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Hemato-oncology / Review
Assessment tools for peripheral neuropathy in multiple myeloma
Sung-Soo Park, Kunye Kwak, Seol-Hee Baek, Changgon Kim, Yoon Seok Choi, Yong Park, Byung Soo Kim, Jin Seok Kim, Chang-Ki Min, Ka-Won Kang
Korean J Intern Med. 2026;41(2):230-241. Published online March 1, 2026
Advances in treating multiple myeloma (MM) have improved survival, shifting the management focus toward quality of life. Peripheral neuropathy (PN) is a common treatment-related toxicity that significantly impairs quality of life. However, standardized assessment methods for PN in patients with MM a..
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Endocrinology-metabolism / Original Article
Association between diabetes duration and hyperuricemia: Korea National Health and Nutrition Examination Survey 2016 to 2021
Kyuho Kim, Kyungdo Han, In Young Kim, Kyuna Lee, Yu-Bae Ahn, Seung-Hyun Ko, Jae-Seung Yun
Korean J Intern Med. 2026;41(1):143-151. Published online January 1, 2026
Background/Aims: We examined the association between diabetes duration and hyperuricemia in Korean subjects based on data from the Korea National Health and Nutrition Examination Survey (KNHANES).
Methods: This cross-sectional study included 4,575 subjects aged 30 years and older with type 2 diabet..
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Endocrinology-metabolism / Original Article
Analysis of experiences on telemedicine pilot projects from the perspectives of doctors, pharmacists, and patients
Yeryeon Jung, Hyunah Kim, Jeong-Yeon Kim, Seongwoo Seo, Youseok Kim, Min Jung Ko, Hun-Sung Kim
Korean J Intern Med. 2026;41(1):131-142. Published online January 1, 2026
Background/Aims: This study is the first to analyze telemedicine pilot project experiences from doctors, pharmacists, and patients with different roles to support sustainable commercialization.
Methods: An online survey targeted individuals (patients, doctors, and pharmacists) who participated in t..
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Cardiology / Original Article
Enhanced prediction of left ventricular ejection fraction using electrocardiography with the addition of clinical metadata
Hyun Woong Park, Taeseen Kang, Young-Hoon Seo, Jae-Hyeong Park
Korean J Intern Med. 2026;41(1):118-130. Published online January 1, 2026
Background/Aims: Left ventricular ejection fraction (LVEF) is a key echocardiographic parameter for assessing LV systolic function, guiding the management of many cardiovascular diseases, including heart failure (HF). While traditional electrocardiography (ECG) has been widely used in clinical pract..
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Cardiology / Original Article
Comparative efficacy and safety of warfarin and direct oral anticoagulants in patients with end-stage kidney disease and atrial fibrillation
[corrected-article]
Yujin Yang, Sun Hwa Lee, Wonmook Hwang, Ji Hoon Jung, Jae-Hyeong Park
Korean J Intern Med. 2026;41(1):107-117. Published online January 1, 2026
Background/Aims: Patients with atrial fibrillation (AF) and end-stage kidney disease (ESKD) require careful anticoagulation because thrombotic and bleeding risks are both elevated. We evaluated the efficacy and safety of warfarin, direct oral anticoagulants (DOACs), and no anticoagulation in Korean ..
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Gastroenterology / Original Article
The effects of Helicobacter pylori eradication and development of immune-mediated disorder in children: a nationwide population-based study in Korea
You Ie Kim, Joon Sung Kim, Sang Yong Kim, Byung-Wook Kim
Korean J Intern Med. 2026;41(1):85-94. Published online January 1, 2026
Background/Aims: Helicobacter pylori may protect against immune-mediated disorders such as inflammatory bowel disease (IBD) and asthma. This study evaluated whether eradication was associated with IBD and asthma in Korean children.
Methods: Data were collected from the Korean National Health..
