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Hemato-oncology
Identification and overcoming rituximab resistance in diffuse large B-cell lymphoma using next-generation sequencing
Min Ji Jeon, Eun Sang Yu, Chul Won Choi, Dae Sik Kim
Korean J Intern Med. 2023;38(6):893-902. Published online August 21, 2023
Background/Aims: Although rituximab, an antiCD20 monoclonal antibody, has dramatically improved the clinical outcomes of diffuse large B-cell lymphoma, rituximab resistance remains a challenge.
Methods: We developed a rituximab-resistant cell line (RRCL) by sequential exposure to gradually increasi..
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Urgent need for novel antibiotics in Republic of Korea to combat multidrug-resistant bacteria
Hyo-Jin Lee, Dong-Gun Lee
Korean J Intern Med. 2022;37(2):271-280. Published online February 28, 2022
Multidrug resistance in bacteria is an important issue and is increasing in frequency worldwide because of the limitations of therapeutic agents. From 2010 to 2019, 14 new systemic antibiotics received regulatory approval in the United States. However, few new antibiotics have been introduced in Rep..
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Gastroenterology
Impact of previous metronidazole exposure on metronidazole-based second-line quadruple therapy for Helicobacter pylori infection
Gil Ho Lee, Kee Myung Lee, Sung Jae Shin, Joon Koo Kang, Choong-Kyun Noh, Jin Hong Kim, Sun Gyo Lim
Korean J Intern Med. 2020;35(5):1094-1103. Published online July 31, 2020
Background/Aims: The negative effects on the eradication success of Helicobacter pylori infection after previous exposure to macrolides, including clarithromycin on clarithromycin-based first-line therapy have been demonstrated. However, whether this is true for metronidazole-based second-lin..
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Infectious diseases
Cancer patients with neutropenic septic shock: etiology and antimicrobial resistance
Sung Min Jung, Youn Jung Kim, Seung Mok Ryoo, Chang Hwan Sohn, Dong Woo Seo, Kyoung Soo Lim, Won Young Kim
Korean J Intern Med. 2020;35(4):979-987. Published online October 28, 2019
Background/Aims: Among patients with febrile neutropenia that developed after chemotherapy, high-risk patients, such as those having clinical instability or Multinational Association of Supportive Care in Cancer score of < 21, require hospitalization for intravenous empiric antibiotic therapy. Mono..
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Pulmonology
Clinical efficacy of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in patients with multidrug-resistant bacteremia: a single-center study in Korea
Jeongha Mok, Eun-Jung Jo, Jung Seop Eom, Mi-Hyun Kim, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee, Kwangha Lee
Korean J Intern Med. 2019;34(5):1058-1067. Published online May 13, 2019
Background/Aims: Matrix-assisted laser desorption/ionization time-of-f light mass spectrometry (MALDI-TOF MS) is a new diagnostic tool for microorganism identification. The clinical usefulness of this approach has not been widely examined in Korea. This retrospective pre–post-intervention quasi-ex..
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Trend of multidrug and fluoroquinolone resistance in Mycobacterium tuberculosis isolates from 2010 to 2014 in Korea: a multicenter study
Hyeonseok Kim, Jeong Ha Mok, Bohyoung Kang, Taehoon Lee, Hyun-Kyung Lee, Hang Jea Jang, Yu Ji Cho, Doosoo Jeon
Korean J Intern Med. 2019;34(2):344-352. Published online July 27, 2018
Background/Aims: This study was conducted to evaluate the recent prevalence and trend of anti-tuberculosis (TB) drug resistance with a focus on multidrug-resistance (MDR) and fluoroquinolone resistance in South Korea.
Methods: We retrospectively reviewed the drug susceptibility testing results of c..
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Infectious diseases
Changing trends in clinical characteristics and antibiotic susceptibility of Klebsiella pneumoniae bacteremia
Miri Hyun, Chang In Noh, Seong Yeol Ryu, Hyun Ah Kim
Korean J Intern Med. 2018;33(3):595-603. Published online November 10, 2017
Background/Aims: Klebsiella pneumoniae is second most common organism of gram-negative bacteremia in Korea and one of the most common cause of urinary tract infection, and intra-abdominal infection.
Methods: We compared clinical and microbiological characteristics about K. pneumoniae ..
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Epidemiology and treatment of antimicrobialresistant gram-negative bacteria in Korea
Young Ah Kim, Yoon Soo Park
Korean J Intern Med. 2018;33(2):247-255. Published online February 27, 2018
Antimicrobial resistance is becoming one of the greatest challenges to public health worldwide. Infections by antimicrobial-resistant organisms could result in the failure of treatment, increased medical costs, prolonged hospital stays, and an increased socioeconomic burden. Antimicrobial usage in K..
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Risk factors and molecular epidemiology of community-onset, multidrug resistance extended-spectrum β-lactamase-producing Escherichia coli infections
So Yeon Park, Cheol-In Kang, Yu Mi Wi, Doo Ryeon Chung, Kyong Ran Peck, Nam-Yong Lee, Jae-Hoon Song
Korean J Intern Med. 2017;32(1):146-157. Published online April 20, 2016
Background/Aims: Although multidrug resistance (MDR) among extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) poses significant therapeutic challenges, little is known regarding the risk factors and epidemiology of community-onset MDR‑ESBL‑EC infections. We performed this study t..
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Emerging strategies for the treatment of pulmonary tuberculosis: promise and limitations?
