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Cardiology / Original Article
Detection rate by time period and predictors of serious arrhythmias in unexplained syncope: a multicenter implantable loop recorder registry study
Juwon Kim, Il-Young Oh, Myung-Jin Cha, Jinhee Ahn, So-Ryoung Lee, Sung Ho Lee, Jae-Sun Uhm, Pil-Sung Yang, Jaemin Shim, Hyoung-Seob Park, Junbeom Park, Jun Hyung Kim, Ki-Hun Kim, Jumsuk Ko, Hong Euy Lim, Ju Youn Kim
Korean J Intern Med. 2025;40(4):616-625. Published online July 1, 2025
Background/Aims: Although an implantable loop recorder (ILR) is a valuable tool for investigation of unexplained syncope, there are limited data regarding time course to diagnosis and predictors of serious arrhythmias as a cause of unexplained syncope. We sought to investigate diagnosis rate by time..
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Gastroenterology / Original Article
Submucosal saline injection and mini-probe endoscopic ultrasound to assess endoscopic resectability of colorectal subepithelial tumors
Jung-Bin Park, Ji Eun Baek, June Hwa Bae, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Dong-Hoon Yang
Korean J Intern Med. 2025;40(4):592-605. Published online July 1, 2025
Background/Aims: This study aimed to evaluate the feasibility and outcomes of mini-probe endoscopic ultrasound (mEUS) followed by submucosal saline injection (SSI-mEUS) for assessing the endoscopic resectability of colorectal subepithelial lesions (SELs).
Methods: From January 2020 to December 2023..
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Gastroenterology / Original Article
Distinct microbial signatures of liquid biopsy samples during gastric carcinogenesis and insights from extracellular vesicle analysis
Hee Sang You, Jae Yong Park, Hochan Seo, Beom Jin Kim, Jae Gyu Kim
Korean J Intern Med. 2025;40(4):571-583. Published online July 1, 2025
Background/Aims: The early detection of gastric cancer is crucial for improving patient outcomes. However, its pathogenesis is not fully understood. The microbiome and extracellular vesicles (EVs) might play a role in gastric carcinogenesis. We aimed to identify gastric-carcinogenesis-associated mic..
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Nephrology / Review
Clinical benefits and future directions of medium cut-off membranes in hemodialysis: a comprehensive review
Hyo Jin Kim, Sang Heon Song
Korean J Intern Med. 2025;40(4):557-570. Published online July 1, 2025
Medium cut-off (MCO) membranes have emerged as a promising innovation in hemodialysis (HD), offering enhanced clearance of large middle-molecules of uremic toxins compared to traditional HD membranes, while maintaining minimal loss of albumin. The introduction of MCO membranes represents a significa..
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Pulmonology / Review
Updates on lung cancer screening for early detection
Se Hyun Kwak, Chi Young Kim, Sang Hoon Lee, Eun Young Kim, Eun Hye Lee, Yoon Soo Chang
Korean J Intern Med. 2025;40(4):546-556. Published online July 1, 2025
This review examines the current status and recent progress in lung cancer screening programs, focusing on low-dose computed tomography (LDCT) and emerging liquid biopsy technologies. In Korea, the National Lung Cancer Screening Program has shown promising results in reducing lung cancer mortality s..
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Allergy / Original Article
Comparison of extrafine and non-extrafine inhaled corticosteroids/long-acting β2-agonists as maintenance and reliever therapy in asthma: a randomized open-label crossover trial
Sang Pyo Lee, Sang Min Lee, Sung-Yoon Kang
Korean J Intern Med. 2025;40(3):491-501. Published online April 30, 2025
Background/Aims: Asthma is characterized by chronic inflammation. Inhaled corticosteroids (ICS) remain the cornerstone of anti-inflammatory therapy, targeting both the large and small airways.
Methods: This randomized open-label crossover trial included 30 patients receiving step 3 inhaled medicati..
