation for suspected pulmonary tuberculosis
Jang Ho Lee, Ock-Hwa Kim, Yeon Joo Kim, Tae Sun Shim, Kyung-Wook Jo
Korean J Intern Med. 2020;35(5):1145-1153. Published online February 18, 2020
Background/Aims: Although re-evaluation of radiographic follow-up after 2 to 3 months of therapy is recommended for patients administered anti-tuberculosis medication owing to suspected pulmonary tuberculosis, reported findings are limited. Therefore, this study aimed to investigate changes in 1- an..
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Geriatrics / Original Article
What are the illnesses associated with frailty in community-dwelling older adults: the Korean Frailty and Aging Cohort Study
Sunyoung Kim, Hee-Won Jung, Chang Won Won
Korean J Intern Med. 2020;35(4):1004-1013. Published online April 9, 2020
Background/Aims: Frailty is mainly due to an age-related decrease in the physiological reserves needed to maintain biological homeostasis, but it can also occur as a result of chronic diseases. The purpose of this study was to identify illnesses associated with frailty in Korean community-dwelling o..
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Infectious diseases / Original Article
Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013
Bongyoung Kim, Hyeonjun Hwang, Jieun Kim, Myoung-jae Lee, Hyunjoo Pai
Korean J Intern Med. 2020;35(3):703-713. Published online September 27, 2018
Background/Aims: This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea.
Methods: This study collated antibiotic prescription data and total patient days for inpatients at a tertiary care hospital in Korea between 2004 and 2013. The consumption of each ..
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Review
Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs
Tae Young Park, Hyoung-Chul Oh, Evan L. Fogel, Glen A. Lehman
Korean J Intern Med. 2020;35(3):535-543. Published online April 29, 2020
Acute pancreatitis is the most common and feared adverse event associated with performance of endoscopic retrograde cholangiopancreatography (ERCP). Unremitting effort has been made for over 40 years to minimize the frequency and severity of this complication. Recently, the use of rectal non-steroid..
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Nephrology / Review
Continuous renal replacement therapy in elderly with acute kidney injury
[corrected-article]
Kristianne Rachel P. Medina-Liabres, Sejoong Kim
Korean J Intern Med. 2020;35(2):284-294. Published online February 28, 2020
The objective of this article is to raise awareness among physicians of the increasing incidence of acute kidney injury in the elderly population and the utility of continuous renal replacement therapy (CRRT) in its management. While CRRT is frequently applied in younger patients, its use in elderly..
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