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Pulmonology
Proteomic differences with and without ozone-exposure in a smoking-induced emphysema lung model
Soo-Taek Uh, So-My Koo, An Soo Jang, Sung Woo Park, Jae Sung Choi, Yong-Hoon Kim, Choon Sik Park
Korean J Intern Med. 2015;30(1):62-72. Published online December 30, 2014
Background/Aims: Acute exacerbations in chronic obstructive pulmonary disease may be related to air pollution, of which ozone is an important constituent. In this study, we investigated the protein profiles associated with ozone-induced exacerbations in a smoking-induced emphysema model.
Methods: M..
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Graves’ disease presenting with acute renal infarction
Cho-Ok Baek, Kyung Ae Lee, Tae Sun Park, Heung Yong Jin
Korean J Intern Med. 2014;29(6):825-826. Published online October 31, 2014
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Hemato-oncology
Etanercept for steroid-refractory acute graft versus host disease following allogeneic hematopoietic stem cell transplantation
Joo Han Park, Hyo Jung Lee, Sei Rhan Kim, Ga Won Song, Seung Kyong Lee, Sun Young Park, Ki Chan Kim, Sun Hyuk Hwang, Joon Seong Park
Korean J Intern Med. 2014;29(5):630-636. Published online August 28, 2014
Background/Aims: The treatment for steroid-refractory acute graft versus host disease (GVHD) after allogeneic stem cell transplantation (allo-SCT) needs to be standardized. We report our clinical experience with etanercept for steroid-refractory acute GVHD.
Methods: Eighteen patients who underwent ..
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Pulmonology
The effects of secondhand smoke on chronic obstructive pulmonary disease in nonsmoking Korean adults
Woong Jun Kim, June Seok Song, Dong Won Park, Hyun Jung Kwak, Ji-Yong Moon, Sang-Heon Kim, Jang Won Sohn, Ho Joo Yoon, Dong Ho Shin, Sung Soo Park, Tae-Hyung Kim
Korean J Intern Med. 2014;29(5):613-619. Published online August 28, 2014
Background/Aims: Smoking is widely acknowledged as the single most important risk factor for chronic obstructive pulmonary disease (COPD). However, the risk of COPD in nonsmokers exposed to secondhand smoke remains controversial. In this study, we investigated the association of secondhand smoke exp..
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Gastroenterology
Crohn’s disease in Korea: past, present, and future
Kang-Moon Lee, Ji Min Lee
Korean J Intern Med. 2014;29(5):558-570. Published online August 28, 2014
The epidemiology, genetics, and clinical manifestations of Crohn’s disease (CD) vary considerably among geographic areas and ethnic groups. Thus, identifying the characteristics of Korean CD is important for establishing management strategies appropriate for Korean patients. Since the mid-2000s, m..
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Cardiology
Recent technological updates and clinical applications of induced pluripotent stem cells
Sebastian Diecke, Seung Min Jung, Jaecheol Lee, Ji Hyeon Ju
Korean J Intern Med. 2014;29(5):547-557. Published online August 28, 2014
Induced pluripotent stem cells (iPSCs) were first described in 2006 and have since emerged as a promising cell source for clinical applications. The rapid progression in iPSC technology is still ongoing and directed toward increasing the efficacy of iPSC production and reducing the immunogenic and t..
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Rheumatology
Resting energy expenditure is not associated with disease activity in women with rheumatoid arthritis: cross-sectional study
Jung-Yoon Choe, Sung-Hoon Park, Hwajeong Lee, Hyun Hee Kwon, Seong-Kyu Kim
Korean J Intern Med. 2014;29(4):516-524. Published online June 27, 2014
Background/Aims: Increased resting energy expenditure (REE) in rheumatoid arthritis (RA) patients is thought to be caused by hypermetabolism associated with production of proinflammatory cytokines. Our aim in the present study was to explore the possible association between REE and disease activity ..
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Pulmonology
Prevalence and risk factors for reflux esophagitis in patients with chronic obstructive pulmonary disease
Seo Woo Kim, Jin Hwa Lee, Yun Su Sim, Yon Ju Ryu, Jung Hyun Chang
Korean J Intern Med. 2014;29(4):466-473. Published online June 27, 2014
Background/Aims: Gastroesophageal reflux disease is one of the most common causes of chronic cough and is a potential risk factor for the exacerbation of chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the prevalence and risk factors for reflux esophagitis (RE)..
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Nephrology
Vitamin D and chronic kidney disease
Chang Seong Kim, Soo Wan Kim
Korean J Intern Med. 2014;29(4):416-427. Published online June 27, 2014
Chronic kidney disease (CKD) has been recognized as a significant global health problem because of the increased risk of total and cardiovascular morbidity and mortality. Vitamin D deficiency or insufficiency is common in patients with CKD, and serum levels of vitamin D appear to have an inverse cor..
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Gastroenterology
Diet, microbiota, and inflammatory bowel disease: lessons from Japanese foods
Takanori Kanai, Katsuyoshi Matsuoka, Makoto Naganuma, Atsushi Hayashi, Tadakazu Hisamatsu
Korean J Intern Med. 2014;29(4):409-415. Published online June 27, 2014
The incidence and prevalence of inflammatory bowel diseases (IBDs) including ulcerative colitis and Crohn disease are rapidly increasing in Western countries and in developed Asian countries. Although biologic agents targeting the immune system have been effective in patients with IBD, cessation of ..
