KJIM :: The Korean Journal of Internal Medicine

Original Article

October 28, 2025

Risk of colorectal cancer in kidney transplant recipients and patients with end-stage renal disease undergoing hemodialysis

Yongchel Ahn, Hoon Yu, Yoonjong Bae, et al.

Korean J Intern Med. 2025;40(6):952-960.

1. Kidney transplant recipients had a significantly lower risk of colorectal cancer compared with patients on dialysis. 2. Landmark analyses at 3 and 5 years confirmed consistently higher cumulative incidence of...

Original Article

October 28, 2025

Long-term clinical outcome and risk stratification across stages of cardiovascular-kidney-metabolic syndrome in a nationwide cohort

Hyun-Jin Kim, Byung Sik Kim, Hasung Kim, et al.

Korean J Intern Med. 2025;40(6):975-989.

1. Higher CKM stages consistently showed worse composite and cardiovascular outcomes over longterm follow-up. 2. Stages 1–2 were already linked to meaningfully higher adverse events after adjustment and in sensitivity checks.

Original Article

October 28, 2025

Treatment satisfaction and its determinants in Korean patients with rheumatoid arthritis and systemic lupus erythematosus

Hyo Jin Choi, Mi Ryoung Seo, Eunji Kim, et al.

Korean J Intern Med. 2025;40(6):1042-1051.

1. Over 80% of patients with both RA and SLE did not report good treatment satisfaction. 2. To maximize treatment satisfaction in patients with RA, an individualized, patient-centered approach that considers...

Original Article

October 28, 2025

Real-world clinical response and efficacy of tacrolimus-based maintenance therapy for Korean patients with lupus nephritis

Ji-Won Kim, Ju-Yang Jung, Hyoun-Ah Kim, et al.

Korean J Intern Med. 2025;40(6):1052-1064.

1. For patients with persistent proteinuria after induction therapy, the addition of tacrolimus to other immunosuppressive agents yielded outcomes comparable to those of patients who responded well to induction treatment...

Original Article

October 31, 2025

Exosomal miRNA-720 as a potential diagnostic and prognostic biomarker for hepatocellular carcinoma

Ji Min Kim, Hye Seon Kim, Jin Seoub Kim, et al.

Korean J Intern Med. 2025;40(6):939-951.

1. Circulating exosomal miR-720 expression was significantly upregulated in HCC vs. non-HCC subjects. 2. Exosomal miR-720 plays an oncogenic role in HCC by targeting StarD13. 3. Circulating exosomal miR-720 could be used...

Original Article

October 31, 2025

Association of the triglyceride-glucose index with cardiovascular outcomes across cardiovascular-kidney-metabolic syndrome stages

Byung Sik Kim, Hyun-Jin Kim, Shinje Moon, et al.

Korean J Intern Med. 2025;40(6):961-974.

1. The TyG index is independently associated with dose-dependent adverse cardiovascular outcomes. 2. Its prognostic value is consistent across all CKM syndrome stages, with the highest risk in early stages. 3. Incorporating...

Original Article

October 31, 2025

Effects of adjunctive dobutamine on outcomes among patients with septic shock: a propensity score matching analysis

Sung Yoon Lim, Kyu Jin Lee, Yeonhoon Jang, et al.

Korean J Intern Med. 2025;40(6):990-1001.

1. In this propensity score-matched analysis, shortterm outcomes, including SOFA scores and lactate levels on ICU day 3, were not significantly affected by the adjunctive use of dobutamine. 2. The addition...

Original Article

October 31, 2025

Predictive value of the modified ROX index for extubation failure in mechanically ventilated patients

Kwonhyung Hyung, Kyung-Eui Lee, Yoon Hae Ahn, et al.

Korean J Intern Med. 2025;40(6):1002-1016.

1. The mROX, calculated as PaO2/FiO2 divided by respiratory rate, is a reliable predictor of extubation failure in mechanically ventilated patients. 2. In comparison to other respiratory indices, an mROX value...

Original Article

October 31, 2025

Comprehensive approaches to diabetes in the elderly: adapting to evolving trends

Jeongmin Lee, Kwang Joon Kim, Yang Sun Park, et al.

Korean J Intern Med. 2025;40(6):1017-1028.

1. Our analysis revealed a notable increase in the prevalence of DM among older Korean adults, rising to 30.9% by 2021, and that the prevalence of prediabetes exceeded 40% across...

Original Article

October 31, 2025

Real-world treatment outcomes in South Korean patients with epidermal growth factor receptor-mutant non-small cell lung cancer

Young Saing Kim, Eun Young Lee, Hyun Woo Lee, et al.

Korean J Intern Med. 2025;40(6):1029-1041.

1. Real-world outcomes of 1L EGFR-TKI therapy in Korean NSCLC patients demonstrate median overall survival of approximately 2 years, highlighting the efficacy of targeted therapy in this population. 2. Detection of...

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