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Nephrology
Treatment of rituximab in patients with idiopathic membranous nephropathy: a case series and literature review
Soo-Jee Jeon, Ji-Hye Kim, Hee-Won Noh, Ga-Young Lee, Jeong-Hoon Lim, Hee-Yeon Jung, Jang-Hee Cho, Ji-Young Choi, Chan-Duck Kim, Yong-Lim Kim, Sun-Hee Park
Korean J Intern Med. 2022;37(4):830-840. Published online April 15, 2022
Background/Aims: Membranous nephropathy (MN) is a major cause of nephrotic syndrome in adults. This study aimed to evaluate the effect of rituximab (RTX) in patients with idiopathic MN (iMN) who have a high risk of progression.
Methods: We retrospectively analyzed data of 13 patients with iMN, who ..
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The optimal anti-phospholipase A2 receptor cutoff for the diagnosis of idiopathic membranous nephropathy: a single-center retrospective study
Chaofan Li, Ping Li, Wenkai Guo, Lei Chen, Jiatong Li, Rong Wang, Bing Chen
Korean J Intern Med. 2022;37(1):154-166. Published online July 22, 2021
Background/Aims: Anti-phospholipase A2 receptor (PLA2R) autoantibody is the main biomarker of idiopathic membranous nephropathy (IMN). We aimed to find a new cutoff value of anti-PLA2R for patients with IMN and to explore the relevance between this antibody and baseline clinical parameters.
Methods..
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Association between the progression of immunoglobulin A nephropathy and a controlled status of hypertension in the first year after diagnosis
Tae Ryom Oh, Hong Sang Choi, Se Won Oh, Jieun Oh, Dong Won Lee, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae; on behalf of the Korean GlomeruloNEphritis sTudy (KoGNET) Group
Korean J Intern Med. 2022;37(1):146-153. Published online April 8, 2021
Background/Aims: Hypertension is considered a risk factor in immunoglobulin A nephropathy (IgAN). However, after IgAN diagnosis, the relationship between early blood pressure control and renal prognosis remains unclear. This study aimed to analyze the association between the prognosis of IgAN patients and ..
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Current findings of kidney biopsy including nephropathy associated with hypertension and diabetes mellitus in Korea
Kipyo Kim, Sang Ho Lee, Sung Woo Lee, Jung Pyo Lee, Ho Jun Chin; on behalf of the Korean GlomeruloNEphritis sTudy (KoGNET) Group
Korean J Intern Med. 2020;35(5):1173-1187. Published online August 14, 2020
Background/Aims: This study aimed to investigate long-term temporal trends and outcomes of biopsy-proven kidney diseases in a multicenter kidney biopsy cohort, focusing on hypertension and diabetes, the leading causes of end-stage kidney disease (ESKD).
Methods: The study included a total of 21,426..
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Clinical outcomes and effects of treatment in older patients with idiopathic membranous nephropathy
Yaeni Kim, Hye Eun Yoon, Byung Ha Chung, Bum Soon Choi, Cheol Whee Park, Chul Woo Yang, Yong-Soo Kim, Yu Ah Hong, Suk Young Kim, Yoon-Kyung Chang, Hyeon Seok Hwang
Korean J Intern Med. 2019;34(5):1091-1099. Published online August 14, 2019
Background/Aims: Membranous nephropathy (MN) is the most common primary glomerular disease diagnosed in older patients. Few reports describe the clinical outcomes in older patients with idiopathic MN.
Methods: The outcomes of 135 patients with histologically proven MN were analyzed. ‘Older’ was ..
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Urine synaptopodin excretion is an important marker of glomerular disease progression
Soon Kil Kwon, Seung Jung Kim, Hye-Young Kim
Korean J Intern Med. 2016;31(5):938-943. Published online September 1, 2016
Background/Aims: Podocytes play an important role in maintaining the glomerular filtration barrier and in formation of the slit diaphragm. Podocyte loss is associated with chronic kidney disease progression, but it is not clear whether urinary podocyte proteins in urine reflect the clinical extent o..
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Effect of low-dose valsartan on proteinuria in normotensive immunoglobulin A nephropathy with minimal proteinuria: a randomized trial
Young-Il Jo, Ha-Young Na, Ju-Young Moon, Sang-Woong Han, Dong-Ho Yang, Sang-Ho Lee, Hyeong-Cheon Park, Hoon-Young Choi, So-Dug Lim, Jeong-Hae Kie, Yong-Kyu Lee, Sug-Kyun Shin
Korean J Intern Med. 2016;31(2):335-343. Published online February 15, 2016
Background/Aims: Immunoglobulin A nephropathy (IgAN) is a generally progressive disease, even in patients with favorable prognostic features. In this study, we aimed to investigate the antiproteinuric effect and tolerability of low-dose valsartan (an angiotensin II receptor blocker) therapy in normo..
