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Infectious diseases
The effects of remdesivir on mortality and the requirement for mechanical ventilation in patients with COVID-19: a systematic review stratified by disease severity
Seungeun Ryoo, Miyoung Choi, Su-Yeon Yu, Young Kyung Yoon, Kyungmin Huh, Eun-Jeong Joo
Korean J Intern Med. 2024;39(1):160-171. Published online December 28, 2023
Background/Aims: The effectiveness of remdesivir treatment in reducing mortality and the requirement for mechanical ventilation (MV) remains uncertain, as randomized controlled trials (RCTs) have produced conflicting results.
Methods: We searched MEDLINE, EMBASE, Cochrane Central Register of Contro..
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Clinical significance of antinuclear antibody positivity in patients with severe coronavirus disease 2019
Soo Hyun Park, Jin Woong Suh, Kyung-Sook Yang, Jeong Yeon Kim, Sun Bean Kim, Jang Wook Sohn, Young Kyung Yoon
Korean J Intern Med. 2023;38(3):417-426. Published online April 6, 2023
Background/Aims: This study aimed to investigate the clinical characteristics and outcomes of fluorescent antinuclear antibody (FANA)-positive patients admitted for coronavirus disease 2019 (COVID‐19) and identify FANA as a prognostic factor of mortality.
Methods: This retrospective study was con..
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Pulmonology
Corticosteroid outcome may be dependent of duration of use in severe COVID-19
[letter]
Jin Hyoung Kim, Yong Sub Na, Song-I Lee, Youn Young Moon, Beom Seuk Hwang, Ae-Rin Baek, Won-Young Kim, Bo Young Lee, Gil Myeong Seong, Moon Seong Baek
Korean J Intern Med. 2023;38(3):382-392. Published online April 11, 2023
Background/Aims: For patients hospitalized with coronavirus disease 2019 (COVID-19) who require supplemental oxygen, the evidence of the optimal duration of corticosteroid is limited. This study aims to identify whether long-term use of corticosteroids is associated with decreased mortality.
Method..
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Rheumatology
Incidence of rheumatic diseases during the COVID-19 pandemic in South Korea
Soo Min Ahn, Seongho Eun, Sunghwan Ji, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Ji Seon Oh, Yong-Gil Kim
Korean J Intern Med. 2023;38(2):248-253. Published online January 17, 2023
Background/Aims: The recent coronavirus disease 2019 (COVID-19) pandemic has been associated with changes in the epidemiology of not only infectious diseases but also several non-infectious conditions. This study investigated changes in the recorded incidence of various rheumatic diseases during the..
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Pulmonology
Timing of corticosteroids in non-severe non-hospitalized COVID-19 patients: open-label, two-center, randomized controlled study (TICS-COV19 study)
Emad R. Issak, Mariam M. Amin
Korean J Intern Med. 2023;38(2):207-217. Published online January 17, 2023
Background/Aims: Corticosteroids (CSs) are frequently used in coronavirus disease 2019 (COVID-19); however, their utility remains controversial in mild to moderate cases. The timing of CSs initiation during the disease course remains unaddressed. The study aims to evaluate the impact of early CSs in..
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Infectious diseases
A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19
Moon Seong Baek, Seong-Ho Choi, Won-Young Kim, Min-Chul Kim, Eun-Jeong Joo, Mi Suk Lee, Hyun Ah Kim, Sook In Jung, Yu Shi Nae, Bongyoung Kim, Yaeji Lim, Jin-Won Chung
Korean J Intern Med. 2023;38(1):101-112. Published online October 25, 2022
Background/Aims: To identify changes in symptoms and pulmonary sequelae in patients with coronavirus disease 2019 (COVID-19).
Methods: Patients with COVID-19 hospitalized at seven university hospitals in Korea between February 2020 and February 2021 were enrolled, provided they had ≥ 1 outpatient..
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Pulmonology
Clinical outcomes of and risk factors for secondary infection in patients with severe COVID-19: a multicenter cohort study in South Korea
Yong Sub Na, Ae-Rin Baek, Moon Seong Baek, Won-Young Kim, Jin Hyoung Kim, Bo young Lee, Gil Myeong Seong, Song-I Lee
Korean J Intern Med. 2023;38(1):68-79. Published online November 24, 2022
Background/Aims: Secondary infection with influenza virus occurs in critically ill patients and is associated with substantial morbidity and mortality; however, there is limited information about it in patients with severe coronavirus disease 2019 (COVID-19). Thus, we investigated the clinical outco..
