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Cardiology
Clinical efficacy of angiotensin receptor-neprilysin inhibitor in de novo heart failure with reduced ejection fraction
Su Yeong Park, Min Gyu Kong, Inki Moon, Hyun Woo Park, Hyung-Oh Choi, Hye Sun Seo, Yoon Haeng Cho, Nae-Hee Lee, Kwan Yong Lee, Ho-Jun Jang, Je Sang Kim, Ik Jun Choi, Jon Suh
Korean J Intern Med. 2023;38(5):692-703. Published online August 31, 2023
Background/Aims: We aimed to analyze the efficacy of angiotensin receptor-neprilysin inhibitor (ARNI) by the disease course of heart failure (HF).
Methods: We evaluated 227 patients with HF in a multi-center retrospective cohort that included those with left ventricular ejection fraction (LVEF) ≤..
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Gastroenterology
Clinical and endoscopic characteristics of sessile serrated lesions with dysplasia/carcinoma
Peel Jung, Hyung Wook Kim, Su Bum Park, Dae Hwan Kang, Cheol Woong Choi, Su Jin Kim, Hyeong Seok Nam, Dae Gon Ryu, Dong Hoon Shin, Joo Young Na, Mi Sook Yun
Korean J Intern Med. 2023;38(3):349-361. Published online March 27, 2023
Background/Aims: Some sessile serrated lesions (SSLs) progress into dysplasia and colorectal cancer, however, the clinical and endoscopic characteristics of SSLs with dysplasia remain to be determined. In this study, we elucidated these characteristics in SSLs with dysplasia/carcinoma, compared with..
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Omega-3 fatty acids and atrial fibrillation
Ji Hye Huh, Sang-Ho Jo
Korean J Intern Med. 2023;38(3):282-289. Published online December 14, 2022
Although some clinical trials have demonstrated reduced incidence of cardiovascular disease with the use of omega-3 fatty acids, others have found an increased risk of atrial fibrillation (AF). AF is the most common sustained cardiac arrhythmia worldwide. It is associated with high morbidity and mor..
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Infectious diseases
Varicella zoster virus (VZV)-specific immunity and subclinical VZV reactivation in patients with autoimmune diseases
Kwang-Hoon Lee, Sungim Choi, Ji-Soo Kwon, Sung-Han Kim, Seong Yeon Park
Korean J Intern Med. 2021;36(4):992-1000. Published online June 15, 2021
Background/Aims: The risk of herpes zoster (HZ) is increased in patients with autoimmune diseases (AID), probably due to immunosuppressive therapy.
Methods: This prospective cross-sectional study investigated varicella zoster virus (VZV)-specific immunity in relation to subclinical VZV reactivation..
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The clinical and economic burden of community-onset complicated skin and skin structure infections in Korea
Yong Kyun Cho, Heung Jeong Woo, Shin Woo Kim, In-Gyu Bae, Young Goo Song, Hee Jin Cheong, Hyuck Lee, Sang Hoon Han, Hee Jung Choi, Chisook Moon, Seong Yeol Ryu, Jian Hur, Ja Cob Lee, Yu Mi Jo, Young Joo Kim
Korean J Intern Med. 2020;35(6):1497-1506. Published online February 20, 2020
Background/Aims: To investigate epidemiologic characteristics, clinical and economic burdens, and factors associated with mortality in complicated skin and skin structure infection (cSSSI) patients in Korea.
Methods: A retrospective, observational, nationwide study was conducted between April to Ju..
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Hemato-oncology
Derivation and validation of modified early warning score plus SpO2/FiO2 score for predicting acute deterioration of patients with hematological malignancies
Ju-Ry Lee, Youn-Kyoung Jung, Hwa Jung Kim, Younsuck Koh, Chae-Man Lim, Sang-Bum Hong, Jin Won Huh
Korean J Intern Med. 2020;35(6):1477-1488. Published online March 3, 2020
Background/Aims: Scoring systems play an important role in predicting intensive care unit (ICU) admission or estimating the risk of death in critically ill patients with hematological malignancies. We evaluated the modified early warning score (MEWS) for predicting ICU admissions and in-hospital mor..
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Endocrinology-metabolism
Risk factors for hypothyroidism in euthyroid thyroid nodule patients with lymphocytic thyroiditis on fine needle aspiration cytology
Jeong-Min Lee, Jeonghoon Ha, Kwanhoon Jo, Yejee Lim, Min-Hee Kim, Chan-Kwan Jung, So-Lyung Jung, Moo-Il Kang, Bong-Yun Cha, Dong-Jun Lim
Korean J Intern Med. 2019;34(6):1287-1296. Published online March 13, 2018
Background/Aims: Lymphocytic thyroiditis as cytology diagnosis from fine needle aspiration (FNA) is frequently detected in patients with thyroid nodules. However, the clinical outcome for upcoming hypothyroid events has been rarely clarified in euthyroid patients.