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Co-existing proteinase 3-antineutrophil cytoplasmic antibody-associated vasculitis with immunoglobulin A nephropathy
Adem Kucuk, Yalcin Solak, Abduzhappar Gaipov, Sinan Bagcaci, Hasan Esen, Suleyman Turk, Recep Tunc
Korean J Intern Med. 2016;31(1):194-196. Published online December 28, 2015
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Nephrology
High serum and urine neutrophil gelatinase-associated lipocalin levels are independent predictors of renal progression in patients with immunoglobulin A nephropathy
Harin Rhee, Nari Shin, Min Ji Shin, Byung Yun Yang, Il Young Kim, Sang Heon Song, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak, Eun Young Seong
Korean J Intern Med. 2015;30(3):354-361. Published online April 29, 2015
Background/Aims: Tubulointerstitial injury plays an important role in the progression of immunoglobulin A nephropathy (IgAN), and neutrophil gelatinase-associated lipocalin (NGAL) is among the most sensitive tubular biomarkers. We investigated whether serum or urine NGAL predicts prognosis in patien..
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Plasma neutrophil gelatinase-associated lipocalin as a potential predictor of adverse renal outcomes in immunoglobulin A nephropathy
Ga-Young Park, Chung-Hoon Yu, Jun-Seop Kim, Yun-Jeong Kang, Owen Kwon, Ji-Young Choi, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim, Sun-Hee Park
Korean J Intern Med. 2015;30(3):345-353. Published online April 29, 2015
Background/Aims: Neutrophil gelatinase-associated lipocalin (NGAL) is a well-known biomarker of acute kidney injury. We evaluated the value of plasma NGAL (pNGAL) as an independent predictor of prognosis in immunoglobulin A nephropathy (IgAN).
Methods: In total, 91 patients with biopsy-proven IgAN ..
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Urinary excretion of β2-microglobulin as a prognostic marker in immunoglobulin A nephropathy
Jae Ryung Shin, Seung Min Kim, Jung Sun Yoo, Ji Yoon Park, Seul Ki Kim, Joo Hee Cho, Kyung Hwan Jeong, Tae Won Lee, Chun Gyoo Ihm
Korean J Intern Med. 2014;29(3):334-340. Published online April 29, 2014
Background/Aims: β2-microglobulin (β2-MG) is freely filtered at the glomerulus and subsequently reabsorbed and catabolized by proximal renal tubular cells. Urinary β2-MG is an early and sensitive biomarker of acute kidney injury; however, its utility as a bio..
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Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis
Ji-Hye Lee, Mee-Hye Oh, Jae-Seok Park, Gyoung-Jae Na, Hye-Wook Gil, Jong-Oh Yang, Eun-Young Lee, Sae-Yong Hong
Korean J Intern Med. 2014;29(2):176-182. Published online February 27, 2014
Background/Aims: The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN).
Methods: Renal biopsy specimens from 52 IgA G..
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A case of Tsutsugamushi disease presenting with nephrotic syndrome
Ju Hyun Lee, Mi Jung Lee, Dong Ho Shin, Shin-Wook Kang, Kyu Hun Choi, Tae-Hyun Yoo
Korean J Intern Med. 2013;28(6):728-731. Published online October 29, 2013
Nephrotic syndrome associated with Tsutsugamushi disease has not been previously reported. We are describing a case of Tsutsugamuchi disease presenting with nephrotic syndrome. A 72-year-old woman presented with fever and generalized edema. Laboratory studies revealed a leukocytosis, hypoalbumine..
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A case of membranoproliferative glomerulonephritis associated with metastatic colon cancer
Jung-Hwa Ryu, Soon Sup Chung, Dong-Ryeol Ryu, Seung-Jung Kim, Duk-Hee Kang, Sun Hee Sung, Kyu-Bok Choi
Korean J Intern Med. 2013;28(2):254-257. Published online February 27, 2013
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Experience of Anti-Viral Therapy in Hepatitis B-Associated Membranous Nephropathy, Including Lamivudine-Resistant Strains
In O Sun, Yu Ah Hong, Hoon Suk Park, Sun Ryoung Choi, Byung Ha Chung, Cheol Whee Park, Chul Woo Yang, Yong Soo Kim, Bum Soon Choi
Korean J Intern Med. 2012;27(4):411-416. Published online November 27, 2012
Background/AimsChronic hepatitis B infection is a common cause of secondary membranous nephropathy (MN) in endemic areas. Lamivudine treatment improves renal outcome in patients with hepatitis B virus-associated MN (HBV-MN), but prolonged use leads to the emergence of lamivudi..
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Validation of the Oxford Classification of IgA Nephropathy: A Single-Center Study in Korean Adults
Hoyoung Lee, Sul Hee Yi, Mi Seon Seo, Jin Nam Hyun, Jin Seok Jeon, Hyunjin Noh, Dong Cheol Han, Seung Duk Hwang, So Young Jin, Soon Hyo Kwon
Korean J Intern Med. 2012;27(3):293-300. Published online September 1, 2012
Background/AimsThe recently published Oxford classification of IgA nephropathy (IgAN) proposed a split system for histological grading, based on prognostic pathological features. This new classification system must be validated in a variety of cohorts. We investigated whether ..
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