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Gastroenterology / Original Article
Risk factors for bleeding from gastric antral vascular ectasia
Sung Hyun Cho, Jinyoung Kim, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Korean J Intern Med. 2026;41(1):74-84. Published online January 1, 2026
Background/Aims: Gastric antral vascular ectasia (GAVE) is a rare but important cause of gastrointestinal (GI) bleeding. The clinical course of GAVE is not well-known, and recurrent bleeding from GAVE is a therapeutic challenge. Therefore, we investigated the clinical course of GAVE and identified t..
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Gastroenterology / Review
Clinical management of gastric mucosa-associated lymphoid tissue lymphoma
Ji Yong Ahn
Korean J Intern Med. 2026;41(1):8-14. Published online December 23, 2025
Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is often associated with chronic Helicobacter pylori infection. For an accurate diagnosis of gastric MALT lymphoma, clinical suspicion and careful endoscopic examination with multiple biopsies should be performed, and the final patholo..
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Rheumatology / Original Article
Treatment satisfaction and its determinants in Korean patients with rheumatoid arthritis and systemic lupus erythematosus
Hyo Jin Choi, Mi Ryoung Seo, Eunji Kim, Han Joo Baek
Korean J Intern Med. 2025;40(6):1042-1051. Published online October 28, 2025
Background/Aims: This study aimed to evaluate the treatment satisfaction and its determinants in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
Methods: This cross-sectional study was conducted between September 2021 and December 2021. Data on demographics, clinical..
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Hemato-oncology / Original Article
Real-world treatment outcomes in South Korean patients with epidermal growth factor receptor-mutant non-small cell lung cancer
Young Saing Kim, Eun Young Lee, Hyun Woo Lee, Jin-Hyuk Choi, Tae-Hwan Kim, Yong Won Choi, Mi Sun Ahn
Korean J Intern Med. 2025;40(6):1029-1041. Published online October 31, 2025
Background/Aims: This study aimed to assess the real-world treatment outcomes in South Korean patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) receiving first-line (1L) EGFR tyrosine kinase inhibitors (TKIs).
Methods: We used the Health Insurance Revie..
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Pulmonology / Original Article
Predictive value of the modified ROX index for extubation failure in mechanically ventilated patients
Kwonhyung Hyung, Kyung-Eui Lee, Yoon Hae Ahn, Jinwoo Lee, Sang-Min Lee, Hong Yeul Lee
Korean J Intern Med. 2025;40(6):1002-1016. Published online October 31, 2025
Background/Aims: Clinicians use several measures to determine whether patients will tolerate liberation from mechanical ventilation. This study aimed to evaluate the predictive value of the modified ROX index (mROX) for extubation failure. In addition, we sought to find its role in guiding personali..
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Gastroenterology / Original Article
Risk of colorectal cancer in kidney transplant recipients and patients with end-stage renal disease undergoing hemodialysis
Yongchel Ahn, Hoon Yu, Yoonjong Bae, Mina Kim, Seung Bum Lee
Korean J Intern Med. 2025;40(6):952-960. Published online October 28, 2025
Background/Aims: Assessing the risk of colorectal cancer (CRC) after kidney transplantation (KT) in patients with endstage renal disease (ESRD) receiving dialysis is crucial to determine KT’s risks and benefits. In Korea, the study results remain unclear. Therefore, using a nationwide health scree..
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Nephrology / Review
Shared decision-making for kidney replacement therapy: a comprehensive review and a proposed model
Hyun Jung Shin, Seoyoung Choi, Sejoong Kim
Korean J Intern Med. 2025;40(6):890-908. Published online October 31, 2025
Shared decision-making (SDM) enables patients to actively engage in healthcare decisions by ensuring that treatment options align with their values and preferences. The use of SDM is increasingly recognized in the context of selecting kidney replacement therapy (KRT) for patients with chronic kidney..
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Pulmonology / Review
Managing dyslipidemia in chronic kidney disease: a comprehensive overview of evidence and recommendations
Ji Yoon Kim, Suk Min Chung, Nam Hoon Kim
Korean J Intern Med. 2025;40(6):876-889. Published online October 31, 2025
Patients with chronic kidney disease (CKD) have a significantly increased risk of developing cardiovascular disease (CVD), making dyslipidemia management a critical component of cardiovascular risk reduction in this population. However, as the estimated glomerular filtration rate declines, distinct p..
