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Review
Clinical spectrum and diagnosis of diabetic neuropathies
Jeeyoung Oh
Korean J Intern Med. 2020;35(5):1059-1069. Published online August 28, 2020
Neuropathy is the most prevalent microvascular complication of diabetes mellitus; it encompasses distal symmetric polyneuropathy, autonomic neuropathy, radiculoplexus neuropathy, mononeuropathy, and treatment-induced neuropathy. The prevalence rate of diabetic neuropathy in Korea was reported to be ..
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Review
Proprotein convertase subtilisin/kexin type 9 inhibition in cardiovascular disease: current status and future perspectives
Kyung Hoon Cho, Young Joon Hong
Korean J Intern Med. 2020;35(5):1045-1058. Published online August 28, 2020
Proprotein convertase subtilisin/kexin type 9 (PCSK9) targets the degradation of low-density lipoprotein (LDL) receptors; it has been proved that its inhibition improves cardiovascular outcomes in patients with established atherosclerotic cardiovascular disease (ASCVD). Herein, we review the current..
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Allergy / Original Article
Serum potential biomarkers according to sputum inflammatory cell profiles in adult asthmatics
Gyu-Young Hur, Young-Min Ye, Eunmi Yang, Hae-Sim Park
Korean J Intern Med. 2020;35(4):988-997. Published online November 15, 2019
Background/Aims: Asthma is not a single disease but, rather, a heterogeneous inf lammatory disorder with various pathogenic mechanisms. We analyzed the associations between the cellular profile of sputum and the serum levels of inflammatory mediators/cytokines in a cohort of adult asthmatics.
Metho..
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Pulmonology / Original Article
The effect of susceptibility variants, identified in never-smoking female lung cancer cases, on male smokers
Seung Soo Yoo, Hyo-Gyoung Kang, Jin Eun Choi, Mi Jeong Hong, Sook Kyung Do, Jang Hyuck Lee, Won Kee Lee, Shin Yup Lee, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, Eung Bae Lee, Jae Yong Park
Korean J Intern Med. 2020;35(4):929-935. Published online December 30, 2019
Background/Aims: Genome wide and candidate gene association studies have identified polymorphisms associated with the risk of lung cancer in never-smokers. This study was conducted to evaluate the association between 11 polymorphisms identified in female never smokers and the lung cancer risk in mal..
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Cardiology / Original Article
Hydrochlorothiazide use and the risk of skin cancer in patients with hypertensive disorder: a nationwide retrospective cohort study from Korea
Eunjung Park, Young Lee, Mihn-Sook Jue
Korean J Intern Med. 2020;35(4):917-928. Published online December 18, 2019
Background/Aims: Recent studies have shown a cumulative dose-dependent association between the use of hydrochlorothiazide (HCTZ) and skin cancer, including melanoma and non-melanoma skin cancer (NMSC) in Western Europe. However, whether this pattern is present in East Asia countries is unknown. The ..
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Gastroenterology / Original Article
Adenoma miss rate of polypectomy-referring hospitals is high in Korea
Ju Hyun Seo, Bo-In Lee, Kyungjin Lee, Jae Myung Park, Jin Soo Kim, Young-Seok Cho, Kang-Moon Lee, Sang Woo Kim, Hwang Choi, Myung-Gyu Choi
Korean J Intern Med. 2020;35(4):881-888. Published online October 17, 2019
Background/Aims: We evaluated the miss rates of polyps, adenomas, and advanced neoplasia of polypectomy-referring hospitals and risk factors for missed adenomas.
Methods: We compared medical records and electronic images of initial colonoscopies from polypectomy-referring hospitals with those of corr..
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Gastroenterology / Original Article
A prospective randomized clinical study evaluating the efficacy and compliance of oral sulfate solution and 2-L ascorbic acid plus polyethylene glycol
Ki Hwan Kwon, Ji Ae Lee, Yun Jeong Lim, Beom Jae Lee, Moon Kyung Joo, Yu Ra Sim, Wonjae Choi, Taehyun Kim, Ji Yoon Kim, Ei Rie Cho, Yoon Tae Jeen, Jong-Jae Park
Korean J Intern Med. 2020;35(4):873-880. Published online January 30, 2019
Background/Aims: Oral sulfate solution (OSS) is an emerging cleansing agent for bowel preparation. However, data comparing OSS to other conventional bowel preparations in Asian patients are limited. Therefore, the objective of this study was to compare the efficacy and tolerability of OSS to ascorbi..
