Pulmonology
Estimating the burden of nosocomial exposure to tuberculosis in South Korea, a nationwide population based cross-sectional study
Hyung Woo Kim, Jun-Pyo Myong, Ju Sang Kim
Korean J Intern Med. 2021;36(5):1134-1145. Published online December 18, 2020
Background/Aims: The aim of the study was to investigate the current nationwide burden of nosocomial exposure to tuberculosis (TB) using national health insurance claims data.
Methods: All patients who had claims for drug susceptibility testing for TB from 2012 to 2016, which indicated culture-prov..
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Improving the care of inflammatory bowel disease (IBD) patients: perspectives and strategies for IBD center management
Jihye Park, Sinyoung Park, Shin Ae Lee, Soo Jung Park, Jae Hee Cheon
Korean J Intern Med. 2021;36(5):1040-1048. Published online August 5, 2021
The incidence and prevalence rates of inf lammatory bowel disease (IBD) have been increasing in East Asian countries over the past few decades. Accordingly, the general understanding and awareness of IBD among healthcare professionals has increased considerably in this region. This increase is ultim..
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Infectious diseases
Varicella zoster virus (VZV)-specific immunity and subclinical VZV reactivation in patients with autoimmune diseases
Kwang-Hoon Lee, Sungim Choi, Ji-Soo Kwon, Sung-Han Kim, Seong Yeon Park
Korean J Intern Med. 2021;36(4):992-1000. Published online June 15, 2021
Background/Aims: The risk of herpes zoster (HZ) is increased in patients with autoimmune diseases (AID), probably due to immunosuppressive therapy.
Methods: This prospective cross-sectional study investigated varicella zoster virus (VZV)-specific immunity in relation to subclinical VZV reactivation..
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Nephrology
Role of Akt1 in renal fibrosis and tubular dedifferentiation during the progression of acute kidney injury to chronic kidney disease
Il Young Kim, Yeon Kyeong Park, Sang Heon Song, Eun Young Seong, Dong Won Lee, Sun Sik Bae, Soo Bong Lee
Korean J Intern Med. 2021;36(4):962-974. Published online December 16, 2020
Background/Aims: Acute kidney injury (AKI) is an underestimated yet important risk factor for the development of chronic kidney disease (CKD), characterized by tubulointerstitial fibrosis and tubular dedifferentiation. Tubular dedifferentiation, which is associated with the loss of epithelial marker..
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Gastroenterology
Subclinical sacroiliitis detected by abdominopelvic computed tomography in Korean patients with Crohn’s disease
You-Jung Ha, Hyo Jin Kim, Eugene Lee, Ji Hye Park, Young Soo Park, Yun Jong Lee, Yusuhn Kang, Hyuk Yoon
Korean J Intern Med. 2021;36(4):868-877. Published online March 22, 2021
Background/Aims: Sacroiliitis is a frequent extraintestinal manifestation of inflammatory bowel diseases (IBDs). This study aimed to assess the prevalence of sacroiliitis using a validated screening tool based on abdominopelvic computed tomography (APCT) in Korean patients with Crohn’s disease (CD..
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Clinical and genetic characteristics of Korean autosomal dominant polycystic kidney disease patients
Yun Kyu Oh, Hayne Cho Park, Hyunjin Ryu, Yong-Chul Kim, Kook-Hwan Oh
Korean J Intern Med. 2021;36(4):767-779. Published online July 1, 2021
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. It is characterized by cyst growth in the kidneys, resulting in kidney enlargement and end-stage kidney disease. The polycystic kidney disease 1 (PKD1) and PKD2 have been identified as ge..
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Rheumatology
Clinical features of Korean elderly patients with antineutrophil cytoplasmic antibody-associated vasculitis
Byung-Woo Yoo, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
Korean J Intern Med. 2021;36(3):731-741. Published online August 20, 2020
Background/Aims: We compared the clinical and laboratory data between elderly and non-elderly patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) at diagnosis; further, we investigated the predictors at diagnosis for all-cause mortality and end-stage renal disease (E..
