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Rheumatology / Original Article
LncRNA as a diagnostic marker for rheumatoid arthritis: a systematic review and meta-analysis
Lin-ling Luo, Yu-tong Chen, Yi-ning Xu, Miao Lu, Xi-de Liu
Korean J Intern Med. 2026;41(3):524-536. Published online May 1, 2026
Background/Aims: Rheumatoid arthritis (RA) is categorized as an autoimmune disorder characterized by the absence of a definitive cure. In this investigation, we executed a systematic review and diagnostic meta-analysis to ascertain the diagnostic efficacy of long non-coding RNAs (lncRNAs) in the ide..
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Gastroenterology / Original Article
Comparison of the efficacy and safety of endoscopic and fluoroscopic balloon dilatation in benign esophageal strictures
Kwangbeom Park, Chang Hoon Oh, Do Hoon Kim, Ji Hoon Shin, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Korean J Intern Med. 2026;41(3):462-473. Published online May 1, 2026
Background/Aims: Balloon dilatation under endoscopic or fluoroscopic guidance is regarded as the gold standard for treating benign esophageal strictures. However, no prior studies have compared endoscopic balloon dilatation (EBD) with fluoroscopic balloon dilatation (FBD). We aimed to compare the ef..
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Cardiology / Review
Transcatheter aortic valve implantation for symptomatic severe aortic stenosis and its expanding clinical indications
Hyungdon Kook, Young-Hyo Lim
Korean J Intern Med. 2026;41(3):373-383. Published online February 24, 2026
Transcatheter aortic valve implantation (TAVI) is a minimally invasive treatment for symptomatic severe aortic stenosis (AS) that was initially developed for patients with prohibitive surgical risk. Since the first-in-human procedure in 2002, TAVI has gained global acceptance owing to its favorable ..
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Infectious diseases / Original Article
Hemodialysis vascular access infections: epidemiology and risk factors for treatment failure
Shi Nae Yu, Eunjung Lee, Se Yoon Park, Oh-Hyun Cho, Sangchul Yun, Tark Kim, Min Seo Kang, Yae Jee Baek, Jongtak Jung, Tae Hyong Kim
Korean J Intern Med. 2026;41(2):317-327. Published online March 1, 2026
Background/Aims: Infection remains the second leading cause of mortality in patients with end-stage renal disease (ESRD). Despite the direct relationship between hemodialysis vascular access-related infections (HD-VARI) and both prognosis and mortality in ESRD patients, there is a paucity of researc..
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Endocrinology-metabolism / Original Article
Development of Simple Assessment tool for predict imminent risk of Fracture in Elderly women
So Young Park, Sujin Kwon, Kyoung Jin Kim, Seong Hee Ahn, Ha Young Kim, Kyoung Min Kim; the Epidemiology Committee of the Korean Society of Bone Metabolism
Korean J Intern Med. 2026;41(2):277-285. Published online March 1, 2026
Background/Aims: Previously developed fracture risk prediction models primarily estimate long-term risk and are limited in their ability to predict imminent fractures. We developed a simplified and practical model to predict the short-term fracture risk (1- to 3-year risk) in elderly Korean women.
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Gastroenterology / Original Article
Clinical features of NAAT-positive, toxin-negative Clostridioides difficile infections in South Korea
In Hyoung Choi, Chang Kyo Oh, Young Wook Cho, Young-Seok Cho
Korean J Intern Med. 2026;41(2):255-264. Published online March 1, 2026
Background/Aims: The clinical characteristics of Clostridioides difficile infection (CDI) in patients within the Asia-Pacific region who test positive on the nucleic acid amplification test (NAAT) and negative on the toxin enzyme immunoassay (EIA, hereafter referred to as “Toxin”) are uncle..
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Infectious diseases / Review
Updates on epidemiology and diagnostic tests of syphilis in South Korea
Dong Youn Kim, Ki-Ho Park
Korean J Intern Med. 2026;41(2):242-254. Published online March 1, 2026
Syphilis is a sexually transmitted disease caused by the spirochete Treponema pallidum. Recently, there has been a global resurgence of syphilis cases. In South Korea, the reported rate of syphilis steadily increased from 1.93 per 100,000 individuals in 2011 to 3.41 per 100,000 individuals in 2019. ..