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Review
Systemic treatment for advanced urothelial cancer: an update on recent clinical trials and current treatment options
Inkeun Park, Jae Lyun Lee
Korean J Intern Med. 2020;35(4):834-853. Published online July 1, 2020
After cisplatin-based chemotherapy became the standard treatment for metastatic urothelial cancer (mUC), very little progress has been made in the treatment landscape of this condition until recently. With increased knowledge about the molecular biology of mUC and advances in the field of cancer imm..
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Review
Distinct functions of eosinophils in severe asthma with type 2 phenotype: clinical implications
Youngwoo Choi, Soyoon Sim, Hae-Sim Park
Korean J Intern Med. 2020;35(4):823-833. Published online May 29, 2020
Asthma is commonly recognized as a heterogeneous condition with a complex pathophysiology. With advances in the development of multiple medications for patients with asthma, most asthma symptoms are well managed. Nevertheless, 5% to 10% of adult asthmatic patients (called severe asthma) are in uncon..
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Original Article / Brief Communication
Lung ultrasound for early diagnosis and severity assessment of pneumonia in patients with coronavirus disease 2019
[corrected-article]
Young-Jae Cho, Kyoung-Ho Song, Yunghee Lee, Joo Heung Yoon, Ji Young Park, Jongtak Jung, Sung Yoon Lim, Hyunju Lee, Ho Il Yoon, Kyoung Un Park, Hong Bin Kim, Eu Suk Kim
Korean J Intern Med. 2020;35(4):771-781. Published online July 1, 2020
Background/Aims: Current evidence supports lung ultrasound as a point-ofcare alternative diagnostic tool for various respiratory diseases. We sought to determine the utility of lung ultrasound for early detection of pneumonia and for assessment of respiratory failure among patients with coronavirus ..
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Review / Brief Communication
Current laboratory diagnosis of coronavirus disease 2019
Jihyang Lim, Jehoon Lee
Korean J Intern Med. 2020;35(4):741-748. Published online July 1, 2020
Coronavirus disease 2019 (COVID-19) emerged in December 2019 in Wuhan, China; it has since caused a pandemic, with more than 10,000 confirmed cases (> 800,000 tests) in Korea as of May 2020. Real-time reverse transcription polymerase chain reaction (RT-PCR) is currently the most commonly used method..
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Rheumatology / Original Article
Liver enzyme elevation in patients with ankylosing spondylitis treated with tumor necrosis factor inhibitors: a single-center historical cohort study
Su Jin Choi, Ji Seon Oh, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Yong-Gil Kim
Korean J Intern Med. 2020;35(3):723-731. Published online December 26, 2019
Background/Aims: Tumor necrosis factor inhibitors (TNFi) have been known to induce liver enzyme elevation, sometimes associated with viral reactivation or toxic hepatitis. We evaluated the incidence and risk factors of TNFi-associated liver enzyme elevation in Korean ankylosing spondylitis (AS) pati..
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Hemato-oncology / Original Article
Prominent seasonal variation in pulmonary embolism than deep vein thrombosis incidence: a Korean venous thrombosis epidemiology study
Junshik Hong, Ju Hyun Lee, Ji Yun Lee, Jeong-Ok Lee, Won-Il Choi, Soyeon Ahn, Youn-Hee Lim, Soo-Mee Bang, Doyeun Oh
Korean J Intern Med. 2020;35(3):682-691. Published online October 25, 2019
Background/Aims: Seasonal variation is an environmental factor proposed to affect the incidence of venous thromboembolism (VTE). However, VTE seasonal variation is not well studied in Asian populations, which have different genetic determinants of VTE compared to Westerners. The present study aimed ..