Methods: We retrospectively review..
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Gastroenterology
Current status of endoscopic submucosal dissection for early gastric cancer in Korea: role and benefits
Sang Gyun Kim, Da Hyun Lyu, Chan Mi Park, Na Rae Lee, Jiyoung Kim, Youngju Cha, Hwoon-Yong Jung
Korean J Intern Med. 2019;34(4):785-793. Published online June 21, 2018
Background/Aims: This study was aimed to investigate the current clinical status of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) in Korea based on a National Health Insurance (NHI) database between 2011 and 2014.
Methods: The claims data of ESD for EGC in Korean NHI were re..
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Allergy
Prevalence of anaphylaxis and prescription rates of epinephrine auto-injectors in urban and rural areas of Korea
Hyunseok Cho, Jae-Woo Kwon
Korean J Intern Med. 2019;34(3):643-650. Published online October 26, 2018
Background/Aims: Despite the clinical importance anaphylaxis and the recent increase in its occurrence, studies regarding the epidemiology of anaphylaxis, risk factors for anaphylaxis, and epinephrine auto-injector (EAI) prescription status for patients with anaphylaxis remain poorly described. Thus..
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Infectious diseases
Incidence and risk factors for tenofovir-associated nephrotoxicity among human immunodeficiency virus-infected patients in Korea
Jeong Eun Lee, Shinwon Lee, Sang Heon Song, Ihm Soo Kwak, Sun Hee Lee
Korean J Intern Med. 2019;34(2):409-417. Published online October 12, 2017
Background/Aims: Little is known about tenofovir disoproxil fumarate (TDF)-induced nephrotoxicity in human immunodeficiency virus (HIV)-infected patients in Korea. The objective of this study was to evaluate the incidence and risk factors of TDF-associated nephrotoxicity among HIV-infected patients ..
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Rheumatology
Clinical outcomes and pathological characteristics of immunoglobulin G4-related ophthalmic disease versus orbital inflammatory pseudotumor
Hong Ki Min, Youn Soo Lee, Suk-Woo Yang, Jennifer Lee, Seung-Ki Kwok, Ji Hyeon Ju, Wan-Uk Kim, Sung-Hwan Park
Korean J Intern Med. 2019;34(1):220-226. Published online October 19, 2017
Background/Aims: This study investigated the clinical and pathological features of immunoglobulin G4 (IgG4)-related ophthalmic disease. To clarify the features, we compared IgG4-related ophthalmic disease and orbital inflammatory pseudotumor.
Methods: We retrospectively reviewed the medical records..
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Rapid onset of efficacy predicts response to therapy with certolizumab plus methotrexate in patients with active rheumatoid arthritis
Young Mo Kang, Young-Eun Park, Won Park, Jung-Yoon Choe, Chul-Soo Cho, Seung-Cheol Shim, Sang Cheol Bae, Chang-Hee Suh, Hoon-Suk Cha, Eun Mi Koh, Yeong-Wook Song, Bin Yoo, Shin-Seok Lee, Min-Chan Park, Sang-Heon Lee, Catherine Arendt, Willem Koetse, Soo-Kon Lee
Korean J Intern Med. 2018;33(6):1224-1233. Published online January 5, 2018
Background/Aims: The objective of this study was to determine the efficacy and safety of add-on therapy with certolizumab pegol (CZP) in active rheumatoid arthritis (RA) patients of a single ethnicity.
Methods: In this 24-week, phase 3, randomized, double-blind, placebo-controlled trial, eligible p..
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Cardiology
Harmonization of laboratory results by data adjustment in multicenter clinical trials
Sang Gon Lee, Hee-Jung Chung, Jeong Bae Park, Hyosoon Park, Eun Hee Lee
Korean J Intern Med. 2018;33(6):1119-1128. Published online October 25, 2017
Background/Aims: In multicenter clinical trials, laboratory tests are performed in the laboratory of each center, mostly using different measuring methodologies. The purpose of this study was to evaluate coefficients of variation (CVs) of laboratory results produced by various measuring methods and ..
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Risk factors for poor prognosis in nosocomial infective endocarditis
Ji-won Hwang, Seung Woo Park, Eun Jeong Cho, Ga Yeon Lee, Eun Kyoung Kim, Sung-A Chang, Sung-Ji Park, Sang-Chol Lee, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck, Jae-Hoon Song
Korean J Intern Med. 2018;33(1):102-112. Published online June 2, 2017
Background/Aims: The aim of our study was to compare the characteristics of nosocomial infective endocarditis (NIE) with community-acquired infective endocarditis (CIE) and to determine independent risk factors for in-hospital death.