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Infectious diseases
Comparison of the rapidity of SARS-CoV-2 immune responses between primary and booster vaccination for COVID-19
Ji Yeun Kim, Ji-Soo Kwon, Hye Hee Cha, So Yun Lim, Seongman Bae, Sung-Han Kim
Korean J Intern Med. 2022;37(6):1234-1240. Published online October 11, 2022
Background/Aims: The rapidity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific memory B or T cell response in vaccinated individuals is important for our understanding of immunopathogenesis of coronavirus disease 2019 (COVID-19). We therefore compared the timing of adequate ..
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Pulmonology
Clinical characteristics of patients with COVID-19 vaccine-related pneumonitis: a case series and literature review
Ji Young Park, Joo-Hee Kim, Sunghoon Park, Yong Il Hwang, Hwan Il Kim, Seung Hun Jang, Ki-Suck Jung, Yong Kyun Kim, Hyun Ah Kim, In Jae Lee
Korean J Intern Med. 2022;37(5):989-1001. Published online August 22, 2022
Background/Aims: Pulmonary toxicities of coronavirus disease 2019 (COVID-19) vaccination are exceedingly rare. However, there are a few reported cases after mRNA vaccination, especially from Asian countries. The purpose of this study was to report the clinical characteristics of patients with COVID-..
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Vaccination strategies for Korean patients with inflammatory bowel disease
Yoo Jin Lee, Eun Soo Kim
Korean J Intern Med. 2022;37(5):920-930. Published online August 8, 2022
Patients with inflammatory bowel disease (IBD) are vulnerable to vaccine-preventable infectious diseases. Immunosuppressive drugs, which are often used to manage IBD, may increase this vulnerability and attenuate vaccine efficacy. Thus, healthcare providers should understand infectious diseases and ..
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Infectious diseases
Risk factors and clinical impact of COVID-19-associated pulmonary aspergillosis: Multicenter retrospective cohort study
Raeseok Lee, Sung-Yeon Cho, Dong-Gun Lee, Hyojin Ahn, Hyeah Choi, Su-Mi Choi, Jae-Ki Choi, Jung-Hyun Choi, Shin Young Kim, Youn Jeong Kim, Hyo-Jin Lee
Korean J Intern Med. 2022;37(4):851-863. Published online May 26, 2022
Background/Aims: The risk factors and clinical impacts of coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) remain controversial, and no data have been reported in Korea. This study aimed to investigate the epidemiology and importance of CAPA diagnostic efforts and to ide..
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Cardiology
Treatment delay and outcomes of ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention during the COVID-19 era in South Korea
Seok Oh, Myung Ho Jeong, Kyung Hoon Cho, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn
Korean J Intern Med. 2022;37(4):786-799. Published online June 28, 2022
Background/Aims: Little is known about the clinical characteristics and treatment outcomes of ST-segment elevation myocardial infarction (STEMI) in Korea during the coronavirus disease 2019 (COVID-19) era. We aimed to evaluate the clinical characteristics and treatment outcomes of patients with STEM..
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Rheumatology
Baseline use of hydroxychloroquine or immunosuppressive drugs and the risk of coronavirus disease 2019
Ji-Won Kim, Sang Gyu Kwak, Hwajeong Lee, Seong-Kyu Kim, Jung-Yoon Choe, Sung-Hoon Park
Korean J Intern Med. 2022;37(3):673-680. Published online March 12, 2021
Background/Aims: The preventive role of hydroxychloroquine (HCQ) on coronavirus disease 2019 (COVID-19) remains unclear. The aim of this study was to examine the effects of HCQ and other immunosuppressive drugs on the incidence of COVID-19.
Methods: The data were collected from the South Korea Nati..