Wing Wai Yew, Won-Jung Koh
Korean J Intern Med. 2016;31(1):15-29. Published online December 28, 2015
A worsening scenario of drug-resistant tuberculosis has increased the need for new treatment strategies to tackle this worldwide emergency. There is a pressing need to simplify and shorten the current 6-month treatment regimen for drug-susceptible tuberculosis. Rifamycins and fluoroquinolones, as we..
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Pulmonology
Clinical manifestations of pneumonia according to the causative organism in patients in the intensive care unit
Jung-Kyu Lee, Jinwoo Lee, Young Sik Park, Chang Hoon Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Sang-Min Lee
Korean J Intern Med. 2015;30(6):829-836. Published online October 30, 2015
Background/Aims: Whether the causative organism influences the clinical course of pneumonia in the intensive care unit (ICU) is controversial. We assessed the clinical manifestations and prognosis of pneumonia according to the causative pathogens in patients in a medical ICU.
Methods: A retrospecti..
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Infectious diseases
Drug utilization review of mupirocin ointment in a Korean university-affiliated hospital
Sung Hee Youn, Seung Soon Lee, Sukyeon Kim, Jeong-a Lee, Bum Joon Kim, Jounghee Kim, Hye-kyung Han, Jae-Seok Kim
Korean J Intern Med. 2015;30(4):515-520. Published online June 29, 2015
Background/Aims: Intranasa l mupirocin and chlorhexidine bathing are candidate strategies to prevent healthcare-associated infections caused by methicillin-resistant Staphylococcus aureus (MRSA). In Korea, intranasal mupirocin is not available, and mupirocin ointment, an over-the-counter drug..
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Clinical and microbiological features of Providencia bacteremia: experience at a tertiary care hospital
Hee Kyoung Choi, Young Keun Kim, Hyo Youl Kim, Jeong Eun Park, Young Uh
Korean J Intern Med. 2015;30(2):219-225. Published online February 27, 2015
Background/Aims: Providencia species frequently colonize urinary catheters and cause urinary tract infections (UTIs); however, bacteremia is uncommon and not well understood. We investigated the clinical features of Providencia bacteremia and the antibiotic susceptibility of Provide..
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The Causes and Treatment Outcomes of 91 Patients with Adult Nosocomial Meningitis
Hye-In Kim, Shin-Woo Kim, Ga-Young Park, Eu-Gene Kwon, Hyo-Hoon Kim, Ju-Young Jeong, Hyun-Ha Chang, Jong-Myung Lee, Neung-Su Kim
Korean J Intern Med. 2012;27(2):171-179. Published online May 31, 2012
Background/AimsFrequent pathogens of nosocomial meningitis were investigated and the adequacy of empiric antibiotic therapy was assessed. Outcomes of nosocomial meningitis were also evaluated. MethodsNinety-one patients, who were diagnosed and t..
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Steroid Response in Refractory Asthmatics
An-Soo Jang
Korean J Intern Med. 2012;27(2):143-148. Published online May 31, 2012
Inhaled glucocorticosteroids are currently the most effective anti-inflammatory controller medications for treating persistent asthma. The efficacies of glucocorticoids include reducing asthma symptoms, reducing exacerbation frequency, improving quality of life, improving lung function, decreasin..
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Epidemiology of Ciprofloxacin Resistance and Its Relationship to Extended-Spectrum β-Lactamase Production in Proteus mirabilis Bacteremia
Kyung Mok Sohn, Cheol-In Kang, Eun-Jeong Joo, Young Eun Ha, Doo Ryeon Chung, Kyong Ran Peck, Nam Yong Lee, Jae-Hoon Song
Korean J Intern Med. 2011;26(1):89-93. Published online March 3, 2011
Background/AimsWe evaluated the clinical features of ciprofloxacin-resistant Proteus mirabilis bacteremia and risk factors for ciprofloxacin resistance. MethodsFrom October 2000 to July 2009, 37 patients with clinically signific..
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Efficacy of Initial Treatment with Clevudine in Naive Patients with Chronic Hepatitis B
Hyeon Woong Yang, Byung Seok Lee, Tae Hee Lee, Heon Young Lee, Kwan Woo Nam, Young Woo Kang, Hee Bok Chae, Seok Hyun Kim, Seok Bae Kim, Hyang Ie Lee, An Na Kim, Il Han Song, Sae Hwan Lee, Hong Su Kim
Korean J Intern Med. 2010;25(4):372-376. Published online November 27, 2010
Background/AimsClevudine, a pyrimidine nucleoside analogue, has potent antiviral effects in patients with chronic viral hepatitis B (CHB). We report the efficacy of initial treatment with clevudine in naïve patients with CHB living in Daejeon and Chungcheong Province, South ..
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Two Lung Masses with Different Responses to Pemetrexed
Kwang Young Park, Jae Wook Jung, Seung Bum Nam, Ho Jin Lee, Hyo Seok Kim, Yoon Hee Choi, Jae Cheol Lee
Korean J Intern Med. 2010;25(2):213-216. Published online June 1, 2010
We described here a patient who had two lung masses. Although the two masses had the same histology and a similar good response to initial chemotherapy with gemcitabine and carboplatin, the response to pemetrexed as a second-line treatment was different after re-growth of the tumors. These two lu..
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Principles and practices of antimicrobial stewardship programs in Korea
Ki Tae Kwon, Shin-Woo Kim
Received November 8, 2023 Accepted January 7, 2024 Published online April 23, 2024
This review addresses the escalating challenge posed by antibiotic resistance, highlighting its profound impact on global public health, including increased mortality rates and healthcare expenditures. The review focuses on the need to adopt the One Health approach to effectively manage antibiotic us..
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