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Nephrology / Original Article
Arteriovenous fistulas are associated with superior outcomes in very elderly hemodialysis patients: a nationwide cohort study
Hyung Duk Kim, Do Hyoung Kim, Hyangkyoung Kim, Hyung-Seok Lee, Seung Boo Yang, Seok Joon Shin, Hoon Suk Park; on behalf of the vascular access working group of the Korean Society of Dialysis Access
Korean J Intern Med. 2026;41(1):152-162. Published online January 1, 2026
Background/Aims: The optimal vascular access strategy for very elderly patients initiating hemodialysis (HD) remains unclear. Arteriovenous fistulas (AVFs) offer long-term benefits but may be limited due to vascular aging. This study evaluated vascular access outcomes in patients aged ≥ 80 years.
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Gastroenterology / Review
From bench to bedside: pancreatic juice as a platform for biomarker discovery in pancreatic disease
Pradeep K. Siddappa, Niwen Kong, Alice Lee, Yi Jiang, Walter G. Park
Korean J Intern Med. 2026;41(1):15-30. Published online January 1, 2026
Pancreatic juice (PJ) analysis has emerged as a promising modality for the diagnosis of pancreatic diseases, particularly pancreatic ductal adenocarcinoma and chronic pancreatitis. This review explores the role of PJ analysis in identifying biomarkers for the early detection and differentiation of p..
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Hemato-oncology / Original Article
Real-world treatment outcomes in South Korean patients with epidermal growth factor receptor-mutant non-small cell lung cancer
Young Saing Kim, Eun Young Lee, Hyun Woo Lee, Jin-Hyuk Choi, Tae-Hwan Kim, Yong Won Choi, Mi Sun Ahn
Korean J Intern Med. 2025;40(6):1029-1041. Published online October 31, 2025
Background/Aims: This study aimed to assess the real-world treatment outcomes in South Korean patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) receiving first-line (1L) EGFR tyrosine kinase inhibitors (TKIs).
Methods: We used the Health Insurance Revie..
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Endocrinology-metabolism / Original Article
Association between metabolic dysfunction-associated steatotic liver disease and the risk of thyroid cancer: a nationwide cohort study
Jeongmin Lee, Jeongeun Kwak, Min-Hee Kim, Seung-Hwan Lee, Jae-Hyoung Cho, Dong-Jun Lim, Jung Min Lee, Sang-Ah Chang, Hun-Sung Kim
Korean J Intern Med. 2025;40(5):813-822. Published online August 26, 2025
Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with various metabolic disorders; however, its relationship with thyroid cancer remains unclear. This study investigated the association between MASLD and the risk of thyroid cancer.
Methods: This retros..
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Cardiology / Original Article
Impact of guideline-directed medical therapy on the cardiac or non-cardiac death in acute myocardial infarction
Jin-Ho Choi, Dahee Hyun, Seung Ho Hur, Seung Woon Rha, Seung Jae Joo, Hyo-Soo Kim, Myung Ho Jeong; on behalf of KAMIR-NIH investigators
Korean J Intern Med. 2025;40(5):780-789. Published online August 29, 2025
Background/Aims: While the clinical effectiveness of guideline-directed medical therapy (GDMT) is well established in patients with acute myocardial infarction (AMI), its specific impact on cause-specific mortality remains unclear. This study aimed to investigate the impact of GDMT on both cardiac a..
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Pulmonology / Review
Diagnostic approach for incidental pulmonary nodules
SeungYong Park, Seoung Ju Park
Korean J Intern Med. 2025;40(5):710-724. Published online August 26, 2025
Lung cancer remains a leading cause of cancer-related mortality worldwide and is often diagnosed at an advanced stage, with poor survival outcomes. Early detection and appropriate management of incidental pulmonary nodules, frequently identified through low-dose computed tomography screening, are cr..
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Gastroenterology / Original Article
Impact of body mass index on clinical outcomes in intestinal Behçet’s disease
Daye Park, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Hee Cheon
Korean J Intern Med. 2025;40(4):606-615. Published online July 1, 2025
Background/Aims: The impact of body mass index (BMI) on the clinical outcomes of intestinal Behçet’s disease (BD) remains unclear. This study assessed the association between BMI and disease progression.