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Hemato-oncology
Pulmonary toxicities of molecular targeted antineoplastic agents: a single-center 10-year experience
Min-Young Lee, Seug Yun Yoon, Kyoung Ha Kim, Namsu Lee, Ha Youn Kim, Jung Hwa Hwang, Jong-Ho Won
Korean J Intern Med. 2021;36(3):689-698. Published online January 8, 2021
Background/Aims: A better understanding of cancer cell biology has led to the discovery and development of several new targeted agents for cancer. These drugs are widely used in cancer treatment and have good toxicity profiles. However, some patients are extremely sensitive to these drugs and can de..
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Nephrology
Effect of urinary angiotensinogen and high-salt diet on blood pressure in patients with chronic kidney disease: results from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease (KNOW-CKD)
Ha Yeon Kim, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Su-Ah Sung, Seung Hyeok Han, Kook-Hwan Oh, Curie Ahn, Soo Wan Kim
Korean J Intern Med. 2021;36(3):659-667. Published online October 8, 2020
Background/Aims: This study aimed to investigate whether urinary angiotensinogen (UAGT) excretion was associated with elevated blood pressure in patients with chronic kidney disease (CKD) and to evaluate the relationship among blood pressure, intra-renal renin-angiotensin system (RAS) activity, and ..
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Pulmonology
Clinical impact of long-term change in air trapping on pulmonary function and computed tomography parameters in chronic obstructive pulmonary disease
Jeong Uk Lim, Jae Seung Lee, Ji-Hyun Lee, Sang-Do Lee, Yeon-Mok Oh, Chin Kook Rhee; for the Korean Obstructive Lung Disease (KOLD) Study Group
Korean J Intern Med. 2021;36(3):636-646. Published online November 25, 2020
Background/Aims: Air trapping is associated with unfavorable outcomes in chronic obstructive pulmonary disease (COPD). The present study evaluated the association between longitudinal changes in air trapping with pulmonary function, computed tomography (CT) parameters and exacerbation.
Methods: Pat..
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Cut-off value of FEV1/FEV6 to determine airflow limitation using handheld spirometry in subjects with risk of chronic obstructive pulmonary disease
Yong Il Hwang, Youlim Kim, Chin Kook Rhee, Deog Kyeom Kim, Yong Bum Park, Kwang Ha Yoo, Ki-Suck Jung, Chang Youl Lee
Korean J Intern Med. 2021;36(3):629-635. Published online June 24, 2020
Background/Aims: Postbronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) less than 0.7 using spirometry is the golden standard to diagnose airf low limitation of chronic obstructive pulmonary disease (COPD). Recently, measuring FEV6 has been s..
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Gastroenterology
Impact of nonalcoholic fatty liver disease on the risk of metachronous colorectal neoplasia after polypectomy
Nam Hee Kim, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
Korean J Intern Med. 2021;36(3):557-567. Published online July 7, 2020
Background/Aims: Metabolic syndrome has been reported to be a risk factor for metachronous colorectal neoplasia (CRN). However, the impact of nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of metabolic syndrome, on the development of metachronous CRN after polypectomy has been rar..
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Recent advances in the diagnosis and management of interstitial pneumonia with autoimmune features: the perspective of rheumatologists
Hong Ki Min, Se-Hee Kim, Sang-Heon Lee, Hae-Rim Kim
Korean J Intern Med. 2021;36(3):515-526. Published online February 8, 2021
Interstitial pneumonia with autoimmune feature (IPAF) is a recently established disease entity that is comprised of interstitial lung diseases with evidence of autoimmune features but that does not fulfill the criteria for definite autoimmune rheumatic diseases. The classification criteria for IPAF ..