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Rheumatology / Original Article
Comprehensive analysis of patients with rheumatoid arthritis associated interstitial lung disease
[letter]
Ji-Won Kim, Ju-Yang Jung, Chang-Hee Suh, Hyoun-Ah Kim
Korean J Intern Med. 2025;40(5):845-855. Published online August 26, 2025
Background/Aims: To investigate the demographics, disease characteristics, and treatment modalities of patients with rheumatoid arthritis (RA) associated interstitial lung disease (ILD), focusing on ILD exacerbation and mortality.
Methods: This retrospective study included individuals aged ≥ 18 y..
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Pulmonology / Original Article
The early impact of COVID-19 vaccines on major events in cardiac, pulmonary, and thromboembolic disease: a population-based study
Myeong Geun Choi, Min-Ho Kim, Eun Mi Chun
Korean J Intern Med. 2025;40(5):801-812. Published online August 26, 2025
Background/Aims: Although COVID-19 vaccines reduce COVID-19 severity, various safety concerns have emerged. This study, involving a population-based cohort, used health insurance data to investigate potential vaccine-related major outcomes, including cardiac, pulmonary, and thromboembolic diseases.
..
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Pulmonology / Original Article
Efficacy and safety of HL-301 compared with erdosteine in acute bronchitis: a randomized, double-blind, non-inferiority trial
Ji-Yong Moon, Joon Young Choi, Youlim Kim, Hye Jung Park, Yong Bum Park, Seong Yong Lim, Kyung Hoon Min, Deog Kyeom Kim, Chin Kook Rhee, Seung Won Ra, Chang Youl Lee, Yong Il Hwang, Kwang Ha Yoo
Korean J Intern Med. 2025;40(5):790-800. Published online August 26, 2025
Background/Aims: This study evaluated the non-inferiority of HL-301 to erdosteine in terms of symptom relief and the anti- inflammatory effects in acute bronchitis patients not treated with antibiotics.
Methods: In a double-blind, non-inferiority trial, patients were randomized 1:1 to receive eithe..
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Cardiology / Original Article
Impact of guideline-directed medical therapy on the cardiac or non-cardiac death in acute myocardial infarction
Jin-Ho Choi, Dahee Hyun, Seung Ho Hur, Seung Woon Rha, Seung Jae Joo, Hyo-Soo Kim, Myung Ho Jeong; on behalf of KAMIR-NIH investigators
Korean J Intern Med. 2025;40(5):780-789. Published online August 29, 2025
Background/Aims: While the clinical effectiveness of guideline-directed medical therapy (GDMT) is well established in patients with acute myocardial infarction (AMI), its specific impact on cause-specific mortality remains unclear. This study aimed to investigate the impact of GDMT on both cardiac a..
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Cardiology / Original Article
Effect of tegoprazan on temporal variability of platelet reactivity in patients treated with clopidogrel after coronary stenting
Oh-Hyun Lee, Ji Woong Roh, Yongcheol Kim, Eui Im, Deok-Kyu Cho
Korean J Intern Med. 2025;40(5):759-766. Published online March 25, 2025
Background/Aims: Data on the interactions between clopidogrel and tegoprazan are limited. We compared the effects of tegoprazan and proton-pump inhibitors (PPIs) on platelet reactivity.
Methods: Using database data from March 2020 to January 2023, we retrospectively evaluated 262 patients who were ..
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Infectious diseases / Review
Appropriate timing of antibiotic initiation in patients with sepsis or septic shock: a systematic review and meta-analysis
Nam Su Ku, Yongseop Lee, Dae Won Park
Korean J Intern Med. 2025;40(5):725-733. Published online August 26, 2025
Evidence supporting antibiotic administration within 3 hours in sepsis without shock is limited. Therefore, we conducted a systematic review and meta-analysis to determine whether the timing of antibiotic initiation influences mortality in patients with sepsis or septic shock. We comprehensively searched Pub..
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