Methods: A retrospective analysis of 760 patients with intestinal BD was conducted. Patients were..
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Gastroenterology / Original Article
Submucosal saline injection and mini-probe endoscopic ultrasound to assess endoscopic resectability of colorectal subepithelial tumors
Jung-Bin Park, Ji Eun Baek, June Hwa Bae, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Dong-Hoon Yang
Korean J Intern Med. 2025;40(4):592-605. Published online July 1, 2025
Background/Aims: This study aimed to evaluate the feasibility and outcomes of mini-probe endoscopic ultrasound (mEUS) followed by submucosal saline injection (SSI-mEUS) for assessing the endoscopic resectability of colorectal subepithelial lesions (SELs).
Methods: From January 2020 to December 2023..
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Gastroenterology / Original Article
Medical disputes involving lower gastrointestinal endoscopies: cases from the Korean Medical Dispute Mediation and Arbitration Agency
Eun Hye Oh, Jeong Eun Shin, Jun Yong Bae, Yoon Suk Lee, Yehyun Park, Yong Hwan Kwon, Chang Nyol Paik, Jun Kyu Lee, Tae Hee Lee
Korean J Intern Med. 2025;40(3):404-426. Published online April 30, 2025
Background/Aims: As the number of lower gastrointestinal endoscopies and high-risk examinees increases, the incidence of adverse events associated with these endoscopies has also increased. Medical disputes and lawsuits related to adverse events are rapidly increasing.
Methods: Medical disputes rel..
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Gastroenterology / Original Article
Endoscopic features of cytomegalovirus disease of the upper gastrointestinal tract between transplant and non-transplant patients
Yuri Kim, Do Hoon Kim, Myeongsook Seo, Hee Kyong Na, Kee Wook Jung, Ji Yong Ahn, Jeong Hoon Lee, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Korean J Intern Med. 2025;40(3):394-403. Published online March 25, 2025
Background/Aims: Cytomegalovirus (CMV) disease in the upper gastrointestinal (UGI) tract frequently occurs in immunocompromised patients. However, data regarding UGI CMV disease in non-transplant patients compared with those in transplant recipients are limited. Therefore, we compared the clinical c..
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Hemato-oncology / Review
Follicular lymphoma: contemporary clinical management with a focus on recent therapeutic advances
Robert Kridel
Korean J Intern Med. 2025;40(3):371-393. Published online February 21, 2025
Follicular lymphoma (FL) is the most common type of indolent lymphoma, and the prognosis is favorable for most patients. However, FL remains generally incurable, and relapse is common. Patients are at risk of developing treatment-resistant lymphoma, particularly when early disease progression occurs..
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Infectious diseases / Original Article
Initial and peak serum levels of Krebs von den Lungen-6 for predicting the prognosis of patients with COVID-19
Geonui Kim, Hyeonwoo Kwon, Sang Hyun Ra, Euijin Chang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim
Korean J Intern Med. 2025;40(2):321-329. Published online February 21, 2025
Background/Aims: Krebs von den Lungen-6 (KL-6) is associated with prognosis in patients with COVID-19. However, there is limited data on the correlation between the prognosis of COVID-19 and varying KL-6 levels at different time points. We investigated the optimal cutoff values of the initial and pe..
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Gastroenterology / Original Article
Characteristics and outcomes of portal vein thrombosis in patients with inflammatory bowel disease in Korea
Ki Jin Kim, Su-Bin Song, Jung-Bin Park, June Hwa Bae, Ji Eun Baek, Ga Hee Kim, Min-Jun Kim, Seung Wook Hong, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Chang Sik Yu, Yong-Sik Yoon, Jong-Lyul Lee, Min Hyun Kim, Ho-Su Lee, Sang Hyoung Park
Korean J Intern Med. 2025;40(2):243-250. Published online December 23, 2024
Background/Aims: Portal vein thrombosis (PVT) frequently occurs in patients with inflammatory bowel disease (IBD), particularly when influenced by factors such as abdominal infections, IBD flare-ups, or surgical procedures. The implications of PVT range from immediate issues such as intestinal ische..
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