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Allergy / Original Article
Clinical and immunologic features of adult primary antibody deficiency according to IVIGRT exposure
Jung-Eun Han, Hyun young Lee, Haeng Jun Kim, Yoo Seob Shin, Yeong-Min Ye, Hae-Sim Park
Korean J Intern Med. 2026;41(5):940-951. Published online September 1, 2026
Background/Aims: Primary antibody deficiency (PAD) in adults is increasingly recognized, but remains underdiagnosed and undertreated. We described the clinical and immunologic features of adult patients with PAD according to real-world exposure to intravenous immunoglobulin replacement therapy (IVIGR..
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Nephrology / Original Article
Mortality risk associated with permanent central venous catheter use in the oldest-old population: a nationwide cohort study
Joo Un Park, Chang Min Park, Do Hyoung Kim, Hyangkyoung Kim, Byung Ha Chung, Hyung Seok Lee, Sang Jun Park, Min-ho Kim, Hoon Suk Park
Korean J Intern Med. 2026;41(5):927-939. Published online September 1, 2026
Background/Aims: Owing to aging-related factors, arteriovenous access (AV) is difficult to establish in older patients; central venous catheter (CVC) access is used instead. However, evidence on long-term outcomes of permanent vascular access types in the oldest-old adults (≥ 80 yr) is lacking. We..
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Endocrinology-metabolism / Original Article
Parathyroid hormone–related protein–mediated hypercalcemia of malignancy: insights from a multicenter clinical data warehouse
Jinyoung Kim, Yuri Shin, Jeonghoon Ha, Chaiho Jeong, Jeongmin Lee, Kwanhoon Jo, Jang Won Son, Jae-Seung Yun, Ihnsuk Lee, Dong-Jun Lim, Hyuk-Sang Kwon, Ki-Ho Song, Ki-Hyun Baek
Korean J Intern Med. 2026;41(5):907-915. Published online September 1, 2026
Background/Aims: Parathyroid hormone–related protein (PTHrP) is a major mediator of hypercalcemia in patients with malignancy; however, understanding of PTHrP-mediated hypercalcemia remains limited because available evidence has largely been derived from small case series.
Methods: We retrospectiv..
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Pulmonology / Original Article
Probable obesity hypoventilation syndrome in a Korean medical intensive care unit: clinical characteristics and outcomes
Kyu Jin Lee, Hong Yeul Lee, Jinwoo Lee, Sang-Min Lee, Jaeyoung Cho
Korean J Intern Med. 2026;41(5):894-904. Published online September 1, 2026
Background/Aims: Obesity hypoventilation syndrome (OHS) is associated with morbidity and intensive care unit (ICU) utilization. However, data from Asian ICUs are limited. We evaluated the proportion, characteristics, and outcomes of probable OHS among obese patients admitted to a medical ICU (MICU) in ..
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Cardiology / Original Article
Prognostic implications of functional significance, high-risk plaque and vessel characteristics in patients with diabetes mellitus
Jin-Eun Song, Seokhun Yang, Masahiro Hoshino, Taishi Yonetsu, Jinlong Zhang, Eun-Seok Shin, Joon-Hyung Doh, Chang-Wook Nam, Jianan Wang, Shaoliang Chen, Nobuhiro Tanaka, Hitoshi Matsuo, Takashi Kubo, Hyuk-Jae Chang, Tsunekazu Kakuta, Bon-Kwon Koo
Korean J Intern Med. 2026;41(5):873-883. Published online September 1, 2026
Background/Aims: We investigated the prognostic value of high-risk plaque (HRP) and high-risk vessel (HRV) characteristics on coronary computed tomography angiography (CCTA) alongside fractional flow reserve (FFR) in patients with diabetes mellitus (DM).
Methods: We analyzed 307 vessels from 184 dia..
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Gastroenterology / Original Article
Population-specific rare variants influence age at diagnosis in Korean inflammatory bowel disease
Mina Cho, DongHwan Shin, Jongwook Yu, Jae Hee Cheon, Ju Han Kim
Korean J Intern Med. 2026;41(5):847-857. Published online September 1, 2026
Background/Aims: Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is increasing in East Asia. Most known susceptibility loci, identified primarily in Europeans, remain insufficient to explain clinical heterogeneity in Asians. We performed whole-exome..
