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Rheumatology
Incidence and prevalence of seropositive rheumatoid arthritis among Korean women of childbearing age: a nationwide population-based study
Min Kyung Chung, Chan Hee Lee, Jin Su Park, Hyun Sun Lim, Jisoo Lee
Korean J Intern Med. 2023;38(1):125-133. Published online May 19, 2022
Background/Aims: Women with rheumatoid arthritis (RA) are often diagnosed with the disease during their reproductive years; however, its incidence and prevalence among women of childbearing age have not been studied. The objective of this study was to estimate the incidence and prevalence of seropos..
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Prevalence, incidence, and risk factors of malignancy in patients with rheumatoid arthritis: a nationwide cohort study from Korea
Kyung Min Ko, Su-Jin Moon
Korean J Intern Med. 2023;38(1):113-124. Published online August 20, 2021
Background/Aims: This study aims to evaluate the incidence of malignancy in patients with rheumatoid arthritis (RA) and to investigate risk factors for such in a nationwide, population-based cohort.
Methods: In a large, prospective, observational cohort study, 5,077 patients with RA were enrolled f..
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Two-year clinical outcomes after discontinuation of long-term golimumab therapy in Korean patients with rheumatoid arthritis
Kichul Shin, Hyun Mi Kwon, Min Jung Kim, Myung Jae Yoon, Hyun Gyung Chai, Seong-Wook Kang, Won Park, Sung-Hwan Park, Chang Hee Suh, Hyun Ah Kim, Seung-Geun Lee, Choong Ki Lee, Sang-Cheol Bae, Yong-Beom Park, Yeong Wook Song
Korean J Intern Med. 2022;37(5):1061-1069. Published online December 13, 2021
Background/Aims: The aim of this study was to investigate long-term post-discontinuation outcomes in patients with rheumatoid arthritis (RA) who had been treated with tumor necrosis factor-α inhibitors (TNF-αi) which was then discontinued.
Methods: Sixty Korean patients with RA who participated i..
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Perioperative and anesthetic management of patients with rheumatoid arthritis
Hae-Rim Kim, Seong-Hyop Kim
Korean J Intern Med. 2022;37(4):732-739. Published online June 3, 2022
Our understanding and management of rheumatoid arthritis (RA) have greatly improved, but perioperative and anesthetic management remain challenging. RA is not limited to joints; systemic evaluation is thus required when planning perioperative management. Especially, careful airway evaluation is need..
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Rheumatology
Trends in hospital visits and healthcare costs of gout and seropositive rheumatoid arthritis in Korea from 2010 to 2017 using National Healthcare Claims
Kyeong Min Son, Ju-Ryoung Kim, Hang A Park, Hyun Ah Kim
Korean J Intern Med. 2022;37(3):681-690. Published online October 26, 2021
Background/Aims: We examined temporal trends in the rate of gout and seropositive rheumatoid arthritis (RA) hospital visits and healthcare costs in Korea.
Methods: We conducted a serial cross-sectional analysis of Korean national healthcare claims. We calculated the annual increase in hospital visi..
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Metformin and its therapeutic applications in autoimmune inflammatory rheumatic disease
Ji-Won Kim, Jung-Yoon Choe, Sung-Hwan Park
Korean J Intern Med. 2022;37(1):13-26. Published online December 10, 2021
Metformin is a first-line therapeutic agent for type 2 diabetes. Apart from its glucose- lowering effect, metformin is attracting interest regarding possible therapeutic benefits in various other conditions. As metformin regulates cell metabolism, proliferation, growth, and autophagy, it may also mo..
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Rheumatology
Developing the Korean Educational Needs Assessment Tool (Korean ENAT) in rheumatoid arthritis: cross-cultural validation using Rasch analysis
Yoon-Kyoung Sung, Hyoungyoung Kim, Sung Joo Cha, Sae-Hyung Kim, Mwidimi Ndosi, Soo-Kyung Cho
Korean J Intern Med. 2021;36(4):1014-1022. Published online October 30, 2020
Background/Aims: This study was performed to undertake cross-cultural adaptation and validation of the Educational Needs Assessment Tool (ENAT) in rheumatoid arthritis (RA) for use in Korea.
Methods: The study involved two main phases: cross-cultural adaptation of the ENAT from English into Korean,..
