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Cardiology
Identification of novel variants for complicating cardiac disease in the scrub typhus infection using whole genome sequencing
Ki-Woon Kang, Kyung-Won Hong, Seong-Kyu Lee
Korean J Intern Med. 2023;38(6):865-871. Published online November 1, 2023
Background/Aims: Scrub typhus infection has been known to complicate cardiovascular diseases mainly attributing to high mortality. Genetic susceptibility loci for complicating cardiac diseases such as atrial fibrillation, heart failure, and ischemic heart disease identified by genomic study have bee..
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Pulmonology
The effect of susceptibility variants, identified in never-smoking female lung cancer cases, on male smokers
Seung Soo Yoo, Hyo-Gyoung Kang, Jin Eun Choi, Mi Jeong Hong, Sook Kyung Do, Jang Hyuck Lee, Won Kee Lee, Shin Yup Lee, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, Eung Bae Lee, Jae Yong Park
Korean J Intern Med. 2020;35(4):929-935. Published online December 30, 2019
Background/Aims: Genome wide and candidate gene association studies have identified polymorphisms associated with the risk of lung cancer in never-smokers. This study was conducted to evaluate the association between 11 polymorphisms identified in female never smokers and the lung cancer risk in mal..
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Gastroenterology
Association of a genetic polymorphism of IL1RN with risk of acute pancreatitis in a Korean ethnic group
Jin Woo Park, Ja Sung Choi, Ki Joon Han, Sang Heun Lee, Eui Joo Kim, Jae Hee Cho
Korean J Intern Med. 2018;33(6):1103-1110. Published online November 10, 2017
Background/Aims: Several epidemiological studies have validated the association of interleukin gene polymorphisms with acute pancreatitis (AP) in different populations. However, there have been few studies in Asian ethnic groups. We aimed to investigate the relationships between inflammatory cytoki..
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Endocrinology-metabolism
p22phox C242T gene polymorphism and overt diabetic nephropathy: a meta-analysis of 1,452 participants
Yan-yan Li, Ge Gong, Hong-yu Geng, Yun Qian
Korean J Intern Med. 2017;32(6):1045-1052. Published online December 8, 2016
Background/Aims: The p22phox C242T gene polymorphism (rs4673) may be linked to an increased susceptibility for overt diabetic nephropathy (ODN), but the study results are still inconclusive.
Methods: To explore the relationship between p22phox C242T gene polymorphism and ODN, the curr..
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Cardiology
LPL gene Pvu II polymorphism and hypertriglyceridemia: a meta-analysis involving 1,640 subjects
Yan-yan Li, Yan-hong Zhou, Ge Gong, Hong-yu Geng, Xin-xing Yang, Xiang-ming Wang, Chuan-wei Zhou, Jian Xu, Yun Qian
Korean J Intern Med. 2017;32(6):1018-1024. Published online May 16, 2017
Background/Aims: Although lipoprotein lipase (LPL) gene Pvu II polymorphism has been associated with an increased risk of hypertriglyceridemia (HT), there is no clear consensus within the scientific community.
Methods: A meta-analysis of 1,640 subjects from six individual studies was conduct..
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Rheumatology
New insights into the genetics of fibromyalgia
Dong-Jin Park, Shin-Seok Lee
Korean J Intern Med. 2017;32(6):984-995. Published online October 23, 2017
Although debate on the concept of fibromyalgia (FM) has been vigorous ever since the classification criteria were first published, FM is now better understood and has become recognized as a disorder. Recently, FM has come to be considered a major health problem, affecting 1% to 5% of the general pop..
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Allergy
Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma
Duy Le Pham, Seung-Hyun Kim, Purevsuren Losol, Eun-Mi Yang, Yoo Seob Shin, Young-Min Ye, Hae-Sim Park
Korean J Intern Med. 2016;31(2):375-385. Published online December 23, 2015
Background/Aims: Role of autophagy in neutrophil function and the association of autophagy and autophagy related (ATG) gene polymorphisms with asthma susceptibility were suggested. In this study, we investigated the genetic association of ATG5 and ATG7 polymorphisms with asthma risk, s..
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Cardiology
Impact of the β-1 adrenergic receptor polymorphism on tolerability and efficacy of bisoprolol therapy in Korean heart failure patients: association between β adrenergic receptor polymorphism and bisoprolol therapy in heart failure (ABBA) study
Hae-Young Lee, Wook-Jin Chung, Hui-Kyung Jeon, Hong-Seog Seo, Dong-Ju Choi, Eun-Seok Jeon, Jae-Joong Kim, Joon Han Shin, Seok-Min Kang, Sung Cil Lim, Sang-Hong Baek
Korean J Intern Med. 2016;31(2):277-287. Published online February 16, 2016
Background/Aims: We evaluated the association between coding region variants of adrenergic receptor genes and therapeutic effect in patients with congestive heart failure (CHF).