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Rheumatology / Original Article
Tumor necrosis factor inhibitor prescribing and persistence by specialty in radiographic axial spondyloarthritis: a Korean claims study
Bon San Koo, Ye-Jee Kim, Yeo-Jin Lee, Yong-Gil Kim, Tae-Hwan Kim
Korean J Intern Med. 2026;41(4):766-778. Published online July 1, 2026
Background/Aims: Although several studies have shown that specialist care may be associated with better outcomes, methodological limitations have made it difficult to draw definitive conclusions. Therefore, we examined real-world patterns of tumor necrosis factor inhibitor (TNFi) use for radiographi..
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Hemato-oncology / Original Article
Prognostic analysis according to adjuvant chemotherapy and anti-HER2 therapy following surgery in T1a/b HER2-positive breast cancer
Woochan Park, Koung Jin Suh, Jeongmin Seo, Se Hyun Kim, Yu Jung Kim, Hee-Chul Shin, Eun-Kyu Kim, In Ah Kim, So Yeon Park, Jee Hyun Kim
Korean J Intern Med. 2026;41(4):734-747. Published online July 1, 2026
Background/Aims: The optimal adjuvant chemotherapy and anti-human epidermal growth factor receptor 2 (HER2) therapy regimen following surgery for T1a/b HER2-positive breast cancer remains debatable.
Methods: In this single-center retrospective analysis, we examined the postoperative treatment strat..
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Hemato-oncology / Original Article
Restrictive lung function and smoking increase lung cancer risk in tuberculosis survivors: a cohort study
Yun-Gyoo Lee, Hyun-Il Gil, Dayeon Seo, Bo-Guen Kim, Hyunjoo Lee, Young Hwan Kim, Heerim Nam, Soo-Youn Ham, Du-Young Kang, Jae-Uk Song
Korean J Intern Med. 2026;41(4):721-730. Published online July 1, 2026
Background/Aims: Individuals with prior tuberculosis (TB) infection represent a high-risk group for lung cancer due to chronic pulmonary damage. Although associations between TB and lung cancer have been established, this study aimed to explore specific risk factors of lung cancer development in TB ..
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Cardiology / Original Article
Distal radial access in acute coronary syndrome patients with good arterial pulsation: a subgroup analysis from the KODRA registry
Jun-Won Lee, Su Yong Kim, Jung Ho Heo, Han-Young Jin, Sung Woo Cho, Yongcheol Kim, Bong-Ki Lee, Sang-Yong Yoo, Sang Yeub Lee, Chan Joon Kim, Jin Sup Park, Do Hoi Kim, Jin Bae Lee, Dong-Kie Kim, Jun Ho Bae, Sung-Yun Lee, Seung-Hwan Lee
Korean J Intern Med. 2026;41(4):663-675. Published online July 1, 2026
Background/Aims: Distal radial access (DRA) has been associated with fewer access-site complications, but evidence in acute coronary syndrome (ACS) remains limited. This study evaluated the feasibility and safety of DRA in ACS patients with good arterial pulsation.
Methods: Patients with good arter..
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Gastroenterology / Original Article
Hepatitis B core-related antigen as a multifaceted biomarker in chronic hepatitis B: implications for immune activity and hepatocellular carcinoma prediction
Kwon Yong Tak, Seok Hwan Kim, Myeong Jun Song
Korean J Intern Med. 2026;41(4):636-648. Published online July 1, 2026
Background/Aims: Hepatitis B core-related antigen (HBcrAg) reflects both serum hepatitis B virus (HBV) DNA and intrahepatic covalently closed circular DNA activity, offering potential advantages over conventional biomarkers in monitoring chronic hepatitis B (CHB). This study evaluated the clinical ut..
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Rheumatology / Review
Autoimmune diseases in the era of COVID-19: emerging mechanisms, clinical implications, vaccine considerations, and future directions
Jaehyun Kong, Seohyun Hong, Jiyeon Oh, Sooji Lee, Lee Smith, Francesco Branda, Hanseul Cho, Jiyoung Hwang, Dong Keon Yon
Korean J Intern Med. 2026;41(4):597-619. Published online July 1, 2026
The coronavirus disease 2019 (COVID-19) pandemic has highlighted a complex, bidirectional relationship between SARSCoV-2 infection and autoimmune diseases. This review examines how SARS-CoV-2 infection influences the incidence, progression, and outcomes of five major autoimmune conditions: systemic ..
