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Hospital medicine / Original Article
Global burden of adverse effects of medical treatment from 1990 to 2021: a Global Burden of Disease Study 2021
GBD 2021 AEMT Collaborators, Yi Deun Jeong, Seoyoung Park, Wonwoo Jang, Min Seo Kim, A Bhoomadevi et al.
Korean J Intern Med. 2026;41(2):350-366. Published online March 1, 2026
Background/Aims: This study aims to evaluate the global burden of adverse effects of medical treatment (AEMT) using data from the Global Burden of Disease Study (GBD) 2021.
Methods: Data were extracted from the GBD 2021, covering 204 countries/territories from 1990 to 2021. AEMT was defined using I..
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Rheumatology / Original Article
Cross-cultural adaptation and preliminary validation of the Korean version of the Psoriatic Arthritis Impact of Disease-12 questionnaire
Bon San Koo, Jung Gon Kim, Bo Young Yoon, Ji-Hyoun Kang, Sung-Eun Choi, Sooin Jung, Seyeong Kim, Tae-Jong Kim
Korean J Intern Med. 2026;41(2):341-349. Published online March 1, 2026
Background/Aims: The Psoriatic Arthritis Impact of Disease (PsAID-12) questionnaire was developed to measure quality of life and disease impact in patients with psoriatic arthritis (PsA). We aimed to translate the English PsAID-12 into Korean and to evaluate its reliability and validity.
Methods: T..
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Gastroenterology / Review
The epidemiology of inflammatory bowel disease: exploring the impacts of environmental factors
Jihye Park, Jae Hee Cheon
Korean J Intern Med. 2026;41(2):186-196. Published online December 4, 2025
Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are distinct chronic immune-mediated intestinal inflammatory disorders. The pathogenesis of IBD is complex and involves a combination of genetic and environmental factors, the gut microbiome, and the host immune syste..
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Cardiology / Original Article
Comparative efficacy and safety of warfarin and direct oral anticoagulants in patients with end-stage kidney disease and atrial fibrillation
Yujin Yang, Sun Hwa Lee, Wonmook Hwang, Ji Hoon Jung, Jae-Hyeong Park
Korean J Intern Med. 2026;41(1):107-117. Published online January 1, 2026
Background/Aims: Patients with atrial fibrillation (AF) and end-stage kidney disease (ESKD) require careful anticoagulation because thrombotic and bleeding risks are both elevated. We evaluated the efficacy and safety of warfarin, direct oral anticoagulants (DOACs), and no anticoagulation in Korean ..
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Gastroenterology / Original Article
Prevalence of viral hepatitis A and C in patients with inflammatory bowel disease: a nationwide population-based study in South Korea
Jin Hwa Park, Sang Hyoung Park, Sang Pyo Lee, Kang Nyeong Lee, Hang Lak Lee, Oh Young Lee, Soorack Ryu, Junwon Go
Korean J Intern Med. 2026;41(1):95-106. Published online January 1, 2026
Background/Aims: We investigated whether patients with inflammatory bowel disease (IBD) in Korea have an increased risk of hepatitis A virus (HAV) and hepatitis C virus (HCV) infections and sought to identify the risk factors for these infections.
Methods: We performed a nationwide population-based..
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Gastroenterology / Original Article
The effects of Helicobacter pylori eradication and development of immune-mediated disorder in children: a nationwide population-based study in Korea
You Ie Kim, Joon Sung Kim, Sang Yong Kim, Byung-Wook Kim
Korean J Intern Med. 2026;41(1):85-94. Published online January 1, 2026
Background/Aims: Helicobacter pylori may protect against immune-mediated disorders such as inflammatory bowel disease (IBD) and asthma. This study evaluated whether eradication was associated with IBD and asthma in Korean children.
Methods: Data were collected from the Korean National Health..
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Endocrinology-metabolism / Review
Advanced strategies for the management of patients with diabetic foot ulcers: a comprehensive review
Ji Min Kim, Chong Hwa Kim, Seon Mee Kang, Jung Hwa Jung, Ki Chun Kim, Sanghyun Ahn, Tae Sun Park, Ie Byung Park
Korean J Intern Med. 2026;41(1):47-59. Published online January 1, 2026
Diabetic foot ulcers (DFUs) are among the most serious and common complications of diabetes mellitus. They significantly affect patients’ quality of life and impose a substantial economic burden on healthcare systems worldwide. In Korea, the prevalence of diabetes and related complications, such a..
