| Editorials |
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Cardiology / Editorial
Hidden benefits beyond herpes zoster: a potential preventive strategy against hepatobiliary diseases
Dong Wook Kim, Tae Jun Song
Korean J Intern Med. 2025;40(5):691-692. Published online August 29, 2025
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| Reviews |
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Cardiology / Review
Physical activity for prevention of cardiovascular disease: consensus statement of Korean Society of Cardio-cerebrovascular Disease Prevention
Ye Seul Yang, Eu Jeong Ku, Seung-Hyun Ko, Eun-Jung Rhee, Sang-Hyun Ihm, Sung Hee Choi, Won-Young Lee; on Behalf of Committee of Clinical Practice Guideline; Korean Society of Cardio-cerebrovascular Disease Prevention
Korean J Intern Med. 2025;40(5):696-709. Published online August 29, 2025
Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, highlighting the need for effective preventive strategies. This consensus statement emphasizes the critical role of regular physical activity, including aerobic and muscle-strengthening exercises, in reducing key CVD risk..
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Pulmonology / Review
Diagnostic approach for incidental pulmonary nodules
SeungYong Park, Seoung Ju Park
Korean J Intern Med. 2025;40(5):710-724. Published online August 26, 2025
Lung cancer remains a leading cause of cancer-related mortality worldwide and is often diagnosed at an advanced stage, with poor survival outcomes. Early detection and appropriate management of incidental pulmonary nodules, frequently identified through low-dose computed tomography screening, are cr..
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Infectious diseases / Review
Appropriate timing of antibiotic initiation in patients with sepsis or septic shock: a systematic review and meta-analysis
Nam Su Ku, Yongseop Lee, Dae Won Park
Korean J Intern Med. 2025;40(5):725-733. Published online August 26, 2025
Evidence supporting antibiotic administration within 3 hours in sepsis without shock is limited. Therefore, we conducted a systematic review and meta-analysis to determine whether the timing of antibiotic initiation influences mortality in patients with sepsis or septic shock. We comprehensively searched Pub..
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| Original Articles |
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Gastroenterology / Original Article
Predicted pro-inflammatory high-sensitivity C-reactive protein score and inflammatory bowel disease: a cross-sectional study
Dong Hyun Kim, Akinkunmi Paul Okekunle, Jioh Kang, Hyun-Soo Kim, Sang Hoon Kim, Min Kyu Jung, Jae Ho Park, Soo Young Na, Hoonjai Chun, Jung Eun Lee, Yun Jeong Lim
Korean J Intern Med. 2025;40(5):734-746. Published online July 17, 2025
Background/Aims: The role of pro-inflammatory factors in the pathogenesis of inflammatory bowel diseases (IBD), is not well understood. This study investigated the association between the predicted pro-inflammatory high-sensitivity C-reactive protein (hs-CRP) score and IBD.
Methods: This study invo..
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Gastroenterology / Original Article
Live zoster vaccination and hepatobiliary risk reduction: a nationwide South Korean study
Junyeol Kim, Kyeongmin Lee, Jiyeon Oh, Hayeon Lee, Jong-In Chang, Tae Young Park, Dong Keon Yon, Hyoung-Chul Oh
Korean J Intern Med. 2025;40(5):747-758. Published online August 29, 2025
Background/Aims: Herpes zoster (HZ) vaccination is primarily administered to prevent shingles, yet its systemic immunomodulatory effects may offer protection against other organ-related diseases, including hepatobiliary and pancreatic diseases. Therefore, this emulated target trial aimed to evaluate..
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Cardiology / Original Article
Effect of tegoprazan on temporal variability of platelet reactivity in patients treated with clopidogrel after coronary stenting
Oh-Hyun Lee, Ji Woong Roh, Yongcheol Kim, Eui Im, Deok-Kyu Cho
Korean J Intern Med. 2025;40(5):759-766. Published online March 25, 2025
Background/Aims: Data on the interactions between clopidogrel and tegoprazan are limited. We compared the effects of tegoprazan and proton-pump inhibitors (PPIs) on platelet reactivity.
Methods: Using database data from March 2020 to January 2023, we retrospectively evaluated 262 patients who were ..
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Cardiology / Original Article
Automatic quantitative analysis of atherosclerotic aortic plaques in patients with embolic cerebral infarction using deep learning
Hye Jin Bang, Jae-Hyeong Park, Sun Geu Chae, Suk Joo Bae, Ji-Hoon Jung, You Hee Cho, Jong Won Park, Dae-Won Kim, Jung Sun Cho
Korean J Intern Med. 2025;40(5):767-779. Published online August 26, 2025
Background/Aims: Transesophageal echocardiography (TEE) is a commonly used imaging modality for assessing embolic stroke of undetermined source (ESUS) in clinical practice. We aimed to develop an automatic plaque segmentation model based on U-net and evaluate its clinical usefulness in patients with..