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Hemato-oncology
The clinical, laboratory, and radiologic improvement due to siltuximab treatment in idiopathic multicentric Castleman’s disease
Gi-June Min, Young-Woo Jeon, Sung-Soo Park, Silvia Park, Seung-Hawn Shin, Seung-Ah Yahng, Jae-Ho Yoon, Sung-Eun Lee, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Chang-Ki Min, Dong-Wook Kim, Jong-Wook Lee, Seok-Goo Cho
Korean J Intern Med. 2021;36(2):424-432. Published online February 24, 2020
Background/Aims: Idiopathic multicentric Castleman disease (iMCD) comprises approximately 30% of all cases of Castleman disease. It is characterized by constitutional symptoms, enlarged lymph nodes at multiple anatomical sites, and laboratory test abnormalities, which are primarily related to the o..
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How lessons learned from the 2015 Middle East respiratory syndrome outbreak affected the response to coronavirus disease 2019 in the Republic of Korea
Tae Un Yang, Ji Yun Noh, Joon-Young Song, Hee Jin Cheong, Woo Joo Kim
Korean J Intern Med. 2021;36(2):271-285. Published online February 5, 2021
The Republic of Korea (ROK) experienced a public health crisis due to Middle East respiratory syndrome (MERS) in 2015 and is currently going through the coronavirus disease 2019 (COVID-19) pandemic. Lessons learned from the disastrous MERS outbreak were ref lected in the preparedness system, and the..
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Severe hypoglycemia as a preventable risk factor for cardiovascular disease in patients with type 2 diabetes mellitus
Soo-Yeon Choi, Seung-Hyun Ko
Korean J Intern Med. 2021;36(2):263-270. Published online January 8, 2021
Glucose-lowering medication and lifestyle modification are essential for optimal glycemic control in patients with type 2 diabetes mellitus (T2DM). However, glucose-lowering agents, particularly insulin and insulin secretagogues, may cause hypoglycemia, which has multiple negative effects on the car..
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Angiotensin-converting enzyme 2 and kidney diseases in the era of coronavirus disease 2019
Sang Heon Suh, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae
Korean J Intern Med. 2021;36(2):247-262. Published online October 16, 2020
In the decades since the discovery of angiotensin-converting enzyme 2 (ACE2), its protective role in terms of antagonizing activation of the classical renin-angiotensin system (RAS) axis has been recognized in clinical and experimental studies on kidney and cardiovascular diseases. The effects of AC..
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Rheumatology
Association of body composition with disease activity and disability in rheumatoid arthritis
Kyeong Min Son, Seong Hun Kang, Young Il Seo, Hyun Ah Kim
Korean J Intern Med. 2021;36(1):214-222. Published online May 15, 2020
Background/Aims: To explore the associations between body composition and pain, disease activity, and disability in rheumatoid arthritis (RA).
Methods: The study enrolled 335 patients with RA and underwent body composition measurement with an InBody analyzer. The associations of body mass index (BM..
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Infectious diseases
Ongoing outbreak of human adenovirus-associated acute respiratory illness in the Republic of Korea military, 2013 to 2018
Jae-Hoon Ko, Hyeong-taek Woo, Hong Sang Oh, Song Mi Moon, Joon Young Choi, Jeong Uk Lim, Donghoon Kim, Junsu Byun, Soon-Hwan Kwon, Daeyoun Kang, Jung Yeon Heo, Kyong Ran Peck
Korean J Intern Med. 2021;36(1):205-213. Published online September 5, 2019
Background/Aims: Human adenovirus type 55 (HAdV-55), an emerging epidemic strain, has caused several large outbreaks in the Korean military since 2014, and HAdV-associated acute respiratory illness (HAdV-ARI) has been continuously reported thereafter.
Methods: To evaluate the epidemiologic characte..
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Cardiology
Clinical characteristics of spontaneous coronary artery dissection in young female patients with acute myocardial infarction in Korea
Yongcheol Kim, Xiongyi Han, Youngkeun Ahn, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong
Korean J Intern Med. 2021;36(1):106-113. Published online July 18, 2019
Background/Aims: We aimed to evaluate the prevalence, characteristics, and clinical outcomes of spontaneous coronary artery dissection (SCAD) in young female patients with acute myocardial infarction (AMI).
Methods: We identified 8,250 patients diagnosed with AMI who underwent coronary angiogram fr..
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