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Effect of biologics in the level of cytokines in the synovial fluid of patients with ankylosing spondylitis
Bon San Koo, Sungsin Jo, Eunji Kwon, Ji Hui Shin, Jin-Wuk Hur, Tae-Hwan Kim
Korean J Intern Med. 2020;35(2):465-473. Published online December 16, 2019
Background/Aims: Biologics are very effective drugs for patients with ankylosing spondylitis (AS). However, there are patients who are not responding to biologics. This study aimed to evaluate the level of tumor necrosis factor α (TNF-α), interleukin (IL)-23, and IL-17 from synovial fluid in patie..
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Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity
Kichul Shin, Sung Soo Kim, Sang-Heon Lee, Seung-Jae Hong, Sung Jae Choi, Jung-Yoon Choe, Seung-Geun Lee, Hoon-Suk Cha, Eun Young Lee, Sung-Hwan Park, Jin-Wuk Hur, Sung Soo Na, Chang-Hee Suh, Min Wook So, Seung Won Choi, Dong-Hyuk Sheen, Won Park, Shin-Seok Lee, Wan Hee Ryu, Jin Seok Kim, Jung Soo Song, Hye Soon Lee, Seong Ho Kim, Dae-Hyun Yoo
Korean J Intern Med. 2020;35(1):231-239. Published online January 28, 2019
Background/Aims: The objective of this study was to compare changes in the simplified disease activity index (SDAI) between biologic (b) and conventional (c) disease-modifying antirheumatic drugs (DMARD) users with seropositive rheumatoid arthritis (RA) in daily clinical practice. Methods: This was ..
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The use of biological disease-modifying antirheumatic drugs for inflammatory arthritis in Korea: results of a Korean Expert Consensus
Eun-Jung Park, Hyungjin Kim, Seung Min Jung, Yoon-Kyoung Sung, Han Joo Baek, Jisoo Lee
Korean J Intern Med. 2020;35(1):41-59. Published online January 2, 2020
Biological disease-modifying antirheumatic drugs (bDMARDs) are highly effective agents for the treatment of inf lammatory arthritis; however, they also possess a potential risk for serious infection. Recently, with the rapid expansion of the bDMARDs market in Korea, reports of serious adverse events ..
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Roles of mast cells in rheumatoid arthritis
Hong Ki Min, Kyoung-Woon Kim, Sang-Heon Lee, Hae-Rim Kim
Korean J Intern Med. 2020;35(1):12-24. Published online November 15, 2019
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory arthritis, and the complex interaction and activation of innate and adaptive immune cells are involved in RA pathogenesis. Mast cells (MCs) are one of the tissue-resident innate immune cells, and they contribute to RA pathogenesis. In th..
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Rheumatology
Rheumatoid arthritis is associated with early tooth loss: results from Korea National Health and Nutrition Examination Survey V to VI
Ji-Won Kim, Jun-Beom Park, Hyeon Woo Yim, Jennifer Lee, Seung-Ki Kwok, Ji Hyeon Ju, Wan-Uk Kim, Sung-Hwan Park
Korean J Intern Med. 2019;34(6):1381-1391. Published online September 1, 2018
Background/aims: To examine the association between rheumatoid arthritis (RA) and periodontitis or tooth loss.
Methods: The study used data from the fifth and sixth Korea National Health and Nutrition Examination Surveys conducted from 2010 to 2015. RA was defined as participant-reported physician-..
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A paradigm shift in studies based on rheumatoid arthritis clinical registries
Soo-Kyung Cho, Yoon-Kyoung Sung
Korean J Intern Med. 2019;34(5):974-981. Published online February 18, 2019
Clinical research is the study of aspects of patient health or illness that are closely related to clinical practice. In the late 20th and early 21th century, outcomes for patients with rheumatoid arthritis (RA) improved dramatically due to breakthroughs in new drugs. Patient-reported outcome measur..
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Rheumatology
Efficacy and safety of tocilizumab in Korean patients with active rheumatoid arthritis
Han Joo Baek, Mie Jin Lim, Won Park, Sung Hwan Park, Seung-Cheol Shim, Dae-Hyun Yoo, Hyun Ah Kim, Soo Kon Lee, Yun Jong Lee, Young Eun Park, Hoon-Suk Cha, Yeong-Wook Song
Korean J Intern Med. 2019;34(4):917-931. Published online January 17, 2018
Background/Aims: To investigate the efficacy and safety of tocilizumab (TCZ) humanized anti-interleukin-6 receptor monoclonal antibody, in Korean patients with active rheumatoid arthritis (RA) refractory to conventional disease modifying anti-rheumatic drugs (DMARDs) including methotrexate (MTX)
Me..
