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Nephrology
Nicotine exacerbates tacrolimus-induced renal injury by programmed cell death
Yu Ji Jiang, Sheng Cui, Kang Luo, Jun Ding, Qi Yan Nan, Shang Guo Piao, Mei Ying Xuan, Hai Lan Zheng, Yong Jie Jin, Ji Zhe Jin, Jung Pyo Lee, Byung Ha Chung, Bum Soon Choi, Chul Woo Yang, Can Li
Korean J Intern Med. 2021;36(6):1437-1449. Published online October 21, 2021
Background/Aims: Cigarette smoking is an important modifiable risk factor in kidney disease progression. However, the underlying mechanisms for this are lacking. This study aimed to assess whether nicotine (NIC), a major toxic component of cigarette smoking, would exacerbates tacrolimus (TAC)-induce..
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The therapeutic efficacy of water-soluble coenzyme Q10 in an experimental model of tacrolimus-induced diabetes mellitus
Yi Quan, Kang Luo, Sheng Cui, Sun Woo Lim, Yoo Jin Shin, Eun Jeong Ko, Ju Hwan Kim, Sang J. Chung, Soo Kyung Bae, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2020;35(6):1443-1456. Published online April 14, 2020
Background/Aims: Coenzyme Q10 (CoQ10) has antioxidant effects and is commercially available and marketed extensively. However, due to its low bioavailability, its effects are still controversial. We developed a water-soluble CoQ10-based micelle formulation (CoQ10-W) ..
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Assessment of nephrotoxicity of herbal medicine containing aristolochic acid in mice
Yi Quan, Long Jin, Kang Luo, Jian Jin, Sun Woo Lim, Yoo Jin Shin, Eun Jeong Ko, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2020;35(2):400-407. Published online November 21, 2019
Background/Aims: It is undetermined if herbal medicines (HM) containing aristolochic acid (AA)-containing have similar nephrotoxicity to AA itself.
Methods: We administered HM containing a high concentration of AA for 5 days (short-term study) or a low concentration of AA for 30 days (long-term stu..
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Shen-Kang protects against tacrolimus-induced renal injury
Long Ye Zhang, Jian Jin, Kang Luo, Shang Guo Piao, Hai Lan Zheng, Ji Zhe Jin, Sun Woo Lim, Bum Soon Choi, Chul Woo Yang, Can Li
Korean J Intern Med. 2019;34(5):1078-1090. Published online February 12, 2018
Background/Aims: Evidence suggests that Shen-Kang (SK), a traditional Chinese herbal medicine, protects against various types of renal injury. In this study, we evaluated whether SK treatment confers renoprotection in a rat model of chronic tacrolimus (TAC) nephropathy.
Methods: Rats were treated d..
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Paricalcitol attenuates indoxyl sulfate-induced apoptosis through the inhibition of MAPK, Akt, and NF-kB activation in HK-2 cells
Jung Sun Park, Hoon In Choi, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Korean J Intern Med. 2019;34(1):146-155. Published online October 10, 2017
Background/Aims: Indoxyl sulfate (IS) is a uremic toxin and an important causative factor in the progression of chronic kidney disease. Recently, paricalcitol (19-nor-1,25-dihydroxyvitamin D2) was shown to exhibit protective effects in kidney injury. Here, we investigated the effects of paricalcitol..
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Pulmonology
Combination of carboplatin and intermittent normobaric hyperoxia synergistically suppresses benzo[a]pyrene-induced lung cancer
Hea Yon Lee, In Kyoung Kim, Hye In Lee, Hwa Young Lee, Hye Seon Kang, Chang Dong Yeo, Hyun Hui Kang, Hwa Sik Moon, Sang Haak Lee
Korean J Intern Med. 2018;33(3):541-551. Published online December 15, 2017
Background/Aims: We explored the effects of intermittent normobaric hyperoxia alone or combined with chemotherapy on the growth, general morphology, oxidative stress, and apoptosis of benzo[a]pyrene (B[a]P)-induced lung tumors in mice.
Methods: Female A/J mice were given a single dose of B[a]P and ..