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Cardiology / Original Article
Impact of guideline-directed medical therapy on the cardiac or non-cardiac death in acute myocardial infarction
Jin-Ho Choi, Dahee Hyun, Seung Ho Hur, Seung Woon Rha, Seung Jae Joo, Hyo-Soo Kim, Myung Ho Jeong; on behalf of KAMIR-NIH investigators
Korean J Intern Med. 2025;40(5):780-789. Published online August 29, 2025
Background/Aims: While the clinical effectiveness of guideline-directed medical therapy (GDMT) is well established in patients with acute myocardial infarction (AMI), its specific impact on cause-specific mortality remains unclear. This study aimed to investigate the impact of GDMT on both cardiac a..
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Pulmonology / Original Article
Efficacy and safety of HL-301 compared with erdosteine in acute bronchitis: a randomized, double-blind, non-inferiority trial
Ji-Yong Moon, Joon Young Choi, Youlim Kim, Hye Jung Park, Yong Bum Park, Seong Yong Lim, Kyung Hoon Min, Deog Kyeom Kim, Chin Kook Rhee, Seung Won Ra, Chang Youl Lee, Yong Il Hwang, Kwang Ha Yoo
Korean J Intern Med. 2025;40(5):790-800. Published online August 26, 2025
Background/Aims: This study evaluated the non-inferiority of HL-301 to erdosteine in terms of symptom relief and the anti- inflammatory effects in acute bronchitis patients not treated with antibiotics.
Methods: In a double-blind, non-inferiority trial, patients were randomized 1:1 to receive eithe..
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Pulmonology / Original Article
The early impact of COVID-19 vaccines on major events in cardiac, pulmonary, and thromboembolic disease: a population-based study
Myeong Geun Choi, Min-Ho Kim, Eun Mi Chun
Korean J Intern Med. 2025;40(5):801-812. Published online August 26, 2025
Background/Aims: Although COVID-19 vaccines reduce COVID-19 severity, various safety concerns have emerged. This study, involving a population-based cohort, used health insurance data to investigate potential vaccine-related major outcomes, including cardiac, pulmonary, and thromboembolic diseases.
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Endocrinology-metabolism / Original Article
Association between metabolic dysfunction-associated steatotic liver disease and the risk of thyroid cancer: a nationwide cohort study
Jeongmin Lee, Jeongeun Kwak, Min-Hee Kim, Seung-Hwan Lee, Jae-Hyoung Cho, Dong-Jun Lim, Jung Min Lee, Sang-Ah Chang, Hun-Sung Kim
Korean J Intern Med. 2025;40(5):813-822. Published online August 26, 2025
Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with various metabolic disorders; however, its relationship with thyroid cancer remains unclear. This study investigated the association between MASLD and the risk of thyroid cancer.
Methods: This retros..
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Nephrology / Original Article
Association of kidney function and proteinuria with lower-extremity dysfunction in older Korean adults: a cross-sectional study
Bongjo Kim, Eun-Bin Lim, Young Sang Lyu, Minkook Son, Youngmin Yoon
Korean J Intern Med. 2025;40(5):823-834. Published online July 25, 2025
Background/Aims: Chronic kidney disease (CKD) is associated with complications that affect physical function and mobility. This study investigated the associations between kidney function, proteinuria, and lower-extremity dysfunction.
Methods: Data were obtained from the Korean National Health Insu..
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Rheumatology / Original Article
Factors influencing delayed attainment of low disease activity in rheumatoid arthritis patients continuing targeted therapy
Yeo-Jin Song, Soo-Kyung Cho, Se Rim Choi, Shin-Seok Lee, Hye-Soon Lee, Sung-Hoon Park, Yeon-Ah Lee, Min-Chan Park, Hyoun-Ah Kim, Soo-Bin Lee, Ha-Rim Park, Eunwoo Nam, Yoon-Kyoung Sung
Korean J Intern Med. 2025;40(5):835-844. Published online August 29, 2025
Background/Aims: To identify factors associated with achieving low disease activity (LDA) after 48 weeks of targeted therapy in patients with rheumatoid arthritis (RA) despite not meeting treat-to-target (T2T) criteria at week 24.
Methods: Data were collected from a multicenter, prospective observa..
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Rheumatology / Original Article
Comprehensive analysis of patients with rheumatoid arthritis associated interstitial lung disease
Ji-Won Kim, Ju-Yang Jung, Chang-Hee Suh, Hyoun-Ah Kim
Korean J Intern Med. 2025;40(5):845-855. Published online August 26, 2025
Background/Aims: To investigate the demographics, disease characteristics, and treatment modalities of patients with rheumatoid arthritis (RA) associated interstitial lung disease (ILD), focusing on ILD exacerbation and mortality.
Methods: This retrospective study included individuals aged ≥ 18 y..
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| Images of interest |
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Nephrology / Image of interest
Findings suggestive of Fanconi syndrome and multiple myeloma
Hwa-Young Lee, Sung Gyul Lim, Han Sang Lee, Won-Ae Lee, So Mi Kim
Korean J Intern Med. 2025;40(5):856-857. Published online July 17, 2025
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Nephrology / Image of interest
Leiomyosarcoma at popliteal vein presented as unilateral leg edema in a patient with kidney transplantation
Sang Heon Song
Korean J Intern Med. 2025;40(5):858-859. Published online August 26, 2025
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