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Pulmonology / Review
Telemedicine in chronic lung disease management: progress and prospects
Hee-Young Yoon, Jin Woo Song
Korean J Intern Med. 2026;41(1):31-46. Published online December 23, 2025
Chronic lung diseases, including asthma, chronic obstructive pulmonary disease, and interstitial lung disease, contribute significantly to morbidity and mortality worldwide. Telemedicine has emerged as a promising approach for addressing these challenges by enabling remote patient monitoring, virtua..
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Endocrinology-metabolism / Original Article
Comprehensive approaches to diabetes in the elderly: adapting to evolving trends
Jeongmin Lee, Kwang Joon Kim, Yang Sun Park, Yong-ho Lee, Kyeong Hye Park, Hee-Won Jung, Bong-Soo Cha, Hun-Sung Kim, Chang Oh Kim
Korean J Intern Med. 2025;40(6):1017-1028. Published online October 31, 2025
Background/Aims: The prevalence of diabetes mellitus (DM) is increasing worldwide owing to aging. This nationwide study aimed to investigate the prevalence of DM and its management status among elderly Koreans.
Methods: We analyzed data from the Korea National Health and Nutrition Examination Survey..
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Cardiology / Original Article
Long-term clinical outcome and risk stratification across stages of cardiovascular-kidney-metabolic syndrome in a nationwide cohort
Hyun-Jin Kim, Byung Sik Kim, Hasung Kim, Jungkuk Lee, Ha Hye Jo, Dong Wook Kim, Jeong-Hun Shin, Ki-Chul Sung
Korean J Intern Med. 2025;40(6):975-989. Published online October 28, 2025
Background/Aims: Cardiovascular-kidney-metabolic (CKM) syndrome is a continuum of metabolic, cardiovascular, and kidney dysfunctions. This study aimed to evaluate the association between CKM stages and the risk of adverse composite clinical outcomes.
Methods: This retrospective cohort study used da..
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Cardiology / Original Article
Association of the triglyceride-glucose index with cardiovascular outcomes across cardiovascular-kidney-metabolic syndrome stages
Byung Sik Kim, Hyun-Jin Kim, Shinje Moon, Hasung Kim, Jungkuk Lee, Jeong-Hun Shin
Korean J Intern Med. 2025;40(6):961-974. Published online October 31, 2025
Background/Aims: Cardiovascular-kidney-metabolic (CKM) syndrome reflects the interplay between metabolic dysfunction, chronic kidney disease, and cardiovascular disease. Insulin resistance (IR) is a key driver of CKM and is associated with adverse cardiovascular outcomes. The triglyceride-glucose (T..
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Cardiology / Review
Coagulopathy and platelet abnormalities in patients with inflammatory bowel disease
Dae Sung Kim, Won Moon
Korean J Intern Med. 2025;40(6):866-875. Published online October 31, 2025
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is associated with a hypercoagulable state that increases thromboembolic complication risk. The interaction between inflammation and coagulation increases risk by upregulating coagulation factors, downregulating natu..
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Rheumatology / Original Article
Comprehensive analysis of patients with rheumatoid arthritis associated interstitial lung disease
[letter]
Ji-Won Kim, Ju-Yang Jung, Chang-Hee Suh, Hyoun-Ah Kim
Korean J Intern Med. 2025;40(5):845-855. Published online August 26, 2025
Background/Aims: To investigate the demographics, disease characteristics, and treatment modalities of patients with rheumatoid arthritis (RA) associated interstitial lung disease (ILD), focusing on ILD exacerbation and mortality.
Methods: This retrospective study included individuals aged ≥ 18 y..
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Endocrinology-metabolism / Original Article
Association between metabolic dysfunction-associated steatotic liver disease and the risk of thyroid cancer: a nationwide cohort study
Jeongmin Lee, Jeongeun Kwak, Min-Hee Kim, Seung-Hwan Lee, Jae-Hyoung Cho, Dong-Jun Lim, Jung Min Lee, Sang-Ah Chang, Hun-Sung Kim
Korean J Intern Med. 2025;40(5):813-822. Published online August 26, 2025
Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with various metabolic disorders; however, its relationship with thyroid cancer remains unclear. This study investigated the association between MASLD and the risk of thyroid cancer.