Methods: We retrospectively reviewed the medical records of 560 ..
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Endocrinology-metabolism
Insulin therapy for adult patients with type 2 diabetes mellitus: a position statement of the Korean Diabetes Association, 2017
Byung-Wan Lee, Jin Hwa Kim, Seung-Hyun Ko, Kyu Yeon Hur, Nan-Hee Kim, Sang Youl Rhee, Hyun Jin Kim, Min Kyong Moon, Seok-O Park, Kyung Mook Choi; on behalf of the Committee of Clinical Practice Guideline of Korean Diabetes Association
Korean J Intern Med. 2017;32(6):967-973. Published online October 23, 2017
The Korean Diabetes Association (KDA) has regularly updated its Clinical Practice Guidelines. In 2017, the KDA published a position statement on the use of antihyperglycemic agents for patients with type 2 diabetes mellitus (T2DM). Growing evidence from new multinational clinical trials using novel ..
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Gastroenterology
Comparing the clinical outcomes of young-onset and adult-onset ulcerative colitis: a multi-center Korean Association for the Study for Intestinal Diseases study
Ji Yeon Kim, Dong Il Park, Dong Soo Han, Kyu-Chan Huh, Chang Kyun Lee, Jeong Eun Shin, Jae Hak Kim, You Sun Kim, Yunho Jung, Sung-Ae Jung, Hyun Joo Song, Hyun Joo Jang, Young-Ho Kim, Sung No Hong
Korean J Intern Med. 2017;32(1):69-78. Published online June 25, 2016
Background/Aims: The aim of this study was to compare the clinical features and outcomes of ulcerative colitis (UC) according to the age of onset in Korea. Methods: A total of 1,141 patients who were diagnosed with UC between July 1987 and November 2013 at 11 tertiary hospitals were enrolled. The ba..
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Prevention of type 2 diabetes mellitus in women with previous gestational diabetes mellitus
Joon Ho Moon, Soo Heon Kwak, Hak C. Jang
Korean J Intern Med. 2017;32(1):26-41. Published online January 1, 2017
Gestational diabetes mellitus (GDM), defined as any degree of glucose intolerance with onset or first recognition during pregnancy, is characterized by underlying maternal defects in the β-cell response to insulin during pregnancy. Women with a previous history of GDM have a greater than 7-fold hi..
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Endocrinology-metabolism
Poor glycemic control is associated with the risk of subclinical hypothyroidism in patients with type 2 diabetes mellitus
Jae Ho Cho, Ho Jin Kim, Jun Ho Lee, Il Rae Park, Jun Sung Moon, Ji Sung Yoon, In-Kyu Lee, Kyu Chang Won, Hyoung Woo Lee
Korean J Intern Med. 2016;31(4):703-711. Published online June 8, 2016
Background/Aims: Overt hypothyroidism is frequently found in patients with type 2 diabetes mellitus (T2DM), but it remains unknown the relationship between subclinical hypothyroidism (SCH) and T2DM. We attempt to evaluate the difference in prevalence of SCH between patients with T2DM and general pop..
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Cardiology
Prognostic value of hyponatremia in heart failure patients: an analysis of the Clinical Characteristics and Outcomes in the Relation with Serum Sodium Level in Asian Patients Hospitalized for Heart Failure (COAST) study
[editorial]
Byung-Su Yoo, Jin Joo Park, Dong-Ju Choi, Seok-Min Kang, Juey-Jen Hwang, Shing-Jong Lin, Ming-Shien Wen, Jian Zhang, Junbo Ge, on behalf of the COAST investigators
Korean J Intern Med. 2015;30(4):460-470. Published online June 29, 2015
Background/Aims: Hyponatremia is a well-known risk factor for poor outcomes in Western studies of heart failure (HF) patients. We evaluated the predictive value of hyponatremia in hospitalized Asian HF patients.
Methods: The Clinical Characteristics and Outcomes in the Relation with Serum Sodium Le..
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Hemato-oncology
Clinical applications of mesenchymal stem cells
Nayoun Kim, Seok-Goo Cho
Korean J Intern Med. 2013;28(4):387-402. Published online July 1, 2013
Mesenchymal stem cells (MSCs) are self-renewing, multipotent progenitor cells with multilineage potential to differentiate into cell types of mesodermal origin, such as adipocytes, osteocytes, and chondrocytes. In addition, MSCs can migrate to sites of inflammation and exert potent immunosuppress..
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