Methods: One hundred patients with stable CHF (left ventricular ejection fraction [LVEF] < 45%) were enrolled. Enrolled ..
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Ect.
Replication of the results of genome-wide and candidate gene association studies on telomere length in a Korean population
Sook Kyung Do, Seung Soo Yoo, Yi Young Choi, Jin Eun Choi, Hyo-Sung Jeon, Won Kee Lee, Shin Yup Lee, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, Jae Yong Park
Korean J Intern Med. 2015;30(5):719-726. Published online August 27, 2015
Background/Aims: A number of genome-wide and candidate gene association studies have identified polymorphisms associated with telomere length in Caucasian populations. This study was conducted to determine the impacts of 17 polymorphisms identified in Caucasians on telomere length in a Korean popula..
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Allergy
A polymorphism in the histone deacetylase 1 gene is associated with the response to corticosteroids in asthmatics
Min-Hye Kim, Sae-Hoon Kim, Yook-Keun Kim, Soo-Jong Hong, Kyung-Up Min, Sang-Heon Cho, Heung-Woo Park
Korean J Intern Med. 2013;28(6):708-714. Published online October 29, 2013
Background/AimsRecent investigations suggest that histone deacetylase 1 (HDAC1) and HDAC2 may be target molecules to predict therapeutic responses to corticosteroids. We evaluated the effects of variation in HDAC1 and ..
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Interleukin-6 -634 C/G and -174 G/C Polymorphisms in Korean Patients Undergoing Hemodialysis
Jung-Hwa Ryu, Seung-Jung Kim
Korean J Intern Med. 2012;27(3):327-337. Published online September 1, 2012
Background/AimsChronic inflammatory status is a possible risk factor for vascular access dysfunction in hemodialysis (HD) patients, but susceptibility differences appear among individuals. Interleukin (IL)-6 is a well-known inflammatory cytokine with various polymorphisms. We ..
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Association of the Superoxide Dismutase (V16A) and Catalase (C262T) Genetic Polymorphisms with the Clinical Outcome of Patients with Acute Paraquat Intoxication
Joong-Rock Hong, Su-Jin Seok, Du-Shin Jeong, Sang-Gon Lee, Hyo-Wook Gil, Jong-Oh Yang, Eun-Young Lee, Sae-Yong Hong
Korean J Intern Med. 2010;25(4):422-428. Published online November 27, 2010
Background/AimsMany patients with acute paraquat (PQ) intoxication die even at low PQ concentrations, whereas others with similar concentrations recover. Therefore, it is possible that individual differences in antioxidant capacity are responsible for the variable clinical out..
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Diagnosis and Species Identification of Mycobacterial Infections by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism Analysis of Sterile Body Fluids
Cheong Ho Cho, Sang Hoon Han, Bum Sik Chin, Suk Hoon Choi, Han Sung Lee, Chang Oh Kim, Myung Soo Kim, Jun Yong Choi, Young Goo Song, June Myung Kim
Korean J Intern Med. 2009;24(2):135-138. Published online June 8, 2009
Background/AimsThe development of effective, accurate, and rapid diagnostic methods for Mycobacterium infection and mycobacterial species identification is required. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) is an easy, rapi..
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p53 Genetic Polymorphism of Gastric cancer in Korea
Woo Chul Chung, Kang Moon Lee, Bo In Lee, Ji Sung Chun, So Yeon Lee, U-Im Chang, Soo Heon Park, Jin Mo Yang, Kyu Yong Choi, In-Sik Chung
Korean J Intern Med. 2006;21(1):28-32. Published online March 30, 2006
Background/AimsDeletion or functional loss of the p53 tumor suppression gene plays a role in oncogenic transformation. The codon 72 polymorphism on exon 4 in the p53 gene produces variant proteins with either arginine (Arg) or proline (Pro), a..
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Comparison of antiplatelet treatment in patients with clopidogrel nonresponders with or without carriage of CYP2C19 polymorphism
Yun Myoung Ko, Jeong Kyung Kim, Jeong Hee Kim, Sang-Ho Park, Rak Kyeong Choi
Received October 31, 2017 Accepted January 8, 2018 Published online May 31, 2018
Background/Aims: Several interventions exist for overcoming high platelet reactivity (HPR) on clopidogrel therapy. The goal of this study was to identify strategies that improve inhibition of platelet reactivity in clopidogrel nonresponders with or without loss of function CYP2C19 genotypes, ..
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