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Infectious diseases
Eosinophil-mediated lung inflammation associated with elevated natural killer T cell response in COVID-19 patients
Dong-Min Kim, Jun-Won Seo, Yuri Kim, Uni Park, Na-Young Ha, Hyoree Park, Na Ra Yun, Da Young Kim, Sung Ho Yoon, Yong Sub Na, Do Sik Moon, Sung-Chul Lim, Choon-Mee Kim, Yeon-Sook Kim, Nam-Hyuk Cho
Korean J Intern Med. 2022;37(1):201-209. Published online September 27, 2021
Background/Aims: Coronavirus disease 2019 (COVID-19) is associated with acute respiratory syndrome. The mechanisms underlying the different degrees of pneumonia severity in patients with COVID-19 remain elusive. This study provides evidence that COVID-19 is associated with eosinophil-mediated inflam..
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Lopinavir-ritonavir versus hydroxychloroquine for viral clearance and clinical improvement in patients with mild to moderate coronavirus disease 2019
Ji-Won Kim, Eun Jin Kim, Hyun Hee Kwon, Chi Young Jung, Kyung Chan Kim, Jung-Yoon Choe, Hyo-Lim Hong
Korean J Intern Med. 2021;36(Suppl 1):S253-S263. Published online June 16, 2020
Background/Aims: The efficacies of lopinavir-ritonavir or hydroxychloroquine remain to be determined in patients with coronavirus disease 2019 (COVID-19). To compare the virological and clinical responses to lopinavir-ritonavir and hydroxychloroquine treatment in COVID-19 patients.
Methods: This re..
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Cardiology
Update on association between exposure to renin-angiotensin-aldosterone system inhibitors and coronavirus disease 2019 in South Korea
Jeongkuk Seo, Minkook Son
Korean J Intern Med. 2021;36(Suppl 1):S114-S122. Published online February 25, 2021
Background/Aims: Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, there have been concerns about the association between exposure to renin-angiotensin-aldosterone system (RAAS) inhibitors and the risk and severity of COVID-19.
Methods: We performed a case-control study that util..
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Infectious diseases
Can reactogenicity predict immunogenicity after COVID-19 vaccination?
Young Hoon Hwang, Kyoung-Ho Song, Yunsang Choi, Suryeong Go, Su-Jin Choi, Jongtak Jung, Chang Kyung Kang, Pyoeng Gyun Choe, Nam-Joong Kim, Wan Beom Park, Myoung-don Oh
Korean J Intern Med. 2021;36(6):1486-1491. Published online May 28, 2021
Background/Aims: This study aimed to assess the association between local and systemic reactogenicity and humoral immunogenicity after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination.
Methods: Adverse events were prospectively evaluated using an electronic diary in 135 heal..
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Pulmonology
Changes in respiratory virus infection trends during the COVID-19 pandemic in South Korea: the effectiveness of public health measures
Ji Young Park, Hwan Il Kim, Joo-Hee Kim, Sunghoon Park, Yong Il Hwang, Seung Hun Jang, Yong Kyun Kim, Ki-Suck Jung
Korean J Intern Med. 2021;36(5):1157-1168. Published online August 18, 2021
Background/Aims: Studies on the effectiveness of public health measures to prevent respiratory virus transmission in real-world settings are lacking. We investigated the effectiveness of universal mask use and adherence to other personal preventive measures on the changing viral respiratory infectio..
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Gastroenterology
Impact of liver cirrhosis on the clinical outcomes of patients with COVID-19: a nationwide cohort study of Korea
Dongsub Jeon, Minkook Son, Jonggi Choi
Korean J Intern Med. 2021;36(5):1092-1101. Published online August 18, 2021
Background/Aims: The impact of liver cirrhosis (LC) on the clinical outcomes of patients with coronavirus disease 2019 (COVID-19) remains elusive. This study evaluated the association between LC and the development of severe complications from COVID-19.
Methods: We used the National Health Insuranc..
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Endocrinology-metabolism
Impact of urgently initiated tele-prescription due to COVID-19 on glycemic control in patients with type 2 diabetes
Sung-Don Park, Na-young Kim, Jae-Han Jeon, Jung-Guk Kim, In-Kyu Lee, Keun-Gyu Park, Yeon-Kyung Choi
Korean J Intern Med. 2021;36(4):942-948. Published online June 7, 2021
Background/Aims: Coronavirus disease 2019 (COVID-19) is a global pandemic that had affected more than 13,000 people in South Korea by July 2020. To prevent spread of COVID-19, tele-prescription was permitted temporarily. This study investigated the impact of tele-prescription on glycemic control in ..
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