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Gastroenterology
Expression of procaspase 3 and activated caspase 3 and its relevance in hormone-responsive gallbladder carcinoma chemotherapy
Sanjeev Kumar Maurya, Mallika Tewari, Bechan Sharma, Hari Shanker Shukla
Korean J Intern Med. 2013;28(5):573-578. Published online August 14, 2013
Background/AimsThe higher incidence of gallbladder cancer (GBC) in females has been accredited to the involvement of hormones. The clinical implications of sex hormone receptors in GBC are well established. Cysteine proteases (such as caspase-3-9, etc.) are known to play a cen..
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Pretreatment with Darbepoetin Attenuates Renal Injury in a Rat Model of Cisplatin-Induced Nephrotoxicity
Dae Eun Choi, Jin Young Jeong, Beom Jin Lim, Kang Wook Lee, Young-Tai Shin, Ki-Ryang Na
Korean J Intern Med. 2009;24(3):238-246. Published online August 26, 2009
Background/AimsDarbepoetin alfa (DPO) exhibits comparable renoprotective effects to erythropoietin (EPO) in several animal models of acute renal injury. We examined whether DPO also attenuated renal injury in a rat model of cisplatin nephrotoxicity. Method.. </div>
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<a class="artiletitle" href="/journal/view.php?number=162325" onmouseover="showAbstract('162325' );" onmouseout="hideAbstract('162325' );"><b><font>Cilostazol Protects Endothelial Cells Against Lipopolysaccharide-Induced <font style='background-color:#CCE4CB'>Apoptosis</font> Through ERK1/2- and P38 MAPK-Dependent Pathways</font></b></a>
<div style="padding-top:2px;padding-left:0px" class="article_authors">Jong-Hoon Lim, Jae-Suk Woo, Yung-Woo Shin</div>
<div style="padding-top:2px;padding-left:0px" class="article_issue">
<em>Korean J Intern Med.</em> 2009;24(2):113-122. Published online June 8, 2009 </div>
<div class="doi">DOI: <a href="https://doi.org/10.3904/kjim.2009.24.2.113"><font class="doi">https://doi.org/10.3904/kjim.2009.24.2.113</font></a>
<a href="/journal/CitedByRenew.php?number=162325" onclick="window.open(this.href, 'CrossRef Citedby', 'width=800,height=800,scrollbars=yes');return false;" style="color:#DD434F;font-size:10pt;"> Crossref 24</a>
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<a href='/journal/view.php?number=162325' style='text-decoration:underline;color:#2046f8'><img src='/image/button/fulltext.gif' alt='Full Text' /></a> <a href='/journal/view.php?viewtype=pubreader&number=162325' style='text-decoration:underline;color:#2046f8'><img src='/image/button/pubreader.gif' alt='PubReader' /></a> <a style='cursor: pointer;' onclick='journal_download("epub", "162325", "path=L2hvbWUvdmlydHVhbC9rYWltL2pvdXJuYWwvdXBsb2FkL2VwdWIva2ppbS0yNC0xMTMuZXB1Yg==&filename=a2ppbS0yNC0xMTMuZXB1Yg==")'><img src='/image/button/epub.gif' alt='ePub' /></a> <a style='cursor: pointer;' onclick='journal_download("pdf", "162325", "kjim-24-113.pdf")'><img src='/image/button/pdf.gif' alt='PDF' /></a> </div>
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<sec><title>Background/AimsWe examined the effects of cilostazol on mitogen-activated protein kinase (MAPK) activity and its relationship with cilostazol-mediated protection against apoptosis in lipopolysaccharide (LPS)-treated endothelial cells. MethodsHum..
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Expression of c-FLIP in Gastric Cancer and its Relation to Tumor Cell Proliferation and Apoptosis
Dae-Yeul Ryang, Young-Eun Joo, Kyoung-Myeun Chung, Sung-Ryoun Lim, Hye-Kyong Jeong, Hyung-Il Kim, Wan-Sik Lee, Chang-Hwan Park, Hyun-Soo Kim, Sung-Kyu Choi, Jong-Sun Rew, Jae-Hyuk Lee, Chang-Soo Park
Korean J Intern Med. 2007;22(4):263-269. Published online December 20, 2007
BackgroundThe expression of c-FLIP (cellular Fas-associated death domain-like interleukin-1 β-converting enzyme (FLICE)-inhibitory protein), which is a member of the family of inhibitors of apoptosis, has been associated with tumor development and progression. The aim of thi..
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