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Factors associated with time to diagnosis from symptom onset in patients with early rheumatoid arthritis
Soo-Kyoung Cho, Dam Kim, Soyoung Won, Jiyoung Lee, Chan-Bum Choi, Jung-Yoon Choe, Seung-Jae Hong, Jae-Bum Jun, Tae-Hwan Kim, Eunmi Koh, Hye-Soon Lee, Jisoo Lee, Dae-Hyun Yoo, Bo Young Yoon, Sang-Cheol Bae, Yoon-Kyoung Sung; Korean Observational Study Network for Arthritis (KORONA) Investigators
Korean J Intern Med. 2019;34(4):910-916. Published online December 15, 2017
Background/Aims: To identify the factors associated with time to diagnosis after symptom onset in patients with early rheumatoid arthritis (RA).
Methods: Early RA patients with ≤ 1 year of disease duration in the KORean Observational study Network for Arthritis (KORONA) database were included in t..
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Magnetic resonance imaging-assessed synovial and bone changes in hand and wrist joints of rheumatoid arthritis patients
Kyung-Ann Lee, Sang-Ho Min, Tae-Hyung Kim, Sang-Heon Lee, Hae-Rim Kim
Korean J Intern Med. 2019;34(3):651-659. Published online November 24, 2017
Background/Aims: Magnetic resonance imaging (MRI) is a sensitive and useful method for the detection of synovitis and joint destruction in rheumatoid arthritis (RA) patients. However, the patterns of MRI-detected bone erosion, bone marrow edema (BME), synovitis, and tenosynovitis have received insuf..
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Clinical characteristics associated with occurrence and poor prognosis of interstitial lung disease in rheumatoid arthritis
Ji Ae Yang, Jeong Seok Lee, Jin Kyun Park, Eun Bong Lee, Yeong Wook Song, Eun Young Lee
Korean J Intern Med. 2019;34(2):434-441. Published online March 28, 2017
Background/Aims: To analyze clinical characteristics of interstitial lung disease (ILD) associated with rheumatoid arthritis (RA), especially in patients with poor prognosis.
Methods: Seventy-seven RA patients with ILD and 231 age, sex, and disease duration-matched RA patients without ILD were enr..
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N-acetyl-l-cysteine controls osteoclastogenesis through regulating Th17 differentiation and RANKL in rheumatoid arthritis
[corrected-article]
Hae-Rim Kim, Kyoung-Woon Kim, Bo-Mi Kim, Kyung-Ann Lee, Sang-Heon Lee
Korean J Intern Med. 2019;34(1):210-219. Published online March 13, 2017
Background/Aims: This study aimed to determine the regulatory role of N-acetyl-l-cysteine (NAC), an antioxidant, in interleukin 17 (IL-17)-induced osteoclast differentiation in rheumatoid arthritis (RA).
Methods: After RA synovial fibroblasts were stimulated by IL-17, the expression and pro..
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Grape seed proanthocyanidin extract ameliorates murine autoimmune arthritis through regulation of TLR4/MyD88/NF-κB signaling pathway
Sang-Hyon Kim, Jihye Bang, Chang-Nam Son, Won-Ki Baek, Ji-Min Kim
Korean J Intern Med. 2018;33(3):612-621. Published online June 3, 2016
Background/Aims: Grape seed proanthocyanidin extract (GSPE) has been reported to have a beneficial effect on regulating inf lammation. However, the anti-inflammatory mechanism of GSPE remains unclear. The aim of this study was to verify the influence of GSPE on the Toll-like receptor 4 (TLR4)-mediat..
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Medication nonadherence in Korean patients with rheumatoid arthritis: the importance of belief
about medication and illness perception
Young Sun Suh, Yun-Hong Cheon, Hyun-Ok Kim, Rock-Bum Kim, Ki Soo Park, Sang-Hyon Kim, Seung-Geun Lee, Eun-Kyoung Park, Jian Hur, Sang-Il Lee
Korean J Intern Med. 2018;33(1):203-210. Published online April 20, 2017
Background/Aims: To investigate medication nonadherence in Korean patients with rheumatoid arthritis (RA) and analyze related factors.
Methods: A total of 292 patients with RA participated in this study. Medication nonadherence, intentional or unintentional, was gauged via self-reported questionnai..
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