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Infectious diseases / Original Article
Clinical approach to sexually transmitted infections and pelvic inflammatory disease in women with acute pyelonephritis
Mi-Hee Kim, Hyojin Ahn, Soyeon Kang, Ahra Lee, Seong-Heon Wie
Korean J Intern Med. 2025;40(3):482-490. Published online April 30, 2025
Background/Aims: This study aimed to investigate co-occurrence and clinical characteristics of sexually transmitted infections (STIs) and pelvic inflammatory disease (PID) in women hospitalized for acute pyelonephritis (APN).
Methods: This single-center retrospective study reviewed medical records ..
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Cardiology / Original Article
Short-term effects of PCSK-9 inhibitors on percutaneous coronary intervention in patients with acute coronary syndrome
Dong Hyun Gim, In Young Choi, Young-Jae Ki, Hyun Kuk Kim, Sung Soo Kim, Keun-Ho Park, Heesang Song, Dong-Hyun Choi
Korean J Intern Med. 2025;40(3):438-448. Published online April 30, 2025
Background/Aims: Proprotein-converting enzyme subtilisin-kexin type 9 (PCSK9) inhibitors act more promptly and efficiently than statins and reduce the risk of cardiovascular events in patients with acute coronary syndrome (ACS). This study aimed to assess the short-term effects of perioperative admi..
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Gastroenterology / Original Article
Endoscopic features of cytomegalovirus disease of the upper gastrointestinal tract between transplant and non-transplant patients
Yuri Kim, Do Hoon Kim, Myeongsook Seo, Hee Kyong Na, Kee Wook Jung, Ji Yong Ahn, Jeong Hoon Lee, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Korean J Intern Med. 2025;40(3):394-403. Published online March 25, 2025
Background/Aims: Cytomegalovirus (CMV) disease in the upper gastrointestinal (UGI) tract frequently occurs in immunocompromised patients. However, data regarding UGI CMV disease in non-transplant patients compared with those in transplant recipients are limited. Therefore, we compared the clinical c..
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Hemato-oncology / Review
Follicular lymphoma: contemporary clinical management with a focus on recent therapeutic advances
Robert Kridel
Korean J Intern Med. 2025;40(3):371-393. Published online February 21, 2025
Follicular lymphoma (FL) is the most common type of indolent lymphoma, and the prognosis is favorable for most patients. However, FL remains generally incurable, and relapse is common. Patients are at risk of developing treatment-resistant lymphoma, particularly when early disease progression occurs..
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Gastroenterology / Review
Herpes zoster infection in patients with inflammatory bowel disease
Dong Hyun Kim, Sang-Bum Kang
Korean J Intern Med. 2025;40(3):347-356. Published online April 30, 2025
Patients with inflammatory bowel disease (IBD) are at increased risk of herpes zoster (HZ), particularly those receiving immunosuppressive treatments such as corticosteroids, thiopurines, and biologics, which elevate the likelihood of varicella-zoster virus reactivation. Despite this, vaccination ra..
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Nephrology / Original Article
Predicting renal function using fundus photography: role of confounders
Hyun-Woong Park, Hae Ri Kim, Ki Yup Nam, Bum Jun Kim, Taeseen Kang
Korean J Intern Med. 2025;40(2):310-320. Published online March 1, 2025
Background/Aims: The kidneys and retina are highly vascularized organs that frequently exhibit shared pathologies, with nephropathy often associated with retinopathy. Previous studies have successfully predicted estimated glomerular filtration rates (eGFRs) using fundus photographs. We evaluated the..
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Pulmonology / Original Article
Impact of tracheostomy on clinical outcomes in ventilated patients with severe pneumonia: a propensity-matched cohort study
Hayoung Seong, Hyojin Jang, Wanho Yoo, Saerom Kim, Soo Han Kim, Kwangha Lee
Korean J Intern Med. 2025;40(2):286-298. Published online March 1, 2025
Background/Aims: Tracheostomy is a crucial intervention for severe pneumonia patients requiring prolonged mechanical ventilation (MV). However, debate persists regarding the influence of tracheostomy timing and performance on long-term survival outcomes. This study utilized propensity score matching..