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Hemato-oncology / Review
Korean expert consensus on the management of thrombotic thrombocytopenic purpura
Seo-Yeon Ahn, Junshik Hong, Jin Seok Kim, Sung-Hyun Kim, Kyoung Ha Kim, Ho-Young Yhim, Yoo Jin Lee, Jaewoo Song, Soo-Mee Bang, Ji Hyun Lee, Seongsoo Jang, Sung Hwa Bae; on behalf of the Korean Society of Hematology Thrombosis and Hemostasis Working Party and the Korean Society on Thrombosis and Hemostasis
Korean J Intern Med. 2026;41(4):572-584. Published online July 1, 2026
Thrombotic thrombocytopenic purpura (TTP) is a rare but life-threatening thrombotic microangiopathy resulting from severe ADAMTS13 deficiency. Although effective treatments, such as therapeutic plasma exchange, immunosuppressive therapy with rituximab, and caplacizumab, have significantly improved s..
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Infectious diseases / Original Article
Cross-neutralizing antibody responses among individuals with or without bivalent vaccine: a six-month prospective cohort study
Hye Hee Cha, Ji Yeun Kim, Seung Beom Kim, Junho Cha, Ji-Soo Kwon, Woori Kim, Ju Yeon Son, Choi Young Jang, Min-Chul Kim, So Yun Lim, Sung-Han Kim
Korean J Intern Med. 2026;41(3):516-523. Published online May 1, 2026
Background/Aims: Although the COVID-19 pandemic has officially ended, SARS-CoV-2 continues to circulate with periodic surges and may exhibit seasonal patterns. Understanding the importance of prompt immunization, particularly in individuals with prior infection, is crucial for developing future vacc..
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Endocrinology-metabolism / Original Article
Trabecular bone score differs among prediabetes phenotypes: the potential mediating role of visceral adiposity
Yong Jun Choi, Ja Young Jeon, Kyoung Hwa Ha, Dae Jung Kim
Korean J Intern Med. 2026;41(3):501-513. Published online May 1, 2026
Background/Aims: Prediabetes comprises heterogeneous metabolic phenotypes that may differentially affect bone quality. While type 2 diabetes increases fracture risk despite preserved bone mineral density, phenotype-specific effects on bone quality during prediabetes remain unclear. We compared trabe..
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Allergy / Review
Targeting immune dysregulation in chronic spontaneous urticaria: beyond antihistamines
Young-Min Ye
Korean J Intern Med. 2026;41(3):418-431. Published online May 1, 2026
Chronic urticaria (CU) is characterized by recurrent wheals and angioedema lasting longer than six weeks. It affects approximately 0.5–1.4% of the population and profoundly impairs the quality of life. The disease exhibits a variable course, with many patients experiencing symptoms for several yea..
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Allergy / Review
Eperisone-induced immediate hypersensitivity reactions
Gyu-Young Hur, Jung-Won Park
Korean J Intern Med. 2026;41(3):411-417. Published online May 1, 2026
Eperisone hydrochloride is a centrally acting muscle relaxant commonly prescribed for musculoskeletal pain, particularly in Korea and Japan. It induces relaxation of skeletal and vascular smooth muscle through central nervous system modulation and peripheral mechanisms, although its precise biochemi..
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Endocrinology-metabolism / Review
Delayed gastric emptying induced by glucagon-like peptide-1 receptor agonists and its implications for perioperative risk during anesthesia
Donghee Kang, Dughyun Choi
Korean J Intern Med. 2026;41(3):384-395. Published online May 1, 2026
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly prescribed for managing type 2 diabetes mellitus and obesity because of their glucose-lowering, weight-reducing, and cardiovascular benefits. However, their potential to delay gastric emptying has raised growing concern in periop..
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Cardiology / Review
Transcatheter aortic valve implantation for symptomatic severe aortic stenosis and its expanding clinical indications
Hyungdon Kook, Young-Hyo Lim
Korean J Intern Med. 2026;41(3):373-383. Published online February 24, 2026
Transcatheter aortic valve implantation (TAVI) is a minimally invasive treatment for symptomatic severe aortic stenosis (AS) that was initially developed for patients with prohibitive surgical risk. Since the first-in-human procedure in 2002, TAVI has gained global acceptance owing to its favorable ..
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Hemato-oncology / Original Article
Real-world use of polatuzumab vedotin combined with bendamustine and rituximab for patients with relapsed or refractory large B-cell lymphoma
Changgon Kim, Sang Eun Yoon, Hyun-Young Kim, Duck Cho, Junhun Cho, Won Seog Kim, Seok Jin Kim
Korean J Intern Med. 2026;41(2):296-306. Published online March 1, 2026
Background/Aims: Polatuzumab vedotin combined with bendamustine and rituximab (Pola-BR) is a treatment option for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL), particularly as bridging therapy before chimeric antigen receptor (CAR) T-cell infusion. However, real-world data regarding..
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