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Gastroenterology / Original Article
Prognostic impact of hepatitis B or C on intrahepatic cholangiocarcinoma
Jung Woong Seo, Byung Soo Kwan, Young Koog Cheon, Tae Yoon Lee, Chan Sup Shim, So Young Kwon, Won Hyeok Choe, Byung Chul Yoo, Jeong Min Yoon, Jung Hoon Lee
Korean J Intern Med. 2020;35(3):566-573. Published online January 10, 2020
Background/Aims: Intrahepatic cholangiocarcinoma (ICC) is the second-most common primary liver malignancy, arising from the peripheral intrahepatic bile duct epithelium. Hepatitis B virus (HBV) or hepatitis C virus (HCV) may be involved in the development of ICC. We explored the prognostic value of ..
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Gastroenterology / Original Article
Clinical correlation between serum pepsinogen level and gastric atrophy in gastric neoplasm
Jae Hwang Cha, Jin Seok Jang
Korean J Intern Med. 2020;35(3):550-558. Published online November 7, 2018
Background/Aims: The relationship between the serum pepsinogen (sPG) level and changes in gastric mucosa has been well studied. Here, we evaluated the usefulness of sPG (I, II, I/II ratio) and intragastric pH as a biomarker of severe gastric atrophy in gastric neoplastic lesions.
Methods: A total of..
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Review
Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs
Tae Young Park, Hyoung-Chul Oh, Evan L. Fogel, Glen A. Lehman
Korean J Intern Med. 2020;35(3):535-543. Published online April 29, 2020
Acute pancreatitis is the most common and feared adverse event associated with performance of endoscopic retrograde cholangiopancreatography (ERCP). Unremitting effort has been made for over 40 years to minimize the frequency and severity of this complication. Recently, the use of rectal non-steroid..
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Rheumatology / Original Article
Effect of biologics in the level of cytokines in the synovial fluid of patients with ankylosing spondylitis
Bon San Koo, Sungsin Jo, Eunji Kwon, Ji Hui Shin, Jin-Wuk Hur, Tae-Hwan Kim
Korean J Intern Med. 2020;35(2):465-473. Published online December 16, 2019
Background/Aims: Biologics are very effective drugs for patients with ankylosing spondylitis (AS). However, there are patients who are not responding to biologics. This study aimed to evaluate the level of tumor necrosis factor α (TNF-α), interleukin (IL)-23, and IL-17 from synovial fluid in patie..
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Allergy / Original Article
Association between primary immunodeficiency and asthma exacerbation in adult asthmatics
So-Hee Lee, Ga-Young Ban, Su-Chin Kim, Chang-Gyu Chung, Hyun-Young Lee, Ji-Ho Lee, Hae-Sim Park
Korean J Intern Med. 2020;35(2):449-456. Published online June 14, 2019
Background/Aims: Primary immunodef iciency (PID) is a serious comorbid condition in adult asthmatics that have frequent exacerbations, which requires monthly replacement of intravenous immunoglobulin (IVIG). However, the prevalence and clinical significance of PID in adult asthmatics in Korea have n..
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Infectious diseases / Original Article
Diagnostic usefulness of the cytomegalovirus (CMV)-specific T cell-based assay for predicting CMV infection after kidney transplant
Taeeun Kim, Hyun-Jeong Lee, Sun-Mi Kim, Joo Hee Jung, Sung Shin, Young-Hoon Kim, Heungsup Sung, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim, Duck Jong Han
Korean J Intern Med. 2020;35(2):438-448. Published online June 7, 2018
Background/Aims: We evaluated the usefulness in kidney transplant (KT) candidates of cytomegalovirus (CMV)-specific enzyme-linked immunospot (ELISPOT) assays for predicting the development of post-transplant CMV infections.
Methods: All adult recipients admitted for living-donor KT between March 20..
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Hemato-oncology / Original Article
Prognostic implications of stromal hyaluronic acid protein expression in resected oropharyngeal and oral cavity cancers
Der Sheng Sun, Hye Sung Won, Soon Auck Hong, Ji Hyung Hong, Heejoon Jo, Heejin Lee, Okran Kim, Myung Ah Lee, Yoon Ho Ko
Korean J Intern Med. 2020;35(2):408-420. Published online July 29, 2019
Background/Aims: Hyaluronic acid (HA) regulates cell adhesion, migration and proliferation in various cancers. The clinical implications of HA in resected head and neck squamous cell carcinoma have not been elucidated. We investigated the clinical significance and prognostic value of the expression ..
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