Methods: This retros..
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Gastroenterology / Original Article
Live zoster vaccination and hepatobiliary risk reduction: a nationwide South Korean study
Junyeol Kim, Kyeongmin Lee, Jiyeon Oh, Hayeon Lee, Jong-In Chang, Tae Young Park, Dong Keon Yon, Hyoung-Chul Oh
Korean J Intern Med. 2025;40(5):747-758. Published online August 29, 2025
Background/Aims: Herpes zoster (HZ) vaccination is primarily administered to prevent shingles, yet its systemic immunomodulatory effects may offer protection against other organ-related diseases, including hepatobiliary and pancreatic diseases. Therefore, this emulated target trial aimed to evaluate..
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Gastroenterology / Original Article
Predicted pro-inflammatory high-sensitivity C-reactive protein score and inflammatory bowel disease: a cross-sectional study
Dong Hyun Kim, Akinkunmi Paul Okekunle, Jioh Kang, Hyun-Soo Kim, Sang Hoon Kim, Min Kyu Jung, Jae Ho Park, Soo Young Na, Hoonjai Chun, Jung Eun Lee, Yun Jeong Lim
Korean J Intern Med. 2025;40(5):734-746. Published online July 17, 2025
Background/Aims: The role of pro-inflammatory factors in the pathogenesis of inflammatory bowel diseases (IBD), is not well understood. This study investigated the association between the predicted pro-inflammatory high-sensitivity C-reactive protein (hs-CRP) score and IBD.
Methods: This study invo..
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Cardiology / Review
Physical activity for prevention of cardiovascular disease: consensus statement of Korean Society of Cardio-cerebrovascular Disease Prevention
Ye Seul Yang, Eu Jeong Ku, Seung-Hyun Ko, Eun-Jung Rhee, Sang-Hyun Ihm, Sung Hee Choi, Won-Young Lee; on Behalf of Committee of Clinical Practice Guideline; Korean Society of Cardio-cerebrovascular Disease Prevention
Korean J Intern Med. 2025;40(5):696-709. Published online August 29, 2025
Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, highlighting the need for effective preventive strategies. This consensus statement emphasizes the critical role of regular physical activity, including aerobic and muscle-strengthening exercises, in reducing key CVD risk..
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Rheumatology / Original Article
Association of peripheral leukocyte telomere length with patients with rheumatoid arthritis with a focus on interstitial lung disease
Young Bin Joo, So-Young Bang, Su Jin Hong, Youkyung Lee, Dongjik Shin, Sang-Cheol Bae, Hye-Soon Lee
Korean J Intern Med. 2025;40(4):676-686. Published online April 1, 2025
Background/Aims: This study investigated whether telomere length (TL) in rheumatoid arthritis (RA) patients is shorter than in controls, whether TL in RA patients with interstitial lung disease (RA-ILD) differs from that in those without ILD (RA-nonILD), and whether TL varies according to RA-ILD pat..
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Hemato-oncology / Original Article
Decreased frequency and inflammatory change of FoxP3+ regulatory T cells in immunopathogenesis of human acute graft-versus-host disease
Nayeon Seong, Cheongin Yang, Kunye Kwak, Ka-Won Kang, Yong Park, Byung Soo Kim, Seong Hyun Jeong, Joon Seong Park, Yoon Seok Choi
Korean J Intern Med. 2025;40(4):657-666. Published online July 1, 2025
Background/Aims: Acute graft-versus-host disease (GvHD) is a severe complication of allogeneic stem cell transplantation, characterized by immune-mediated tissue damage primarily affecting the skin, liver, and gastrointestinal tract. Regulatory T (Treg) cells play a critical role in maintaining immu..
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Pulmonology / Original Article
Clinical impacts of COVID-19 on severe exacerbation and mortality in interstitial lung disease: prognosis 30 days after infection
Bo-Guen Kim, Sun-Kyung Lee, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Tae-Hyung Kim, Sang-Heon Kim, Ho Joo Yoon, Hyun Lee
Korean J Intern Med. 2025;40(4):634-644. Published online July 1, 2025
Background/Aims: The impact of coronavirus disease 2019 (COVID-19) on severe exacerbation and mortality in interstitial lung disease (ILD) is unclear. In this study, we evaluate the risk of severe exacerbation and mortality in individuals with ILD following COVID-19.
Methods: Using the Korean Natio..
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