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Cardiology / Original Article
Explainable paroxysmal atrial fibrillation diagnosis using an artificial intelligence-enabled electrocardiogram
Yeongbong Jin, Bonggyun Ko, Woojin Chang, Kang-Ho Choi, Ki Hong Lee
Korean J Intern Med. 2025;40(2):251-261. Published online February 21, 2025
Background/Aims: Atrial fibrillation (AF) significantly contributes to global morbidity and mortality. Paroxysmal atrial fibrillation (PAF) is particularly common among patients with cryptogenic strokes or transient ischemic attacks and has a silent nature. This study aims to develop reliable artifi..
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Nephrology / Review
Glial cell line-derived neurotrophic factor and its role in attenuating renal fibrosis: a review
Yousuf Abdulkarim Waheed, Wokuheleza Buberwa, Dong Sun
Korean J Intern Med. 2025;40(2):219-229. Published online December 13, 2023
Chronic kidney disease is estimated to affect approximately 10 to 15% of the Chinese population. Renal fibrosis is characterized by progressive extracellular matrix deposition in the kidney parenchyma with eventual tissue scarring and inevitable deterioration of renal function. Vascular rarefaction,..
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Gastroenterology / Review
Role of endoscopic ultrasound in the diagnosis and local ablative therapy of pancreatic neuroendocrine tumors
Yun Je Song, Jun Kyeong Lim, Jun-Ho Choi
Korean J Intern Med. 2025;40(2):170-180. Published online February 25, 2025
Advancements in diagnostic technology have led to the improved detection of pancreatic neuroendocrine tumors (PNETs) and thus to an increase in the number of reported cases. Endoscopic ultrasound (EUS) technology, including in combination with contrast-enhanced harmonic imaging, aids in distinguishi..
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Hemato-oncology / Original Article
Reduced-intensity chemotherapy with tyrosine kinase inhibitor followed by allogeneic transplantation is effective in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia
Jung Min Lee, Do Young Kim, Hee Jeong Cho, Joon Ho Moon, Sang Kyun Sohn, Ho Jin Shin, Young Rok Do, Mi Hwa Heo, Min Kyoung Kim, Young Seob Park, Dong Won Baek
Korean J Intern Med. 2025;40(1):124-134. Published online January 1, 2025
Background/Aims: To determine the effectiveness of tyrosine kinase inhibitor (TKI) plus reduced-intensity therapy in adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-positive ALL), this retrospective study compared treatment outcomes and induction..
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Hemato-oncology / Original Article
The characteristics of Korean elderly multiple myeloma patients aged 80 years or over
Sang Hwan Lee, Hee-Jeong Cho, Joon Ho Moon, Ji Yoon Jung, Min Kyoung Kim, Mi Hwa Heo, Young Rok Do, Yunhwi Hwang, Sung Hwa Bae
Korean J Intern Med. 2025;40(1):115-123. Published online January 1, 2025
Background/Aims: Multiple myeloma (MM) predominantly affects elderly individuals, but studies on older patients with MM are limited. The clinical characteristics and survival outcomes of patients with MM aged 80 years or over were retrospectively analyzed.
Methods: This retrospective multicenter st..
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Cardiology / Review
Screening and diagnosis of atrial fibrillation using wearable devices
Yoon Jung Park, Myung Hwan Bae
Korean J Intern Med. 2025;40(1):7-14. Published online May 3, 2024
In recent years, the development and use of various devices for the screening of atrial fibrillation (AF) have significantly increased. Such devices include 12-lead electrocardiogram (ECG), photoplethysmography systems, and single-lead ECG and ECG patches. This review outlines several studies that h..
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Geriatrics / Original Article
A link between systemic low-grade inflammation and frailty in older adults: clinical evidence from a nationwide population-based study
Min-gu Kang, Hee-Won Jung, Beom-Jun Kim
Korean J Intern Med. 2024;39(6):1011-1020. Published online July 23, 2024
Background/Aims: Despite the possible role of systemic low-grade inflammation on frailty, the majority of previous studies have focused solely on the phenotypic frailty with limited participant numbers, thereby weakening the evidence supporting the notion that circulating C-reactive protein (CRP) co..
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