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Acute esophageal necrosis occurring in a patient undergoing percutaneous coronary intervention
Hyung-Jin Kwon, Sang-Ho Park, Ji-Hoon Ahn, Tae-Hoon Lee, Chang-Kyun Lee
Korean J Intern Med. 2014;29(3):379-382. Published online April 29, 2014
Acute esophageal necrosis is uncommon in the literature. Its etiology is unknown, although cardiovascular disease, hemodynamic compromise, gastric outlet obstruction, alcohol ingestion, hypoxemia, hypercoagulable state, infection, and trauma have all been suggested as possible causes. A 67-year-old ..
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A case of primary aldosteronism presenting as non-ST elevation myocardial infarction
Ja Min Byun, Suk Chon, Soo-Joong Kim
Korean J Intern Med. 2013;28(6):739-742. Published online October 29, 2013
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Postinfectious Guillain-Barre syndrome in a patient with methimazole-induced agranulocytosis
Yoon Young Cho, Ji Young Joung, Hyemin Jeong, Dongmo Je, Yun Soo Hong, Sunghwan Suh, Sun Wook Kim
Korean J Intern Med. 2013;28(6):724-727. Published online October 29, 2013
Both Graves disease and Guillain-Barre syndrome (GBS) are autoimmune disorders caused by impaired self-tolerance mechanisms and triggered by interactions between genetic and environmental factors. GBS in patients who suffer from other autoimmune diseases is rarely reported, and the development of..
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Nephrology
Serum osteoprotegerin is associated with vascular stiffness and the onset of new cardiovascular events in hemodialysis patients
Jung Eun Lee, Hyung Jong Kim, Sung Jin Moon, Ji Sun Nam, Jwa-Kyung Kim, Seung Kyu Kim, Gi Young Yun, Sung Kyu Ha, Hyeong Cheon Park
Korean J Intern Med. 2013;28(6):668-677. Published online October 29, 2013
Background/AimsOsteoprotegerin (OPG) and fetuin-A are vascular calcification regulators that may be related to high cardiovascular (CV) mortality in hemodialysis (HD) patients. We evaluated the relationship between OPG, fetuin-A, and pulse wave velocity (PWV), a marker of vasc..
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Endocrinology-metabolism
Neuroprotective effects of Vitis vinifera extract on prediabetic mice induced by a high-fat diet
Heung Yong Jin, Youn Soo Cha, Hong Sun Baek, Tae Sun Park
Korean J Intern Med. 2013;28(5):579-586. Published online August 14, 2013
Background/AimsVitis vinifera grape seed extract (VVE) contains oligomeric proanthocyanidins that show antioxidant and free radical-scavenging activities. We evaluated VVE for its neuroprotective effect in prediabetic mice induce by a high-fat diet (HD).
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Nephrology
Renal outcomes and clinical course of nondiabetic renal diseases in patients with type 2 diabetes
Ja Min Byun, Cheol Hyun Lee, Sul Ra Lee, Ju Young Moon, Sang Ho Lee, Tae Won Lee, Chun Gyoo Ihm, Kyung Hwan Jeong
Korean J Intern Med. 2013;28(5):565-572. Published online August 14, 2013
Background/AimsIn several recent studies, renal biopsies in patients with type 2 diabetes and renal disease have revealed a heterogeneous group of disease entities. Our aim was to study the prognosis and clinical course of nondiabetic renal disease (NDRD) and to determine risk..
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Cardiology
Impact of family history on the presentation and clinical outcomes of coronary heart disease: data from the Korea Acute Myocardial Infarction Registry
Choongki Kim, Hyuk-Jae Chang, Iksung Cho, Ji Min Sung, Donghoon Choi, Myung Ho Jeong, Yang Soo Jang,
Korean J Intern Med. 2013;28(5):547-556. Published online August 14, 2013
Background/AimsFamily history (FHx) of coronary heart disease (CHD) is a well-known risk factor for CHD. However, the prognostic implication of FHx has not been established clearly in patients with acute myocardial infarction (AMI). MethodsIn t..
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Gastroenterology
Effects of D-002, a mixture of high molecular weight beeswax alcohols, on patients with nonalcoholic fatty liver disease
José Illnait, Iván Rodríguez, Sarahí Mendoza, Yolanda Fernández, Rosa Mas, Mirtha Miranda, Jesús Piñera, Julio César Fernández, Meilis Mesa, Lilia Fernández, Daisy Carbajal, Rafael Gámez
Korean J Intern Med. 2013;28(4):439-448. Published online July 1, 2013
Background/AimsNonalcoholic fatty liver disease (NAFLD) is intimately related to insulin resistance and ranges from a benign course to liver fibrosis and cirrhosis. NAFLD management mainly involves dietary modification and weight loss. Although no fully successful pharmacologi..
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Hemato-oncology
Clinical applications of mesenchymal stem cells
Nayoun Kim, Seok-Goo Cho
Korean J Intern Med. 2013;28(4):387-402. Published online July 1, 2013
Mesenchymal stem cells (MSCs) are self-renewing, multipotent progenitor cells with multilineage potential to differentiate into cell types of mesodermal origin, such as adipocytes, osteocytes, and chondrocytes. In addition, MSCs can migrate to sites of inflammation and exert potent immunosuppress..
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A case of polymyositis associated with Hashimoto's thyroiditis
Shi Jung Sung, Se Jin Hwang, Jong Min Kim, Young Am Lee, Ji Seon Oh, Jae Hee Suh, Seung Won Choi
Korean J Intern Med. 2013;28(3):380-382. Published online May 1, 2013
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